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Article
The relationship between bcl-2, and p53 protiens in transitional cell carcinoma of the bladder
العلاقة بين بروتين Bcl- 2 و P53 في امراضية سرطان المثانة الانتقالي

Authors: Amina Y. Abd Ullateef أمنة يوسف --- Dina W. Abed دينا وائل --- Wasan A. Bakir وسن عبد الاله
Journal: Iraqi Journal of Cancer and Medical Genetics المجلة العراقية للسرطان والوراثة الطبية ISSN: 20786123 Year: 2011 Volume: 4 Issue: 1 Pages: 1-6
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Transitional cell carcinoma (TCC) of the bladder in patients has historically a favorable prognosis. Bcl-2 and p53genes are implicated in cell cycle regulation with roles on programmed cell death. Presence of nuclear accumulationof p53 and cytoplasmic accumulation of bcl-2 were proposed to confer a growth advantage to tumor cells. In this study,we investigated the roles of p53 and bcl-2 as prognostic factors in TCC of bladder.Method: Investigated 25 patients with transitional cell carcinoma (TCC) and 27 patients with cystitis (control group) forthe expression of Bcl-2 and P53 by immunohistochemical staining with specific monoclonal antibodies.Results: Bcl-2 was significantly expressed in TCC compared to those with cystitis (control). Moreover, P53 was significantlyexpressed in TCC compared to those with cystitis (control). A significant positive correlation between these twoparameters in Tcc.Conclusions: These observations detect that increased the expression of Bcl-2 and P53 in TCC play a potential role inthe development of bladder cancer.

الهدف : قياس مستوى تعبير بروتين Bcl-2 وp53 لمرضى سرطان المثانة الانتقالي .
الطريقة : استخدمت طريقة التحليل الكيميائي المناعي لكشف وتحديد مستوى بروتين Bcl-2 ,p53 في المقاطع النسيجية المطمورة في البرافين والتي تم الحصول عليها من 25 مريضا مصابا بسرطان المثانة الانتقالي Tcc )) والمجموعة الثانية تشمل 27 مريضا مصابا بالتهاب المثانة حيث اعتبروا محموعة سيطرة. النتائج : التحليل الكيميائي المناعي لمستوى بروتين Bcl-2 يزداد زيادة معنوية في حالة سرطان المثانة الانتقالي عن مجموعة السيطرة . ومستوى تعبير بروتين الp53 يزداد ايضا معنويا مقارنة مجموعة السيطرة .وهناك ارتباط موجب بين BCL-2 و P53 .
الاستنتاج : بروتينات لBcl-2 ,P53 تلعب دورا مهما في مرضى سرطان المثانة الانتقالي وان تعبير Bcl-2 يرتبط ارتباطا موجبا مع تعبير 53P .

Keywords

Bcl-2 --- P53 --- TCC --- IHC. --- Bcl-2 --- P53 --- TCC --- IHC.


Article
Immunohistochemical study of BCL-2, PCNA and VIMENTIN markers in oral and laryngeal squamous cell carcinoma (Comparative study)

Authors: Shaimaa F. Muhsin شيماء محسن --- Kadhim A. Alsodani كاظم السوداني
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2011 Volume: 23 Issue: special issue Pages: 82-86
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Squamous cell carcinoma (SCC) may arise in any stratified squamous epithelium or muosa that hasundergone squamous metaplasia. The aims of the study were immunohistochemical evaluation and comparison ofPCNA, BCL-2 and VIMENTIN expressions in oral and laryngeal squamous cell carcinoma and correlating suchexpressions with the clinicopathological behavior in both sites.Materials and Methods: This study was performed on thirty formalin-fixed, paraffin-embedded pathologicallydiagnosed oral and laryngeal SCC blocks for the period of June 2006 till July 2010.Age, sex, site and histologic gradeswere recognized. The samples were immunohistochemically stained with monoclonal antibodies toBCL-2, PCNA andVIMENTIN.Results: The age of the patients with squamous cell carcinoma of the oral cavity was between 40 and 86 andbetween 32 and 66 years in larynx. The male/female ratio was 10/5 and 8/7 for oral and Larynx respectively. Themajority of the cases of Oral squamous cell carcinoma were located on the buccal mucosa, Whereas Laryngealsquamous cell carcinoma cases were distributed on glottic mainly..No significant statistical difference in the age andgender between the two groups .Histological grading was recognized for each case of oral and laryngeal squamouscell carcinoma. Two thirds of the oral cases were well differentiated. While 8 of the fifteen cases were moderatelydifferentiated SCC. Regarding histological grading there was no statistically significant difference between the twogroups .PCNA expressed in 14 of the fifteen oral cases whereas in laryngeal, 12 cases were positive. Collectively, 9 ofthe 30 cases were positive for vimentin antibody with different score values,.Bcl-2 was expressed in one case onlyfrom fifteen immunostaining laryngeal cases and all the oral squamous cell carcinoma cases were negative Nosignificant relationship in immunoexpression of he above markers between the tow groups.Conclusions: The results of this study proved that the biological behavior namely the PCNA, VIMENTIN and BCL-2activities was comparable between SCC of the oral cavity and larynx with a spectrum of clinical behavior, due tothe differences in location

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