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Article
Study theeffect ofTamoxifenon Lipid profilein Male Albino Rats
دراسة تأثير عقار التاموكسيفين على صورة الدهون في ذكور الجرذان البيض

Authors: Aqeel H. Qasim عقيل حسين قاسم --- Abed H. Baraj عبد حسن براج
Journal: Iraqi Journal of Science المجلة العراقية للعلوم ISSN: 00672904/23121637 Year: 2017 Volume: 58 Issue: 4A Pages: 1815-1819
Publisher: Baghdad University جامعة بغداد

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Abstract

Tamoxifen(TAM) is an effective anticancer drug. This study was conducted to evaluate the side effects of Tamoxifenon the lipid profile. 40 rats divided into 4 equal groups,3 groups were given different doses (30, 40, 50)mg/kg body weight of TAM three times a week for 8 weeks as well as control group that was given with physiological solution.At the end ofexperiment, The results showed significant differences in the treated groups were the results showed a significant degrees (p<0.05) in the HDL level in the treatment group (50mg/kg) while the three groups showed a significant increase in the levels of (Ch, TG, LDL, VLDL). The results of the study showed that Tamoxifen caused an accumulation in fats.

تاموكسيفين هو دواء فعال مضاد للسرطان. أجريت هذه الدراسة لتقييم الآثار الجانبية للتاموكسيفين على صورةالدهون.استخدم لهذا الغرض أربعونجرذ بيضوقسمت إلى 4 مجموعات متساوية. أعطيت 3 مجموعات جرعات مختلفة (30, 40, 50)ملغم/كغم من وزن الجسم من عقار التاموكسيفين ثلاث مرات في الأسبوع و لمدة ثمانية أسابيع . فضلا عن مجموعة السيطرة التي تم تجريعها بالمحلول الفسيولوجي.في نهاية التجربة أظهرت نتائج الاختبارات البايوكيميائية وجود فروق معنوية في مجموعة المعاملة حيث أظهرت النتائج وجود انخفاض معنوي(P<0.05) في مستوى HDL في مجموعة المعالجة (50) ملغم/كغم بينما أظهرت المجموعات الثلاث زيادة معنوية في مستويات (Ch, TG, LDL, VLDL) مقارنة مع مجموعة السيطرة .وأظهرت نتائج الدراسة أن التاموكسيفين يسبب تراكم في الدهون.


Article
Influence of smoking on lipid profile in Iraqi men

Author: Safa W. Azize
Journal: Muthanna Medical Journal مجلة المثنى الطبية ISSN: 2226146x Year: 2017 Volume: 4 Issue: 2 Pages: 85-91
Publisher: Al-Muthanna University جامعة المثنى

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Abstract

Cigarette smoking is generally considered as associated with increased risk of a variety of medical disorders. Several studies provide the evidences that a smoking is strongly associated with change the normal status of the lipid profile. The present study aimed to compare the lipid profile between smokers and non-smokers and to determine the influence smoking on the lipid profile in our community. Forty smoking males and thirty non-smoking males from different areas of Babylon governorate were included in this study. Their age was ranged between 20 and 40 years. Fasting blood was withdrawn from all groups and used for determination of lipid profile [Cholesterol, Triglyceride (TG), High density lipoprotein (HDL) and low-density lipoprotein (LDL)]. Significantly increased of serum Cholesterol,Triglyceride and Low density lipoprotein with significant decreased in serum High density lipoprotein level in smokers as compared to nonsmokers . These results showed that the mean levels of TC, TG and LDL were elevated with increase in the duration of smoking while HDL showed a decreased with the increases duration of smoking. This study concluded that smoking causes alteration in lipid profile. This smoking might be related in the alteration in serum lipids levels and increases risk for coronary artery disease and other diseases.


Article
THE ROLE OF L-CARNITINE IN THE IMPROVING LIVER FUNCTIONS AND LIPID PROFILE IN VOLUNTEERS FROM KIRKUK CITY
دور Lــ كارنيتين في تحسين وظائف الكبد والدهون في المتطوعين من مدينة كركوك

Author: Fidan Fikrat. Ahmed فدان فكرت احمد
Journal: AL-TAQANI مجلة التقني ISSN: 1818653X Year: 2017 Volume: 30 Issue: 2 Pages: E27-E34
Publisher: Foundation of technical education هيئة التعليم التقني

