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Article
CD-Markers as an immunological aspect in patients with visceral leishmaniasis

Author: Jabbar R. Zangor Al-Autabbi* VM, PhD د. جبار رسن زنكور
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2009 Volume: 51 Issue: 4 Pages: 411-415
Publisher: Baghdad University جامعة بغداد

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Abstract

Summary: Back ground: Visceral leishmaniasis is an endemic protozoan disease in Iraq. Recovery from this disease confers a solid and permanent immunity. Immunological assessment of our patients was carried out and the results showed a significant reduction in the percentage of CD3, CD56 and a significant increase in the percentage of CD19 in the peripheral blood lymphocyte of VL in comparison with control group.Patients and methods: Indirect immunofluorescence technique analysis was performed to detect the percentage of CD3, CD19and CD56 positive lymphocytes.Results: Our results in the patients groups showed decrease in the percentage of CD3, CD56 and increase in the percentage of CD19. Follow up of patients after treatment showed a significant increase in the percentage of CD3, CD56, but they were still lower than their normal range . Conclusion:- CD3,CD56, were decreased in VL infection then increased after treatment but it was less than its normal range, while CD19 was increased in VL when compared with control group.Key words: CD-Markers profile, leishmania donovani, amastigote form


Article
The efficiency of Mytrus comminis and Peganum harmala plant extracts on pro and axenic amastigote stages of Leishmania donovani
كفاءة comminis Mytrus ومستخلصات نبات الحرمل Peganum على مراحل يشمانة المؤيدة وممحوضة من الليشمانيا الدونوفانية

Authors: Al-Dulimy, S.K --- Al-Bashir,N.M --- Al-Tae A.A
Journal: The Medical Journal of Tikrit مجلة تكريت الطبية ISSN: 16831813 Year: 2009 Volume: 1 Issue: 151 Pages: 93-99
Publisher: Tikrit University جامعة تكريت

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Abstract

The effect of aqueous extracts from leaves of Mytrus comminis(Mytraceae) and seeds of Peganum harmala (Zygophyllacea) were studied against the in vitro activity and growth of both Promastigote and axenic a mastigote stages of Leishmania donovani which was isolated from Iraqi patient infected with visceral leishmaniasis. The results of the study showed variation between the effect of the aqueous extract of these two plants on the inhibiting activity of the growth of this parasite in both promastigote and axenic amastigote stages. The values of the median effective dose (ED50) had shown that the promastigotes are more resistance to high concertrations of plant extract, while the axenic amastigote were more sensitive to the lower concentrations of the plant extract mentioned above and this was provided by the statistical analysis that showed significant differences at (P < 0.01) between Promastigote and axenic amastigote for the different strains and different plant extracts.

وتمت دراسة تأثير مستخلص المائي من أوراق comminis Mytrus (Mytraceae) وبذور الحرمل Peganum (Zygophyllacea) ضد النشاط في المختبر، ونمو كل من المشيقة وممحوضة 1 مراحل mastigote من الدونوفانية الليشمانيا التي تم عزلها من المريض العراقي المصابين الحشوية داء الليشمانيات. وأظهرت نتائج الدراسة اختلاف بين تأثير المستخلص المائي لهذه النباتات اثنين على تثبيط نشاط لنمو هذا الطفيل في كل من المشيقة ومراحل يشمانة ممحوضة. وقد قيم الجرعة الفعالة وسيطة (ED50) أظهرت أن promastigotes هي أكثر مقاومة للconcertrations عالية من مستخلصات نباتية، في حين أن يشمانة ممحوضة كانت أكثر حساسية لتركيز أقل من مستخلصات نباتية المذكورة أعلاه، وقدمت عن طريق التحليل الإحصائي وأظهرت أن اختلافات كبيرة في (P <0.01) بين المشيقة ويشمانة ممحوضة لمختلف السلالات وخلاصات نباتية مختلفة.

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