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Article
Serum Magnesium Concentration in Patients with Leukemia and Lymphoma

Authors: Munaf S. Daoud --- Ali Y. majid** --- Wafa M. Merza
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2009 Volume: 51 Issue: 1 Pages: 101-104
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Leukemias and lymphomas are malignant disorders that occur in the blood forming organs and lymphoid tissue respectively. They are classified to types and several subtypes such as acute or chronic, lymphocytic or myelocytic and T-cell or B-cell lymphocytic for leukemias and histologically into Hodgkin’s and Non-Hodgkin’s for lymphomas. Literatures do not contain many research work on magnesium in patients with these disorders, although this mineral is essential for many metabolic, enzymic, regulatory and immune reactions in the human body. Therefore, the present study was aimed to evaluate the level of magnesium in the sera of patients with different types of leukemia and lymphoma. Patients and Methods: Fifty five patients with leukemia and lymphoma and twenty five healthy controls were studied. The patients were attendants of Baghdad Teaching Hospital and Pediatric Teaching Hospital from September 2006 to January 2007. The diagnosis was confirmed by examination of both peripheral blood, lymph node biopsy and/or bone marrow examination. Patients were categorized according to French-American-British Criteria. Thirty five patients with ALL, one with CLL, six with AML, three with CML, three with HL and seven with NHL. Venous blood was collected from each patient or control person and sera were obtained by centrifugation. S[Mg] was measured by Atomic Absorption Flame Spectrophotometry.Results:The Mean ± SD of S[Mg] in mg/dl of all types of leukemic and lymphomatous patients was lower than the controls. There was a high statistically significant difference (P<0.01) in patients with ALL and significant difference (P<0.05) in patients with AML and NHL and non-significant difference (P>0.05) in patients with CML and HL, compared with the control. Total patients group showed high significant difference (P<0.01) compared with control group. The mean distribution of S[Mg] among total patients indicated decreased (58.2%), normal (38.2%) and increased (3.6%) levels.Conclusion:The present study disclosed the existence of normal to decreased level of S[Mg] in patients with leukemia and lymphoma suggesting an influence of many variable factors. Although the decreased S[Mg] was statistically significant, it was still within lower normal range.


Article
Complications of High Serum Ferritin Level after Splenectomy in β Thalassemic Patients

Author: Zuhair Omran Easa
Journal: KUFA MEDICAL JOURNAL مجلة الكوفة الطبية ISSN: 1993517X Year: 2009 Volume: 12 Issue: 1 Pages: 243-250
Publisher: University of Kufa جامعة الكوفة

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Abstract

Objectives: Compare between splenectomized and non splenectomized β -thalassemic patients regarding clinical, biochemical and therapeutic characteristics. Methods: This study was conducted on 140 patients with beta thalassemia major and thalassemia intermedia, expressed as two groups (group I) splenectomized patients and (group II) non splenectomized patients, who were attending Thalassemia Center in Karbala Teaching Hospital for Children from the first of November 2007 through 30th of April 2008. Both groups were studied by physical examination, biochemical analysis, hemoglobin level, serum ferritin, hepatitis C virus antibodies, and hepatitis B surface antigen. Echocardiography was done for most of patients. Results: In group I patients, 82.9% were under transfused and 80% were underchelated, whereas 91.4% of group II patients were under transfused and 74.3% of them were underchelated. Complications including, cardiac complications, diabetes mellitus, bone deformities, and gall stone were higher in group I than group II patients, moreover, only bone deformities was detected in β- thalassemia intermedia patients of both groups. Splenectomy was beneficial in reducing frequency of blood transfusion in 77.1% of group I patients. Conclusions: There is an aggravating effect of splenectomy on hemosiderosis. High serum ferritin level in splenectomized patients is associated with higher incidence of complications.


