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The Role of Estrogen Receptors Immunohistochemical Study in Prognosis of Bladder Transitional Cell Carcinoma

Authors: Ahmed Aswed Hussein --- Nemah Hassony Al-Jubori --- Ali Hasan Al-Timimi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 4 Pages: 882 -889
Publisher: Babylon University جامعة بابل


Urothelial Bladder cancer (UBC) is a common and complex disease that have various internal and external risk factors and represent 90% of bladder cancer.Various studies involving immunohistochemical staining of estrogen receptors(ER) have rendered inconsistent results regarding the expression of ERα and ERβ for different bladder cancer stages and grades.Ninety five Paraff in embedded blocks of UBC (68 male and 27 female) were studied by immunohistochemical technique for detection of estrogen receptor expression and its correlation to some of prognostic parameters such as sex, age, grade and stage of UBC. The study was carried out in the Department of Pathology College of Medicine Babylon University during the period from November 2013 to Augest 2015. Mean age of all cases was 64.6 and they ranged from 30 to 90 years old. The results showed that there were low rate of estrogen receptor expression (only 15 positive cases) and no significant correlation between estrogen receptor expression and the involved prognostic parameters (p value > 0.05). So estrogen receptor expression cannot be used to assess the prognostic outcome for Urothelial bladder cancer.

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