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Article
Assessment of Omentin-1 as a predictor and Renoprotective for type 2 Diabetic Nephropathy
تقدير الاومنتين_1كمؤشر ااستباقي وحماية كلوية للنوع الثاني لاعتلال الكلويالسكري

Authors: Sarah Salim Mohammed Al-Fahdawi ساره سالم محمد --- Isam Noori Al-Karawi عصام نوري سلمان
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2017 Volume: 30 Issue: 1 Pages: 18-23
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Diabetic nephropathy is one of the most serious microvascular complications of diabetes, which may lead to chronic kidney disease in diabetic patients.Objective: to explore correlation of omentin-1 and diabetic nephropathy in type 2 diabetic patients.Method: Serum omentin-1 levels were measured by enzyme-linked immunosorbent assay (ELISA) in 61 type 2 diabetic patients. These patients were classified into two groups according to their albumin/creatinine ratio (ACR), into patients with normoalbuminuria, group C (ACR< 30 mg/mmol), patients with microalbuminuria, group B (ACR=30-300 mg/mmol), twenty five (25) (10 male and15 female) apparently healthy matching the Pearson were selected as a control group (group A).In addition, glucose and lipid profile and morphological characters were assessed.Result: The serum OMT level of group B was much lower than those of group C and group A. While, there was non-difference in OMT level between group C and group A.Conclusion: Detection of serum OMT level may play an important role in early diagnosis and prevention of diabetic nephropathy in T2DM.


Article
Evaluate the Plasma Iron Levels on Iraqi Type 2 Diabetic Nephropathy
تقييم مستويات الحديد في بلازما الدم لدى العراقيين المصابين بالسكر الكلوي من النوع الثاني

Authors: Shakir Faris Tuleab شاكر فارس طليب --- Sarah Mohammed Abd-Allah ساره محمد عبدالله --- Maher Ahmed Abed ماهر أحمد عبد
Journal: Journal of university of Anbar for Pure science مجلة جامعة الانبار للعلوم الصرفة ISSN: ISSN:PISSN: 19918941/EISSN: 27066703 Year: 2017 Volume: 11 Issue: 1 Pages: 9-13
Publisher: University of Anbar جامعة الانبار

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Abstract

Diabetes is linked with a change of homeostasis for the plasma iron in human, that have the ability to produce reactive oxygen species (ROS) induced by this disease and its microangiopathy complication especially diabetic nephropathy (DN). In addition, iron indicators are associated with obesity and insulin sensitivity as contribute to the development and improvement of oxidative damage. The objective of the study was to measure and evaluate the level of iron in the plasma in diabetic patients with and without DN, and in normal individuals, The current study was conducted on sixty T2D patients diagnosed beforehand, these patients were categorized into two equal groups according to their albumin to Creatinine ratio (ACR), including patient with nephropathy (UAC=30-300 mg/g Creatinine), (I) and patients without nephropathy (UAC<30mg/g Creatinine), (II). Twenty four healthy persons were chosen as a control group. Each group included the same numbers of male and female. The age of patients ranged from (36-65) year . The results showed that the plasma level of iron showed a high significant increasing in patients without DN group (177.10±76.36 μg/dl) compared to patients with DN and healthy control groups (126.77±61.16 vs 116.79±26.16 μg/dl, respectively).

يرتبط مرض السكري مع توازن الحديد في الإنسان. حيث أن له القابلية على توليد الجذور الحرة وأنواع الأوكسجين التفاعلية (ROS) وترتبط مؤشرات الحديد مع السمنة والحساسية للانسولين والتي يمكن أن تسهم في تطور وتقدم الإعتلال الكلوي السكري . الهدف من هذه الدراسة تقدير ومقارنة مستوى بلازما الحديد في الأشخاص الطبيعيين وفي مرضى السكري مع أو بدون اعتلال الكللى السكري. أجريت الدراسة الحالية على ستون مريضاً مصاباً بمرض السكري النوع الثاني حيث كانت تتراوح أعمارهم بين (36-65)سنة لكلا الجنسين تم تشخيصهم مسبقاً. تم تقسيم المرضى الى مجموعتين متساويتين وفقا الى نسبة الألبومين-كرياتينين ضمت المجموعة الأولى المرضى الذين يملكون إعتلال الكلى وسميت مجموعة مرضى إعتلال الكلى السكري في حين إحتوت المجوعة الثانية المرضى الذين لديهم نسبة الألبومين طبيعية وسميت مجموعة المرضى بدون إعتلال الكلى السكري, ولغرض المقارنة تم إختيار أربع وعشرون شخصاً سليماً كمجوعة أصحاء. في المقابل مستوى بلازما الحديد أظهر زيادة معنوية عالية لدى مرضى السكري الذين لايمتلكون إعتلال الكلى السكري ( 177.10± 76.36 مايكرجرام/ديسيلتر) بالمقارنة مع مجوعتي المرضى بدون إعتلال الكلى السكري والأصحاء(126.77 ± 61.16 و 116.79 ± 26.16, مايكرجرام/ديسيلترعلى التوالي).


