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Article
The Clinical Effect of Phenytoin on Oral Wound

Author: Fayhaa AM Al- Mashhadane
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2012 Volume: 12 Issue: 1 Pages: 165-170
Publisher: Mosul University جامعة الموصل

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Abstract

Aims: To study the effect of oral phenytoin on healing of oral wound in buccal mucosa of rab-bits.Materials and Methods: This study was carried out on twenty healthy male rabbits weighing be-tween 1.0 – 1.5 Kg, they were divided into 2 groups; first group consisted of 10 untreated rabbits (con-trol) and second group consisted of 10 rabbits treated by phenytoin at dose of 60 mg/Kg orally along with 3 ml/Kg of sterile water using cavage needle for 10 days. All animals were anesthetized with amixture of xylazine hydrochloride and ketamine hydrochloride at 0.5, 50 mg/Kg intramuscular respec-tively, then a standard wound was made on buccal mucosa of each rabbit, all animals were kept under observation, and their wounds was measured every day with respect to surface area (length x width) in cm2, type of wound tissue and duration of healing. Results: t – test analysis was performed to test the differences in wound characteristics of both groups, it was found that there was significant differences between control and treatment groups (p< 0.001). Conclusions: Systemic use of phenytoin can delay oral wound healing of buccal mucosa.


Article
Therapeutic use of honey for skin wounds healing in Iraqi Awassi sheep
الاستخدام العلاجي للعسل في شفاء جروح الجلد للأغنام العواسية العراقية

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Abstract

Abstract: The current study was conducted to evaluate the efficacy of honey in the treatment of skin wounds in sheep. Twelve Awassi rams were used in this study. The animals were randomly divided into two equal groups. A 5cm full-thickness skin wound was created on the right flank region of each animal. The wounds in first group were treated with honey single daily after operation until complete healing was occurred, while its in second group treated with sterile saline solution as control group. The results revealed the wound healing process in honey treated group occurred faster than the control group; the healing occurred in 14-15 days after wounding in first group, while in second group it was more than 4 weeks. Within the clinical follow up, no complications occurred in the first group, while the second group showed some complications such as infection and abscess formation. Histopathological examination showed formation of granulation tissue in honey treated group was faster than control group and the regular collagen fiber noticed at 15 days post treated with honey. The present study demonstrates that use of honey is useful for treatment and accelerates healing of full thickness wounds of skin in sheep.

الخلاصة: أجريت هذه الدراسة لتقييم كفاءة العسل في علاج الجروح الجلدية في الاغنام حيث استخدم اثنا عشر كبش عواسي والتي قسمت عشوائيا الى مجموعتين متساويتين . احدث جرح جلدي بسمك كامل وبطول 5 سم في منطقة الخاصرة اليمنى لكل حيوان. تم علاج الجروح في المجموعة الاولى باستخدام العسل بعد العملية وبواقع مرة واحدة في اليوم ولحين حدوث الشفاء التام ، بينما المجموعة الثانية عولجت بالمحلول الملحي المعقم واعتبرت مجموعة سيطرة . اوضحت النتائج بان عملية شفاء الجروح في مجموعة العلاج بالعسل حدثت بشكل اسرع من مجموعة السيطرة حيث ان الشفاء حدث بعد العملية بمدة 14-15 يوم في حين كان في المجموعة الثانية اكثر من 4 اسبوع. خلال فترة المتابعة السريرية لم تحدث اي مضاعفات في المجموعة الاولى بينما في المجموعة الثانية حدثت بعض المضاعفات مثل الخمج وتكوين الخراج. بين الفحص النسجي المرضي تكون النسيج الحبيبي كان اسرع في مجموعة العلاج بالعسل عن مجموعة السيطرة ولوحظ تكون الالياف الغراوية المنتظمه في اليوم الخامس عشر بعد العلاج بالعسل . اوضحت الدراسة الحالية بان استعمال العسل ذو فائدة في علاج وتسريع شفاء جروح الجلد في الاغنام.


