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Article
Effect of Metformin Therapy on Reducing Leptin

Author: Wafaa Issa Tuama*
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2012 Volume: 8 Issue: 2 Pages: 65-68
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: The relation between insulin resistance ,leptin levels and other hormones in women with polycystic ovary syndrome(PCOS) is still controversial.Metformin therapy is proved effective in reducing insulin resistance and also in some studies it was seen to be effective in reducing leptin levels.Al- Kindy Col Med J 2012 ; Vol .8 No. (2) p: 65Objective: to study the effect of metformin on reducing leptin levels and enhancing ovulation in PCOS women.Methods:metformin 500mg 3 times daily for 3 months was was given to 36 womenwith proved PCOS, in addition to that, other parameters were included.Results:28 women out of 36(77.78%) showed an evidence of ovulation ovulation after 3 months of metformin therapy(p<0.01) with significant ◌ٌreduction in leptin levels(p<0.001).Conclusion: it can be concluded that metformin can reduce leptin resistance and enhance ovulation in PCOS women.Keywords: leptin, PCOS, metformin.

Keywords

Keywords: leptin --- PCOS --- metformin


Article
Serum leptin level in women with polycystic ovarian syndrome
دورة مصل اللبتين في النساء اللواتي يعانون من متلازمة تكيس المبايض

Authors: بتول حسين كاظم --- وليد حميد يوسف
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2012 Volume: 2 Issue: 4 Pages: 25-28
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:Leptin, a key hormone in energy homeostasis and neuroendocrine function, has a permissive role in the pathogenesis of reproductive dysfunction.Objective:To assess the role of serum leptin in women with PCOS and to evaluate leptin and insulin levels in PCOS women before and after treatment with metformin.Materials and Methods:Sixty women of reproductive age (18- 38years) were allocated to four groups: 15 obese women with PCOS (BMI >30 kg/m2), 15 obese controls, 15 non-obese women with PCOS (BMI 18 -30 kg/m2), and 15 non-obese controls. Serum leptin and insulin levels were measured and compared between case and control subjects also comparison done pretreatment and after treatment with metformin.Results:There was a significant increase in leptin in non-obese PCOS group(8.2+ 2.73) compared to non-obese control (5.64+1.43), (P value=0.0032), insulin level was significantly higher in PCOS group (15.87 ±6.65) than control (5.47 +1.68), (P value<0.001). There was significant decrease in BMI ,leptin and insulin levels after 12 month of metformin treatment in obese and non-obese PCOS subjects. Conclusion:Leptin level increased remarkably with increasing body weight and it is higher in non-obese PCOS women in comparison with non-obese healthy women.


Article
The effect of inhibin B on ovarian response in subjects with polycystic ovary
تأثير هرمون الانهبين ب على استجابة المبايض لدى الاشخاص المصابين بمتلازمة تكيس المبايض

Author: Affan E. Hassan عفان عزت حسن
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2012 Volume: 54 Issue: 1 Pages: 100-105
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Inhibin B hormone is one of the indicative parameters in measuring ovarian reserve ,which is important to be evaluated, since it is one of the markers of the female reproductive potential especially in polycystic ovary patients (PCOS) which is a common cause of anovulatory infertility.Patients and methods: Ninty four infertile polycystic ovaries women, attending the infertility clinic at Baghdad teaching hospital, during the period of October 2005 to December 2006, were compared to 62 control group women who have unexplained infertility. After exact history and examination, inhibin level measurement was done in cycle day 3, the patients are divided according to age into 2 groups (more than 35 years and less than 35 years) .Ovarian stimulation by one of 3 protocols (clomiphene citrate (CC), CC + gonadotropins, goadotropins alone) was applied. Then the ovarian response is measured after that. Results: It was found that inhibin is significantly higher in PCOS patients as compared to control [201.1 ±122.40 vs 71.81 ± 40.63 pg/ml] (P=0.0003).After treatment with ovulation induction drugs, those who are less than 35 years with inhibin level less than 75 pg/ml, have no significant difference in response between the 3 protocols, while in those with inhibin more than 75 pg/ml the response was significantly high to protocol 1(CC only). In more than 35 years patients with inhibin level less than 75 pg/ml ,there was no significant difference in response between protocols while in those with inhibin more than 75 pg/ml the response was significantly higher to protocol 2 (CC+ Gonadotropins). Conclusion: Polycystic ovary patients have significantly higher concentration of inhibin B. Young patients less than 35 years with inhibin level less than 75 pg/ml showed no difference in response between the 3 protocols (CC, CC+ Gonadotropins, and Gonadotropins), while those with higher inhibin level ,the response was significantly higher to protocol 1. In older patients with inhibin more than 75 pg/ml there is no significant difference in response among the 3 protocols.

