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The relationship of Heat Shock Protein-70(HSP-70) and toxoplasmosis among women with abortion

Authors: Hanaa A.Al-Sagheer --- .Salman A.Al-Jobouri --- Baqur A. Sultan --- Dr.Kareem G.Mohammed
Journal: kufa Journal for Nursing sciences مجلة الكوفة لعلوم التمريض ISSN: 22234055 Year: 2012 Volume: 2 Issue: 2 Pages: 110-117
Publisher: University of Kufa جامعة الكوفة

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Abstract

Abstract: Toxoplasmosis is a wide spread disease in our society,moreover it plays an important role in causation of abortion in pregnant women. The present study was carried out to evaluate the role of Heat Shock Protein-70(HSP-70) in the immune response against infection with Toxoplasma gondii among women with abortion. The present study was carried out on(35) women ,all of them having abortion and proved by confirmatory tests that they have an active form of toxoplasma infection. It also included twenty apparently healthy women as a control group . The patients were between 15 to 50 years of age, blood samples were collected from them during the period between May 2010 to May 2011. The Cytokines that were measured among studied groups by ELISA technique included HSP-70,Interleukin-10(IL10) , Gamma Interferon(IFNγ) and Interleukin-12(IL-12), thereafter cytokines were remeasured after receiving complete course of treatment. The study showed a high significant increase in serum level of HSP-70 in patients with IgM seropositivity (4.138pg/ml) when compared with serum levels in control and post treated groups (1.990pg/ml , 1.015pg/ml) respectively.It was also found that there was a concomitant increase in serum level of HSP-70 and serum level of both IFNγ and IL-12 in the early stage of acute infection (19.023, 81.292) respectively.

الخلاصه: مرض داء المقوسات من الامراض الواسعة الانتشار في مجتمعاتنا ،علاوة على كونه يلعب دورا مهما في احداث الاسقاط لدى النساء الحوامل. اجريت هذه الدراسه لمعرفة دور (Heat Shock Protein-70 (HSP-70 في الاستجابه المناعيه ضد هذا المرض لدى النساء اللاتي عانين اسقاطا. تضمنت تلك الدراسه جمع عينات من دم (35( من اولئك المرضى والذي ثبت مختبريا اصابتهن بهذا المرض كما تم جمع عينات من (20) من النساء الاصحاء كمجموعه ضابطه، تراوحت اعمار من شملتهم تلك الدراسه مابين 15-50 سنه وللفتره مابين مايس 2010 و مايس 2011 وقد تم قياس مستوى HSP-70 في مصل اولئك المرضى والمجموعة الضابطه بالاضافه الى قياس مستوى السايتوكاين العاشر((Interleukin-10،السايتكاين الثاني عشر (IL-12 ) والكاما انتفيرون( Gamma Interfeon ,IFNγ ) واخيرا تم قياسهن بعد اخذ العلاج اللازم. اظهرت نتائج تلك الدراسه زياده وبصوره معنويه في مستوى ال( HSP-70 ) في دم اولئك المرضى(pg/ml 4.138 ) في المراحل المبكره من الاصابه عند مقارنتها لمستواه في المجموعه الضابطه ومجموعة المرضى بعد اخذهم العلاج اللازم ( pg/ml1.015, 1.990pg/ml ) وعلى التوالي ،كما تبين بان الزياده في مستوى HSP-70 ترافق مع الزياده الحاصله في مستوى ( IL-12 & IFNγ ) في المراحل المبكره للمرض (pg/ml 81.2 ; 19.023 pg/ml ) وعلى التوالي.

Keywords

heat shock --- pratein --- to xoplasmasis --- women --- abortion

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