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Article
Biochemical Characterization of Protease and Its Impact By Nano Particles in Sera of Iraqi Patients with Burns

Authors: Sura Ahmed Abdul sattar --- Dhia Hadi Hussain --- Hasan Hadi Algam
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 4 Pages: 870 -881
Publisher: Babylon University جامعة بابل

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Abstract

Proteases have great medical and pharmaceutical importance due to their key role in biological processes and in the life-cycle of many pathogens. The present study aims to characterization of protease and evaluate their impact by Gold Nano Particles and Nickel Nano Particles. A total of 30 patients with burn and 25 healthy individual with matches were included in this study. Gold nanoparticle and nickel nanoparticle were prepared using Pulsed Laser Ablation in Liquid method .The activity of serum protease was determined using casein as substrate. The results indicated increased protease activity in sera of burn patients and inhibition effects of both gold and nickel nanoparticles on protease activity. Thermodynamically favorability of the reaction can depend on the temperature. We conclude that nanoparticles such as gold and nickel can be used as treatment of burns through their role in homeostasis due to their inhibition impact on protease activity.


Article
Immunological and Hormonal Changes in Thyroid Goiter Patients in Correlation with Histopathological Types

Authors: Enas A. Abbas --- Hadi M. AL-Mosawi --- Hussein N. Al-Shammary
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 2 Pages: 413-420
Publisher: Babylon University جامعة بابل

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Abstract

The patients with thyroid goiter presented in hyperthyroidism, hypothyroidism or euothyroid state, included multinodular goiter (MNG), Hashimoto thyroiditis and thyroid tumor, these type of diseases suffering from different immunological changes in correlation with thyroid function test and histopathological types. The present study was conducted in Hilla city from November 2013 to August 2014. This study was included 101 cases dividing into three groups according to the histopathological diagnosis after total thyroidoctomy. The first group included sixty eight cases of MNG patients, the second group included nineteen cases of patients with thyroid tumor, and the third group included fourteen cases of patients with thyroiditis. For all cases, thyroid function test, the immunological analysis studies included immunoglobulins (Igs) and complement componants were done. Results of present study were showed that the IgM was highest among patients with MNG meanwhile; the mean IgA was highest among patients with thyroid tumor. The mean IgG was highest among patients with MNG. There were significant associations between thyroid diseases and IgA, IgG and C3, p<0.05. Other result show the mean C3 was highest among patients with tumor changes meanwhile; the mean C4 was highest among patients with tumor changes. Also other result show there was significant association between thyroid diseases with TSH, patients with thyroiditis were most likely to be hypothyroidism, p<0.05.The aim of study to determine the types of immunological changes in correlation with histopathological types and hormonal changes. So as the immunoglobulin level (Ig) was high in different types of thyroid disease especially IgG. The complement component (C3) level was high in different thyroid disease, while the C4 level was low in different thyroid diseases.


Article
The Effect of Fixed Space Maintainer Appliances on Salivary Level of Immunoglobulin A and other Saliva Properties

Author: Esra Hassan Abd Ali1 , Maha Abdul- Kareem Mahmood1
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2015 Volume: 14 Issue: 1 Pages: 99-106
Publisher: Baghdad University جامعة بغداد

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Abstract

Abstract: Secretary immunoglobulin A SIgA , play an important role in mucosal immunity, and the salivary level change in response to infection ,social , psychological and physical stress, also the change in level of salivary IgA and other saliva properties include salivary pH, salivary flow rate SFR, and body mass index BMI in children with fixed appliances were measured .The aim of this work was to compare the values of SIgA, PH, SFR and BMI in children with and without fixed appliances. This work included 20 children (10 males and 10 females) with mean age 6 years old who were users of fixed space maintainer for at least 12 weeks, and 20 children (12 males and 8 females) without fixed appliances and with mean age = 6.7 years. The level of SIgA in saliva were assessed by ELISA test. The results revealed that the mean values of SIgA and SFR were higher in fixed appliance group than the group without fixed appliance, with statistical significant difference, but no statistical significant differences were reported for salivary pH and BMI between the studied groups. The results also showed a weak positive correlation between SIgA and SFR (r = 0.07) while negative correlation between SIgA and pH in fixed appliance children (r = 0.1). In conclusion, children with fixed appliances associated with high level of SIgA and SFR and the level of salivary pH and BMI do not correlated with fixed appliance.


