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Effect of non surgical periodontal treatment on TNF-α levels in serum of patients with chronic periodontitis
تأثير علاج اللثة غير الجراحي على مستويات TNF-α في مصل المرضى الذين يعانون من التهاب اللثة المزمن

Authors: Haween T. Nanakaly --- Sazan Sartip Abdulhameed
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2016 Volume: 20 Issue: 1 Pages: 1167-1174
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Chronic periodontitis is a multifactorial inflammatory disease characterized by destruction of tooth supporting tissues. Tumor necrosis factor-α, a key inflammatory cytokine, plays an important role in periodontal destruction. This study aimed to analyze the effect of non-surgical periodontal treatment on tumor necrosis factor-α levels in serum of patient with chronic periodontitis (with and without using chlorhexidine 0.2% mouthwash).Methods: A total of 44 patients with moderate to severe localized chronic periodontitis were divided into: Group I (n=22) without using of chlorhexidine mouthwash and Group II (n=22) with 0.2% chlorhexidine mouthwash. Serum samples collected from each subjectsat baseline and four weeks after scaling and root planning treatment were quantified fortumor necrosis factor-α levels using ELISA technique.Results: The mean concentration of TNF-α were significantly reduced one month after treatment in sera of patients with chronic periodontitis for group I when compared to its mean concentration before treatment (P <0.05), while in group II a highly significant reduction after one month treatment (P <0.001) was observed.Conclusion: The effect of non-surgical periodontal therapy with chlorohexidine mouth wash showed more reduction in the levels of serum tumor necrosis factor-α.


Article
Study of Serum Level of Interleukin 2, Interleukin 10 and Tumor necrosis factor-α in sample of Iraqi psoriasis patients

Author: ss. Prof. Dr. Talib Abdulla Hussein Azhar Jassim Mohsen Hind yousif khalaf
Journal: journal of the college of basic education مجلة كلية التربية الاساسية ISSN: 18157467 Year: 2016 Volume: 21 Issue: 91/علمي Pages: 1-12
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Abstract :The aim of this study was to determine the Th1 and Th2 serum cytokines, in patients with psoriasis and to compare their cytokine levels with those of normal control subjects. where study included 55 Iraqi patients with psoriasis:30 (15 females ,15 males) were untreated with any drugs. The other patient group consist of 25 (9 female and 16 male) treated with a biological treatment (infliximab) ,and 30 healthy control group were withdrawn (5) ml of venous blood for both patients and members of the control ,to conduct Immunological tests to determine the quantitative for each of level of IL-2,IL-10 and TNF-α in a manner (ELISA). The results showed significant increase in the level of probability (P <0.05) in the rate of level of IL-10 and TNF-α in patients compared to the control (healthy) .As well as the result also show no significant increases of IL-2.From this we can deduce that pro inflammatory and anti-inflammatory cytokines have an important role in the pathogenesis of psoriasis, the increase of IL-10 and TNF-α indicated the balance between the proinflammatory and the anti-inflammatory cytokine .

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