research centers

Search results: Found 1

Listing 1 - 1 of 1
Sort by

The Possible Cytoprotective Effects of Antioxidant Drugs (Vitamin E and C) Against the Toxicity of Doxorubicin in Breast Cancer Patients

Authors: Anmar H. Kashkool * MSc --- May S. Al-Sabbagh** MSc --- Dawser K. Al-Kashali*** PhD --- Kudair .J.Al-Rawaq**** DMRT خضير الرواق
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2009 Volume: 51 Issue: 1 Pages: 95-100
Publisher: Baghdad University جامعة بغداد


Background: Breast cancer is the culmination of a multi-step process that occurs over a period of severalyears or decades and as a cause of death, is a salient "free radical" disease. Aim: The present study aimson investigating the possible protective role of antioxidant drugs (vitamins E and C) to cardiac cellsagainst the oxidative stress induced damage during doxorubicin chemotherapy in patients with breastcancer.Patients and methods: Thirty two patients with different stages of breast carcinoma attending to BaghdadTeaching Hospital and ten healthy control subjects with age range between (29-61) years, mean(43.6±1.37) were included in this study. The patients were randomized into 3 groups, they were treatedwith either doxorubicin alone 60 mg/M² every 21 days, doxorubicin 60 mg/M² every 21 days +vitamin E800IU/day for 42 days or a combination of vitamins E 800IU/day and vitamin C 1000mg/day for 42 days+ doxorubicin 60 mg/M² every 21days. The oxidative stress and cardiac function parameters wereevaluated before starting treatment and after 21 and 42 days respectively including assessment of serumlevels of MDA, creatine kinase and lactate dehedrogenase activities.Results: Using doxorubicin alone produce an elevation in the markers of oxidative stress and cardiacdamage that can be reduced when antioxidant drugs vitamin E alone or a combination of vitamin E andvitamin C being added.Conclusion: Antioxidant drugs, vitamin E or a combination of vitamins E and C when co-administeredwith the antineoplastic drug doxorubicin reduces its cytotoxicity on cardiac cells in breast cancer patients.Key words: Breast cancer, Doxorubicin, Vitamin E, Vitamin C, MDA, Cardiotoxicity

Listing 1 - 1 of 1
Sort by
Narrow your search

Resource type

article (1)


English (1)

From To Submit

2009 (1)