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Article
Relation between Serum Leptin, Lipid Profiles and other biomarkers levels in patients with type 2 diabetic nephropathy
علاقة مستوى اللبتين مع شاكلة الدهون وبعض المتغيرات الكيمياحياتية في مصل دم مرضى السكري من النمط الثاني المصاحب بأعتلال الكلى

Authors: Sahar Abdul W- Shaban سحر عبد الواحد شعبان --- Esam Noori Al-Kirwi عصام نوري --- Khitam Abdul W. Ali ختام عبد الوهاب
Journal: Baghdad Science Journal مجلة بغداد للعلوم ISSN: 20788665 24117986 Year: 2010 Volume: 7 Issue: عدد خاص بمؤتمر العلمي النسوي 1 Pages: 678-686
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: In advanced diabetes mellitus, serum levels of the most hormones are altered due to several interplaying mechanisms.Objective: To assess the relation of serum leptin and lipid profile in type 2 diabetic nephropathy.Patients and Method: Serum leptin levels and its relation to lipid profile were estimated in 62 patients with type 2 diabetic nephropathy attending the National Diabetes Center in Al- Mustansiriya University, and (26) healthy individuals considered as control group. The diabetic patients were classified into three groups, (24) pathients with normoalbuminuria (21) patients with microalbuminuria and (17) patients with macroalbuminuria.Fasting plasma glucose, serum creatinine, Hb A1c %, lipid profile (Total cholesterol, LDL- Cholesterol, HDL- Cholesterol and Triglyceride) and urinary albumin, were measured to establish the possibility of using these biomarkers as a supplementary to serum leptin to be a diagnostic test for type 2 diabetic nephropathy.Results: Serum leptin levels showed a significant elevation in microalbuminuria (20.08± 4.50 ng/ml) and macroalbuminuria groups (22.35± 6.89 ng/ml) as compared to nondiabetic normal control group (10.64 ± 3.17 ng/ml). There was no significant differences observed in serum leptin levels between the normoalbuminuria group (13.96 ± 5.73 ng/ml) and healthy controls, but a significant positive differences were noticed in the levels of fasting plasma glucose, serum creatinine, Hb A1c% and lipid profile in the three patient groups in comparison with the control group. While no significant correlation was observed between these biomarkers levels and serum leptin values.Conclusion: It might be concluded that serum leptin levels were elevated in type 2 diabetic patients with microalbuminuria and macroalbuminuria, suggesting that renal leptin degradation is impaired in early stage of kidney damage and this impairment increase with the progression of this disease. Leptin hormone may consider according to these results as a risk factor for progression of kidney disease in diabetic patients.

1-( المقدمة) : في المراحل المتقدمة لمرضى السكري يحدث تغير في مستويات معظم الهورمونات نتيجة لتداخل ميكانيكية التفاعلات الحيوية المختلفة.2- (هدف البحث) : دراسة العلاقة بين مستوى اللبتين مع شاكلة الدهون لدى مرضى السكري من النمط الثاني المصاحب بأعتلال الكلى.3- (طريقة البحث) : تم قياس مستوى اللبتين وعلاقته مع شاكلة الدهون في مصل (62) مريض يعانون من مرض السكري النمط الثاني والمصاحب بأعتلال الكلى والذين حضروا الى مركز السكري في الجامعة المستنصرية.وشملت الدراسة كذلك (26) شخص سوي (كمجموعة ضابطة) لغرض المقارنة.قسمت اعداد المرضى الى ثلاثة مجاميع (24) مريض (نسبة تركيز البومين البول الى الكرياتين اقل من 30 ملغم/ غم ) كمجموعة اولى ، (22) مريض (نسبة تركيز البومين البول الى الكرياتين يتراوح بين 30-300 ملغم/ غم) كمجموعة ثانية ، اما المجموعة الثالثة فتضمنت (17) مريض (نسبة تركيز البومين البول الى الكرياتين اكثر من 300 ملغم/غم). تم قياس تراكيز كل من الكرياتين ، شاكلة الدهون والتي تشمل (الكوليسترول الكلي ، كوليسترول البروتينات الدهنية واطئة الكثافة ، كوليسترول البروتينات عالية الكثافة وثلاثي الكليسرول) في مصل الدم مع قياس تركيز البومين البول كمتغيرات كيمياحياتية مساندة لامكانية اعتماد قياس مستوى هرمون اللبتين في مصل الدم كفحص مختبري مساعد في تشخيص مرضى السكري النمط الثاني المصاحب لاعتلال الكلى.4- (النتائج) : مستوى اللبتين اظهر زيادة واضحة في مصل دم المجموعة الثانية للمرضى (4.50 ± 20.08 ng/ml ) وكذلك في مصل دم المجموعة الثالثة (6.89 ± 2.35 ng/ml ) مقارنة بالمجموعة الضابطة (3.17 ± 0.64 ng/ml ) بفرق ذي دلالة احصائية (P< 0.05 ) ولم يلاحظ فرق احصائي موجب في مستويات هرمون اللبتين بين المجموعة الاولى من المرضى (5.73 ± 13.96 ng/ml ) والمجموعة الضابطة ، ولوحظ ان هناك فرق احصائي موجب (P< 0.05 ) في مستوى الكلوكوز ، الكرياتين في مصل الدم ، الهيموكلوبين وكذلك عند مقارنتها مع المجموعة الضابطة. ولم تظهر دلالة احصائية بين مستوى هذه المتغيرات الكيمياحياتية ومستويات هرمون اللبتين في مصل الدم.5- (الاستنتاج) : يستنتج ان مستوى هرمون اللبتين يرتفع بصورة واضحة عند مرضى السكري النمط الثاني المصاحب بأعتلال الكلى ، وخاصة في مراحله المتقدمة نتيجة لضعف قابلية الكلى على تجزئة هذا الهرمون وتحلله في مراحل المرض المختلفة ، وان هذا الارتفاع يزيد من تطور المرض.من نتائج هذه الدراسة يمكن اعتماد هرمون اللبتين كعامل قياس لمدى تطور وخطورة امراض الكلى.


