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Pure red cell aplasia in chronic lymphocytic leukemia: Case report and review of literature

Authors: Liqaa M. Al‑Shareefy --- Hassanain H. Al‑Charrakh
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2016 Volume: 5 Issue: 2 Pages: 187-191
Publisher: Al-Mustansyriah University الجامعة المستنصرية


Despite being immune deficient, chronic lymphocytic leukemia (CLL) patients have an increased incidence ofautoimmune cytopenias secondary to autoantibody formation. These are: warm autoimmune hemolytic anemia;idiopathic thrombocytopenia; pure red cell aplasia (PRCA), and In this case report, we describe a patient withCLL who developed severe anemia requiring frequent red cell transfusion after the third cycle of chemotherapy.Blood film showed no evidence of hemolysis and absolute reticulocytopenia. Bone marrow showed erythroidhypoplasia and residual interstitial infiltrate of CLL. The diagnosis of CLL‑induced PRCA was made, and thepatient showed a prompt and dramatic response to treatment with cyclosporine.

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