Article
PATHOLOGICAL CHANGES OF ACUTE TOXICITY INDUCED BY ORAL ADMINISTRATION OF MALATHION IN PIGEONS
التغيرات المرضية للتسمم الحاد الناتج عن تجريع الحمام بالمالاثيون

Author: Harith, A.N. حارث عبد الله نجم
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2009 Volume: 8 Issue: 2 Pages: 65-77
Publisher: Basrah University جامعة البصرة

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Abstract

The objective of the present study was to investigate the pathological changes of the acute toxicity of Malathion as organophosphorus insecticide in wild pigeons (Rock dove). Liver enzyme Alanine Transaminase (ALT) in the serum of treated pigeons was measured. The maximum tolerated dose of malathion was 3.525mg / kg B.W. However, when the maximum tolerated dose of the malathion was given to group A, two out of eight pigeons died within two hours after treatment .The insecticide caused clinical signs appeared within two hours before death, they included salivation, lacrimation , gasping, frequent defecation, drooping of wings, tremors, convulsion and recumbancy. Also the histopathological changes of the acute toxicity of present study included vacculation of nerve fibers in the spinal cord and sciatic nerve, meningitis associated with lymphocytic infiltration in the brain, myocardial fibrosis, aggregation of lymphocytes and hepatic septal fibrosis. Cortical fibrosis with inflammatory cells, regenerating renal cortical tubules and dilated cortical tubules were also seen. Compared to control values the exposure to insecticide caused increase of the ALT level in the serum for treated pigeons, and this increment was significant. In conclusion Malathion insecticide administered orally at maximum tolerated dose induced clinical signs of poisoning, pathological changes in different organs of pigeons and increased the ALT value.

إن هدف الدراسة الحالية هو معرفة التأثير المرضي للمبيد الفسفوري المالاثيون في الحمام، وقياس مستوى إنزيم الالينين ترانس امينيز في مصل دم الحمام المعامل. الجرعة الأعلى التي يتحملها الطير كانت 3.525 ملغم/ كغم من وزن الجسم. أعطيت هذه الجرعة إلى مجموعة A اثنان من ثمان حمامات ماتت خلال ساعتين من المعاملة. واظهر الحمام قبل الموت علامات التسمم بعد ساعتين من التجريع والتي تتضمن، إفرازات لعابية، تدمع، صعوبة تنفس، التبرز المتكرر، تهدل الأجنحة، رعشة، تشنج واضطجاع. بينت النتائج تغيرات مرضية تتضمن تنكس الألياف العصبية للحبل ألشوكي والعصب ألوركي، التهاب الدماغ واتشاح الخلايا اللمفية، تليف عضلة القلب، تنكس حويجزي، تجمع خلايا اللمفية في الكبد، ، تليف قشرة الكلية مع تواجد خلايا التهابية,تجدد الخلايا المبطنة للأنابيب الكلوية وتوسع الأنابيب الكلوية في منطقة القشرة .كما سبب المبيد الفسفوري زيادة في مستوى إنزيم الالينين ترانس امينيز وهذه الزيادة كانت معنوية مقارنة مع مجموعة السيطرة. ان المبيد الفسفوري الحشري المعطى فمويا بالجرعة الأعلى التي يتحملها الطير يظهر العلامات السريرية للتسمم، تغيرات مرضية في عدد من الأعضاء التي تم فحصها في الحمام المعاملة بهذه المادة. و زيادة في مستوى إنزيم الالينين ترانس امينيز

Keywords

Pigeon --- Insecticide --- Serum.


Article
Early Evaluation of Serum Albumin Level in Pediatric Burned Patients

Authors: Kadhum J. A. Shaba'a --- Hasan Th. Ghanem --- Suhad R. Majeed
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2009 Volume: 2 no.8, 9 Issue: 5 Pages: 681-686
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: Burn patients are unique in that not only do they reduce albuminsynthesis in response to trauma, but also they experience accelerated albuminlosses into their wound dressings and soft tissue.Methods: Serum albumin has been determined in 26 children with age rangedbetween (l-14) years and with total body surface area of burn (11-60%) during theirinitial few weeks of care. Their serum albumin levels were estimated at second day,seventh day and fourteenth day after burn. Intravenous albumin was administered byinfusion of 1-2 g/kg/d when plasma Albumin fell bellow 2 g/100ml. or bellows 2.5g/100ml in the presence of enteral feeding intolerance or pulmonary dysfunction,their further results were excluded.Results: The mean plasma Albumin was 3.062 g/100ml) at day 2 , 2.952 g/100mlat day 7 and 2.45 g/100ml at day 14 . The relationship between the surface area ofburn and albumin concentration was not significant, (r = - 0.1111406). The valueof albumin was found to be 0.752 g/dl under the normal average value (p< 0.005).Conclusion: Hypoalbuminemia is usual in pediatric burned patients especiallyafter 7 -14 day of the accident, the period of high risk of septic complications.Keywords: Serum albumin, Hypoalbuminemia, Burn


