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Article
Histopathological and Serological Study of Goitre

Author: Talib Mohsin
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 1 Pages: 139-143
Publisher: Babylon University جامعة بابل

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Abstract

The correlation of histopathology and serology results in patient with goiter.Accurate detection of thyroid autoantibodies by enzyme linked immunosorbant assay technique namely thyroglobulin antibody, thyroid peroxidase antibody is crucial in the differentiation of autoimmune thyroid disorders from other form of thyroid diseases.Evaluation of the detection of thyroglobulin antibody and thyroid peroxidase antibody in different thyroid diseases using enzyme linked immunosorbant assay technique. Eighty patients admitted to Surgical Units of Al-Zahraa Teaching Hospital in Al-Kut from the period between august 2010 to August 2012 they were waiting to do thyroidectomy. They were chosen nonselective for serological evaluation of above autoantibodies, and correlation of the results with histopathological diagnosis. Colloid goiter is known cause of hyperthyroidism (5 were colloid goiter out of 10 total hyperthyroid patients) (50%), and still common thyroid surgery (60 were colloid goiterout of 80 thyroid surgery) (75%). 58 cases (72.5%) had colloid goiter, 11 patients had Graves' disease (13.75%), and 3 had lymphocytic thyroiditis (3.75%), 8 had thyroid neoplasia (both benign and malignant) (10%). The serological results; Antibodies results were positive in 7 patients (11%) in colloid goiter (p-> 0.05), 6 patients (66.6%) and 1 patient (33.3%) for Grave’s disease, and lymphocytic thyroiditis respectively (P-< 0.05)., while its all were negative in thyroid neoplasia. Serum thyroid autoantibodies determination is valuable test in clinical practice of autoimmune thyroid diseases.


Article
HISTOLOGICAL LESIONS OF SLAUGHTERED CALVE'S KIDNEYS IN MOSUL SLAUGHTER HOUSE

Author: H. K. Ismail
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2015 Volume: 14 Issue: 1 Pages: 112-123
Publisher: Basrah University جامعة البصرة

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Abstract

The objective of present study was to investigate the gross and histopathological findings of calves kidneys slaughtered in Mosul abattoir. Pathological examination were carried out on fifty calves' kidneys. The most common gross lesions were included 20% multifocal white spots, 16% enlarged pale kidneys20% congested enlarged kidneys , 10% small shrunken kidneys, 14% hyperemic hemorrhagic kidneys, 20% kidneys without any gross lesions. The common observation in the histopathological examination of the kidneys revealed slight to severe mononuclear infiltration were commonly observed, widening of the Bowman's space were common, nephrosis, glomerulonephritis, interstitial nephritis, acute tubular degeneration and necrosis. Cysts were observed also in this study.


Article
Role of Two Biocides in The Wounds Healing and side Effect in Rabbits

Author: Zainab B.Abdul-Kareem
Journal: Kufa Journal For Veterinary Medical Sciences مجلة الكوفة للعلوم الطبية البيطرية ISSN: 20779798 Year: 2015 Volume: 6 Issue: 1 Pages: 67-75
Publisher: University of Kufa جامعة الكوفة

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Abstract

This study was aimed to show the influence of two bioformulation on wounds healing ,side effect in liver and kidneys in rabbits . The results indicated that no effect on wound healing were observed in bioformulation treated group compared with the controls. There were toxic effects on the liver which was shown on histopathological examination as centrilobular vacuolation, necrosis of hepatocytes around congested central vein, pyogranulomatous lesion around dilated central vein with marked vacuolation of hepatocytes. On kidneys , histopathological results revealed severe hemorrhage in the cortical area between glomeruli and renal tubules, severe atrophy of glomeruli in the cortical area with some congested blood vessels in the renal parenchyma , severe atrophy of glomeruli in the cortical area with some congested blood vessels in the renal parenchyma and some degree of dilation of renal tubules.


