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Article
Evaluation of urinary secretary immunoglobulin (sIg) level in diabetic patients at Karbala city
تقويم مستوى الامينوكلوبين المناعي الافرازي في ادرار مرضى داء السكري في مدينة كربلاء

Author: SalimHussien Hassan Al-Greti سالم حسين حسن الكريطي
Journal: karbala journal of pharmaceutical sciences مجلة كربلاء للعلوم الصيدلانية ISSN: 70272221 Year: 2012 Issue: 3 Pages: 52-56
Publisher: Kerbala University جامعة كربلاء

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Abstract

This study was designed to evaluate the prevalence of urinary tract infections (UTI) and measure the levels of urinary secretaryimmunoglobulin (sIg) in diabetic patients during the period from January until November 2009. A study was included ( 64) patients with diabetes mellitus (D.M.) and (30 person diagnosed by clinician as UTI without diabetes mellitus) as control. From both groupsurine samples were collected, general urine examination (GUE),countof pus cells, urine culture for bacterial isolates and measured the levelof urinary sIg. Results shows out of (64) diabetic patients, pyuria>10 pus cells/high power field was present in( 39/64, 60.9%) cases. Out of these (39) cases, positive urine culture was seen only in (22, 56.4%) cases. Overall frequency of UTI was (34.44%) and the commonest microorganism isolated was E.coli (45.5%). Also result shows decreased significantly (p<0.01) of urinary sIg levels in D.M patients as compared with control subjects.

صممت هذه الدراسة لتقويم مدى شيوع التهاب المجاري البولية وحساب مستوى الامينوكلوبين المناعي الافرازي في ادرار مرضى داء السكري للفترة من حزيران ولغاية تشرين الثاني 2009.تضمنت الدراسة (64 ) مريض بالسكري تراوحت اعمارهم بين (40-70 سنة) و(30 ) شخص مصابين بالتهاب المجاري البولية ليس لديهم داء السكري وبنفس المدى العمري كمجموعة سيطرة . من كلا المجموعتين تم اخذ عينات الادرار لغرض فحص الادرار العام وزرع الادرار وحساب تركيز الامينوكلوبين المناعي الافرازي. اوضحت النتائج ان (39/64 ,60.9 %) كانو لديهم عدد الخلايا القيحية في الحقل المجهري الواحد اكثر من 10 خلاياومن هؤلاء ال (39) حالة مرضية فقط ( 22 , 56.4% ) كانت النتيجة موجبة للنمو البكتيري على الاوساط الزرعية .بصورة عامة اوضحت النتائج ان نسبة التهاب المجاري البولية كانت(34.44 % ) عند هؤلاء المرضى وكانت البكتيريا ( E.coli ) هي السائدة بنسبة (45.5%) كما ان النتائج اوضحت انخفاض معنوي في الكلوبين المناعي الافرازي في ادرارمرضى السكري مقارنة بمجموعة السيطرة .