Article
Salivary IgA in chronic kidney disease patients undergoing hemodialysis in Missan governorate

Authors: Faris Abid Hatem فارس عبد حاتم --- Zaheda Jassim Mohammad زاهدة جاسم محمد
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2015 Volume: 27 Issue: 2 Pages: 54-57
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Chronic kidney disease is a worldwide health problem, with adverse outcomes of cardiovasculardisease and premature death, can be divided into five stages, depending on how severe the damage is to thekidneys, or the level of decrease in kidney function, the final stage of chronic kidney disease is called end-stagerenal disease, salivary immunoglobulin A is the main immunoglobulin found in mucous secretions, including tears,saliva, colostrum and secretions from the genitourinary tract gastrointestinal tract, prostate and respiratoryepithelium. It is also found in small amounts in blood.This study aimedto measuresalivary flow rate andsalivaryimmunoglobulin Alevels in chronic kidney disease patients on hemodialysis treatment in comparison withhealthy control subjects.Materials and Methods: Ninety (90) subjects were participated in this study; 45 Patients undergoing hemodialysis withchronic kidney diseases; 45 health control subjects. Saliva collected was measured and levels of salivaryimmunoglobulin A were measured by Enzyme Link Immunosorbent Assay (Elisa).Results:The present studyrevealed that the mean value of salivary flow rate in chronic kidney disease patients was(0.34 ± 0.19) ml/min, while for healthy control subjects was (1.02 ± 0.39) ml/min, there wasstatisticallysignificantlydecrease in salivary flow rate ofchronic kidney disease on hemodialysis patients as compared to control healthysubjects.The present study revealed that the (Mean±SD) of the immunoglobulin A in chronic kidney disease patientson hemodialysis (388.81±227.86) μg./ml, while in control group (273.98±155.89) μg./ml, the result revealed statisticallysignificant increase in chronic kidney disease patients on hemodialysis as compared to control subjects.Conclusions: Salivary immunoglobulin (IgA) reflects the functional capacity of the glands. Increased concentrationof this component is usually marker of a poor general condition


Article
Impact give Specific immunoglobulin IgY isolated from the egg yolk in different ways in the productive performance of Ross 308 of experimental infected with Eimeria tenella parasite
تأثير إعطاء الكلوبيولين المناعي النوعي IgY المعزول من صفار البيض بطرق مختلفة في الأداء الإنتاجي لفروج اللحم نوع Ross 308 المخّمج تجريبياً بالطفيلي Eimeria tenella

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Abstract

AbstractThe current study was conducted in the laboratory of the Faculty of Science / University of Anbar, for the period from 09/27/2012 until 11/17/2012 day for the purpose of comparison methods give treat disease Coccidosis in the productive performance of broiler through the use of 135 chick is one day old unsexal ( Ross strain 308) where distributed randomly to nine treatment and by five replicates per treatment and 3 chicks each repeater (15 chicks / treatment), gavage chicks in treatment first with distilled water (control negative) , and treatment second chicks for by gavage (Intra - Crop) challenge dose for the E. tenella locally isolated and by 5x 104 Oocyst / chick (2.5 ml) at 28 days for the treatment of positive control For the purpose of comparison methods give immunoglobulin IgY locally isolate, has been giving him a concentration of 11.013748 mg / ml amount of 0.5 ml / chick on all transactions, and in the third treatment given by antibodies capsule was given in the fourth treatment by gavage (Intra - Crop) after administration of 1 ml of acidity equalizer after preparing a tea spoon of equivalent acidity in 10 ml of distilled water (Sodium bicarbonate 2.80 gm, Tartaric acid 1.33gm, Citric acid 0.82 gm, Flavour to 5gm) . In the fifth treatment injected antibodies peritoneal membrane, and the sixth-treatment antibody was injected in the muscle (thigh, chest, neck) and in the seventh treatment injected objects counterrevolution in the yolk sac one day old and in the eighth treatment antibody injected under the skin (thigh, chest, neck) and in the ninth treatment antibody was injected intravenously. Notes from the current results of the experiment that the antibody injection in peritoneal membrane has led to a significant increase in body weight and the weighted increase in the seventh week of life compared to the rest of the transactions. In addition, got a significant increase (p> 0.05) in cumulative feed conversion ratio while significantly decreased the proportion of cumulative mortality (1-49 days) in the treatment of peritoneal injection and yolk sac injection treatment compared to the rest of the treatment. Inferred from the current study that giving intravenous IgY peritoneal membrane was significantly better than the rest of the transactions in its effect on the productive performance down Representative proportion of cumulative mortality and improve feed conversion efficiency, which is reflected in the body weight and increase the cumulative weighted.