Article
The Effects of Green Tea Extract on Liver and Kidney Functions in The Sprague–Dawley Male Rats Treated with Lead Nitrate

Authors: Ekhlass H. AL-Alasde --- Hameda Abd-Al Mahdi G
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 1 Pages: 215-224
Publisher: Babylon University جامعة بابل

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Abstract

Green tea has become a subject of interest because of its beneficial effects on human health, health hazards from increased Pb exposure as a result of industrial and environmental pollution are recognized. In this study, the effect of green tea extract (GTE) on lead nitrate induced toxicity was conducted to investigate the biochemical and histopathological effects on liver and kidney in Sprague–Dawley rats. Four groups of rats were used in this study, 6 animals in each group. First group was given distilled water, second group was given green tea, third group was given lead and forth group was given Lead and GTE orally to the rats with drinking water for 8 weeks, blood sample were collected and then animals sacrificed for histological test. Liver enzymes ALT, AST and ALP, and creatinin , urea for the kidney in the serum, determinations indicated the protective effects of green tea extract. Histopathological studies of liver and kidney revealed that supplementation of green tea extract resulted in mild tissue damage, decrease the inflammation, an enhanced Immunological reaction and regenerative capacity of the cells.


Article
Study of histopathological changes in brian of mice infected with Toxoplasma gondii isolated from domestic rabbit
دراسة التغيرات النسجية لدماغ الفئران المصابة بطفيلي التوكسوبلازما المعزولة من الارانب

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Abstract

The study was designed to determine the infection rate of Toxoplasma gondii in the rabbits and histopathological changes of infected internal organs in mice. A total of 60 blood samples were collected from clinically healthy rabbits from different region of Baghdad city for the serological detection of T. gondii infection. Biological assay in mice was performed by intraperitoneal inoculation of 0.1 ml digested organs suspension, (lungs, heart, liver, spleen, kidney, muscles, and brain) during the period from October 2013 until July 2014. The results revealed histopathological changes in bioassay mice infected by T. gondii isolated from domestic rabbit, no histopathological changes in the brain of animals of first group1 (control group), but in the group 2 (killed at day 15) the main pathological changes were perivascular perineuronal edema with presence of some degenerated neurons characterized by shrunken dark blue stained (basophilic) cell bodies. In the animals of the group 2 (killed at day 21) the main brain histopathological changes were Sever congestion of meningeal blood vessels with infiltration of inflammatory cells and focal aggregation of microglial cells with diffuse obvious focal gliosis, whereas, in the same group animals that killed at day 28 the main brain histopathological changes were focal encephalomalacia and edema between molecular and granular layer

استهدفت الدراسة الحالية تحديد نسبة الاصابة بداء المقوسات الكوندية في الارانب، ودراسة التغيرات النسجية الاعضاء المصابة في الفئران، لتحقيق هذين الهدفين تم جمع 60 نموذج دم من ارانب سليمة سريريا من مناطق مختلفة من مدينه بغداد لتحديد الاصابة بداء المقوسات الكوندية مصليا، اما التحليل الحيوي في الفئران فقد تم اجراءه من خلال حقن 0.1 مل من خليط الاعضاء المهضومة (الرئتين، القلب، الكبد، الطحال، الكليتين، العضلات والدماغ) في البريتون وذلك للفترة من تشرين الاول 2013 لغاية تموز2014. واظهرت النتائج عدم وجود اي تغيرات نسجية مرضية في ادمغة فئران مجموعة السيطرة، بينما اظهرت وذمة حول الاوعية الدموية وحول الاعصاب مع وجود بعض الاعصاب المتنكسة تميزت بانكماش الجسيمات الخلوية وتلونها بلون ازرق داكن في الفئران المقتولة في يوم 15 من الحقن، اما الفئران المقتولة في يوم 21 من الحقن فقد كانت التغيرات النسجية الرئيسية في الدماغ عبارة عن احتقان شديد في الاوعية الدموية للسحايا مع ارتشاح للخلايا الالتهابية وتجمع موضعي للخلايا الدبقية الدقيقة وتدبق موضعي واضح ,بينما تمثلت التغيرات النسجية في الفئران المقتولة في يوم 28 بعد الحقن بوذمة بين الطقة الحبيبية والطبقة الجزيئية.


Article
Effects of sub lethal doses of endosulfan on histopathological and biochemical parameters of common carp (Cyprinus carpio)
تأثير الجرعة تحت القاتلة لمبيد الاندوسلفان على بعض الصفات المرضية النسيجية والكيموحيوية لأسماك الكارب الاعتيادي (cyprinus carpio)

Author: Mohanad obayes abdullah AL-jubouri مهند عبيس عبد الله الجبوري
Journal: Al-Qadisiyah Journal of Veterinary Medicine Sciences مجلة القادسية لعلوم الطب البيطري ISSN: 18185746 23134429 Year: 2015 Volume: 14 Issue: 1 Pages: 88-94
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

