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EFFECTS OF THE CYCLOSPORINE ON SOME HEMATOLOGICAL INDICES IN BONE MARROW TRANSPLANTED-RABBIT

Author: Adel Ch. Awid Abdulbary A. Alfaris, Alaa A.Sawad
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2014 Volume: 13 Issue: 2 Pages: 23-35
Publisher: Basrah University جامعة البصرة

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Abstract

This study was conducted to evaluate the effects of cyclosporine on some hematological indices in male rabbits after bone marrow transplantation operation. Thirty male rabbits were used in the present study which divided into three groups equally (ten rabbit each group).Rabbit of first group were give0.5 ml of normal slain from Day zerotill Day 10 of experiment then applied to intra bone marrow-Bone marrow transplantation (IBM-BMT) at Day 11 then after, these rabbit give normal slain from Day 12 till Day 20 and considered as shame group. Rabbits of second and third groups were applied to same protocol that used in first group except that the rabbit were give 12.5 (T1) and (T2) 25 mg/kg/BW of cyclosporine respectively instead of normal slain. blood was collected At Day10 and Day 21 from all rabbit of the experiment via heart puncture and Red blood cell (RBCs)count , white blood cell (WBCs) count, Deferential leukocyte count, Packed cell volume(PCV) and hemoglobin concentration(Hb) were measured.Results of the present study showed significant decrease (p<0.05) WBCs count, Neutrophils, Lymphocytes, in groups treated with 12.5 and 25 mg/kg/BW in compare to shame group at Day 10 and Day 21whileRBCs count, PCV and Hb values were significantly decrease (p<0.05) T1 and T2 groups compare with that in shame group at Day 10 only then return to normal at Day 21.Results of the present study suggested that the cyclosporine at both doses act as immune suppresser in bone marrow transplanted- rabbits.

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