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Histopathological evaluation of aragonitic calcium carbonate as a bone graft substitute in rabbit's mandible (An experimental study)

Authors: Samir W. Abrahem سامر ابراهيم --- Kadhim A. Al-Soudani كاظم السوداني
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2012 Volume: 24 Issue: 4 Pages: 58-61
Publisher: Baghdad University جامعة بغداد


Background: Augmentation of the craniomaxillofacial region is required for many aesthetic and reconstructiveprocedures. Many bone grafts substitutes have been developed .These products differ in their osteoconductive andosteoinductive properties .The use of bone graft substitutes offers the ability to lessen the possible morbidity of theharvest site inautograft. Aragonitic calcium carbonate has proved to have biocompatible properties as bone graftsubstitute. This study aimed to evaluate the histopathological effects of aragonitic calcium carbonate inexperimentally induced bone defect in rabbit's mandible.Material & method: Twenty five adult male healthy rabbits were used in current study. Two holes were prepared inthe rabbit's mandible, first hole remain empty as control, the second filled with aragonitic calcium carbonate.Samples were taken after 2, 6,8,12 and 24 weeks. Histopathological evaluation include; examination of new boneformation and inflammatory response, in both control and experimental groups.Results: At 2 weeks, there was no new bone formation in both defects with moderate amount of inflammation .At6,12 and 24 weeks the amount of new bone formation in implant group was more than that formed in control group( statistically highly significant correlation, p<0.01). At 8 weeks, less bone amount in implant group .There weremarked degradation of implant particles at 6 weeks.Conclusions: ACC is suitable bone graft substitute and induce new bone formation by acting as bioactive,osteoconductive bone graft when come in contact with bone.

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