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Abstract

The dietary supplement industry is constantly developing, continuously offering a wide variety of products for athletes and non-athletes. This study has conducted to investigated the biological activity of L-carnitine on some physiological criteria in the sera of sixty sportsmen (volunteers) male only in age of ( 18-24 ) years in Kirkukcity in spring of ( 2015 ) , the particular testing period continue for (4) weeks and the volunteers were randomly divided into (2) groups each group include (30) volunteer as following: The first group of athletes was control groupin which did not supplysupplementations,the second group of athletes who have used L- carnitine (500 mg) per day and an average of twice a day for 15 dayssupplementations. The results have been indicated the following: The sportsmen whom received L- carnitine every day for 15 days showed a significant increase in the concentrations of High-density lipoproteinHDL –cholesterol while there was a significant decrease in the concentrations ofAspartate Transaminase (GOT) ,Alanine Transaminase (GPT) andAlkaline phosphatase(Alp) enzymes , total cholesterol(Cho) and Triglycerides(T.G) in comparison with control group before and after the exercise. The current study revealed that using L-carnitine as supplements for sportsmen have an important effects on most of physiological and biochemical activities of the body and a positive effect to improve exercise performance.

صناعة المكملات الغذائية تتطور باستمرار، وتقدم مجموعة واسعة من المنتجات للرياضيين وغير الرياضيين. أجريت الدراسة الحالية على ستين رياضي (متطوعين)ذكور فقط في سن (18-24) سنة في مدينة كركوك في ربيع عام (2015)، واستمرت الاختبارات لمدة (4) أسابيع , تم تقــسيــم المتــــطوعين عشوائـــيا ً الى مجموعتييـــــن كل مجموعة تضم (30) متطوع على النحو التالي:المجموعة الاولى (مجموعة السيطرة)تضم الرياضيين دون اخذ اي نوع من المكملات والمجموعة الثانية تضم الرياضيين الذين استخدموا L- الكارنيتين بكمية (500 ملغ) يوميا وبمعدل مرتين في اليوم لمدة 15 يوما.هدفـــت هذه الدراسة الــتحـقــق من النشاط البيولوجي Lـ كارنيتين على بعض المعايير الفسيولوجية في مصل الرياضييناظهرت النتائج زيادة كبيرة في تركيزHDL -cholesterolفي الرياضيين الذين حصلوا على Lـ كارنيتين كل يوم لمدة 15 يوما , في حين كان هناك انخفاض ملحوظ في تراكيز انزيمات GPT GOT,وAlpوالكوليسترول الكلي والشحوم الثلاثية مقارنة مع مجموعة السيطرة قبل وبعد ممارسة الرياضة. يستنتج من هذه الدراسة أن استخدام L ــ كارنيتين كمكملات للرياضيين لها تأثيرات هامة على معظم الأنشطة الفسيولوجية والبيوكيميائية للجسم ولها تأثير إيجابي على تحسين أداء التمارين الرياضية.


Article
Effects of Metformin and diet on hemoglobin, cholesterol and triglyceride levels of Type 2 diabetic Patients

Authors: Shaymaa Z. Al-Rumaidh --- Rana Talib Almuswie --- Luma R. Lafta --- Alyaa A.Hafedh
Journal: JOURNAL OF THI-QAR SCIENCE مجلة علوم ذي قار ISSN: 19918690 Year: 2017 Volume: 6 Issue: 2 Pages: 45-49
Publisher: Thi-Qar University جامعة ذي قار

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Abstract

Metformin is recommend as the first line oral agent to be used patients with non-insulin-dependent diabetes mellitus(Type 2 Diabetic).The study was prospectively performed in diabetic and endocrine center of Nassiriyah city .The present study aimed to shed light on metformin and hemoglobin(Hb) and lipid profile in type II diabetic patients with diet and without diet . Our study included 60 patients treated with metformin for Twelve-week . The subjects were divided into three groups. Group I as control, group II patients received Metformin- (1000/2 mg/day) with diet and group III patients received the Metformin-(1000/2 mg/day) without diet all these patient had been selected from those patients visit . The Hb concentration and lipid profile were been examine after 3 months of treatment.In present study we found the hemoglobin concentration reduced in group II with diet patient compare with the group III and control group also reduced in the group III without diet patient compare with control group, as same time This study showed that the treatment with metformine led to, reductions observed in the cholesterol concentrations of the group II diabetic patients with diet compared with the group III administered MET respective without diet diabetic and compared with control, Also we found the triglyceride concentrations of diabetic patients in group administered MET respective with diet were significantly (p<0.05) reduced compared with that of without diet diabetic and control therefore it was considered predisposing factor to reduced damage diabetes. For this reason; continuous taking of metaformin should be important in medicine and general healthy, and they must be not used unless consult of specialists.