Article
Leptin Effect in the Development of Obesity –Related Hypertension in Postmenopausal Women

Author: Waleed Kh. Hussein
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2010 Volume: 9 Issue: 2 Pages: 155-157
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Obesity in humans causes hypertension, myocardial hypertrophy and coronary atherosclerosis, and increased cardiovascular morbidity and mortality that is thought to be related to sympathetic overactivity. Leptin is an adipocyte-derived hormone that acts in the hypothalamus to regulate appetite, energy expenditure and sympathetic nervous system outflow. One of the major mechanisms leading to the development of obesity-induced hypertension appears to be leptin-mediated sympatho-activation.OBJECTIVE:This study is done to evaluate the contribution of leptin in the development of obesity related hypertension in post menopausal women.SUBJECTS AND METHODS:A total number of 64 subjects (post menopausal women) included in the study were divided into obese hypertensive group (n= 38 )and non obese non hypertensive group (n=26) , age(57+4.5year) and (56+2.7year) respectively(mean+SD).Obese hypertensive group defined as (BMI ≥ 30 kg/m2 and blood pressure ≥ 140/90 mmHg with or without history of taking anti hypertensive medications)and Non-obese non hypertensive group defined as (BMI < 30 kg/m2- blood pressure < 140/90 mmHg).In the present study leptin had been measured.RESULTS:Leptin level is higher in obese hypertensive group than in non obese non hypertensive group and it was 29.2+4 and 15.2+2.1(mean+SD) respectively and this difference is statistically significant with p value < 0.001.CONCLUSION :leptin may play a role in the development of obesity- related hypertension and may be an independent predictor of hypertension

Keywords

leptin --- obesity --- hypertension


Article
Influence of Primary Hypothyroidism on Serum Leptin Level

Authors: Aras A. Abdullah --- Abdul Hussein A. Farage --- Maryam S. Mohammad
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2010 Volume: 9 Issue: 2 Pages: 120-124
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT: BACKGROUND: Leptin is the protein product of the ob gene, secreted by adipocytes. It has been suggested that it may plays an important role in regulating appetite and energy expenditure, but beside that, little is known about the physiological actions of leptin in humans. OBJECTIVE: To evaluate a possible influence of primary hypothyroidism on serum leptin levels. METHODS: Fifty-six newly diagnosed patients with primary hypothyroidism (40 females and 16 males) and 32 normal controls matched for age, ethnic status and body mass index (BMI) were studied. Body mass index (BMI; kg/m2), thyroid function(using enzyme-linked immunoflourescent assay) and serum levels of leptin, thyroid autoantibodies (measured by enzyme-linked immunosorbant assay) and lipid profile(measured by enzymatic colourimeteric assays) were assessed in all studied subjects. RESULTS: No significant difference in serum leptin levels was recorded between hypothyroid patients and controls (16.3±14.9; 14.8 ± 12.9, P> 0.05), but women in each group had significant higher leptin concentrations than men (patients: 19.6 ±16.3 vs. 8.3 ±5.0; controls: 19.0 ±14.4 vs. 7.7 ±4.1; P< 0.05). Serum levels of cholesterol (p<0.002), LDL-cholesterol (p<0.004) and atherogenic ratio (p<0.03) were generally higher in patients than controls. The serum leptin concentration correlated positively with BMI within both patients (r=0.32; p<0.016) and controls (r=0.28; p<0.024). However, no association was demonstrated between values of serum T3, T4, TSH, triglyceride, HDL-cholesterol and thyroid auto antibodies. CONCLUSION: Circulating thyroid hormones do not appear to play any significant effect on leptin levels in patients with primary hypothyroidism.


