research centers


Search results: Found 16

Listing 1 - 10 of 16 << page
of 2
>>
Sort by

Article
Relationship between Lipid per oxidation, Lepton and Lipid Profile in Iraqi Women with Preeclampsia
العلاقة بين الاكسدة الفوقية للدهون ومستويات الدهون واللبتين في الحوامل العراقيات المصابات بمرض سمد ية الحمل

Authors: Hasan F.Al-Azzawie --- Dina H.Sahib
Journal: Engineering and Technology Journal مجلة الهندسة والتكنولوجيا ISSN: 16816900 24120758 Year: 2014 Volume: 32 Issue: 2 Part (B) Scientific Pages: 225-237
Publisher: University of Technology الجامعة التكنولوجية

Loading...
Loading...
Abstract

The present study was carried out on two groups of pregnant Iraqi women .Group one consisted of 45 preeclampsia 23 mild and 22 severe preeclampsia compared to second group consisted of 25 normotensive pregnant women .The two groups were with same age, body mass indices and gestational age. Serum lipid peroxidation marker malondialdehyde (MDA), lipid profile, leptin, total antioxidant capacity (TAO) and paraoxanse activity (PON) were measured. Mean systolic and diastolic blood pressure between preeclamptic and control group showed a marked difference (p<0.01) ranging from 154.67 ± 4.2 and 118.73 ± 3.7mmHg in severe preeclampsia, 135.3 ± 4.8 and 95.45 ± 4.2 mmHg in mild preeclampsia compared to 120.2 ± 1.88 and 70.50 ± 2.2 mmHg in control respectively . Serum MDA level was significantly higher in women with severe preeclampsia (3.51 ± 0.45 µmoles /dl) than mild preeclampsia (2.52 ± 0.14 µmoles /dl) compared with (0.92 ± 0.12 µmoles /dl) in control group, when adjusting to cholesterol, the peroxidation remained significantly increased MDA/Cholesterol ratio: 1.41 vs. 1.18 pmol/L.The serum triglycerides and cholesterol were higher in women with preeclampsia especially in the severe preeclampsia. Mean serum leptin level was significantly high (p<0.01) in all preeclamptic (76 ±5.3ng/ml), when compared with a control group (26 ± 3.3ng/ml and the value of serum leptin level was much higher in severe preeclamptics (76 ±5.3ng/ml) than in women with mild preeclampsia (42±4.1ng/ml). All the variables of the lipid profile of preeclamptic patients were found to be significantly elevated as compared to controls. The total lipid profile was also compared to the severity of preeclampsia and total cholesterol was found to be significantly raised (p <0.01) in severe preeclampsia when compared to mild. On correlating serum leptin with lipid profile again total cholesterol was found to be significantly high (p <0.05) in preeclamptic group compared to controls. A significant reduce in TAC status and in paraoxanse activity (PON) was noticed in severe and mild preeclampsia than control group .We conclude that hypercholesterolemia leads to excessive lipid peroxidation. Coexistent diminution in antioxidant activity leads to an imbalance between prooxidants and antioxidants, resulting in oxidative stress. Oxidative stress and elevated atherogenic index may contribute to atherogenicity in preeclampsia.

