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Article
Substituted Polyitaconicacid with Different Amines as Biodegradable Polymers.

Authors: Huda S.H. --- Jassem M.S. --- Firyal M.A فريال محمد علي السلامي
Journal: Journal of College of Education مجلة كلية التربية ISSN: 18120380 Year: 2011 Issue: 6 Pages: 366-377
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

New biodegradable poly itaconic acid which substituted withdifferent primary amines such as 4-aminopyridine,2-aminopyrimidine, 2-amino naphthol, amoxilline, cephalexine.All the prepared polymers were characterized by IR.,UV.Spectroscopy, thermal analysis, chemical tests, C.H.N analysis andphysical properties were studied, and the intrinsic viscosities weredetermined at 30ºC.The swelling % of the prepared polymers were calculated. Weconcluded from all the results that the inserted different units as apendant groups which enhanced the biodegradable andbiocompatible behaviors of the prepared polymers.

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Article
Preparation of Condensed Polymers of Sulfonated Aminoacids with Benzidine.
تحضير البوليمرات التكاثفية للحوامض الامينية المسلفنة مع البنزدين

Authors: Firyal M.A فريال محمد علي السلامي --- Amel A.A امل عبد الامير --- Khudheyer G.K. خضير جواد كاظم
Journal: Journal of College of Education مجلة كلية التربية ISSN: 18120380 Year: 2011 Issue: 6 Pages: 333-343
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

In this paper many new condensed polymers were synthesized from reactionof sulfonated amino acids such as histidine, alanine and asparging with benzidine. Thenew condensed polymers were characterized by FTIR and UV. spectroscopy.The physical properties were measured, and the swelling % were studied withdifferent non solvents. The intrinsic viscosity was measured by Ostwald-viscometer,using DMF as a solvent The TGA and DTA were studied. The high softening pointswere measured for all condensed polymers which have higher than 240 OC. Thecontrolled release were studied in different pH values at 37 0C.The inserted moiety units of sulfonated aminoacids could enhanced thebiocompatibility, bioactivity and biodegradability properties for these preparedbiomaterials polymers, and the incorporation of aminoacids through backbone of thecondensed polymers.

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Article
Synthesis of [ N-Ampicilline Amic acids]as Drug Polymers

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Abstract

Abstract In this paper two monomers have been prepared such as [N-Ampicilline male amic acid M1, and N-Ampicilline citraconic amic acid M2] , from reaction of ampicillin with maleic anhydride or citraconic anhydride at room temperature using dioxane as a solvent. The two new prepared monomers M1andM2 were polymerized by free radical with Azobisisobutyronitrile (AIBN) to their corresponding poly amic acids P1 and P2. Which were converted to their sodium salt polymers P3 and P4 to enhanced their solubility in water. The physical and chemical properties were studied, the prepared monomers and polymers were characterized by FTIR and UV. spectroscopy, the intrinsic viscosity was measured Ostwald viscometer at 30 0C with DMF as a solvent, the swelling % was calculated and the drug release rate was studied. Experimental results showed that the hydrolysis of ampicilline in alkaline medium was higher than acidic medium. TG and DTA and DSC Analysis were studied for P1 and P2.

الخلاصة حضر في هذا البحث المونومرات N- امبيسيلين حامض المالي اميك M1و N- امبيسيلين حامض الستراكونيك M2 . من تفاعل الامبيسيلين مع حامض الماليئك او الستراكونيك اللامائي وبدرجة حرارة الغرفة باستخدام الدايوكسان مذيبا. بلمر المونيمران المحضران M1 و M2 بالجذور الحرة باستخدام ازوبيس ايسوبيتيرونايتريلAIBN بادئا, الى البوليمرات المقابلة P1 وP2 , ثم حولت الى املاح الصوديوم للبوليمرات المحضرة P3 و P4 لتسهيل قابلية الإذابة بالماء . درست الصفات الفيزيائية للمونمرين المحضرين والبوليمرات المقابلة , شخصت بواسطة استخدام أطياف الأشعة تحت الحمراء والأشعة فوق البنفسجية وقيست اللزوجة الجوهرية باستخدام استوالد فسكوميتر بدرجة 30 مº واستخدام DMFمذيبا,وقيست كذلك درجة الانتفاخ , وقيست سرع التحرر الدوائي للامبيسيلين وكانت في الوسط القاعدي أعلى من الوسط ألحامضي ,درست التحاليل DSC ,DTA ,TG للبوليمرين P1, P2 .

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