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Article
Increase serum leptin level in Helicobacter pylori infection in Iraqi gastritis patients

Author: Sana’a Khudhur سناء خضر
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2011 Volume: 7 Issue: 2 Pages: 74-77
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: H.pylori colonized gastric mucosal epithelium will virtually develop gastritis and had the capacity to persist for decades. Pathogenesis is dependent upon strain, virulence host genetic susceptibility, and environmental cofactors. Leptin is a member of the class 1 cytokine family so altered leptin production during ifnect and inflammation that leptin part of the cytokine cascade ,which orchestrates the defense mechanism. Objective: Examin the effect of H.pylori infection on serum leptin level. Methods: One hundred and thirty(130) Patients attending the Endoscopic Unit at "Gastroenterology and Hepatology Teaching Hospital/ Baghdad Medical City"were included in this study with ages range from 18 years to 65 years are the source of specimens to undergo oesophageal gastroduodenoscopy (OGD) compared with twenty healthy control the study began from April 2009 to the end of March 2010 were eligible for this study.Tow types of samples were taken, biopsy for rapid urease test and histopathological examination to detect H.pylori and blood sample for estimation of serum leptin by ELISA test. Results: The results show significant increase in serum leptin concentration(P<0.001)in gastritis patients caused by H.pylori compared with patients control and healthy control. Conclusion: Increase of serum leptin concentration explained the role of leptin in the immune response to H.pylori infection that leptin consider as member of cytokine.

Keywords

Leptin --- H.pylori --- gastritis


Article
Helicobacter Pylori Seropositivity and Acute Myocardial Infarction

Author: Wathiq K. Abdul-Gafour واثق عبد الغفور
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2011 Volume: 7 Issue: 2 Pages: 9-15
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Acute myocardial infarction (AMI) is one of the most common diagnoses in hospitalized patients. The stimulus that initiates the acute inflammatory process in AMI has not been identified. Conventional risk factors account only for approximately half of the patients with clinically apparent atherosclerosis which can leads to AMI. Recently a potential link between infectious agents and atherosclerosis has been suggested Objective: To find a possible association between Helicobacter pylori (H. Pylori) infection and AMI. Method: We studied the prevalence of anti-H. pylori antibodies in 94 patients who were admitted with the diagnosis of AMI and a similar number of healthy individuals who were age and sex matched. This was done using ELISA technique. Results: Overall prevalence of anti-H. pyroli antibodies in patients with AMI was 82.9% whereas the prevalence in the control group was 78.7% . This difference yielded an odd ratio of 1.317. Chi square test shows that this difference was insignificant statistically (p-value 0.458) Conclusion: We feel that our results do not support the hypothesis which stated that chronic infection with H. pylori is a major risk factor for AMI.


Article
The Role of Some Medicinal Plants in the Management of Peptic Ulcer

Author: Faruk H. Al-Jawad فاروق الجواد
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2011 Volume: 7 Issue: 2 Pages: 51-58
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Plants used in folk medicine for the treatment of peptic ulcer diseases is a very promising approach to overcome the limitations of classical medicines. Aim: To explore the efficacy of medicinal plants, namely turmeric, garlic and marshmallow, in eradication of H. pylori. Methods: This prospective study was carried out on 225 of well-known dyspeptic patients who were divided into four groups; a control group (received classical medical therapy) and three other groups that received one of the three medicinal plants, plus the same therapy used in the control group. The follow up was done by using a questionnaire form, endoscopic examination, and determination of serum levels of anti H.pylori antibodies & gastrin by using ELISA test. In addition, liver enzymes were monitored by using spectro-photometer to prove the safety of medicinal plants. Results: The rate of recurrence of peptic ulcer disease was decreased in patients who received the combined therapy when compared to the patients in control group. Medicinal plants were effective in decreasing the recurrence of H. pylori infection when each one of them was used in combination with the medical therapy without causing harmful effects on the liver. Conclusion: Turmeric, garlic & marshmallow are effective in management of peptic ulcer with low cost.