Article
SERUM PROTEINS IN RICKETS PATIENTS AND THEIR MOTHERS

Author: Suad Y. Al-Kass
Journal: AL-TAQANI مجلة التقني ISSN: 1818653X Year: 2009 Volume: 22 Issue: 2 Pages: 35-40
Publisher: Foundation of technical education هيئة التعليم التقني

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Abstract

This research is mainly concerned with study of changes of serum total protein, albumin & globulin in rachitic patients and their mothers. Effect of order of the baby in his/her family, feeding type, skin pigmentation and the stage of the disorder for infants were studied. Also the number of siblings breast fed, socioeconomic state and lactation effect for their mothers were studied. The results showed a decrease in albumin as order of the baby increased, increase in total protein, albumin and globulin in those infants fed human milk in addition to other type of food, total protein and globulin decreased in black skin pigment patients and albumin decreased in severe cases of rickets. In mothers, the results indicate a decrease in total protein and a significant decrease in globulin was observed as parity increase, a significant decrease in globulin in mothers of good socioeconomic state and no effect of lactation was observed.

يتضمن البحث قياس البروتين الكلي والالبومين والكلوبيولين في مصل الدم لمرضى الكساح وامهاتهم. ثم تم دراسة تغيرهذه المتغيرات حسب تسلسل الطفل في العائلة ونوع الغذاء الذي يتناوله ولون الجلد ودرجة الاصابة بالمرض عند الاطفال. اما بالنسبة للامهات فقد تم دراسة تاثير عدد الاطفال الذين ارضعتهم وتاثير الحالة الاقتصادية وتاثير الرضاعة. اوضحت نتائج الدراسة على مرضى الكساح, انخفاض الالبومين مع زيادة تسلسل الطفل في العائلة, زيادة البروتين الكلي والالبومين والكلوبيولين عند الاطفال الذين يتغذون على حليب الام بالاضافة الى انواع اخرى من الاغذية. كذلك لوحظ انخفاض البروتين الكلي والكلوبيولين عند المرضى ذوي صبغة الجلد الغامقة وانخفاض الالبومين في الحالات الحادة من مرض الكساح. اما بالنسبة للامهات فقد اوضحت النتائج انخفاض في البروتين الكلي وانخفاض معنوي في الكلوبيولين مع زيادة عدد الاطفال الذين ارضعتهم وانخفاض معنوي في الكلوبيولين عند الامهات ذوي الحالة الاقتصادية الجيدة واخيرا لوحظ عدم وجود تاثير للرضاعة


Article
Threshold sensitivity of taste perception and the role of saliva and Zinc level in some physiological & pathological conditions

Authors: Tahani A. Al-Sandook --- Wasan M. Al-Omary --- Taghreed F. Zaidan
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2009 Volume: 51 Issue: 1 Pages: 90-94
Publisher: Baghdad University جامعة بغداد

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Abstract

Summary:
Background: Decreased taste acuity to the four basic tastes is closely related to health problems (diseases & medications), aging, and smoking. This study aimed to determine taste detection and recognition thresholds to the four basic tastes in some physiological and pathological conditions, determine saliva flow rate, serum and saliva zinc levels in these groups.
Objective and Methods: The study includes 218 individuals (35–80) years old divided into six groups; the control, aging (subjects over 60 years), smokers, diabetics, haemodialysis patients and hypertensive patients on chronic use of captopril.The taste detection and recognition thresholds of sweet, salty, sour and bitter tastes, saliva flow rate were determined. Zinc concentration was assessed in serum and saliva spectrophotometricaly.
Results: The results showed a significant increase in the taste detection and recognition thresholds of the four basic tastes of all groups than in the control, except the salty taste thresholds of the haemodialysis group and the salty taste detection threshold of the diabetics.
Saliva flow rates, serum and saliva zinc levels decreased significantly at p<0.001 in study groups as compared to the control group.
Conclusions:The taste acuity was impaired in aged subjects, smokers, diabetics, haemodialysis patients, and hypertensive patients on chronic use of captopril.
Decreased saliva flow rate and saliva zinc concentration could be causative factors for hypogeusia.


