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Article
Efficacy of Azithromycin in Comparison with Metronidazole in the Treatment of Chronic Periodontitis

Author: Jawna’a K Mammdoh
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2011 Volume: 11 Issue: 2 Pages: 323-330
Publisher: Mosul University جامعة الموصل

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Abstract

Aims: The aim of this study was to evaluate the clinical effects of systemic azithromycin as an adjunct to scaling and root planning (SRP) and compared it with metronidazole in the treatment of chronic per-iodontitis. Materials and Methods: Forty four patients with clinical diagnosis of chronic periodontitis underwent scaling and root planing were divided into three groups. The first group (n = 20) patients received azithromycin 500 mg once daily for 3 days plus SRP. The second group (n= 11) received met-ronidazole 500 mg 3 times daily for 7 days plus SRP. The third control group (n= 13) patient received SRP plus placebo treatment once daily for 3 days. Clinical measurement including gingival index, bleeding on probing and probing pocket depth were performed at the base line visit and 40 days after taking the treatment. Results: The results obtained at 40 days from the base line showed better signifi-cant improvement in all clinical parameters (p≤ 0.05) in the treated groups, except for bleeding on probing in control group were no significant improvement was reported. Azithromycin plus SRP give the greatest improvement in mean gingival index and bleeding on probing (p< 0.05) when compared with the control group but no significant differences were observed between metronidazole treated group and the control group. Conclusions: The adjunctive use of azithromycin with SRP has potential to improve periodontal health over SRP only and could be an interesting alternative to metronidazole from patients with chronic periodontitis


Article
Bacteriological and immunological study of aggressive periodontitis in Mosul

Authors: Alaa M. Altaei --- Mahmoud Y.M. Taha
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2011 Volume: 11 Issue: 3 Pages: 207-214
Publisher: Mosul University جامعة الموصل

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Abstract

Aims of the study: to isolate and identify microorganisms causing aggressive periodontitis, and to estimate the changes in the levels of IL-1, TNF- and CRP in serum as well as to determine peroxidase activity in saliva of patients with aggressive periodontitis. Materials and Methods: This study was carried out on total number of 40 (35 patients with aggressive periodontitis, 18 females and 17 males aged between 16-35 years and 5 control group between 20-30 years old). Samples were taken from the lesion for bacteriological study. Serum and saliva were collected and ELISA test was performed. Results: The bacteriological results showed that A. actinomycetemcomitans was the most prevalent bacteria in aggressive periodontitis, followed by facultative anaerobic. The serological and biochemical studies showed that interleukin-1 was significantly elevated in the study group while tumor necrosis factor was not, whereas peroxidase enzyme activity and C-reactive protein were also highly significant elevated in the study group. Conclusion: Actinobacillus actinomycetemcomitans was the major etiologic bacteria of this disease as well as significantly high levels of, CRP, peroxidase activity and IL-1 could be regarded as strong markers for more precise understanding the immunological aspect of this disease


Article
Detection of specific IgG and IgA anti Epstein-Barr virus in saliva of chronic periodontitis patients and healthy subjects

Authors: Wasan A. Abid Aun وسن عبد عون --- Maha Shukri مها شكري
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2011 Volume: 23 Issue: special issue Pages: 125-128
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Chronic periodontitis is an inflammatory disease that extends into the tissues supporting the teeth.Recent studies have demonstrated that various human herpesviruses especially Epstein-Barr virus (EBV) may play apart in the pathogenesis of human chronic periodontitis. This study aimed to detect anti EBV IgG and IgA in saliva ofchronic periodontitis patients and healthy control subjects by enzyme linked immunosorbent assay (ELISA) test and todetermine the differences between males and females regarding the periodontal condition and the levels of antiEBV IgG and IgA .Materials and methods: The study sample consisted of sixty chronic periodontitis patients of both gender (32 malesand 28 females) and thirty healthy control subjects of both gender (16 males and 14 females) with age ranged from30 to 50 years. Both groups without any systemic disease.Periodontal parameters used in this study were plaque index (PLI), gingival index (GI), bleeding on probing (BOP),probing pocket depth (PPD) and clinical attachment level (CAL). Unstimulated saliva samples were collected fromall subjects and examined by ELISA test for EBV IgG and IgA antibodies detection.Results: The results of the present study observed that there was no significant difference of PLI and GI betweenmales and females in chronic periodntitis patients. Concerning BOP the number of bleeding sites in females wasmore than in males. For PPD and CAL, there was increased PPD with its different scores (0, 1, 2) in males comparedwith females and there was increased CAL with its different scales (scales 0, 1, 2, 3) in males than females. Thepercentage of control group who were positive for anti- EBV IgG was (36.7%) and in chronic periodontitis was (81.7%). Concerning IgA, 40.0% of healthy group and 68.3% of chronic periodontitis patients showed a positivereaction for anti- EBV IgA .Conclusions: The present study showed that EBV Abs (IgG and IgA) were detectable in saliva from healthy individualsbut they were significantly more frequently found in saliva of chronic periodontitis patients. The present study showedthat there was no significant gender difference regarding the salivary level of anti- EBV IgG and IgA.