Article
Increase serum IL-8 Level in Iraqi Patients with Helicobacter Pylori CagA Genotype Infection

Authors: Sanaa Khudhur --- Jasim Karhoot* --- Jassim AL-Khafaji --- Jasim Mohsin*
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 1 Pages: 120-124
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:More than half of all humans are colonized in their stomachs by Helicobacter pylori . That carriage was nearly universal among adults in developing countries suggests that in earlier times most humans carried these organisms.H. pylori was an important human pathogen that causes gastritis and is strongly associated with gastric ulcers, gastric adenocarcinomas, and mucosa-associated lymphoid tissue lymphomas. In response to H. pylori, interleukin-8 (IL-8) was secreted from host cells to attract components of the innate and adaptive immune systems to the site of infection.CagA+ cells induce higher levels of the proinflammatory IL-8 cytokine. That such effects are specific for CagA island genes had been shown by our study.OBJECTIVE:To determine the role of incidence of H.pylori CagA positive strain in induce higher level of the proinflammatory cytokine IL-8.METHODS:One hundred and fifty(150) Patients attended the Endoscopic Unit at"Gastroenterology and Hepatology Teaching Hospital/ Baghdad Medical City"were included in this study with ages range from 18 years to 65 years . The source of specimens to undergo oesophageal gastroduodenoscopy (OGD) collected from April 2009 to end of March 2010 were eligible for this study.Two types biopsy of samples for histopathology to detect H.pylori and detection of CagA gene by In Situ hybridization(ISH) and blood samples for estimation of serum IL-8 level by ELISA.RESULTS:There was a significant increase in IL-8 serum levels that P<0.05 due to the significant increase of Cag A in H.pylori positive strains.CONCLUSION:Our study revealed that increased in CagA expression in H.pylori positive strains and induced higher levels of the proinflammatory cytokines

Keywords

h.pylori --- IL-8 --- cag A.


Article
Helicobacter Pylori positivity in Children with Recurrent Abdominal Pain and possible Risk factors

Author: Dr. Shaker K. Gatea C.A.B.P; D.C.H أ.م.د. شاكر كريم گاطع
Journal: KUFA MEDICAL JOURNAL مجلة الكوفة الطبية ISSN: 1993517X Year: 2011 Volume: 14 Issue: 2 Pages: 78-84
Publisher: University of Kufa جامعة الكوفة

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Abstract

OBJECTIVE: To assses the association of H -pylori infection and recurrent abdominaal pain in children.Material and methods: The association of H -pylori infection and recurrent abdominal pain were studied in 44 children, aged 4-12 yrs. Using stool antigen test (HpSA) and serlogical identification of IgG by ELISA. 26 children without RAP were subject for HP identification also as acontrol group. Cases with specific causes for abdominal pain were excluded from the study.Information about demographic ,socioeconomic, envirometal living state were obtained to lable possible risk factors. High percentage (85%) of HpSA and sero positive children with abdominal pain had complete symptomatic relief after eradication of organism.Results: High percentage (64%) of children with recurrent abdominal pain show positivite result for H-pylori stool antigen test and IgG identification in comporism with asymptometc children (46%).Conclusion: There is apossible association of H –pylori infection and recurrent abdominaal pain in children and these patients should be consider for H –pylori eradication.

هدف الدراسة : لتقييم علاقة الاصابة بالجرثومة الحلزونية وألام البطن المتكررة عند الاطفال .طريقة العمل: تم فحص 44 طفلا يعانون من الام البطن المتكررة وخاصة في المنطقة الشرسوفية و26 لا يعانون من نفس الاعراض (كونترول) أعمارهم مابين ال4 سنوات وال12 سنة وخلال فترة 9 أشهر, تم الفحص بواسطة البحث عن المضادات الخاصة بالجرثومة الحلزونية في مصل الدم والمستضد في الخروج, دونت معلومات عن هؤلاء الاطفال تخص الحالة الاجتماعية والاقتصادية ومعلومات تخص السكن والعمر والجنس والازدحام في السكن.النتائج:أوضحت الدراسة ان نسبة الاطفال الذين يعانون من امراض البطن المتكررة والمصابون بالجرثومة الحلزونية (64%) بينما النسبة في الاطفال الذين لا يعانون من الام البطن هي (46 %) , وان انتشار هذه الجرثومة يتأثر عكسيا مع الحالة الاقتصادية والاجتماعية بينما تزداد نسبة الاصابة مع العمر .الاستنتاجات: أوضحت الدراسة ان هناك احتمال علاقة بين الام البطن المتكررة عند الاطفال والاصابة بالجرثومة الحلزونية وهؤلاء الاطفال يجب ان يعرضون للبحث عن الاصابة بالجرثومة الحلزونية ومن ثم اعطاء العلاج اللازم لاستئصالهاالكلمة المرجعية: الجرثومة الحلزونية, والام البطن المتكررة

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