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Article
Microbiological Profile of Neonatal Septicemia

Author: Sinan Abdulrazzaq Ibrahim
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 1 Pages: 13-18
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND :Neonatal septicemia is a major cause of morbidity and mortality in developing countries.OBJECTIVE:The study is to determine the prevalence , the pattern of organisms and the mortality of neonatalsepticemia in a neonatal care unit.PATIENTS AND METHODS:All the cases of neonatal septicemia diagnosed and treated in the neonatal care unit at al-kadimiyateaching hospital for the period january-june 2010 were included in this study. The collected datawere : Gender, Birth weight, Gestational age, Onset of sepsis, Place of delivery and Outcome ofdisease.RESULTS:Out of 589 newborns admitted, 73(12.4%) were confirmed cases of neonatal septicemia. Themortality from neonatal sepsis was 16.4%.Low birth weight and prematurity were independentfactors associated with death (P value=0.004 and 0.020 respectively).There were 24 cases (32.9%)of early onset sepsis and 49 cases (67.1%) cases of late onset sepsis. The most common pathogenswere gram- negative bacilli causing early-onset sepsis (54%) and late onset sepsis (59%). Only 6cases out of the total 73 cases of neonatal septicemia were caused by staphylococus aureus (8.2%) .Over 50% of gram-negative bacilli are antibiotic resistant.CONCLUSION:The high rate of gram-negative septicemia and the antibiotic resistance to both ampicillin andgentamycin indicate that the infection was most probably nosocomial in origin.


Article
Diagnostic Value of C - Reactive Protein and Other Hematological Parameters in Neonatal Sepsis

Authors: Hafadh Jaleel Hussein --- Yusra Fayyadh Alwan
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 3 Pages: 370-375
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:There have been many attempts to develop screening tests or scoring systems that can identify infected infants at the time of initial assessment, sparing others from invasive diagnostic procedures, intravenous antibiotics therapy, mother-infant separation and parental anxiety.OBJECTIVE:Is to analyze hematological parameters and C - reactive protein so as to evaluate their diagnostic value in neonatal sepsis.PATIENTS AND METHODS:A cross-sectional study was performed in the neonatal care unit (N.C.U) at the Central Teaching Hospital for Pediatrics and Al-Habibiya Maternity and Children Teaching Hospital during a period from the first of June 2005 to the first of January2006One hundred neonates having clinical features of sepsis and 100 normal asymptomatic neonates were evaluated with a set of investigations including C-reactive protein(CRP), White Blood cellsCount(WBC), Absolute Neutrophil count (ANC), Platelets count (thrombocytopenia), Immature to Total neutrophil ratio (I/T ratio) and Erythrocyte Sedimentation Rate (ESR) to diagnose neonatal sepsis.RESULTS:C-reactive protein (CRP) was positive in (82.4%) of group-A and (81.8%) of group-B and had a specificity of 93.0%. ANC was the second most sensitive test having sensitivity of 61.8% for group-A and 48.5% for group-B and specificity of 86.0%.The sensitivities of platelets count (thrombocytopenia), WBC, I/T ratio and ESR for group-A were: 55.9%, 29.4%, 17.6% and 26.5% respectively, with specificities of 91.0%,89.0%, 92.0% and 81.0% respectively. While group-B had sensitivities of 42.0%, 33.3%,15.2% and 22.7% respectively with specificities of 91.0%, 89.0%, 92.0% and 81.0%respective ly.CONCLUSION:The implementation of CRP and other hematological parameters (ANC, Platelets count and WBCs) are useful in early detection of neonatal sepsis and diagnosis of neonatal sepsis in those who have false negative blood cultures

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