Article
Apolipoprotein (a) as Predictive Factor in Fibromyalgia Syndrome

Authors: Mohammad H. Al-Osami محمد الوسمي --- Kismat M. Turki حكمت تركي --- Lubna M. H. Farid لبني محمد
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2010 Volume: 52 Issue: 2 Pages: 217-220
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Fibromyalgia syndrome (FMS) is characterized by widespread musculoskeletal pain with associated symptoms including stiffness, fatigue, sleep disturbance and functional impairment. FMS is depicted by chronic pain for at least three months and tender points identified by the American Collage of Rheumatology (ACR). Although several hypotheses have been developed; the cause of FMS is currently unknown.This study aims to evaluate the contribution of serum apolipoprotein (a) [Apo (a)], leptin, and serum lipid profile to the pathophysiology of FMS.Subjects & Methods: The study has included 160 patients with FMS with age range (18-72) years and 60 control individuals who were age and sex matching with FMS patients: 29 patients with chronic musculoskeletal complaints but without FMS and 31 healthy controls. Elisa technique was used for the determination of Apo (a) and leptin. Colorimetric method was used to determine serum lipid profile. BMI was measured in all subjects. Results were evaluated using descriptive and inferential statistics; data were expressed as (mean ± SEM). P value of <0.05 was accepted as significant.Results: Serum Apo (a) in FMS patients was significantly higher than healthy control group (P < 0.05). There were no significant differences among the three subject groups in serum lipid profile and leptin levels.Conclusion: Apo (a) may play an important role in FMS pathogenesis. Lipid profile and leptin have no role in FMS patients as a cause or result of this syndrome.Key words: Fibromyalgia, Apo (a), leptin, lipid profile.

Keywords

Fibromyalgia --- Apo --- a --- leptin --- lipid profile.


Article
Metabolic Syndrome and Serum Leptin Levels in Erbil Population
متلازمة التمثيل الغذائي ومستويات مصل اللبتين في أربيل

Authors: Shatha R. Mustaffa --- Ava T. Ismail --- Sanaa G. Hama AL-Mandalawi
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2010 Volume: 14 Issue: 2 Pages: 76-84
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and Objectives: Metabolic syndrome is a potent risk factor for cardiovascu-lar diseases (CVDs), has not been adequately explored in Erbil individuals and its relation to leptin hormone. The present study aim to evaluate such a relationship between serum leptin and metabolic syndrome in Erbil individuals.Methods: Samples collection were carried out in Razgary teaching hospital, 45 cases with metabolic syndrome and 30 healthy control subjects, anthropometric variables measure-ments (blood pressure, body weight, body height, body mass index) and biochemical tests: fasting, serum glucose, serum triglycerides, high-density lipoprotein cholesterol and serum leptin were obtained from the study samples.Results: Serum leptin levels were significantly higher in females in comparison to the males in metabolic syndromes group (with median 53.6 Vs 23.8 ng/dl with P value < 0.05) with also present statistical significant difference in leptin between metabolic syndrome group and control group in both males and females. No important association between se-rum leptin and each of selected criteria of metabolic syndrome. The observed case-control difference in serum leptin is mainly attributed to gender and body mass index (BMI) differ-ences and not a function of metabolic syndrome itself.Conclusions: Among subjects with metabolic syndrome, only age , gender and body mass index were important in determining the magnitude of serum leptin among cases groups.


Article
Association of Erythropoietin, Adiponectin and Leptin levels with Anemia in uremic diabetic patients (Under hemodialysis):