Article
13.EVALUATION OF ANTEMORTEM AND POSTMORTEM LEVELS OF ORGANOCHLORINE PESTICIDES IN A SAMPLE OF IRAQI PEOPLE

Authors: Harb S. Hmood حرب سلمان حمود --- Noor M. Ali نور مصطفى علي --- Muataz A. Al-Qazzaz معتز عبد المجيد القزاز
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2017 Volume: 15 Issue: 4 Pages: 420-430
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background: Organochlorine pesticides have long been widely used in agriculture and in public health as highly effective pest control agents. They are lipophilic and have prolonged half-lives of years to decades; as a consequence, they accumulate in human adipose tissues and can cause chronic toxicity after long-term exposure.Objective: To detect and measure the concentrations of organochlorine pesticides (trans-nonachlor and oxychlordane) in postmortem organs and fatty tissue as well as their concentrations in antemortem serum and fatty tissue samples and study their correlation with lipids in order to reveal the need for human monitoring.Methods: The study was conducted on 40 antemortem samples of blood and fatty tissues and 41 postmortem samples of blood and different organ tissues to determine their lipid concentrations and detect metabolites of organochlorine pesticides and asses their correlations using spectrophotometer and HPLC techniques. Results: The study observed that there was normal serum concentration of triglyceride (TG) and elevated cholesterol level, which were verse correlated with elevated serum concentrations of trans-nonachlore and oxychlordane pesticides. Serum concentrations of TG were (153.75 mg/dl) within “normal” range while mean serum of total cholesterol was (209.89 mg/dl) elevated above normal range. Percentage of concentration of serum to lipid trans-nonachlordane was (40.28 mg/dl) higher than that of oxychlordane was (28.42 mg/dl) in living subjects. The study observed that elevated concentrations of trans-nonachlor more than oxychlordane in postmortem tissue organs.Conclusion: The study revealed that traces of organochlorines (trans-nonchlore and oxychlordane) were detected in human serum, fatty tissue and postmortem organs and positively correlated with some lipid profiles indicating the presence of human contamination. Both trans-nonchlore and oxychlordane were higher in lipid tissue than in serum and other tissues among postmortem cases.Keywords: Organochlorine, trans-nonachlore, oxychlordane, postmortem, lipid profileCitation: Hmood HS, Ali NM, Al-Qazzaz MA. Evaluation of antemortem and postmortem levels of organochlorine pesticides in a sample of Iraqi people. Iraqi JMS. 2017; Vol. 15(4). 420-430. doi: 10.22578/IJMS.15.4.13


Article
Evaluation of lipid fractions in serum of premenopausal and postmenopausal women in Kirkuk city
تقييم صورة دهون مصل الدم في النساء قبل وبعد سن اليأس في مدينة كركوك

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Abstract

The study aimed to investigate the levels of lipid fractions in the serum of premenopausal and postmenopausal women in Kirkuk city, because an alteration of there concentrations considered an important predisposing factors for incidence of cardiovascular disease . The study included 100 premenopausal women raged age 27- 45 years and 90 postmenopausal women ranged age 51- 67 years. The blood samples were collected and centerfuged for determination of total cholesterol( TC ) , triglyceride( TG ), low density lipoprotein( LDL-C ), high density lipoprotein( HDL-C), and very low density lipoprotein ( VLDL-C ) concentrations .The results of the study revealed no significant differences ( p>o.o5 ) for TC level, but there was a significant increase ( p<0.05 ) in the level of TG in postmenopausal women ( 143.13 ± 38.14 ) mg/dl When compared with the premenopausal women ( 102.88 ± 34.11 gm/dl. While concentration of HDL-C recorded a significant decrease ( p<0.05 ) in postmenopausal women ( 33.01 ± 10.22 ) mg/dl, when compared with the premenopausal women ( 42.20 ± 15.24 ) mg/dl, also the same results recorded for LDL-C concentration ( 106.55 ± 23.2 ) mg/dl in postmenopausal women and ( 76.26 ± 32.06 ) mg/dl in premenopausal women. Whereas the significant increase ( p<0.05 ) in concentration of VLDL-C ( 31.63 ± 7.64 ) mg/dl in postmenopausal women when compared with the premenopausal women ( 20.58 ± 6.82 ) mg/dl. Finally we concluded that, there was a significant alterations in the level of lipid profile between premenopausal and postmenopausal women groups ,which were considered the most critical predisposing factor for incidence of cardiovascular disease in postmenopausal women.

