research centers

Search results: Found 1

Listing 1 - 1 of 1
Sort by

Patterns of Sensitization to Inhalant Allergens among Asthmatic Children in Karbala Province

Authors: Mohammad R. I. Ghazal --- Zuhair M. Al-Musawi --- Haidar A. N. Abood*,
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2013 Volume: 6 Issue: 2 Pages: 1630-1636
Publisher: Kerbala University جامعة كربلاء


background: The patterns of sensitization to inhalant allergens among asthmaticchildren varies greatly in different countries. The detection of sensitization to inhalantallergens in asthmatic patients is used primarily to establish the diagnosis of allergicasthma. Also it is helpful in reducing asthma exacerbations through allergen exposureavoidance.Objectives: This study aims to determine the most common inhalant allergens associatedwith childhood asthma in Karbala province using allergen-specific IgE immunoassay.Patients and Methods: The present study was conducted in Karbala Teaching Hospital forChildren on 75 asthmatic children with elevated total serum IgE levels. All patients werescreened for the presence of specific IgE against inhalant allergens most frequently involvedin childhood asthma using EUROLINE Pediatric Inhalation IgE test kit that include 20inhalant allergens. The position of the band was used to determine the specific allergen whilethe color intensity of the band was used as predictive for the specific IgE concentration inserum samples.Results: Among 75 patients screened for specific IgE, 60 patients (80%) were sensitized to atleast one allergen and allergen-specific IgE was not detected in 15 (20%) patients. 30% ofsensitized patients, were sensitized to single allergen and 70% were sensitized to multipleallergens. Cat allergen was found in 60% of sensitized patients followed by European housedust mite allergen (55%). However, dog and aspergillus fumigatus allergens accounted for45% and 33.3% respectively. Most patients sensitized to cat and dog allergens (55.5% and52% respectively) showed clear bands signal intensity (moderate allergen-specific IgEconcentration). However the majority of patients sensitized to other inhalant allergensshowed weak bands signal intensity (low allergen-specific IgE concentration).Conclusions: Animal allergens (mostly cat) are the predominant inhalant allergens associatedwith childhood asthma in Karbala province with relatively higher allergen-specific IgEconcentrations than house dust mite and fungal allergens.

Listing 1 - 1 of 1
Sort by
Narrow your search

Resource type

article (1)


Arabic and English (1)

From To Submit

2013 (1)