Article
Evaluation of Postnatal Prophylactic Program for Rhesus Isoimmunization

Authors: Taghreed K. Alhaidari --- Murooge Abdul-Razza
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 4 Pages: 542-550
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND: Since the introduction of routine postpartum prophylaxis in the 1960s, the crude incidence of Rhesus isoimmunization has been declined all over the world. Iraq and due to many years of sanctions and wars had many occasions where there was a limited supply of this valuable injection. OBJECTIVE To evaluate the effectiveness of our preventive postnatal prophylactic protocol for Rhesus isoimmunization. METHODS: A Cohort observational study conducted at a private clinic and AL-Elwyia Maternity Teaching Hospital between the start of April 2010 till the end of June 2011. A total of 500 women were enrolled in the study; who were Rhesus D-ve pregnant women, married to Rhesus D+ve husbands, and had a Rhesus D+ve neonate and received the usual postpartum prophylactic dose after the previous deliveries when needed. Maternal plasma level of IgG-D concentration was determined by performing Indirect Coomb’s test to the mother on admission and neonatal blood group and plasma level of IgG-D concentration was determined by performing direct Coomb’s test to the neonate. All the previous and current relevant obstetrical and gynecological events were included in the study and analyzed. Data analysis was done using SPSS which included percentages according to cross tabulation of background of sample groups and Chi- square test for the associations.RESULTS: The prevalence rate of positive Indirect Coomb’s test in the study sample was (10.4%) (95% confidence interval ranging between 7.9 to 13.5%), and it was strongly related to gravidity, were gravidity group (G5+) increased the rate of positive Indirect Coomb’s test to (25.4%), which is significantly higher than that of primigravida(G1). A positive past history of early pregnancy loss significantly increased the rate of having a positive Indirect Coomb’s test by (29.9%).CONCLUSION: There is an urgent need in our country to improve our current postnatal prophylactic program based on the high sensitization rate which is so far from the global rate


Article
The precipitating factors and outcome of a thirty nine Patients with Guillain-Barre Syndrome admitted in the ICU of Al-Mawani General Hospital in the Governorate of Al- Basrah

Authors: Alaa Khuttar Mousa --- AhmedAubed Sherhan
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2012 Volume: 5 no 1 Issue: 11 Pages: 1343-1349
Publisher: Kerbala University جامعة كربلاء

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Abstract

Objectives: To study the possible precipitating factors and the variability of the outcome in patients with severe Guillian- baree syndrome according to age, sex and types of treatment.Methods : A single center, retrospective, descriptive study of 39 Patients with Guillain-Barré syndrome were studied between April 2007 to October 2010, their ages were between 3-63 year. They were 21 males and 18 females. Diagnosis was confirmed by typical clinical feature and ancillary investigations like electro diagnosis plus exclusion of other diagnoses. The history of any preceded or associated diseases before one month were clarified, treatment strategies and outcomes of the diseases were also analyzed. The study was conducted in the intensive care unit in Almawani general hospital Basrah, Iraq.Results: 23 patients had respiratory tract infection precede the neurological deficit, 7 patients had diarrhea and 22 patients occur at winter season. All the 39 patients develop limbs weakness, 30 patients develop shortness of breath and 24 of them needed mechanical ventilation. From the 26 patients with intravenous immunoglobulin therapy (IVIG) 17 had complete recovery, 5 left with neurological deficit and 4 of them died.Conclusions: respiratory tract infections are the commonest precipitating diseases preceding GBS in this study, most cases occur in winter. Early immunoglobulin therapies result in a high percentage of complete recovery and a less percentage of death.Key Words: Guillain- Barre Syndrome. Precipitating diseases. Immunoglobulin therapy.


Article
Quantitative analysis of IgG antinuclear antibody in chronic periodontitis patients

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Abstract

Background: Periodontitis is a bacterial infection of tooth-supporting tissues; the immunopathologic mechanismsinclude inflammatory cells and chemical mediators, which persist inflammation and develop a local autoimmune.The presence of autoantibodies against extracellular matrix components, anti-neutrophil cytoplasmic antibodies(ANCA) and anti-DNA was detected. This study aimed to provide evidence of altered humoral immune response inchronic periodontitis, as well as to determine the presence of auto-antibodies in this disease.Subjects and Methods: Blood samples were collected from 35 patients with chronic periodontitis (20 with severperiodontitis and 15 with moderate periodontitis) and from 30 healthy age and sex matched individuals served ascontrols. Clinical periodontal parameters used in this study were plaque index, gingival index, probing pocket depth,clinical attachment level and bleeding on probing. The levels of serum IgG-antinuclear antibody were determinedusing enzyme-linked immunosorbent assays, whereas serum immunoglobulin (IgG, IgM and IgA) were estimated bysingle radial immune diffusion method.Results: Serum levels of IgG-antinuclear antibody and IgG were significantly higher in sever chronic periodontitis thanin moderate chronic periodontitis and healthy controls (p<0.05). On the other hand, the serum levels of IgM and IgAshowed no significant differences among three studied groups (p>0.05). Concerning the correlation between serumIgG-antinuclear antibody and clinical periodontal parameters, the level of this autoantibody did not show anycorrelation with clinical parameters of periodontitis (p>0.05).Conclusion: The production of antibodies against self structures could be involved in the pathogenic mechanism ofchronic periodontitis