Authors: Tahrir E. Al-Kadium --- Munaf S. Daoud --- Salim M. Al-Rubaâe
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2010 Volume: 52 Issue: 4 Pages: 432-437
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: End stage renal disease in patients with diabetes mellitus has been called a medical catastrophe of worldwide dimensions .It was recognized that anemia is a complication of diabetes, particularly in patients with diabetic kidney diseases. The purpose of the present study is to determine whether erythropoietin, adiponectin, and leptin levels correlate with anemia in uremic diabetic patients (under hemodialysis).
Patients and Methods: The studied groups were comprised of (30) diabetic patients(9 patients with type1 and 21 type2 diabetes) with renal failure (group2) who had been under hemodialysis compared with (30) healthy controls (group1). Blood film was obtained in addition to blood tests include fasting serum glucose (FSG), glycosylated hemoglobin (A1c), insulin, urea, creatinine, uric acid, estimated glomerular filtration rate (eGFR), serum erythropoietin (EPO), Adiponectin (ADPN),and leptin.Results: It was found that uremic diabetic patients in group2(G2) had higher FSG, A1c, insulin and higher levels of urea, creatinine, uric acid and lower levels of eGFR when compared to healthy controls (P <0.05). Anemia was confirmed in the diabetic patients by Hemoglobin (Hb) and hematocrit (Hct) that were lower than healthy control (group1) (G1) (P<0.05).EPO, ADPN levels were increased in uremic diabetic patients as compared to control subjects (P <0.05). While, leptin levels were higher in type2 diabetes when compared to type1 diabetes and control subjects (group1) (P <0.05). There were positive significant correlations between (FSG and A1c), (Hb and Hct), (EPO and leptin), (EPO and Hct), (ADPN and urea). In addition there were significant negative correlations between (FSG and EPO), (A1c and leptin), (ADPN and leptin).Creatinine was negatively associated with Hb and Hct. ADPN was negatively associated with Hb in uremic diabetics.Conclusions: Anemia is a common accompaniment to diabetes, particularly in those with renal failure or under hemodialysis .Adipocytokines like leptin and adiponectin may involved with anemia in these patients. Leptin in the present study was positively associated with EPO levels (the hormone that stimulates red blood cells production in the bone marrow). ADPN was negatively associated with Hb. These elevated levels of ADPN may antagonize EPO and leptin to increase the hemopoiesis rate and Hb levels in uremic diabetic patients in addition to other factors involved with diabetes.


Article
Serum leptin level as a cardiovascular risk factor in type 2 diabetic patients
مستوى اللبتين في مصل الدم كعامل خطر قلبي وعائي عند مرضى السكري من النوع الثاني

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Abstract

Type 2 diabetes mellitus ( T2DM ) is a metabolic disease that is associated with an increased risk for atherosclerosis. Leptin is a hormone – like cytokine that is derived mainly from adipose tissue and has multiple functions. Recently, many vascular and atherogenic effects for leptin have been demonstrated. The aim was to study serum leptin level and its relationship with some cardiovascular risk factors in T2DM patients. Forty diabetic males with ischemic heart disease (IHD group), aged ≥ 40 years old, were compared with 40 diabetic males of similar ages who had no clinical history of IHD (DM group). Each main study group was divided into two subgroups according to the presence or absence of metabolic syndrome. The IHD group was also subdivided according to their clinical endpoints into stable angina pectoris (angina group), significant coronary artery disease on angiography (angiography group ) and myocardial infarction (MI group ).In addition to anthropometric measurements; serum lipid profile, thiobarbituric acid -reactive substances (TBARS) and leptin levels as well as plasma fibrinogen level were quantified .

أن السكري من النوع الثاني مرض أيضي يزيد من خطورة الاصابة با لتصلب العصيدي . اللبتين هو محرك خلوي (سايتوكين) أو شبيه هرمون يشتق في الدرجة الاساس من النسيج الدهني في الجسم وله وظائف ايضية متنوعة وكذلك تأثيرات وعائية وتعصدية تم كشفها حديثا. أن هدف هذه الدراسة هو دراسة مستوى اللبتين في مصل الدم والعلاقة مع بعض عوامل الخطر القلبي الوعائي عند مرضى السكري من النوع الثاني .تم مقارنة اربعين مريضا من الرجال مصابين بالسكري مع داء قلبي أقفاري و اطلق عليهم (مجموعة الداء القلبي الأقفاري ) و اعمارهم (≥ 40 سنة ) ، تم مقارنتهم مع اربعين مريضا من الرجال مصابين بلسكري فقط ومن نفس الفئة العمرية وليس لديهم اصابة سابقة بداء قلبي أقفاري و اطلق عليهم (مجموعة السكري) . أن كل مجموعة دراسة رئيسية قد قسمت الى مجموعتين فرعيتين اعتمادا على وجود او غياب المتلازمة الايضية كما أن مجموعة الداء القلبي الأقفاري كذلك قسمت الى ثلاثة مجاميع فرعية وهي : مجموعة الذبحة الصدرية ومجموعة قصور الشريان التاجي و مجموعة احتشاء العضلة القلبية.تم قياس مرتسم شحوم مصل الدم ومؤشرفوق اكسدة الشحوم (TBARS) كدالة للاجهاد التاكسدي وهرمون اللبتين واخيرا مكون الليفين في البلازما كدالة للالتهاب،بالاضافة الى قياسات جسم الانسان.

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