تمت هذه الدراسة على مجموعتين من الحوامل شملت المجموعة الاولى على خمسة واربعون منها ثلاثة وعشرون مصابة بمرض سمدية الحمل من النوع المتوسط بينما الاثنان والعشرين مصابات بمرض سمدية الحمل من النوع الشديد,وتمت مقارنتهم مع خمسة وعشرين من الحوامل الاصحاء ذو الضغط السليم, وهاتين المجموعتين متشابهتين من حيث معدل العمر وموشر كتلة الجسم الحيوية ومعدل عمر الجنين .تم قياس مؤشر الاكسدة الفوقية للدهون (المالوندالدهايد)’مستويات الدهون’سعة مضادات الاكسدة الكلية بالاضافة الى فعالية انزيم البارااوكسانيزفي مصول هولاء الحوامل .اظهرت النتائج وجود فرقا معنويا كبيرا(P<0.01) في معدل الضغط الانبساطي والانقباضي بين الحوامل المصابة بسمدية الحمل بكلا النوعين مقارنة بمجموعة السيطرة ’اذ تراوحت معدلات الضغط الانقباضي 154.67 ±7.5 والانبساطى 118.73 ±3.7 mmHg لدى الحوامل المصابات بسمدية الحمل الشديد ’بينما كانت 4.8 ± 135.3و 2. 4±.45 95 في الحوامل المصابات بسمدية الحمل المتوسط’ مقارنة 120.2±1.88 و 70.50±2.2 mmHg في الحوامل الاصحاء ذو الضغط السليم على التوالي .لوحظ زيادة معنوية كبيرة في مستويات المالوندالديهايد في الحوامل المصابة بسمدية الحمل بكلا النوعين مقارنة بمجموعة السيطرة كذلك لوحظ زيادة واضحة في مستويات الدهون الثلاثية والكولستيرول ’من جهه اخرى لوحظ زيادة معنوية p<0.01) ) في مستوى اللبتين في الحوامل المصابة بسمدية الحمل بكلآ النوعين الشديد والمتوسط ng/ml 3.3 ±76 و 42±4.1 مقارنة بمجموعة السيطرة 26±3.3 ng/ml . بينت النتائج ان مستويات الدهون يتغير في حالة الحوامل المصابات بسمدية الحمل وان هذه المتغيرات تزداد كلما ازدادت شدة المرض مقارنة بمجموعة السيطرة , وان هنالك معامل ارتباط معنوي موجب بين مستويات اللبتين والكولستيرول((P<0.01 بينما لوحظ انخفاضا معنويا في مستويات سعة مضادات الاكسدة الكلية و مستويات انزيم البارااوكينيز في حالة الحوامل المصابات بسمدية الحمل الشديد اكثر من المتوسط . نستنتج من هذة النتائج ان لزيادة الكولستيرول دورا هاما في زيادة الاكسدة الفوقية للدهون من خلال زيادة المالوندالديهايد.ان انخفاض مستويات مضادات الاكسدة ادى الى وجود حالة الاجهاد التاكسدى التى في النهاية مؤشر لبداية تصلب الشرايين في سمدية الحمل.


Article
Lipid Profile of Controlled and Uncontrolled Diabetics in Erbil, Iraq

Author: Kameran Hassan Ismail د.كامران حسن اسماعيل
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2014 Volume: 27 Issue: 1 Pages: 10-13
Publisher: Al-Mustansyriah University الجامعة المستنصرية

Loading...
Loading...
Abstract

ABSTRACT:Background: Diabetes mellitus is a clinical syndrome characterized by hyperglycemia due to absolute or relative deficiency of insulin. This study was carried out to; compare lipid profile between uncontrolled and controlled diabetics, and find out; the prevalence, age and gender distribution of uncontrolled diabetics in a group of diabetic patients in Erbil, Iraq.Methods: A cross-sectional study was conducted between March 1st, 2012 and October 1st, 2012. A convenience sample of 351 diabetic patients attending Erbil Teaching Hospital was taken. The recommended goal for (controlled) HbA1C is ≤ 7%. Venous blood was collected after at least 8 hours fasting for HbA1c, total cholesterol, triglycerides, high-density and low-density lipoprotein cholesterol.Results: The sample included 351 patients (168 males and 183 females); their mean ± SD age was 61.71 ± 9.5 years (ranged from 40 to 79 years) with a male: female ratio of 0.92:1. The mean ± SD ages of controlled and uncontrolled diabetics were 59.91 ±9.95 and 62.90 ±9.02 years, respectively. ). Results revealed that the prevalence of uncontrolled diabetes is 60.1% and it is increased with age (P=0.015), and the prevalence of uncontrolled diabetes in males (65.5%) is significantly higher than (55.2%) that in females (P=0.049). The means ± SD of serum total cholesterol (198.49± 54.79 mg/dl), serum triglycerides, serum LDL-cholesterol of uncontrolled diabetes were significantly higher than that of controlled diabetes (P<0.001, P=0.042, and P=0.004, respectively).Conclusions: More than half of diabetic were uncontrolled and the prevalence of uncontrolled diabetes was higher in males than that in females and it was increased with age. There was significant difference of means of total cholesterol, triglycerides and LDL-cholesterol levels between controlled and uncontrolled diabetic patients. Key words: Uncontrolled Diabetes, HbA1c, Lipid

Keywords

Uncontrolled Diabetes --- HbA1c --- Lipid


Article
Effects of Ramadan fasting on body weight and metabolic profile
آثار صيام رمضان على وزن الجسم و الشاكلة الاستقلابية