The study aim to determine the LD50 of endosulfan in fishes. Sixty (60) fishes of common carp 140-160 gm. body weight were utilized. The fishes were adapted and acclimated to the laboratory conditions in the college of Veterinary Medicine, AL-Qassim Green University for 2 days before starting of the experiment, then were exposed to (10 mg/L, 5mg/L, 3mg/L, 2mg/L, 1mg/L) of endosulfan for 24 hours. Results were demonstrated that the LD50 of endosulfan in fish was (2.28mg/L). The ALT and AST Liver enzymes were show significant elevation compare with control. Kidney sections show inflammatory cells infiltration particularly macrophage and neutrophils around the tubules with necrotic area in addition to vacuolar degeneration of epithelial lining cells of renal tubules. Histological sections of liver show cellular hypertrophy, swelling, and apoptosis of hepatic cells, and at the same time hepatocytes lost their normal polygonal structure in addition to necrosis of hepatocytes.

هدفت الدراسة الى تحديد الجرعة نصف القاتلة لمبيد الاندوسلفان في الاسماك. استخدمت في التجربة 60 سمكة من اسماك الكارب الاعتيادي (Cyprinus carpio) تراوحت اوزانها ما بين 140- 160 غرام. أجريت التجربة في مختبر كلية الطب البيطري / جامعة القاسم الخضراء. حيث تم تكيف الأسماك وتأقلمها على ظروف المختبر لمدة يومين قبل إجراء التجربة بعدها تعرضت الأسماك إلى تراكيز مختلفة من الاندوسلفان لمدة 24 ساعة (10mg/L, 5mg/L, 3mg/L, 2mg/L, 1mg/L) اظهرت النتائج ان الجرعة نصف القاتلة كانت (2.28mg/L) ، ومن جانب أخر أظهرت فحوصات أنزيمات الكبد زيادة معنوية مقارنة بمجموعة السيطرة ، وقد أظهرت المقاطع النسيجية للكلية ارتشاح حول النبيبات الكلوية مع مناطق تنخريه بالإضافة إلى وجود الفجوات في بطانة النبيبات الكلوية وارتشاح خلايا البلعمة والعدلة حول المناطق التنخرية والنبيبات. أظهرت المقاطع النسيجية للكبد وجود تضخم في خلايا الكبد وكذلك تورم الخلايا الكبدية ، تفمم الخلايا الكبدية وفقدان شكلها الطبيعي بالإضافة إلى زيادة الخلايا التنخرية .


Article
Histopathological effects of Doxorubicin on pancreas in male Albino rats
التأثيرات المرضية النسجية لعقار الدوكسوروبسين على البنكرياس في ذكور الجرذان البيض

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Abstract

The aim of this study was to investigate the histopathological side effects of doxorubicin on pancreas tissue in male albinorats Rattus norvegicus. This study were used 55 adult rats (2.5-3.5) month of age. The rats divided into two groups, the firstgroup include (35) rats. The second group were (20) rats. Microscopial examination of pancreas lesion demonstrated oedemaaround the acini, swelling of the epithelial cells of acini, occurance of cystic fibrosis (mucoviscidosis) at the concentration of(4,5) mg/kg of body weight ,occurrence of small islets that form of few cells and exocrine-endocrine transformation. Therewere thickness in the walls of blood vessels, thrombus, congestion of blood vessels, we conclude, that doxorubicin hadhistopathological effect on pancreas in sub-acute doses more than chronic doses.

ھدفت الدراسة الحالية الى تقصي التأثيرات الجانبية المرضية لعقار الدوكسوروبسين(٣,٥ ) شھر. قسمت الجرذان الى مجموعتين، - أستخدم في ھذه الدراسة ٥٥ جرذا بالغا بعمر( ٢,٥ .Rattus norvegicus الجرذان البيض المجموعة الاولى ضمت ( ٣٥ ) جرذا، المجموعة الثانية ضمت ( ٢٠ ) جرذا. أظھرت الدراسة النسجية للبنكرياس, الوذمة في النسيج العنبي، تضخم في الخلايا المبطنة للعنبات، ظھور التليف الكيسي، تحول النسيج العنبي الى الصماوي، والتثخن في جدران الاوعيةالدموية، الخثرة، الاحتقان في الاوعية الدموية. نستنتج ان للدوكسوروبسين تأثيرات نسجية مرضية في البنكرياس في الجرح تحت الحادة اكثر من الجرع المزمنة.

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