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Article
The Effect of Obesity on Serum Leptin and Lipid Profile

Author: Kismat Mohammad Turki
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2009 Volume: 8 Issue: 1 Pages: 27-32
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Obesity has become a leading health concern; this condition is a chronic, complex, multifactorial disease in which a person's weight is ≥ 20% of the ideal weight for a given height.OBJECTIVE:To measure serum leptin level and lipid profiles levels in Iraqi obese individuals comparing the results with matching non obese subjects.METHODS:The study was carried on 30 individuals divided into two groups:1. Obese subjects group (n=20).2. Non-obese subjects group (n=10).For all subjects studied measurements of fasting serum leptin and lipid profile have been done.RESULT:Our study showed that mean serum leptin level was significantly higher in obese than non-obese individuals (P<0.001). In addition serum leptin correlates positively and strongly with body mass index (BMI) ( r=0.765,P<0.01). Serum leptin also correlates positively with both triglyceride (TC)(r =0.394, P<0.05) and low density lipoprotein (LDL) (r=0.366,P<0.05) but correlates negatively with high density lipoprotein (HDL)(r=-0.408,P<0.05).CONCLUSION:circulating leptin levels appear to be one of the best biological markers of obesity and hyperleptinemia is closely associated with several risk factors related to obesity syndrome.

Keywords

obesity --- leptin --- lipid profile.


Article
Effect of leptin level in non insulin dependant (type 2) obese diabetic subjects

Authors: Othman G. Othman --- Maysaa J. Majeed
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2009 Volume: 51 Issue: 1 Pages: 76-80
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Determine how do obesity and type2 diabetes intertwined? and what it takes to turn an obese person into a person with diabetes. That link may help to understand why some obese people never develop diabetes while many others do.Serum sugar level was used as indicator of insulin level; leptin level was used as indicator of leptin resistance.A total of 50 obese subjects were involved in this study, 25 obese subject (BMI >30) had diabetes mellitus type 2(no insulin dependant), selected from Baghdad teaching Hospital in Baghdad /Iraq. The remaining 25 obese (BMI >30) were normal healthy individuals.Patients and Methods: ELSA technique was used for the measurement of serum leptin. Blood sugar was determined by using colorimetric method. Data were expressed as mean ± SD results and were evaluated using the student t-test for paired data. Conventional methods were used for the correlation and regression analyses.Results: Obtained results showed that the level of serum leptin in healthy obese subjects were significantly lower than that of obese diabetes subjects. , serum sugar in non diabetic obese subjects was significantly lower than obese diabetes type2 subjects.Serum leptin correlated negatively with level of serum sugar at the same time had a positive correlation with BMI in non diabetic obese group whereas level of serum leptin correlated positively with each of BMI and serum sugar in diabetic type2 group. All results are thoroughly discussed in the text.Conclusion: The present study indicates the possibility of future development of a new class of anti diabetic agents that act centrally and independent of insulin action.


Article
Leptin in Goitrous patients

Author: Feryal Hashim Rada
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2009 Volume: 8 Issue: 1 Pages: 33-35
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Objective To evaluate the relationship between serum Leptin levels and metabolic syndrome, in (obese, non-obese) control subjects, untreated hypothyroid and hyperthyroid patients. Methods A study was made on 63 goitrous patients and 25 control subjects. Body mass index (BMI) was calculated. Serum T3, T4, TSH were measured by RIA method, serum lipid profile was measured by spectrophotometric method, serum Leptin was measured by ELISA method. Results The mean serum Leptin level was significantly higher in obese than in non-obese control subjects (29.1 vs. 5.8 ngm / ml) and higher in hypothyroid patients (27.9 ngm /ml), and lowest levels in hyperthyroid patients (3.4 ngm /ml). Conclusion Leptin reduce body weight by decreasing food intake (appetite), fat deposition and increasing energy expenditure. Serum Leptin is highly correlated with the body mass index (BMI), other indices of adiposity (lipid profile) in normal obese human and hypothyroid patients.


Article
Estimation of serum leptin in female patients with nodal osteoarthritis

Author: Raid D. Hashim * MBChB د. رائد هاشم
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2009 Volume: 51 Issue: 4 Pages: 392-394
Publisher: Baghdad University جامعة بغداد

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Abstract

Summary:Background: Nodal osteoarthritis is one of the most common arthropathy worldwide, the etiology is uncertain but many biochemical markers are recognized. Many studies have shown that leptin might have a role in the pathogenesis of osteoarthritis, but little is known about the relation between serum leptin and nodal osteoarthritis. Subjects and method: 52 women with nodal osteoarthritis and 40 apparently healthy women as a control were included in the study; serum leptin was measured in all subjects. Student t-test was applied to find out the significance of difference in the mean v Results: There was a significant difference in the mean of serum leptin between patients and control groups.Conclusion: the results of the current study suggest that leptin might have a role in the pathogenesis of nodal osteoarthritisKeywords: leptin, nodal osteoarthritis, pathogenesis, Body Mass Index.

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