Article
Neutrophil gelatinase associated lipocalin (NGAL) in early detection of nephropathy in type 2 diabetic Iraqi patients

Authors: Ahmed A. kahdem احمد عبد كاظم --- AliA.DyabAllawi علي عبد المجيد ذياب --- Shaymaa Z. Nada شيماء زهراو ندى --- Kismat M. Turki قسمه محمد تركي
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2017 Volume: 59 Issue: 1 Pages: 74-78
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Diabetic nephropathy is a common complication of diabetes mellitus type2. The neutrophil gelatinase Associated lippocallin (NGAL) is an ubiquitous protein consist of 178 amino acid. NGAL can be identified in plasma and urine starting 2- 4 hours after a kidney injury resulting changes in glomerular filtration and tubular reabsorption and with increased secretion in tubular epithelial cells.Objective: This study aimed to evaluate the role of serum Neutrophil Gelatinse Associated Lipocallin (NGAL) in early detection nephropathy.Method : This study was conducted in Medical City, Baghdad Teaching Hospital during the period from December 2015to June 2016.The study included (90) subjects with age range between (30 – 56)years, divided in to three groups , 30 healthy control,30 type 2 diabetic mellitus patients with normal albuminuria and 30 type2 diabetic mellitus patients with micro albuminuria .Body mass index (BMI) was determined, serum NGAL, Fasting serum glucose (FBS),serum creatinine ,serum urea ,andglycated hemoglobin (HbA1c%) were measured for each individual in addition to the concentration of albumin in urine and Glomerular Filtration Rate (eGFR) was calculated.Results:The results of the present study showed that the levels of NGAL, FBS, HbA1c, urea creatinin, were significantly higher in micro albuminuria than normal albuminuria and healthy control. In diabetic patients with micro albuminuria, Serum NGAL shows significant positive correlation with FBS, HbA1c% and urine albumin. Serum NGAL shows significant positive correlation with duration of diabetes but significant negative correlation with GFR.Conclusion:Serum NGAL increased markedly with the reduction of GFR.Serum NGAL is may be considered predictive marker for early detection of diabetic nephropathy in type2 diabetes mellitus.Keywords:diabetic mellitus,diabetic nephropathy,micro albuminuria, serum NGAL, HbA1c.


Article
Evaluation of Haptoglobin and Neutrophil Gelatinase Associated Lipocalin in Iraqi Patient with Type 2 Diabetic Nephropathy

Authors: Sarah Mohammed Abd-Allah Al-Amri --- Shakir Faris Tuleab Al-Aaraji
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2017 Volume: 20 Issue: 2 Pages: 7-16
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Diabetic Nephropathy (DN) is refereed as the kidney injury that occurs in individuals with diabetes, the earliest detectable change is the thickening in the glomerulus. The study objectives to estimate the diagnostic value plasma levels of Haptoglobin (HPt) and neutrophil gelatinase associated lipocalin (NGAL) as biomarkers for early disclosure of nephropathy in type 2 diabetic (T2D) patients. The present study was conducted on sixty T2D patients diagnosed beforehand, these patients were categorized into two equal groups according to their albumin/ creatinine ratio (ACR), including patients with normoalbuminuria (I) (ACR<30mg/g Creatinine) and patients with microalbuminuria (II) (ACR=30-300 mg/g creatinine), twenty four healthy were chosen as a control group (III). Aspartate aminotransferase (AST), alanine aminotransferase (ALT), hemoglobin (Hb), U.Mic, U.Cr, ACR, HPt and NGAL were measured in the studied groups. NGAL & HP were found to have a strong positive correlation with fasting plasma glucose (FPG), urine microalbuminuria (U.Mic), urine Creatinine (U.Cr) and (ACR). The present study reveals high significant differences between male and female diabetic patient groups in terms of Hb.In conclusion, a significant role for plasma NGAL and HPt in pathogenesis and progression of renal harm in DM, and a strongly positive correlated with the severity of proteinuria. This may be clinically useful variables for predicting the improvement of DN in the early stages of T2DM in the Iraqi population.


Article
Evaluation of Serum Chemerin Level in Diabetic, Hemodialized Patients
تقييم مستوى الكيميرين في مصل دم المرضى المصابين باعتلال الكلية السكري المزمن

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Abstract

Background: Diabetic nephropathy (DN) also called diabetic kidney disease (DKD) is one of the maincomplications of diabetes mellitus (DM) and it is the most common cause of end-stage renal disease(ESRD). Diabetes mellitus has been proved as conventional risk factors for the development of coronaryartery diseases (CAD). Adipose tissue is now considered as an active endocrine gland secretes severalinflammatory cytokines, namely, adipokines or adipocytokines such as chemerin, visfatin, leptin andothers, which interfere with insulin sensitivity, with glucose and lipid metabolism, and with theinflammatory process. Aim: The aim of this study was to evaluate serum chemerin level and otherbiochemical parameters in in diabetic hemodialized patients to determine the risk of cardiovasculardiseases (CVD) in DKD. Materials and methods: This case control study was conducted on a samplecomposed of 50 patients with diabetic nephropathy and a control group consists of 50 apparently normalhealthy subjects. Estimation of serum chemerin level by ELIZA, lipid profile, Blood urea, serumcreatinine, serum albumin, serum electrolytes, serum uric acid and serum malondialdehyde (MDA) weredone for both patients and control. Body mass index (BMI) and glomerular filtration rate (GFR) werecalculated for both patients and control. Atherogenic index of plasma (AIP) and coronary artery diseaserisk percentage (CAD risk %) were also calculated for both patients and control group. Results: Theresults of this study showed that the level of serum chemerin was significantly higher in DN patientscompared to control.Serum chemerin level was correlated with other parameters.

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