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Article
Long Term Complications of Type 1 Diabetes Mellitus in Children and Young Adults

Authors: Munib Ahmed Alzubaidi --- Esraa Majid Mutashar --- Numan Nafie Hameed
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2010 Volume: 9 Issue: 1 Pages: 21-24
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Diabetes mellitus is a common chronic metabolic syndrome characterized by impaired metabolism of glucose; morbidity and mortality come from acute metabolic derangement and from long term complications that affect small and large vessels.OBJECTIVE:The assessment of the long term complications of diabetes mellitus in children and young adultsPATIENTS AND METHODS:The study included 150 patients with type1 diabetes mellitus attending the diabetic clinic of Children Welfare Teaching Hospital who were assessed for the presence of long term complications of diabetes mellitus.RESULTS:The total number of the sample was 150 patients with male to female ratio of 1:1.2 with median age of 12.2 years.Long term complications occurred in 26.7% of patients; (75%) of them had diabetes for more than 5 years. These complications include eye complications (retinopathy and cataract) 12.6%, Renal complications (albuminuria, oedema, and hypertension) 10.6%, peripheral neuropathy 4.6%, limited joint mobility 6.6%, and short stature 17.3%.CONCLUSION:Long term complications were found in significant number of patients with type I diabetes mellitus which can occur in children with short duration of diabetes, and their frequency increases significantly with increasing duration of diabetes.


Article
Correlation between Serum Sialic Acid Level and frequent risk factors of Diabetic Retinopathy

Author: Nada F. Rashid ندى فيصل
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2010 Volume: 52 Issue: 4 Pages: 449-452
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Diabetic retinopathy is an important complication of diabetes mellitus. It is supposed that elevated sialic acid in diabetes mellitus plays an important role in diabetic retinopathy. This study investigated serum total sialic acid levels related to glycemic control, blood pressure, retinopathy, and serum lipid level in diabetic retinopathy patients.Patients & Methods: Type 2 diabetic patients aged (56.47±10.68) years were recruited for the study. Fasting venous blood samples were collected from 132 diabetic subjects of whom 79 without retinopathy and 53 were diabetic with retinopathy. All the blood samples were processed for serum total sialic acid (TSA), fasting serum glucose (FSG), HbA1c, and lipid profile. Systolic and diastolic blood pressure was recorded by standard mercury sphygmomanometer.Results: Serum (TSA), FSG, HbA1c, triglycerides (TG), and LDL-cholesterol were increased significantly (P<0.01 for TSA, FSG, HbA1c; P<0.05 for TG, and LDL) in patients with diabetic retinopathy (DR) compared to diabetics without retinopathy. Duration of diabetes and blood pressure were also significantly higher in DR patient compared to those without retinopathy. Correlation analysis showed a significant positive correlation between serum TSA and several risk factors of diabetic retinopathy: diabetic duration, FSG, HbA1c, systolic blood pressure SBP, diastolic blood pressure DBP, and LDL in diabetic patients with retinopathy.Conclusion: It is concluded that elevated serum total sialic acid level is strongly associated with the presence of diabetic retinopathy, a microvascular complication of diabetes. Increasing concentration of sialic acid is clinically correlated with several risk factors of diabetic retinopathy including glycemic control (blood sugar and HbA1c), hypertension, and duration of diabetes, triglycerides, and LDL. These findings strengthen the hypothesis that the increase in serum sialic acid is early manifestation of diabetic retinal disease.Keywords: Type 2 diabetes, sialic acid, diabetic retinopathy, risk factors

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