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Article
Azithomycin as an adjunctive to non-surgical treatment in comparison with doxycycline in chronic periodontitis patients: 2-months randomized clinical trial

Authors: Saif S.Saleim سيف سهام سليم --- Raghad F. Abbas رغد فاضل عباس --- Suzan Ali سوزان علي
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2012 Volume: 24 Issue: 1 Pages: 72-75
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Antibiotic therapy can be used in very specific periodontal treatment situations such as in refractorycases of periodontal disease which is found to be more prevalent in smokers. The aim of study was to asses theclinical effect of systemic use of Azithromycin and Doxycycline as adjunctive to non surgical scaling and rootplanning in patients with chronic periodontitis.Materials and methods: The study participants were 21 adult male, divided to three groups. 1n: GI treated by nonsurgical root planning with systemic intake of Azithromycin of 500 mg once daily for three days only. In GIIDoxycycline 100mg once daily was given for one week in addition to non surgical root planning while in the G III(control group) the patients were treated only by a routine scaling and root planning with out using any type of drug..The periodontal parameters used are the following:- Plaque index system(PLI) Gingival index (GI),Probing pocketdepth (PPD) and Bleeding on probing (BoP)Results: The study based on three periodontal parameters to asses the results of study, first of which is plaque indexand there was a significant low in all groups from the base line until the 4th visit while the bleeding on probing showeda highly significant difference between the groups whom take antibiotics as an adjunctive to a non surgicaltreatment and the group with out antibiotics. While for probing pocket depth the difference was only between thegroups whom take Azithromycin and control group this difference was start in the 2nd visit until the last visitConclusion: Although both treatment strategies seemed to be a successful therapy, the adjunctive use of 500 mgazithromycin systemically enhanced the clinical results

Keywords

Azithromycin --- Doxycycline


Article
Formulation of Azithromycin Suspension as an Oral Dosage Form
تحضير الازثرومايسين كمعلق فموي

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Abstract

Azithromycin is the drug of choice in the treatment of several bacterial infections, most often those causing middle ear infection, bronchitis, pneumonia, typhoid and sinusitis. It’s also effective against certain urinary tract infections and venereal diseases. This study was carried out to prepare an acceptable suspension either as dry physical mixture powder or granules to be reconstituted, through studying the effect of various type and concentration of suspending agent (xanthan gum, hydroxypropyl methylcellulose (HPMC), either alone or in combination) on the release profile of the drug. The best prepared suspension formulas (H& III) were selected depending on the dissolution profile of each formulas and then compared with the reference suspensions (Zithromax and Azi-once).The viscosity, sedimentation volume, Resuspendability and expiration date were evaluated for the chosen formulas (H&III) and compared with references Zithromax and Azi-once.The result indicated that the chosen formula – H had better dissolution rate compared with references suspensions, Also it was less viscous than them.While other chosen formula – III had lower dissolution rate compared with Zithromax and higher dissolution rate than AZi – once, also it was less viscous than both references.It was found that the dry physically mixed powder (formula – H) was more stable than the granular suspension (Formula III) since the expiration date for formula H and formula III were 3.24 and 2.7 years respectively.

الازثرومايسين هو الدواء المفضل لعلاج التهابات الجهاز التنفسي وحمى التيفوئيد هذا بالاضافة الى فعاليته في علاج العديد من امراض المسالك البولية والامراض الانتقالية . تم اجراء هذه الدراسة لتحضير معلق ثابت ( بشكل حبيبات او مسحوق جاهز للحل ) من الازثرومايسين من خلال دراسة تأثير انواع وتراكيز مختلفة من المواد المعلقة ( زاتثان كم وهايدروكسي بروبل مثيل سليلوز ) على سرعة تحرر الدواء . ان الصيغ التركيبية المختارة ( III & H) اختيرت اعتمادا على مقارنتها مع الصيغ الاخرى من خلال قياس سرعة تحرر الدواء ثم تمت كذلك مقارنتها مع التركيبة التجارية ( ازي – اونس و زثروماكس ) . كذلك تمت دراسة الكثير من الخواص الفيزيائية للصيغ التركيبية المختارة (III & H) وتتمثل بجريان المحلول، حجم المواد المترسبة،اعادة التجانس للمحلول بعد الرج وفعالية المواد الحافظة ومقارنتها مع التركيبات التجارية المرجعية ( ازي - اونس وز ثروماكس ) . وقد اظهرت النتائج ان الصيغ التركيبية التي اعطت سرعة تحرر اعلى من التركيبة المرجعية هي اقل لزوجة. وكذلك وجد ان معلق الازثرومايسين المحضر بشكل مسحوق جاهز للحل هو نوعا ما اكثر استقرارية من المعلق المحضر على شكل حبيبات حيث ان فترة انتهاء الصلاحية كانت 3.2 سنة للمسحوق و 2.7 سنة للحبيبات .

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