Keywords

chronic periodontitis --- EBV --- IgG --- IgA


Article
Periodontal treatment needs of type 2 diabetic Iraqi patients

Author: Dr. Dalia Kudier Abbas. د. داليا خضير
Journal: MUSTANSIRIA DENTAL JOURNAL مجلة المستنصرية لطب الاسنان ISSN: 18138500 Year: 2011 Volume: 8 Issue: 1 Pages: 79-85
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

AbstractPeriodontitis is a persistent bacterial infection causing chronic inflammation inperiodontal tissues. Type 2 diabetes mellitus (DM) is a common metabolic diseasethat is associated with increased prevalence and severity of periodontitis.Our aim is to evaluate periodontal treatment needs of type 2 diabetic Iraqi patientsaccording to the age and the duration of DM.One hundred and seventy one type 2 diabetic Iraqi patients were enrolled in thisstudy. Recording of gender, age, and duration of DM was done. Periodontalexamination to evaluate treatment needs (TN) was performed by using communityperiodontal index of treatment needs (CPITN), Scoring for each patient was done bydividing his mouth into six sextants.CPITN showed a variation in the distribution of the patients according to age. Inthe age category (30-39) years; code 0 and code 1 represented 23.6 % and 59.8 % ofthe sextants respectively. Concerning treatment needs, only 11.8 % of patients did notneed any treatment (TN 0). In the age category (40-49) years; code 1 was the mostfrequent code and represented 61.5% of the sextants . All patients in this age categoryneed a sort of treatment . In the age categories (50-59) years and (60-69) years; code 3represented 21.8% and 30.6% of the sextants respectively and TN3 represented 50%and 49.2% of the patients respectively. In this study, when the duration of DM is 1-5years, code 3 represented only 13.6% of the sextants and periodontal treatment needsTN3 was 26.3% of patients while code 3 reached 26% of the sextants and TN3represented 52.7% of the patients when the duration of DM was > 5 years.In conclusion periodontal treatment needs of type 2 diabetic patients became morecomplicated if the patients were older and the duration of DM was longer.


Article
Alummouth Wash as an Adjunctive Treatment in Chronic Periodontits

Authors: Dr. Hussain Auwaid. B.D.S. MSc. * د.حسين عويد --- Dr. Kadhim Jawad B.D.S. MSc. ** د.كاظم جواد
Journal: MUSTANSIRIA DENTAL JOURNAL مجلة المستنصرية لطب الاسنان ISSN: 18138500 Year: 2011 Volume: 8 Issue: 3 Pages: 328-334
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

The term of (Alum) refers to various isomorphous double sulfates composed oftrivalent and univalent metals, especially aluminum potassium sulfate, KAl(SO4)2·12H2O, Alum as a compound has been used in past to treat different oral andmedical conditions. Using of alum as a mouth wash in periodontology was notcompletely explored and only a few studies were carried out regarding this subject.This study was carried out to observe the effect of alum as an adjunctive therapy inperiodontitis.One hundred twenty patients with chronic periodontitis were randomly allocatedinto four groups. The first group treated with conventional root planing procedureusing periodontal curette. The other three groups were treated with the sameconventional procedure followed by twice a day mouth rinse with differentconcentrations of Alum solutions for three weeks after root planing. Means of PLI, GI& PD were calculated for the participants before treatment and three weeks after.Results of this research showed a significant decrease in all study parameters in allgroups with significant differences between the two different modalities of treatment.Alum solution can be a good adjunctive treatment for chronic periodontitis, butmore studies are needed on both short and long terms.


Article
Sensitivity of treponema denticola isolated from infected periodontal pockets to some mouth rinses and common antibiotic

Authors: Amera M. M. Al-Rawi --- Summaya A. S. Muhammad
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2011 Volume: 11 Issue: 3 Pages: 220-227
Publisher: Mosul University جامعة الموصل

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Abstract

Aims: Treponema denticola is one of the most important periodontal pathogens because of its high lytic enzymatic activity leading to tooth lose and its ability to invade tissues and spread via blood stream causing systemic infections, this study coming to be the first local study concerning with this anaerobic fastidious bacterium and looking at the possibility of rely on the culturing methods in determining the most preferred chemotherapeutic drugs for limiting of bacterial activity and spread, as well as investigating the range of the antimicrobial activity of some mouth rinses and number of antibiotics. Materials and Methods: 139 samples were collected from periodontal pockets with a depth of 3 mm under supervision of specialist dentitist, then placed in a reduced transport medium. The activity and effective spectrum of different concentrations for three kinds of widely used mouth rinses in the treatment of periodontal infections including Biofresh K, Biofresh F and Zak towards this bacterium was studied using sensitivity test methods, furthermore, the minimum inhibitory cocentration of antibiotics amoxillin, ciprofloxacin, clindamycin, azithromycin and mitronidazole was determined using antibiotic discs diffusion method. Results: The results showed that Biofresh K is the best in the term of bacterial killing as its inhibition activity continued to 1:16 dilution and when the sensitivity of T.denticola isolates to some antibiotics was tested, it was appeared that ciprofloxacin is the best causing growth inhibition with the lowest minimum inhibitory cocentration (0.0001mg), and when the synergistic effect of the tested antibiotics was studied it is becoming clear that the lowest antibiotic concentrations can cause growth inhibition when the two antibiotics (mitronidazole + ciprofloxacin) or (mitronidazole + amoxillin) are used in combination. Conclusions: It is possible to depend on culturing methods for determining the sensitivity of the bacterium T.denticola to chemotherapeutic drugs. Biofresh K is the best among the rinses under study and the antibiotic CIP is the best one with the lowest MIC and the lowest concentration of the antibiotics resulting in growth inhibition can be achieved when they are used in combination

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