Article
Evaluation of Serum (immunoglobulin G, M) in children with nephrotic syndrome relapse
تقيم المصل للغلوبينات المناعية G,M لدى الاطفال الذين يعانون من الانتكاس لمتلازمةالتناذر الكلوي

Author: Nariman F. A.Azat نريمان فهمي احمد عزت
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2012 Volume: 54 Issue: 1 Pages: 15-17
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Nephrotic syndrome is an immune mediated disorder of the kidney associated with T cell dysfunction and secondary disturbance of B cell with changes in levels of immunoglobulin. Objectives: The objectives of this study were to compare immunoglobulin levels in children with nephrotic syndrome in relapse and healthy children, and to assess relationship between the degree of albuminuria and the mean concentrations of immunoglobulin.Methods: We studied 60 children with nephrotic syndrome during January 2008 to January 2011 in the Pediatric Nephrology consultation clinic, Children Welfare Teaching Hospital –Baghdad Medical Complex –Iraq. Urine protein and blood samples were collected from the 60 patients, and serum levels of IgG, IgM were measured. Another 20 healthy children attending the clinic were enrolled as controls.Results: In the 60 relapse cases of steroid sensitive nephrotic syndrome, compared with healthy children, the IgG level was low, IgM level was high and a highly significant relationship was found between the degree of albuminuria and the mean concentration of immunoglobulin in sera of patients (p< 0.01)Conclusion: immunoglobulin abnormalities support growing evidence that functional glomerular changes in nephrotic syndrome may result from T-cell disturbance and B-cell involvement.Key words:

خلفية: المتلازمة الكلوية هو اضطراب المناعة بوساطة الكلى المرتبطة بخلل الخلايا(T) و اضطراب ثانوي في الخلايا (B) مع التغييرات في مستويات الغلوبولين المناعيالأهداف: أهداف هذه الدراسة هي المقارنة بين مستويات الغلوبولين المناعي في الأطفال الذين يعانون من المتلازمة الكلوية في الانتكاس والأطفال الأصحاء، وتقييم العلاقة بين درجة بيلةالبروتين وتركيزات متوسط الغلوبين المناعي. طريفة العمل: لقد درسنا 60 طفلا مع متلازمةالتناذر الكلوية خلال شهر يناير 2008 الى يناير 2011 في العيادةالاستشاريةلأمراض الكلىللاطفال في مستشفى حماية الاطفال التعليمي مجمع مدينة الطب- بغداد -العراق .لقد تم جمع بروتين البول وعينات الدم من60 من المرضى ، وتم قياس مستويات المصل للغلوبين المناعي وتم تسجيل 20 طفلا آخر صحي حضروا العيادة كمجموعة سيطرة. النتائج: كان مستوى الغلوبولين المناعيG في حالات الانتكاس للاطفال من المتلازمة الكلوية الحساسة الستيرويد منخفضا، وكان هناك ارتفاعا في مستوى الغلوبولين المناعيM وعثر على علاقة كبيرة جدا بين درجة بيلة البروتين ومتوسط تركيز الغلوبولين المناعي في أمصال المرضى.الخلاصة: المتغيرات في الغلوبينات المناعية تدعم ألادلة المتزايدة على أن التغييرات الوظيفية في الكبيبات الكلوية للمرضى في متلازمة التناذر الكلوي قد تنجم عن اضطراب في خلايا TوخلاياB.

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