Authors: Namir G. Al-Tawil --- Bashdar M. Hussen --- Saleem S. Qader --- Halgurd F. Ahmed
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2014 Volume: 18 Issue: 3 Pages: 816-821
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

Loading...
Loading...
Abstract

Background and objective: Fasting during the Ramadan month is a religious duty and it is obligatory for all healthy adult Muslims. The aim of this study was to investigate the effects of fasting during Ramadan in different times and place on body weight, blood sugar, serum lipids and blood pressure.Methods: Fifty three healthy adult fasting volunteers were included in the study. Peripheral venous blood samples were taken three days before Ramadan, at the end of the first week, and at the end of the fourth week of fasting. The last blood sample was taken one week after the end of Ramadan. Serum total cholesterol, HDL and LDL, triglycerides and glucose were measured. Vital signs and body mass index were taken by one of the researchers.Results: Thirty three (62.3%) volunteers were males, 93.4% were below 40 years of age. Weight changed significantly during Ramadan. Mean systolic blood pressure decreased by 11 mmHg while diastolic blood pressure decreased by 9 mmHg (P <0.001). Fasting blood sugar decreased by 14.96 mg/dl (P <0.001). Plasma lipids; cholesterol decreased by 19.3 mg/dl (P <0.027), LDL by 23 mg/dl (P <0.001), triglyceride by 44 mg/dl (P <0.003) but the HDL increased by 5.4 mg/dl (P <0.002) during Ramadan fasting. Before Ramadan, 19% of participants had abnormal serum cholesterol and 37% had abnormal LDL level, while after Ramadan all had normal lipid levels (P <0.001). The proportion of participants with abnormal HDL decreased from 94% before Ramadan to 50% after Ramadan (P <0.001).Conclusion: Ramadan affects the body physiology and lowers the weight, serum lipids, blood pressure and blood glucose levels.

Keywords

Ramadan --- Fasting --- Lipid profile


Article
Lipid Profile in Iraqi Children with ß-thalassemia Major

Authors: Jawad k.Mashaali --- Fatma A. Obed --- Noor Thair Tahir
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2014 Volume: 3 Issue: 2 Pages: 108-115
Publisher: Al-Mustansyriah University الجامعة المستنصرية

Loading...
Loading...
Abstract

ABSTRACTBackground: Thalassemia are group of genetic disorders in which production of normalhemoglobin (Hb) is partly or completely suppressed because of defective synthesis of one ormore globin chains, vary from asymptomatic forms to severe or even fatal entities . Peoplewith thalassemia make less hemoglobin which results in mild or severe anemia presentas microcytic anemia. thalassemias are classified according to which chain of the hemoglobinmolecule is affected. In α thalassemias, α globin chain is affected, while in β thalassemia,production of the β globin chain is affected. Lipid abnormalities have been detected indifferent types of beta thalassemia, suggested mechanisms including plasma dilution due toanemia, accelerated erythropoiesis resulting in increased cholesterol uptake by macrophagesand histiocytes of the reticuloen-dothelial system, defective liver functioning due to ironoverload, macrophage system activation with cytokine release, and hormonal disturbances,Objectives: The purpose of the study was to examine the blood lipid profile in children withbeta-Thalassemia major in Iraq , and to determine the factors that affect it.Material and Method: Blood lipid profiles of forty-five patients between the ages of threeand ten years with beta-Thalassemia major who were receiving regular chelation therapyfollowed by from paediatric clinic of Ibn-albalady hospital were examined retrospectively.Blood lipid profiles of thirty healthy children were taken for use as the control group.Results: Hb and Hct values of the group with Beta-Thalassemia major were significantlylower than the control group . Ferritin values in the group with Beta-Thalassemia major werefound to be significantly higher than in the control group . Cholesterol, HDL-cholesterol,LDL-cholesterol levels were found to be significantly lower in patients with Beta-Thalassemia major than in the control group , while the triglyceride level was found to behigher .Conclusion: lower total cholesterol, LDL-HDLcholesterol and high TG was found in BTMgroups compared to healthy control participants. The suggested mechanisms for the decreasesin lipids are increased erythropoiesis and cholesterol consumption, iron overload, hormonalchange and oxidative stress in BTM.

