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Effectivness of 10% povidone iodine as ascolicidal agent in hydatid cyst surgery in compared with other scolicidal agents

Author: Ali Nayyef Assi علي نايف عيسى
Journal: Al-Qadisiyah Medical Journal مجلة القادسية الطبية ISSN: 18170153 Year: 2013 Volume: 9 Issue: 16 Pages: 181-195
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

Hydatid disease or Echinococcal disease, is a parasitic disease that affects both humans and other mammals such as sheep, dogs, rodents and horses.[1] There are three different forms of Echinococcosis found in humans, each of which is caused by the larval stages of different species of the tapeworm of genus Echinococcus[1].This study was done in the AL-Husseinteaching hospital (AL-Nassiyria)during3 years (between 1st January 2004 to december2006) and follow up for5 years,120 patients [70 females and 50 males] ages range between 12years to 56years presented withhydatid cyst in the liver only we concentrate on the hydatid cyst of liver( un complicated cases) confirm the diagnosis by U/S and CTscan ,and after surgery follow upalso by U/S and CTscan for 5 years.Povidone-iodine (PVP-I) is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. It contains from 9.0% to 12.0% available iodine, calculated on a dry basis.[1]To evaluate effectiveness of 10% povidone iodine as ascolicidal agent in liver hydatid cystsurgery in compare with hypertonic salinesolution and alcohol,povidone iodine have a better effect as a scolisidal effect because(1)there'sa lowerrecurrencerate during 5 years post operativlyfollow up (2) there is little post operative complication related to the povidone iodine(3)mild direct effect on the liver cell during six months follow up postoperativelyaccording to the liver function tests results as compare with other scolicidal agents, so we can use povidone iodine10% in surgical operation for hydatid cyst as ascolicidal because it highly effective against the scolices,little intra or post operative effects on the liver cells , cheep and widely available.

دراسه اجريت على 120 مريض خلال 3 سنوات2004 كانون الثاني الى كانون الاول 2006 في مستشفى الحسين التعليمي في الناصريه والمتابعة للمرضى خلال فتره 5 سنوات.هدف الدرسه هو معرفه مدى قوه البوفادين ايودين 10% في قتل طفيليات مرض الاكياس المائية مقارنه بالسائل عالي التركيز (الهايبر تونك) والكحول من خلال حقن كيس الماء الموجود بالكبد ب10 سي سي من البوفادين ايودين 10% او من الهايبر تونك او الكحول لا على التعيين للمرضى اثناء عمليه ازاله الكيس وننتظر لمده 20 دقيقه بعدها تتم عمليه ازاله الكيس بالسحب السوائل وسحب الكيس ثم تتم عمليه المتابعه المتواصله للمريض للتاكد من عوده الاكياس المائية فى الكبد او في الغلاف التجويفي للبطن وكذالك التأكد من مدى تأثيرهذه المواد الثلاثه على خلايا الكبد او وضائف الكبد من خلال فحص وظائف الكبد الدوري لمده ستة شهور.تبين من خلال دراستنا بان مفعول البوفادين ايودين فعال جدا في قتل طفيليات الاكياس المائيةمقارنه بالمادتين الاخريين وله تاثيرات جانبيه قليله على الكبد ووضائفه وله اق نسبه على عوده الاكياس المائيه بالنسبه الى المادتين الاخريتين,لذا ننصح باستخدام البوفادين ايودين 10% كمحلول قاتل لطفيليات الاكياس المائيه اثناء عمليه رفع الاكياس ولأنه ايضا رخيص ومتوفر


Article
In vitro effects of hypertonic saline solution on whole blood clotting

Author: Mohammed Shnain Ali;
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2013 Volume: 6 Issue: 1 Pages: 1568-1572
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: hypertonic saline solution is frequently used to in the management ofhemorrhagic shock.Objective: To determine the effects of hypertonic (7%) saline solution on wholeblood coagulation (clotting) in vitro.Patients and methods: Ten healthy volunteers (5 males and 5 females with age range of 28-44 years) with no previous medical history of bleeding tendency and no medical history ofdrug intake were studied after their consent. Hypertonic (7%) saline was preparedimmediately before use. For each patient, 4 ml of venous blood sample was obtained andinvestigated as follows:Undiluted 450 µl of whole blood for baseline coagulation tests [prothrmbin Time (PT),activated partial thromboplastin time (APTT) and thrombin time (TT)]. After that, the sameabove tests were done after dilutions of whole blood (i.e whole blood replacement byhypertonic saline and isotonic saline for each dilution). An Isotonic (0.9%) saline dilutionserves as control. Blood volume replacements at 2.5%, 5%, 7.5% and 10% were done andstudied.Results: The baseline coagulation tests (PT, APTT, and TT) were normal for all 10 (100%)of subjects. At 2.5% and 5% of blood volume replacement PT, APTT and TT were slightlyprolonged, but showed no statistically significant difference between hypertonic (7%) salineand the control (isotonic saline) while PT, APTT and TT were prolonged in hypertonic (7%)saline with statistically significant difference (p<0.05) from isotonic (0.9%) saline at 7.5%and 10% of whole blood volume replacement in 10, (100%) of subjects.Conclusion: The study showed that hypertonic (7%) saline disturbs coagulation in vitro whenit replaces 7.5% or 10% of whole blood volume.

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