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SELENIUM LEVEL IN LICHEN PLANUS AND IN PSORIASIS AND ITS RELATION TO CHRONICITY AND SEVERITY OF BOTH DISEASES

Author: Nadheer A. Matloob نظير احمد مطلوب
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2011 Volume: 9 Issue: 1 Pages: 11-17
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background: Lichen planus characterized by its violaceous color most commonly seen on the flexor surfaces of the upper extremities, the genitalia and the mucous membranes. Psoriasis is a common, chronic, relapsing, inflammatory skin disorder with a strong genetic basis. Plaque type of psoriasis is the most common. Selenium is a component of the enzyme glutathione peroxidase, and is important in protection against damage by peroxides and free radicals.Objectives: To measure selenium level in Iraqi patients with lichen planus and in patients with psoriasis and its relation to the chronicity and the severity of both diseases.Methods: One hundred twenty patients were included in this study, 68 males and 52 females, with ages between 18-54 years. Full history and examination, including dermatological examination, were done for all patients. The patients were divided into three groups. The first group includes lichen planus patients, the second group includes psoriasis patients and the third group was a control group study. Serum selenium level was measured for all patients by spectrophotometer.ResultsSerum selenium level was decreased in 20 (50%) patients of the first group, in 32 (80%) patients of the second group and 14 (35%) of the third group. The results were of high statistical significance when compared between groups 2 & 3 but it was insignificant when compared between groups 1 & 3. Selenium level was decreased in 12 of the first group who had the disease for two years and above while it was decreased in 18 of the second group who had psoriasis for two years and above, selenium level was decreased in patients with severe and diffuse variants of both lichen planus and psoriasis.Conclusion: Serum selenium level was decreased in both lichen planus and psoriasis but it was more significant in psoriasis and this decrease was related to both chronicity and severity.Keywords: Selenium, Lichen planus, Psoriasis, Chronicity, Severity.


Article
SERUM COPPER, ZINC AND OXIDATIVE STRESS IN PATIENTS WITH PSORIASIS

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Abstract

Background: Psoriasis is a chronic inflammatory skin disease characterized by well-demarcated erythema and scaly plaques. The pathogenesis of psoriasis still remains unclear. An increased reactive oxygen species (ROS) and insufficient antioxidant activity associated with the pathogenesis of psoriasis lesions.Objective: To evaluate the link between oxidative stress parameters and some trace elements like zinc (Zn) and copper (Cu) ions with the pathogenesis of psoriasis disease.Method: Fifty patients with psoriasis were included in this study, 32 patients with localized psoriasis, and 18 with general psoriasis, another fifty healthy controls were included in this study. We measured serum malondialdehyde (MDA), super oxide dismutase (SOD), vitamins E and A, and Zn and Cu in patients and control subjects.Results: Serum MDA in total psoriasis patients (1.8±0.2 nmol/ml) was significantly higher than those of control (0.6±0.19 nmol/ml; p<0.001). The SOD activity (9.1±1.0 U/ml) in serum of total psoriasis patients was significantly lower than that of controls (10.8±0.3 U/ml). serum vitamin A and E patients (56.8±3, 9.0±1.0 µg/ml respectively) were significantly lower than control (59.0±1.3, 9.7±0.9 µg/ml correspondingly p<0.0001), for trace elements the level of Zn in serum patients (79.0±9.1µg/ml) was significantly lower than control (83.3±5.8 µg/ml), while for Cu statistically significant higher levels were noted in patients (111.8±14.2 µg/ml) as compared with control (106.0±9.0 µg/ml).Conclusion: Our results suggest that lipid peroxidation of cellular membrane of keratiocytes by free radicals and decreased antioxidants may associate the pathogenesis of psoriasis lesion. In addition, there was a possible benefit of an enriched diet or of a supplement of vitamins A, E and Zn in treatment of psoriasis diseases.Key words: Psoriasis, Zinc, Copper, Oxidative Stress, malondialdehyde, super oxide dismutase


Article
Serum lipid profile in Psoriasis: a controlled study

Author: Ahmed Abdul-Aziz Ahmed. احمد عبد العزيز
Journal: The Medical Journal of Tikrit University المجلة الطبية لجامعة تكريت ISSN: 18131638 Year: 2011 Volume: 1 Issue: 171 Pages: 38-42
Publisher: Tikrit University جامعة تكريت

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Abstract

Psoriasis is an inflammatory dermatosis that is characterized with hyperproliferation of keratinocytes and inflammatory infiltration in the epidermis and dermis. The high prevalence of atherosclerosis has been reported in psoriatic patients. High serum lipid level has been suggested in the pathogenesis of this phenomenon. In this study, our purpose was to compare the lipid profile in psoriatic patients with non-affected persons. This study was designed and conducted as a case-control assay with 19 patients in the first group and24 cases as control groups. The lipid profile, including serum level of triglyceride, cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL), were assessed in both groups. The patient group consisted of 19 (6 male and 13 female )and control group consisted of 24cases (11 male and 13 female). The serum triglyceride, and LDL was significantly higher in psoriatic patients (P < 0.05).
CONCLUSION: This study, like previous assays, shows that high serum lipid level is significantly more common in psoriasis. This fact may be responsible for higher prevalence of cardiovascular accident in psoriatic patients. It may be useful to do early screening and treatment of hyperlipidaemia in psoriasis to prevent the atherosclerosis and its complications.

الصدفية هو مرض جلدي التهابي التي تتميز مع المفرط لمن الخلايا الكيراتينية وتسلل التهابات في البشرة والأدمة. تم الإبلاغ عن ارتفاع معدل انتشار مرض تصلب الشرايين لدى مرضى الصدفية. وقد اقترح ارتفاع مستوى الدهون في الدم في التسبب في هذه الظاهرة. في هذه الدراسة، وكان هدفنا للمقارنة بين الدهون لدى مرضى الصدفية مع المنظمات غير الأشخاص المتضررين. وقد تم تصميم هذه الدراسة والتي أجريت على أنه فحص الحالات والشواهد مع 19 مريضا في المجموعة الأولى and24 الحالات باعتبارها مجموعات المراقبة. وجرى تقييم الوضع الدهون، بما في ذلك مستوى مصل الدهون الثلاثية والكوليسترول والبروتين الدهني منخفض الكثافة (LDL)، والبروتين الدهني عالي الكثافة (HDL)، في كل من المجموعتين. وتألفت المجموعة المريض من 19 (6 من الذكور والإناث 13)، وسيطرة مجموعة تتألف من 24cases (11 من الذكور والإناث 13). كانت الدهون الثلاثية في الدم، والكولسترول أعلى بكثير في المرضى الذين يعانون الصدفي (P <0.05). الخلاصة: هذه الدراسة، مثل فحوصات السابقة، تبين أن ارتفاع مستوى الدهون في الدم بشكل ملحوظ أكثر شيوعا في مرض الصدفية. قد يكون هذا الواقع تكون مسؤولة عن ارتفاع معدل انتشار حادث القلب والأوعية الدموية لدى مرضى الصدفية. قد يكون من المفيد للقيام الفحص المبكر والعلاج من مرض الصدفية في hyperlipidaemia لمنع تصلب الشرايين ومضاعفاتها.

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