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Article
The Role of IL-1 and Tumor Necrosis Factor-α in Pathogenesis of Rheumatoid Arthritis

Authors: Eman Sh.Al-Obeidy --- Shatha F. Abdullah
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 2 Pages: 161-165
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Rheumatoid Arthritis (RA) is a common chronic inflammatory and destructive arthropathy that cannot be cured.Interlukin-1 (IL-1), IL-6 and tumor necrosis factor (TNF- α) are the key cytokines that drive inflammation in the disease.OBJECTIVE:The study was established to shed light on the possible role of IL-1 and TNF- α in pathogenesis of RA.PATIENTS AND METHODS:Rheumatoid Factors (RF),TNF-α and IL-1 were detected by Enzyme-Linked Immunosorbent Assay (ELISA) .C-reactive protein(CRP) on the other hand has been detected by using latex agglutination kit in the serum of 50 Iraqi patients with RA in comparison with 50 healthy individuals.RESULTS:Significant high levels of IL-1and TNF- α were observed in RA patients sera with P-value ( 0.04 and 0.001) respectively compared to healthy control group, in addition a positive linear association was found between the concentration of IL-1and TNF- α and CRP with P-value ( 0.05 and 0.001) respectively.CONCLUSION:IL-1and TNF- α play a role in pathogenesis of RA


Article
H. Pylori Infection in Iraqi patients with ischemic heart diseases

Authors: Basil. N. Saeed ايمان العبيدي --- Eman Sh. AL-Obeidy
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2011 Volume: 53 Issue: 1 Pages: 29-31
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Cardiovascular diseases are among the most common cause of death in Developed countries. In addition to traditional risk factors for cardiovascular disease, nowadays, accumulating evidence indicates that a variety of infectious agents may contribute to pathogenesis of ischemic heart disease.Patients and methods: 125 patients (25 females and 100 males) attending the department of cardiology, Baghdad, teaching hospital over the period December 2008- June 2009were enrolled. Their age range between (39-75 years) compared with 50 healthy individuation (Age & sex matched).The sera were tested for H. pylori antibodies using enzyme linked immunosorbent assay (ELISA).Results: 80% of patients showed the anti-H. Pylori IgGs (P < 0.05). But there were no significant association between risk factors & H. pylori infection (P > 0.05).Conclusions: These findings raise the possibility that exposure to H. pylori may lead to increased risk of coronary artery disease independent of other risk factors.Keywords: coronary artery disease, Helicobacter pylori, RAO

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