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BIOCHEMICAL CHANGES IN PATIENTS WITH HYPERTHYROIDISM
التغييرات الكيموحيوية لدى المرضى المصابين بفرط افراز الغدة الدرقية

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Abstract

This study is an attempt to investigate the biochemical changes caused by hyperthyroidism. It has been carried out on the sera of (106) Patients diagnosed with hyperthyroidism collected during their attendance to the endocrinology department, Tikrit teaching hospital – Tikrit and Kirkuk general hospital – Kirkuk / Iraq, compared with (50 ) samples of normal individuals used as control. The results indicated that the rate of hyperthyroidism is the highest among the age group (40-50) years old. Calcium, Phosphorus, and Potassium serum levels increase, while the level of Sodium remains within the normal range. Total Cholesterol, Triglycerides, LDL, VLDL and HDL levels decrease. Deficiency in the level of total protein and Albumin has been detected in patients with hyperthyroidism.

استهدفت هذه الدراسه التحري عن التغييرات الكيموحيويه التي تحصل نتيجة الاصابه بفرط افراز الغده الدرقيه. تمت هذه الدراسه باستخدام مصل الدم ل ( 106) من المرضى المشخصين باصابتهم بفرط افراز الغدة الدرقية الذين راجعوا قسم الغدد الصماء في مستشفى تكريت التعليمي- مدينة تكريت ومستشفى كركوك العام-كركوك / العراق , كما تم اختيار 50 شخصاً طبيعياً كمجموعة سيطرة . بينت النتائج بأن معدل الاصابة بمرض فرط افراز الغدة الدرقية كان الاعلى في المجموعة العمرية ( 40 – 50 سنة ) كما اظهرت النتائج زيادة مستوى الكالسيوم و الفوسفور , والبوتاسيوم وكان مستوى الصوديوم ضمن الحدود الطبيعية .اظهرت نتائج هذه الدراسه ايضا انخفاض مستوى الكوليسترول والكليسرايد الثلاثي ومستويات الدهون البروتينية LDL,VLDL &HDL , كذلك وجد نقص في مستويات البروتين الكلي والزلال عند الاشخاص المصابين بفرط افراز الغده الدرقيه .


Article
Serum Enzyme Activities in Human Thyroid Diseases

Authors: Maysoon Mohammad Najeeb Mohammad Saleem, --- Arieg Abdul Wahab Mohammad --- Majid Syki Jabir
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2010 Volume: 9 Issue: 4 Pages: 549-554
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:The study enrolled a total of 76 patients with thyroid gland diseases, hyperthyroidism andhypothyroidism. The activities of the enzyme amylase, gamma glutamyltransferase and alkalinephosphatase were evaluated in these diseases state and were compared with normal healthy thyroidgland. The specimens were obtained from different hospitals in Baghdad and from routine clinicalworks.OBJECTIVE:Diagnosis of patients with thyroid gland diseases hyper and hypothyroidism by evaluation ofenzymes activity of amylase, GGT and ALP.METHOD:Two groups of patients were used: The first consists of 38 patients with hyperthyroidism, thesecond consists of also 38 are patients with hypothyroidism. Twenty five of each group wasinvestigated for amylase, GGT, ALP and were compared with third group of 25 normal healthythyroid gland. The remaining 13 out of 38 patients of each group were tested for enzymes,amylase, GGT, ALP, GOT, GPT and evaluate the hormones, they were compared with third groupof 10 normal healthy thyroid gland.RESULTS:There was a highly significant increase and decrease in the activity of amylase, GGT and ALP inhyper and hypothyroidism patients (P<0.001) when compared with third group normal.CONCLUSION:Diagnosis of patients with thyroid gland diseases can be confirmed by enzymes investigation inblood serum and hormonal assay

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