Article
The Inhibitory Effect of Gallic Acid on Human Serum Cholinesterase

Authors: Methal A. Ali --- Mohamed J.Al-Azzaw --- Sabah M.K. Al-Shafi
Journal: Iraqi Journal of Pharmaceutical Sciences المجلة العراقية للعلوم الصيدلانية ISSN: 16833597 Year: 2009 Volume: 18 Issue: 1 Pages: 33-37
Publisher: Baghdad University جامعة بغداد

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Abstract

The dried fruit peel of pomegranate in Punicaceae family was fractionated chromatographically on Sephadex-LH-20 column .Gallic acid (trihydroxybenzoic acid) and its related galloyl esters such as gallotannin(i.e. â-penta-O-galloyl–D-glucose) were obtained homogenously. Different concentrations of gallic acid and gallotannin were used to determine their inhibitory effect on human serum cholinesterase. The enzyme activity was measured according to the method reported by the WHO .The inhibitory effect of these compounds on the activity of human serum cholinesterase have been studied in vitro .The inhibitory effect was remarkably clear with increasing concentration of gallic acid .Whereas galloyl ester showed no inhibitory effect. The inhibition with gallic acid indicates a noncompetitive pattern. Therefore, we can not recommended gallic acid and its related compounds , as preservative substances in food industry or in pharmacological preparations since they might have some side effect on certain biological systems.

تم فصل بعض المركبات من القشور الجافة لثمرة الرمان من العائلة الرمانية( Punicaceae family) بواسطة العمود السائل اللوني الحاوي على مادة السفادكس ألـ20.و تم الحصول على مادتين متجانستين هما حامض الكاليك ( trihydroxybenzoic benzoic acid ) وأحد مركبات أسترات الكالوليل التابعة له وهي مادة الكالوتانين(β-penta –O-galloyl –D-glucose ) . أن تأثير حامض الكاليك و الكالوتانين لم تدرس بشكل واسع على فعالية ألأنزيمات. استخدمت تراكيز مختلفة من حامض الكاليك والكالوتابين لقياس تأثير تثبيطهما على مصل الكوليستريز( (cholinesterase البشري . أن فعالية هذا الإنزيم تم قياسها طبقا لطريقة منظمة الصحة العالمية ( (WHO.. هذه الدراسة اختيرت لتقييم فعالية هذه المركبات مختبريا على مصل الكوليستريز البشري لزيادة معرفتنا حول الفعاليات البيولوجية . أن تأثير تثبيط هذه المركبات جدير بالملاحظة مع زيادة بتراكيز حامض الكاليك بينما لم يلاحظ أي تثبيط معنوي لمادة الكالوتانين . وأن التثبيط بحامض الكاليك تكشف بأنه غير تنافسي بطبيعته .لذلك لا نستطيع أن نوصى بحامض الكاليك والمركبات التابعة له كمواد حافظة في الصناعات الغذائية أو في التحضيرات الصيدلانية نظرا" لاحتمال احتوائها على بعض التأثيرات الجانبية على بعض الأنظمة البيولوجية .


Article
Effect of Cement Pollution on some Biochemical Parameters in the Blood Serum of Hamam AL-Alil Cement Factory Workers
تأثير ملوثات الأسمنت على بعض المتغيرات الكيموحيوية في دم عمال معمل سمنت حمام العليل

Author: Haitham L. Al-Hayali هيثم لقمان الحيالي
Journal: Rafidain journal of science مجلة علوم الرافدين ISSN: 16089391 Year: 2009 Volume: 20 Issue: 2 E Pages: 19-28
Publisher: Mosul University جامعة الموصل

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Abstract

Long time exposure to cement industry pollution leads to several health problems. This study was designed to investigate the effects on 55 workers which were divided into groups according to the departments of Hamam AL-Alil Cement Factory-Iraq. The biochemical parameters included in the study are: calcium, zinc, lactate dehydrogenase, alkaline phosphatase, acid phosphatase, glutathione and malonaldehyde. The results showed that there was a significant increase in calcium, lactate dehydrogenase, alkaline phosphatase, acid phosphatase and malonaldehyde in workers serum which increased with increasing exposure time. The results also showed a significant decrease in glutathione and zinc in workers serum which increased with increasing exposure time in all factory department.