الخلفية البحث:هرمون الانهبين ب هو احد مؤشرات قياس احتياطي المبيض والذي من المهم تقييمه لمعرفة مؤشرات القدرة التكاثرية لدى مرضى تكيس المبايض و الذي يعتبر من اكثر الاسباب شيوعا للعقم .المرضى و طريقة العمل: اربعة و تسعون امرأة مصابة بتكيس المبايض تراجع في عيادة العقم التابعة لمستشفى بغداد التعليمي خلال الفترة من شهر تشرين الاول عام2005 لغاية شهر كانون الاول من عام 2006 تمت مقارنتهن مع اثنان وستون من النساء الصحيحات الواتي يعانين من العقم غير المعروف الاسباب بعد اخذ التاريخ المرضي و اجراء الفحص الطبي عليهن. تم قياس مستوى الانهبين في اليوم الثالث للدورة الشهرية و تم تقسيم المرضى الى مجموعتين على اساس العمر (اكثر و اقل من 35 سنة) . جرى تحفيز المبايض بالاعتماد على احد الاعراف الثلاثة وهي (الكلومفين ,الكلومفين و الكونادوتروبين , الكونادوتروبين لوحده) .ثم تم قياس استجابة المبايض.النتائج: اظهرت النتائج ان مستوى الانهبين ازداد زيادة معتدة احصائيا لدى مرضى تكيس المبايض مقارنة بالاصحاء .بعد العلاج بمحفزات المبايض لدى المريضات ذوات العمر الاقل من 35 سنة لايوجد اختلاف احصائي بين الاعراف الثلاثة بينما لدى المريضات ذوات العمر الاكثر من 35 سنة لايوجد اختلاف معتد به احصائيا اللواتي لديهن مستوى الانهبين اكثر من 75 بيكو غرام/مل.الاستنتاج: مريضات تكيس المبايض لديهن مستوى عالي من الانهبين ب . المريضات الاقل عمرا من 35 سنة و اللواتي لديهن مستوى منخفض من الانهبين لم يظهر لديهن اختلاف في استجابة المبايض للتحفيز بالاعتماد على الاعراف الثلاثة.


Article
Evaluation of PSA tumor marker in some Iraqi women with polycystic ovarian syndrome.
تقييم المستضد البروستاتي النوعي لدى بعض النساء العراقيات المصابات بمتلازمة تكيس المبيض المتعدد

Authors: زينب فائق رزيج --- نوال خيري العاني
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2012 Volume: 2 Issue: 4 Pages: 22-24
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Polycystic ovarian syndrome (PCOS) is the most common cause of hyperandrogenism anovulatory infertility; it affects 5-10% female reproductive age.The present study aims to investigate the total prostate specific antigen levels, total serum testosterone, FSH and LH in women with PCOS and compare the results with control group of normal fertile females of corresponding age group on Iraqis PCOS patients.Materials and Methods:Seventy patients with PCOS diagnosed depending on three criteria: Menstrual history: Oligomenorrhea, Ultrasound reveals polycystic ovaries and Biomedical and I or clinical hyperandrogenism.Twenty normal fertile females who serve as control group in this study. Blood samples were aspirated from all individuals from 24- day of menstrual cycle to measure total prostate specific antigen(PSA), total testosterone and FSH, LH .Results:Patients with PCOS and controls differed significantly in PSA, Total serum testosterone (p<0.05). Patients with PCOS and controls have highly significant difference in LH level, the mean was (7.88+ 1.83 vs 3.90+ 0.73) respectively (p<0.001 )and, highly significant difference in LH/FSH ratio and BMI parameters. (p<0.001). No significant differences were found in FSH (p>0.05). Positive correlation between PSA and testosterone, PSA and BMI. Conclusion:Total serum prostate specific antigen levels are higher in patient with PCOS.Total testosterone levels are higher in patient with PCOS.Serum PSA measurement might be marker of hyperandrogenism in females suffering from PCOS.

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