Keywords

lipid --- thalassemia --- children


Article
Study of Some Miswak (Salvadora persica L) Components and Effect of Their Aqueous Extract on Antioxidant

Author: Mustafa Taha Mohammed
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2014 Volume: 13 Issue: 1 Pages: 55-60
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND: Oxidative stress defines that, the level of Reactive Oxygen Species (ROS) exists in excess of antioxidant defenses. This imbalance in the redox milieu results in a switch from ROS-stimulated ambient signaling processes to ROS-mediated pathophysiological consequences. Oxidative stress has been implicated in the installation and progression of several degenerative diseases via DNA mutation, protein oxidation and/or lipid peroxidation. Therefore, possible use aqueous extracts of Miswak to protect brain against the Lipid peroxidation.OBJECTIVE: The present study was undertaken to evaluate the potential of Salvadora persica L. (miswak) against the DPPH Free Radical Scavenging System and Lipid peroxidation.METHODS: The chemical components of the prepared aqueous extracts of Miswak were detected as: glycosides, alkaloids, saponins, phenolic compounds, tannins, flavonoids , proteins ,steroids and Vitamine C. and then estimate DPPH Free Radical Scavenging System and Lipid peroxidationRESULTS: The study showed that the Miswak ( Salvadora persica L.) in the aqueous extracts contain : glycosides , proteins, saponins ,tannins ,phenolic compounds, flavonoids , alkaloids , steroids and vitamine C . Aqueas extracts were found effective in scavenging DPPH(62.45℅) in concentration (250µl/ml), as well as inhibiting the lipid peroxidation (42.04℅). CONCLUSION: Our results suggest that Miswak ( Salvadora persica L.) treatment protects the rat brain against lipid peroxidation and DPPH free radical scavenging..


Article
Androgenic –Anabolic Steroids Abusing Effect on Liver Enzymes and Lipid Profile in Male and Female Rats

Author: Nehaya M. Al-Aubody & Mohammad A. AL-Diwan
Journal: Journal of Education for Pure Science مجلة التربية للعلوم الصرفة ISSN: 20736592 Year: 2014 Volume: 4 Issue: 2 Pages: 191-204
Publisher: Thi-Qar University جامعة ذي قار

Loading...
Loading...
Abstract

The present study was conducted at Veterinary Medicine College–University of Basrha /Iraq to investigate the effect of testosterone( Sustanon ® 250) abusing on some physiological and biochemical parameters. Sixty four male and female rats were divided into four groups(each group consisted of 8 males and 8 females). The first group served as control group in which the rats dosed by intramuscular injection with 10 μ l olive oil weekly for 12 weeks, the rest 3 treated groups (G1 . G2 and G3) in which the rats dosed by intramuscular injection with 50 . 100 and 150 mg Sustanon ® 250 / kg B.W. respectively weekly for 12 weeks , then all rats were terminated for the physiological and biochemical tests . The Sustanon ® 250 through its effect on liver caused increasing both ALT and AST and decreasing the ALP in treated rats compared with control group . The lipid profile was significantly affected by Sustanon ® 250 injection through elevation of TG and VLDL , but lowering the HDL ,LDL and AI.

أجريت الدراسة الحالية في كلية الطب البيطري / جامعة البصرة لدراسة تأثير فرط استخدام (sustanon®250) على مستوى بعض انزيمات الكبد ومستوى الدهون في ذكور و اناث الجرذان المختبرية. قسمت الجرذان المختبرية إلى أربعة مجاميع , المجموعة الأولى اعتبرت مجموعة سيطرة حقنت عضليا ب 10 مايكرولتر من زيت الزيتون أسبوعيا لمدة ثلاثة شهور . أما المجاميع الثلاثة الباقية فهي مجاميع معاملة بال sustanon®250 إذ حقنت المجموعة الأولى ب50ملغم / كغم من وزن الجسم والثانية 100 ملغم / كغم من وزن الجسم والثالثة ب 150 ملغم / كغم من وزن الجسم أسبوعيا لمدة ثلاثة شهور ، ثم بعد انتهاء فترة الحقن ضحي بالجرذان لدراسة المعايير الفسلجية والكيموحيوية. أظهرت النتائج زيادة معنوية في إنزيمي ALT و AST ونقصان معنوي لإنزيم ALP في الجرذان المعاملة بمادة ال sustanon®25 مقارنة مع مجموعة السيطرة. كما تأثر مستوى الدهون معنويا بسبب حقن ال sustanon®250إذ أظهر زيادة في مستوى الدهون الثلاثية والدهون واطئة الكثافة جدا ونقصان الدهون عالية الكثافة والدهون واطئة الكثافة والدليل التعضدي


