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The effect of cigarette smoking on salivary IgA and periodontal disease

Author: Omar Husham Ali عمر هشام علي
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2015 Volume: 27 Issue: 3 Pages: 116-119
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Chronic periodontitis is an inflammatory disease of tissues supporting the teeth. Salivary compositionshave been most intensely studied as a potential marker for periodontal disease. In this study, analysis of salivaprovides a simple and non-invasive method of evaluating the role of salivary IgA (s-IgA) levels in periodontal diseaseby detecting the level of (s-IgA) in patients with chronic periodontitis smokers and non smokers patients and correlatethe mean (s-IgA) levels with clinical periodontal parameters Plaque index (PLI) gingival index (GI), probing pocketdepth (PPD) and clinical attachment level (CAL).Materials and Methods: The study samples consists of (15) patients with chronic periodontitis who were non smokers(Group I) and (15) patients with chronic periodontitis who were smokers (Group II) of both gender with an ageranged (35-45) years were the periodontal parameters used in this study (PLI, GI, PPD and CAL), unstimulated salivarysample were collected from all subjects and the levels of salivary IgA (s-IgA) in each sample were analyzed for eachgroup by using enzyme-linked immunosorbent assay (ELISA) technique. A statistical analysis was done by using excel2013.Results: There was a significant difference with high mean level in the clinical periodontal parameters in smokersgroup compared to non smokers with chronic periodontitis (PLI, PPD and CAL) except GI which showed nosignificant difference between the same groups. The biochemical finding showed significant difference with lowmean level for (s-IgA) in smokers group compared to non smokers.Conclusion: The findings in this study showed that the concentrations of salivary IgA might be used as an indicator forperiodontal disease progression in smokers with chronic periodontitis as a resultant to the effect of smoking whichlowering the concentration of the salivary IgA and subsequent reducing of the host’s defense lead to increase in theprogression of periodontal disease

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