research centers


Search results: Found 2

Listing 1 - 2 of 2
Sort by

Article
Lipid Peroxidation and Oxidative Stress in Patients with Fibromyalgia Syndrome

Authors: Halla G. AL-Gebouri --- Zuhair AL-Mashhadani --- Mohammad H. AL-Osami* --- Kisma M. Turki
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 1 Pages: 101-105
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACK GROUND:Fibromyalgia (FMS) is a common, chronic widespread pain syndrome usually associated with other somatic and psychologic symptoms including fatigue, sleep disturbances, cognitive difficulties Oxidative stress means an alteration in the delicate balance between free radicals and the scavenging capacity of antioxidant enzymes in favor of free radical in the body system.OBJECTIVE:To evaluate and compare the antioxidants and lipid peroxidation in patients with fibromyalgia and healthy control.PATIENTS AND METHOD;The study has included sixty patients with FMS (40 females and 20 males) and thirty healthy subjects. The subjects were selected from people attending the out patients clinic in Medical City- Baghdad Teaching Hospital- Rheumatology& Rehabilitation Consultation Unit. Laboratory parameters included: uric acid,albumin,caeruloplasmin,total thaiol,malondiaaldehyde(MDA) and peroxinitrate(ONOO¯ ).RESULTS:MDA and uric acid levels in serum of patients with fibromyalgia were significantly higher than in the control group. While the levels of ONOO¯ GSH,CP,albumin in serum of patients with fibromyalgia were significantly lower than in healthy control.CONCLUSION:oxidative stress may have a role in the pathophysiology of fibromyalgia syndrome.

Keywords

lipidperoxide --- ONOO¯ --- GSH --- CP --- uricacid --- albumin --- fibromyalgia.


Article
Oxidative stress in schizophrenia

Author: Ahmed M. Issa, Hafidh M. Frhan, Laith A. Younis
Journal: KUFA MEDICAL JOURNAL مجلة الكوفة الطبية ISSN: 1993517X Year: 2011 Volume: 14 Issue: 2 Pages: 41-46
Publisher: University of Kufa جامعة الكوفة

Loading...
Loading...
Abstract

The present study was conducted to verify the oxidative stress status in schizophrenia. Malondialdehyde, reduce glutathione, superoxide dismutase, and vitamin C levels were measured in sera of seventy schizophrenic patients and thirty healthy individuals. The statistical analysis (student`s t-test) showed a significant (p<0.005) increase of malondialdehyde (MDA) while a significant (p<0.005) decrease in reduce glutathione (GSH) also a significant (p<0.005) decrease in superoxide dismutase and a significant (p<0.005) decrease in vitamin C levels in schizophrenic patients when compared with those of the control group. The evaluation of sex differences effect on oxidative stress in schizophrenic patients show a significant (p<0.025) increase in MDA but a significant (p<0.005) decrease in GSH and a significant (p<0.025) decrease in SOD in female in comparison to male groups. According to the symptoms of schizophrenia show there are a significant (p<0.05) increase in MDA in positive symptom when compare to negative symptoms while a significant (p<0.005) decrease in SOD and GSH in negative symptom when compare to positive symptoms The results indicate that schizophrenia is associated with oxidative stress. And it appears that when the case gets worse the oxidative stress parameters will dependently changes. So schizophrenia is a sever psychiatric disorder and since there is an evidence that an excessive free radicals production or oxidative stress may be involved in the pathophysiology of schizophrenic patient. So that the excess quantities of ROS that are produced by schizophrenic patients may overcome the host antioxidant defenses and cause oxidative stress.

تم تصميم الدراسة الحالية لتقصي التغيرات في حالات الإجهاد التأكسدي عند مرضى الفصام . فقد تم تقدير مستويات (MDA, SOD, GSH and vitamin C) في أمصال المرضى ومجموعة السيطرة . أظهر التحليل الإحصائي باستعمال ( student`s t-test) وجد زيادة ملحوظة (p<0.005) في مستوى MDA)) مع نقصان ملحوظ p<0.005)) في مستويات GSH, SOD and vitamin C)) لدى مرضى الفصام عند مقارنتها مع مثيلاتها في مجموعة السيطرة. ولتقييم اختلاف الجنس وتأثيره على حالة الإجهاد التأكسدي على مرضى الفصام فقد أظهرت النتائج زيادة ملحوظة(p<0.025) في (MDA)و لكن هنالك نقصان ملحوظ (p<0.005) في (GSH) و نقصان ملحوظ(<0.025) في (SOD) في الإناث مقارنة بالذكور.إما بالنسبة لعلاقة الإجهاد التأكسدي بأعراض المرض أظهرت النتائج زيادة ملحوظة (p<0.05) في (MDA), بالنسبة للمرضى (positive symptoms) مقارنة بالمرضى (negative symptoms) بينما هنالك نقصان ملحوظ(p<0.05) في (SOD) و(GSH) بالنسبة للمرضى (negative symptoms) مقارنة بالمرضى (positive symptoms) . النتائج توضح إن هناك دور لمرض الفصام في زيادة حالة الإجهاد التأكسدي. و انه بازدياد حالة الفصام سوء فان متغيرات الجهاد التاكسدي تتغير تبعا لذلك.

Listing 1 - 2 of 2
Sort by
Narrow your search

Resource type

article (2)


Language

English (2)


Year
From To Submit

2011 (2)