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Article
The Effect of Phoenix Dactyliferia Extract on Giardiasis in Laboratory Mice: Case Control Study

Author: Mehdi A Al-Ruhalaty
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2017 Volume: 10 Issue: 2 Pages: 2792-2799
Publisher: Kerbala University جامعة كربلاء

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Abstract

back ground: Giardiasis is a common parasitic infection in the tropical and subtropical areas. It is a common cause of gastroenteritis in humans and other domestic animals. This parasite cause great morbidity and ill health, like mal absorption, irritable bowel and loss of work days. It is usually treated by drug called metronidazole which has bad neurological and gastro intestinal side effects. Recently many plant extract are tried in treatment of some intestinal parasite to avoid the risk of chemical compound and one of these extract is the phoenix dactyliferia.Objectives: To study the effect of Phoenix dactyliferia on intestinal giardisis in mice and compare its effect with metronidazole. This extract of date palm is a natural herbal medicine with supposed negligible side effect.Material and methods: This is a case-control study done in cage of al- Al- Habboby laboratory in corporation with the college of pharmacy, Karbala University. The study was done in the period from 1/11/2013 to 20/11/2013. Sufficient amount of the extract phoenix dactyliferia had been prepared for treatment trial. 75 mice rendered infected with giardisis by giving 2 ml of the dilute stool from infected animals. Then the animals are classified into 5 groups, each group composed of 15 mice. The first three groups were given, 1000mg/ kg, 2000 mg/ kg, and 3000mg/kg respectively. The fourth group was given metronidazole, 200mg/kg and lastly the fifth group was given distil water as a control group. The mice were sacrificed according to the protocols of animal rights and all biopsies sent to histological lab of our college.Results: the group of mice given 3000mg/kg of the extract, showed negative stool examination for giardiasis in the 4th day which is similar to the result of metronidazole. It was also statically significant.Conclusion and recommendation: Phoenix dactyliferia has similar efficacy to metronidazole in laboratory animal. This natural treatment may be beneficial in treatment of human giardiasis.


Article
Prevalence the Infection with Giardiasis in Baghdad Province / Iraq

Author: Qater Al-nada Ali Kanaem AL-Ibady
Journal: Journal of University of Babylon مجلة جامعة بابل ISSN: 19920652 23128135 Year: 2017 Volume: 25 Issue: 3 Pages: 962-967
Publisher: Babylon University جامعة بابل

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Abstract

The source of water and low educational level family played very important role in prevalence of giardiasis because of poor habits, overcrowded in schools and families and poor hygiene. Therefore, the aims of this study have been undertaken to study the prevalence of infection with intestinal parasite Giardia lamblia for both sexes (males and females). The results recorded there are no significant differences in the gender and prevalence rate of the giardiasis. Which whereas for males 51.55% and 48.45% for females from 97 cases which examined in Baghdad teaching and children central hospitals to Baghdad province, and the samples examined by laboratory examination, general stool examination, direct stool examination, in direct stool examination and concentration stool method (CSM), at period from October 2011 to the end of March 2012. While recorded the highest ratio of prevalence infection with this parasites in children with age group (1-10) years, which were 25.77%. Also in this study recorded the highest rate of infection for patients whose drinking contaminated water sources , which were 85.57%, because these water contents on the highest ratio of cyst stages , which whereas 79.3%, that causes chronic infection with G. lamblia.

تلعب مصادر المياه وانخفاض المستوى الثقافي للعائلة دوراً مهماً في انتشار الاصابة بمرض الجيارديا (Giardiasis) بسبب العادات الخاطئة وازدحام العوائل والمدارس وسوء النظافة الشخصية. تهدف هذه الدراسة إلى معرفة نسب انتشار الاصابة بالطفيليات المعوية Giardia lamblia لكلا الجنسين (الذكور والاناث) . كانت الاختلافات غير معنوية ما بين الجنسين وانتشار الاصابة بمرض الجيارديا والتي بلغت 51.55% للذكور و48.45% للإناث من مجموع 97 حالة تم فحصها في مختبرات مستشفيي بغداد التعليمي والطفل المركزي لمحافظة بغداد، وفحصت العينات بطريقة الفحص المختبري وطريقة فحص البراز العام بوساطة فحص البراز المباشر وغير المباشر وطريقة تركيز البراز، للمدة من تشرين الأول 2011 حتى نهاية آذار 2012. بينما سجلت اعلى نسبة لانتشار الاصابة بهذه الطفيليات في الاطفال لمجاميع الاعمار (1-10) سنوات والتي كانت 25.77% . كذلك سجلت في هذه الدراسة اعلى نسبة للإصابة في المرضى الذين يشربون مصادر مياه ملوثة والتي كانت 85.57%، لان هذه المياه تحوي اعلى نسبة من الاطوار الكيسية (cysts) والتي بلغت 79.3% وبالتالي تسبب الاصابة المزمنة بالجيارديا لامبيليا .

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