Article
Antihyperlipidemic Effect of L-Thyroxine Combined with Carvedilol in Induced Hyperlipidemia in Rabbits

Authors: Muayyad Sraibit Abbod --- Faruk H. Al-Jawad --- Adnan A. Anoze --- Mufeda Ali Jawad
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2014 Volume: 11 Issue: 4 Pages: 1047-1059
Publisher: Babylon University جامعة بابل

Loading...
Loading...
Abstract

Background:Hyperlipidemia is defined as an elevation of one or more of the plasma lipids, including cholesterol, cholesterol esters, triglycerides (TG) and phospholipids .An elevation of plasma lipids may be caused by primary or secondary factors.Objective:To evaluate the effect of L-thyroxine - Carvedilol combination on hyperlipidemia induced in rabbits. Material and method:Forty healthy, domestic rabbits of both sexes, weighing (800 – 1100 grams) were used in this study. They were divided into five groups each one contains eight rabbits. The first group (G1) was given a standard diet to be considered as a control group while all other groups fed with high cholesterol diet. The second group (G2) was given high cholesterol diet only, third group (G3) treated with atorvastatin , (G4) treated with L-thyroxine and (G5) received L-thyroxine combined with carvedilol. Then lipid profile, heart rate and body weight were measured for all groups to be compared. Results:Because atorvastatin is a known antihyperlipidemic drug, the results of using combination of L-thyroxin with carvedilol were compared to those produced by atorvastatin alone. The results showed insignificant (p˂0.05) difference in all biochemical parameters, heart rate and body weight of the hyperlipidemic group treated with the combination of L- thyroxin and carvedilol (G5) when compared with those treated with atorvastatin alone (G3). Conclusion:The use of the combination of L-thyroxine and carvedilol has antihyperlipidemic effect similar to that of atorvastatin which is well known antihyperlipidemic drug.


Article
OMENTIN-1 LEVEL IN MIDDLE AGE WOMEN WITH HYPOTHYROIDISM AND THEIR RELATIONS TO RISK FACTORS OF CARDIOVASCULAR DISEASE

Author: Salma A. Abbas سلمى عبد الرضا عباس
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2014 Volume: 12 Issue: 3 Pages: 273-278
Publisher: Al-Nahrain University جامعة النهرين

Loading...
Loading...
Abstract

Background:Omentin-1 is fat deposition-specific adipokine that is highly and selectively expressed in visceral adipose tissue. Low circulating levels of Omentin-1 have been associated with endothelial dysfunction and cardiovascular disease. Abnormalities of lipid metabolism associated with subclinical and overt hypothyroidisms patients, low Omentin-1 level can affect risk factors for cardiovascular disease.Objective:To determine the differences in the levels of Omentin-1 in middle age women with subclinical and overt hypothyroidisms and correlate its level with parameters which considered risk factor for cardiovascular disease.Methods:Ninety middle age women divided into three groups as follows: group I consisted of 30 healthy women as a control subject, group II comprised 30 women with subclinical hypothyroidisms, group III include 30 women with overt hypothyroidisms, serum of Omentin-1, high sensitive c-reactive protein and lipid profile levels were evaluated in patients and control groups.Results:Serum omentin-1 levels were significant decreased in patients with subclinical and overt hypothyroidisms compared with control group. Significant negative correlation between omentin-1 and thyroid-stimulating hormone, high sensitive c-reactive protein, total cholesterol, atherogenic index in patients was found. Significant positive correlation was observed between Omentin-1 and high-density lipoprotein in the patients.Conclusion:we conclude that serum Omentin-1 levels were decrease in middle age women with hypothyroidism and its correlate with altering lipid profile, high levels of atherogenic index and high sensitive c-reactive protein, all of these conditions is correlated with cardiovascular disease, so Omentin-1 in hypothyroidism patients is a risk factor for cardiovascular disease, our suggestion that possible follow up serum lipid profile and omentin-1 monthly for middle age women to prevent cardiovascular disease.Keywords:Omentin-1, lipid profile, hypothyroidism disease


Article
Study of the Interaction Effect Between Parsley Petroselinum crispum and Cadmium on Lipid Profile, Lipid Peroxidation and Catalase Activity of Albino Mice Males' Liver and Kidney
دراسة التأثير التداخلي بين نبات المعدنوس Petroselinum crispum والكادميوم على صورة الدهون وبيروكسدة الدهون وفعالية إنزيم الكاتاليز في كبد وكلى ذكور الفئران البيض.

