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Immunohistochemical and clinicopathological study of non-Hodgkin's lymphoma in Erbil, Kurdistan
دراسة كيميائية مناعية ونباتية لأورام ليمفوما اللاهودجكين في أربيل، كوردستان

Authors: Maysoon Alhaideri --- Rafal Abdul Razaq Al-rawi --- Tara Sirwan Kamil
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2014 Volume: 18 Issue: 2 Pages: 756-762
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Non-Hodgkin lymphoma is a cancer of the lymphatic system. Types of non-Hodgkin lymphoma vary significantly in their severity from indolent to very aggressive. The aim of this study was to investigate the incidence, immunohistochemical expression, clinical and histopathological prognostic factors of patients with non-Hodgkin lymphoma.Methods: A total of 59 patients with non-Hodgkin lymphoma cases were reviewed and investigated at Razgary Teaching Hospital in Erbil city during the period from January, 2011 to January, 2013. Data of patients were tabulated and distributed according to their age, sex, site, immunohistochemical expression and WHO classification.Results: Age of non-Hodgkin lymphoma patients ranged from 2 to 88 years with a mean of 45 year. Around 49% of the patients were of age group over 50 years and 54.2% of pa-tients were male. Immunohistochemical investigation indicated that 71.2% of non-Hodgkin lymphomas were of B cell type, the highest percentage (33.3%) of them was of diffuse large cell type. While the T cell type was found in 20.3%, the highest percentage (33.3%) of them was of Anaplastic lymphoma. CD20 and CD3 showed more consistent and strong expression for B and T cells non-Hodgkin lymphoma, respectively. Results showed high BCL2 expression. Nodal non-Hodgkin lymphoma account for 50.8% of the total cases.Conclusion: Most non-Hodgkin lymphomas were of B cell type and highest percentage is of diffuse large cell type. CD20 and CD3 were more reliable as an indicator of B and T cell lineage, respectively. Most non-Hodgkin lymphomas were of intermediate-high grade. Nodal site represent highest rate for primary non-Hodgkin lymphoma.


Article
Immunophenotypic study of non-Hodgkin lymphomas in adult and elderly patients at National Center of Hematology-Baghdad.

Authors: Abdusalam Hatim Mohammed --- Sajid Saad Mohammed --- Jawad. k. Mashaali
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2014 Volume: 3 Issue: 2 Pages: 127-131
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Non-Hodgkin lymphomas (NHL) are a heterogeneous group of lymphoproliferativemalignancies with different patterns of behavior and responses to treatment. The understanding andhistopathological diagnosis of NHL has improved with the use of advanced technology. Theimmunophenotyping of tumors of hematopoietic origin serves in the first place to distinguish theseneoplasms from others, and to distinguish neoplasms from reactive processes.Objectives: The aim of this study was to determine the percent of each category of NHLPatients and Methods: Sixty eight patients who were diagnosed to have stage 4 non-Hodgkin lymphomaby histopathological examination of bone marrow aspirate and biopsy at National Center ofHematology/Baghdad were subjected to immunohistochemistry examination, two cases diagnosed ashairy cell leukemia by histopathological examination but not by immunohistochemistry as there were noCD markers available at the time of study so they were discarded from this study. Immunohistochemistrywas done either in hospital or in private laboratory for proper subtyping of the disease and yet to receivecorrect therapy and better response.Results: Cases were diagnosed as fallowsB-cell lymphoma constitute 57 cases 86.36%T-cell non-hodgkin lymphoma 6 cases 9.09%Splenic lymphoma 1 case 1.5%Mantle cell lymphoma 2 cases 3.03%Conclusion: Immunohistochemical study is a specific method to aid histopathology in proper diagnosisand subtyping of non-Hodgkin lymphoma

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