إن التعرض المستمر لملوثات صناعة الاسمنت يؤدي إلى العديد من المشاكل الصحية. لذلك صممت الدراسة للبحث في تأثير هذه الملوثات على 55 عامل والذين تم توزيعهم إلى مجاميع حسب مواقع عملهم في معمل سمنت حمام العليل- العراق. تناولت الدراسة قياس عدد من المتغيرات الكيموحيوية مثل الكالسيوم، الزنك، اللاكتيت ديهايدروجينيز الفوسفاتيز القاعدي، الفوسفاتيز الحامضي، الكلوتاثيون والمالونالديهايد.أظهرت النتائج بأن هنالك زيادة معنوية في كل من مستوى ايونات الكالسيوم وأنزيمات اللاكتيت ديهايدروجينيز والفوسفاتيز القاعدي والفوسفاتيز الحامضي والمالونالديهايد مع انخفاض معنوي في مستوى الكلوتاثيون وايونات الزنك في مصل دم العاملين مع ازدياد فترة التعرض.


Article
SPECTROPHOTOMETRIC DETERMINATION OF HUMAN SERUM ALBUMIN BY A HOME-MADE SEMI-AUTOMATED
التقدير الطيفي للآلبومين في مصل الدم البشريبأستخدام نظام حقن جرياني محلي الصنع شبه آلي

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Abstract

The bromcresol green method was applied for spectrophotometric determination of albumin by using a home-made semi-automated flow injection in some pharmaceutical preparation with recoveries of 98.5-102 % and 54 serum samples of male and female patients in the range 32.48-51.25 g/L.The method is convenient, simple and sensitive with detection limit (2x noise) 0.625 g/L. The r.s.d % is 0.74 % for 8 measurements of 40 g/L albumin.

تم التقدير الطيفي للآلبومين بطريقة بروموكريسول الأخضر بأستخدام جهاز تحليل حقن جرياني محلي الصنع في المستحضرات الصيدلانية و بأستعادية 98.5- 102% وكذلك في مصل دم الذكور و الآناث بمدى 32.85-51.25 غم/ لتر. اثبتت الطريقة بأنها مناسبة و بسيطة و حساسة و بحد كشف 0.625 غم / لتر و انحراف معياري قياسي 0.74 % لثماني قراءات من محلول 40 غم / لتر البومين.


Article
The Influence of Body Weight on the Serum Sialic Acid Levels in Lymphoma Patients

Authors: Dafer A. Faysel --- suaad L. Ibraheem
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2009 Volume: 2 no.8, 9 Issue: 5 Pages: 623-629
Publisher: Kerbala University جامعة كربلاء

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the a prospective study of the effect of body weight of 70 patients withlymphoma on the levels of serum sialic acid forms, total sialic acid, boundsialic acid, free sialic acid and lipid sialic acid were measured. The resultswere compared with those obtained from control groups which consisted of 50 personof matched age and sex.Objective: To determine the influence of body weight on the serum sialic acid forms.Methods: The patients were categorized into four groups according to the certainstatistical methods. The first group comprised 24 patients who have weight 5-20Kgrange. The second group comprised 13 patients who have weight 21-40Kg range. Thethird group comprised 12 patients who have weight 41-60Kg range. The fourth groupcomprised 21 patients who have weight >60Kg.Results: Significant elevations (P<0.005) of total sialic acid, bound sialic acid, freesialic acid, and lipid associated sialic acid (TSA, BSA, FSA, and LSA respectively)levels were seen in all groups of lymphoma patients when compared with those of thehealthy subjects. Total serum protein was decreased significantly (P<0.005) andTSA/TP, BSA/TP, FSA/TP, and LSA/TP ratios raised significantly (P<0.005) in thecancer patients in comparison with those of the healthy individuals.Conclusion: Sialic acid is not specific marker for detecting lymphoma patients.Keywords: Body weight, lymphoma patients, serum sialic acid

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