Authors: Huda A. Yousuf هدى عبد المسيح يوسف --- Fawzi S. Al-Zubaidi فوزي شناوه الزبيدي --- Waleed H. Yousif وليد حميد يوسف
Journal: Iraqi Journal of Science المجلة العراقية للعلوم ISSN: 00672904/23121637 Year: 2014 Volume: 55 Issue: 2Supplement Pages: 711-721
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

This study was designed to investigate the effect of different cadmium concentrations on albino mice males' oxidative balance through lipid profile, malondialdehyde (MDA) concentration and catalase (CAT) activity estimation in liver and kidney. Parsley Petroselinum crispum was chosen to detect its effect as a natural antioxidant. Five groups of albino mice males (10 mice each) were treated with (0.0, 0.25, 0.5, 0.75 and 7.5) mg Cd/kg b.w. orally by using gavages needle for 60 days according to 5 days/week protocol, another five mice groups were treated with the same cadmium concentrations mentioned above and 0.1 ml of parsley Petroselinum crispum juice. The results showed an adverse effect of cadmium on mice oxidative balance, while parsley showed an effective antioxidant effect which was revealed through lipid profile protection, MDA concentrations decrease and CAT activity increase.

صُمّمت هذه الدراسة للتحري عن تأثير التراكيز المختلفة من الكادميوم على التوازن التأكسدي لذكور الفئران البيض من خلال تقدير صورة الدهون وتركيز المالوندايالديهالد MDA وفعالية إنزيم الكاتاليز CAT في الكبد والكلى. تمّ اختيار المعدنوس Petroselinum crispum للكشف عن تأثيره كمضاد تأكسدي طبيعي. عومِلت خمس مجموعات من ذكور الفئران البيض مقسمة إلى عشرة فئران لكل مجموعة بتراكيز مختلفة من الكادميوم (0.0 و 0.25 و 0.5 و 0.75 و 7.5) ملغم كادميوم/ كغم وزن جسم بطريقة التجريع الفموي الإجباري لمدة 60 يوما بواقع 5 أيام في الاسبوع وخمس مجموعات أخرى بنفس التقسيم عومِلت بنفس تراكيز الكادميوم المذكورة أعلاه و 0.1 مل من عصير المعدنوس. أظهرت النتائج تأثيراً ضاراً للكادميوم على التوازن التأكسدي للفئران، بينما أظهر المعدنوس تأثيراً مضاداً للتأكسد والذي أتضح من خلال حماية صورة الدهون وانخفاض تركيز المالوندايالديهايد MDA وزيادة تأثير إنزيم الكاتاليز.


Article
Glycemic Control, Serum Leptin and Lipid Profile in Patients With Pulmonary Tuberculosis: Effect of Initial Two Months Anti-Tuberculosis Therapy

Authors: Imad Abdul-Jabbar Thanoon عماد عبد الجبار ذي النون --- Aseel Abed-Alelah Aded- Alrahman اسيل عبد الاله عبد الرحيم
Journal: Al-Qadisiyah Medical Journal مجلة القادسية الطبية ISSN: 18170153 Year: 2014 Volume: 10 Issue: 17 Pages: 1-10
Publisher: Al-Qadisiyah University جامعة القادسية