الخلاصةأجريت الدراسة الحالية في مختبر كلية العلوم / جامعة الانبار للفترة من يوم 27-9-2012 ولغاية 17-11-2012 يوم لغرض مقارنة طرائق إعطاء علاج داء الاكريات Coccidosis في الأداء الإنتاجي لفروج اللحم عن طريق استعمال 135فرخ لحم غير مجنس بعمر يوم واحد سلالة Ross 308 وزعت فيها الأفراخ عشوائياً على تسع معاملات وبواقع خمس مكررات لكل معاملة و3 أفراخ لكل مكرر ( 15 فرخ / معاملة)، جرعت الأفراخ في المعاملة الأولى بالماء المقطر ( سيطرة سالبة ) عن طريق الحوصلة ( جرعة / فرخ)، وفي المعاملة الثانية جرعت الأفراخ عن طريق الحوصلة( Intra – Crop ) بالعترة الضارية لطفيلي الاكريات المعزولة محلياً وبواقع 5x 104كيس بيض / فرخ (2.5 مل ) بعمر 28 يوم لتكون معاملة السيطرة الموجبة ولغرض مقارنة طرائق إعطاء الكلوبيولين المناعي IgY المحضر محلياً، فقد تم إعطاءه بواقع 0.5 مل / فرخ وبتركيز 11.013748 mg/ml على جميع المعاملات ، وفي المعاملة الثالثة أعطيت الأجسام المضادة عن طريق كبسولة أعطيت الأجسام المضادة في المعاملة الرابعة عن طريق الحوصلة Intra – Crop)) بعد إعطاء 1 مل من معادل الحموضة بعد تحضير ملعقة شاي من معادل الحموضة في 10 مل ماء مقطر( Sodium bicarbonate 2.80 gm , Tartaric acid 1.33gm , Citric acid 0.82 gm , Flavour to 5gm ) وفي المعاملة الخامسة حقنت الأجسام المضادة بالغشاء البريتوني ، أما المعاملة السادسة فقد حقنت الأجسام المضادة في العضلة ( فخذ ، صدر ، رقبة ) وفي المعاملة السابعة حقنت الأجسام المضادة في كيس الصفار بعمر يوم واحد وفي المعاملة الثامنة حقنت الأجسام المضادة تحت الجلد ( فخذ، صدر، رقبة) وفي المعاملة التاسعة حقنت الأجسام المضادة وريدياً ( الوريد الجناحي ).يلاحظ من نتائج التجربة الحالية إن حقن الأجسام المضادة في غشاء البريتون قد أدى إلى حدوث زيادة معنوية في وزن الجسم والزيادة الوزنية في الأسبوع السابع من العمر مقارنه ببقية المعاملات. وحصلت زيادة معنوية (p>0.05) في معامل التحويل الغذائي التراكمي بينما انخفضت معنوياً نسبة الهلاكات التراكمية (1-49 يوم) في معاملة الحقن بالبريتون ومعاملة الحقن بالصفار مقارنه ببقية المعاملات.


Article
التحري عن قياس تركيز بروتينات الطور الحاد وبعض المعايير المناعية في امصال الحوامل في أشهر مختلفة من الحمل .

Authors: علاء طارق الحسناوي --- لبنى عبد العظيم --- رشا كاظم مهدي --- احمد عباس --- et al.
Journal: Journal of University of Babylon مجلة جامعة بابل ISSN: 19920652 23128135 Year: 2015 Volume: 23 Issue: 3 Pages: 73-80
Publisher: Babylon University جامعة بابل

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Abstract

AbstractThe aims of this study to detect the concentrations and titers of CRP (C-reactive protein) in serum of pregnant women, Blood samples subdivided into three groups according to gestation period. These were the first group (first, second, third months), the second group (fourth, fifth, sixth months) and the third group (the last three months of gestation) .Ten samples for each groups as compare with control groups (10). The present study showed significant differences between second and control group in C3 concentration and between third and control group in C3 concentration by using LSD

هدفت هذه الدراسة الى التحري عن تراكيز وعيارات بروتينات الطور الحاد C-reactive protein في مصل النساء الحوامل ,حيث تم جمع عينات دم من النساء الحوامل بعد تقسيمهم على ثلاث مجاميع ,تضمنت المجموعة الأولى الأشهر الثلاثة الأولى من الحمل (الشهر الأول ,الشهر الثاني ,الشهر الثالث) والمجموعة الثانية تضمنت الأشهر الثلاثة الوسطية من الحمل (الشهر الرابع ,الشهر الخامس ,الشهر السادس) ,في حين شملت المجموعة الثالثة الأشهر الثلاثة الأخيرة من فترة الحمل (الشهر السابع ,الشهر الثامن ,الشهر التاسع) وبواقع عشر عينات لكل مجموعة ,وقد تم دراسة هذه المجاميع بالمقارنة مع مجموعة السيطرة والتي كانت ايضا بواقع 10 عينات وأظهرت الدراسة وجود فرق معنوي في تركيز C3 بين المجموعتين الثانية والثالثة وفرق معنوي بين المجموعتين الثالثة ومجموعة السيطرة .

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