Article
Effect of application of Fenugreek (Trigonella foenum-graecum) on skin wound healing in rabbits
تأثير نبات الحلبة Trigonella foenum-graecum على التئام الجروح في الجلد في الأرانب

Authors: D. O. Muhammed ديرين عمر محمد --- N. A. Salih نادية عبد الكريم صالح
Journal: Al-Qadisiyah Journal of Veterinary Medicine Sciences مجلة القادسية لعلوم الطب البيطري ISSN: 18185746 23134429 Year: 2012 Volume: 11 Issue: 2 Pages: 86-93
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

Fenugreek has a long history of medical uses in Chinese and Kurdish medicine, the objective of this study is to determine the effectiveness of topical application of fenugreek on the wound healing in rabbits. Twenty adult healthy local breed male rabbits weighing 1600-1800 gram were used. Animals were divided into two equal groups, by surgical aseptic technique, two surgical skin incision at length of 3 cm in the back region were done on both side of the vertebrae, then they closed by simple interrupted pattern by silk (3/0). Control group treated with Vaseline while in treated group the wounds were covered with 10% fenugreek ointment twice daily for 21 days. The clinical and histopathological evaluation revealed that fenugreek promote the wound healing by early formation of cellular fibrous connective tissue, granulation tissue and early maturation of fibrous connective tissues, which characterized by regular and complete layer of epidermis, when compared with control group, in conclusion this study indicated that the fenugreek was enhanced wound healing and that may be due to it is therapeutic and nutritional activities.

استهدف البحث دراسة تاثير الاستعمال الموضعي لنبات الحلبة على التئام الجروح في الارانب.استعمل في التجربة عشرون ارنب من الذكور و قسمت الى مجموعتين (كل مجموعة تحتوي على عشرة ارانب) وبعد تحضيرها جراحيا و تخديرها عمل شقين جراحيين في الجلد بطول 3سنتيمتر في منطقة الظهر وخيط الجرح بطريقة المتقطع البسيط بواسطة الحرير قياس 03 , مجموعة السطرة عولجت بمادة الفاسالين ,في حين استعمل في مجموعة الثانيةمطحون حبوب نبات الحلبة مع الفاسلين بنسبة 10% مرتين في اليوم و لمدة 21 يوم و اظهرت نتائج الفحص العياني والنسيجي ان نبات الحلبة قد ساعد في شفاء الجروح عن طريق تكوين المبكر للنسيج الحبيبي و نضوج النسيج الضام والذي تميز بانتضام اليافه و اكتمال طبقة البشرة التي تغطيه.


Article
The Effect of Hyaluronic Acid and Platelet - Rich Plasma on Soft Tissue Wound Healing: An Experimental Studyon Rabbits

Author: Wafaa K Fathi
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2012 Volume: 12 Issue: 1 Pages: 115-125
Publisher: Mosul University جامعة الموصل

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Abstract

Aims: This study aimed to evaluate the benefits of using platelet– rich plasma and hyaluronic acid when used alone or in combination with each other on wound healing. Materials and methods: The study performed on 15 adult male rabbits divided into three group according to healing periods (3,7,14 days), each group containing 5 animals. Four longitudinal incisions were made on the back of each rabbit, 2 in the right and 2 in the left. A distance of about 1.5 cm was left between one incision and another. The defects were filled with platelet–rich plasma, hyaluronic acid, or mixture of both, and the last incision served as control. Animals were sacrificed at 3rd, 7th, and 14th day after intervention, and biopsy were taken. Histopathological analyses were performed to evaluate the effect of these materials on acceleration of wound healing of skin. Statistical analyses was performed with Analysis of Variance and Duncan's Multiple Range Analysis Test, using a significant level of p ≤ 0.01. Results: Histopatho-logical analysis revealed significant improvement of wound healing when treated with PRP, and with mixed application of PRP and HA compared with control and HA groups in 3rd and 7th day postope-ratively, while there was no significant differences in wound healing between all groups at the end of the second week. Conclusions: The use of PRP alone or in combination with HA will accelerate wound healing , while the use of low concentration of HA alone presents no improvement of wound healing in comparison with normal one.

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