Loading...
Loading...
Abstract

Objectives:To evaluate the effect of pulmonary tuberculosis (TB) on glycemic control (fasting serum glucose "FSG", serum insulin, C-peptide and insulin resistance), serum leptin and lipid profile (total cholesterol 'Tc', triglyceride "TG", low density lipoprotein cholesterol "LDL-C", high density lipoprotein cholesterol "HDL-C" and atherogenic index AI) and to evaluate the effects of intensive 2-months anti-tuberculosis therapy on these parameters in comparison to healthy controls.Methods:Forty three patients with active pulmonary tuberculosis from the Advisory Clinic for Chest and Pulmonary Diseases in Mosul City were included in this study, with 40 apparently healthy age and sex matched subjects as controls. Assessment of serum concentration of FSG, C-peptide, serum insulin levels and insulin resistance, with serum leptin and lipid profile were done for the patients and controls. After two months with intensive anti-TB therapy (isoniozid "INH" 75 mg, rifampicin 150mg, pyrazinamide 400mg and ethambutol 275mg) 4 tablets as a single dose in the morning with vitamin B6 10mg daily, the same parameters were reassessed for the patients. Body mass index were calculated for both the patients and control using especial equation.Results:With the exception of body mass index (BMI), there was insignificant differences with regard the parameters of glycemic control, serum leptin and parameters of lipid profile between newly diagnosed patients with pulmonary TB in the pre-therapy stage and healthy controls.After 2 months of therapy, there was a significant increase in BMI, serum leptin and serum TG with insignificant differences in the other parameters under study.Conclusion: In this study active pulmonary TB as a disease did not affect parameters that represent glycemic controls, serum leptin and lipid profile. Intensive 2-months therapy with anti-TB drugs brings about a significant increase in BMI, serum leptin and TG with insignificant effect on glycemic control, and other parameters of lipid profile.

الاهداف: لتقييم تاثيرات التدرن الرئوي على علامات السيطرة السكريه(مستوى سكر الدم، الببتيد-ج, مستوى الانسولين ومقاومة الانسولين ) مستوى اللبتين وصورة الدهون ( الكوليسترول، الدهون الثلاثية، الكوليسترول في الدهون الواطئة الكثافة، الكوليسترول في الدهون العالية الكثافة ومؤشر تصلب الشرايين) ولتقييم تاثيرات العلاج المكثف لمدة شهرين بالادوية المضادة للتدرن على مستوى هذه المفردات بالمقارنة مع مجموعة الضبط من الاصحاء.الطرق: ادخل لهذه الدراسه43 مريضاَ بالتدرن الرئوي الفعال، محالين من العيادة الاستشارية للامراض الصدرية والتنفسية في الموصل (العراق) مع اربعين من الاصحاء من اعمار واجناس مقاربة لمجموعة المرضى كمجموعة ضبط. تم تحديد مستوى الكلوكوز، السي- بيبتاد، الانسولين واللبتين مع مفردات صورة دهون الدم، وتحديد مقاومة الانسولين بمعادلة خاصة .بعد شهرين من العلاج المكثف لمجموعة المرضى (الايزونيزايد 75ملغم والريفامبسين 150ملغم وبيرازين امايد 400ملغم وايثامبيوتول275ملغم) كجرعة يومية اربع حبات من المركب المذكور مع جرعة يوميه واحده من فيتامين بي 6 10ملغم, تم اعادة قياس لبعض المفردات المذكورة اعلاه.تم حساب دلالة كتلة الجسم للمرضى ومجموعة الضبط باستخدام معادله خاصه.النتائج: لم يكن هنالك اختلافاَ معنوياَ في مفردات السيطرة السكرية ومستوى اللبتين ومفردات صورة الدهون في الدم بين مجموعة مرضى التدرن الرئوي الحاد قبل العلاج ومجموعة الضبط.بعد شهرين من العلاج كانت هنالك زيادة معنوية في دلالة كتلة الجسم، مستوى اللبتين ومستوى الدهون الثلاثية في مرضى التدرن الرئوي بالمقارنة مع فترة ما قبل العلاج.الخلاصة: مرضى التدرن الرئوي الحاد (كمرض) لم يؤثر تاثيراَ معنوياَ على مفردات السيطرة السكرية، مستوى اللبتين، ومفردات صورة دهون الدم. كان العلاج المركز للشهرين الاوليينتأثيرا معنويا على دلالة كتلة الجسم, مستوى اللبتين ومستوى الدهون الثلاثية في مرضى التدرن الرئوي بينما لم يكن له تاثير معنوي على مفردات السيطرة السكرية وبقية مفردات صورة دهون الدم.مفتاح الكلمات: التدرن الرئوي, السيطره السكريه, مستوى اللبتين في مصل الدم, صورة الدهون.

Listing 1 - 10 of 16 << page
of 2
>>
Sort by
Narrow your search

Resource type

article (16)


Language

English (15)


Year
From To Submit

2014 (16)