تهدف هذه الدراسة الى قياس مستويات الدهون في النساء قبل وبعد سن الياس والتي تعتبر كمؤشر لزيادة احتمالية الاصابة بالأمراض القلبية الوعائية. فقد شملت هذه الدراسة على100أمرأة من النساء قبل سن الياس والتي تراوحت اعمارهن بين (27-45) و90 امرأة بعد سن اليأس كانت اعمارهم تتراوح بين (51-67) فقد جمعت عينات الدم وتم قياس الكولسترول والدهون الثلاثية والبروتين العالي الكثافة والبروتين المنخفض الكثافة والبروتين الدهني المنخفض الكثافة جدا . فقد اظهرت النتائج عدم وجود فروق معنوية في مستوى الكولسترول TCكما إن نتائج الدراسة اظهرت بأن هناك فروقات ذات دلالة احصائية معنوية بالنسبة للدهون الثلاثية (TG) حيث سجلت النتائج زيادة معنوية (P<0.05) في النساء بعد سن اليأس عند مقارنتها مع ا لنساء قبل سن اليأس حيث كانت النتائج (143.13±38.14) (102.88±34.11)ملغم/ديسيلتر على التوالي. اما بالنسبة للــ (HDL-C) فقد كان هناك انخفاض معنوي (P<0.05) في النساء بعد سن اليأس (33.01±10.22) عند مقارنتها مع نساء قبل سن اليأس (42.20±15.24)، وكذلك الحال بالنسبة إلى (LDL-C) حيث كانت هناك زيادة معنوية ذات دلالة احصائية (P<0.05) حيث سجلت النتائج (106.55±23.2) في النساء بعد سن اليأس و (76.26±32.06) في النساء قبل سن اليأس. أما (VLDL-C) في النساء بعد سن اليأس فقد سجلت النتائج زيادة معنوية (P<0.5) حيث كانت نسبتها (31.63±7.64) عند مقارنتها مع النساء قبل سن اليأس (20.58±6.82).نستنتج من هذه الدراسة وجود تغيرات ملموسة احصائيا في نسب الدهون في مصل الدم النساء بعد سن اليأس بالمقارنة مع النساء ما قبل سن اليأس والتي تعتبر من اكثر العوامل الخطرة المهيأة للإصابة بأمراض القلب والاوعية الدموية لدى النساء بعد سن اليأس .


Article
The Effect of Fish Oil and Omega-3 Fatty Acid on Some Physiological and Biochemical Criteria in Male Rabbits

Author: Israa Seger Salman
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2017 Volume: 20 Issue: 1 Pages: 108-113
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Fish oil and omega-3 have many benefits and effects on human and animals health, such heart diseases, lipids, liver and many other diseases, so the aim of the this study was to investigate the effect of fish oil and omega-3 on complete blood picture test (CBC), Lipid profile, some liver enzymes and kidney parameters in male rabbits. Twelve adult male rabbits were used in this study that divided into two groups: (Six rabbits for each group) and treated daily for 4 weeks.Group 1: 0.2 ml/Kg B.W fish oil dose orally.Group 2: 0.2 ml/Kg B.W omega-3 dose orally.Blood samples were collected and divided from both two groups at the end of the experiment and then parameters were measured. Results explained that fish oil and omega-3 had the same effect in male rabbits. The level of complete blood picture (CBC) showed a significant decrease (p<0.05), but did not go beyond the normal reference value. The study explained that there were significant reduction in total cholesterol, serum triacylglycerol (TAG), serum low density lipoprotein (LDL) and very low density lipoprotein (VLDL) while the high density lipoprotein (HDL) was elevated significantly as compared with control. Significant increase in serum level of glutamic oxalic transaminase (GOT) and glutamic pyruvic transferees (GPT) in fish oil and omega-3 treated animals as compared with the control. While the effect of fish oil and omega-3 on kidney parameters (Uric acid, Creatinine) showed non-significant changes or a slight increase significant in kidney parameters as compared with the control. [DOI: 10.22401/JNUS.20.1.15]


Article
Effects of Dose Amount for Antiepileptic Drugs on Lipid Profile of Male Rats (Rattus Norvegicus).
تأثير كمية الجرعة للأدوية المضادة للصرع في مستوى الدهون لذكور الجرذان المختبرية

Author: Abbas Mohsin Abbas عباس محسن عباس
Journal: JOURNAL OF THI-QAR SCIENCE مجلة علوم ذي قار ISSN: 19918690 Year: 2017 Volume: 6 Issue: 2 Pages: 90-95
Publisher: Thi-Qar University جامعة ذي قار

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Abstract

The present study aimd to estimate the changes in lipid profile depend on dosage amount of two AEDs ,Phenytoin (PHT) and Carbamazepine (CBZ) , and make a comparison between them in rats. A 30 healthy male Wistar rats (150-200 g) ( subdivide to five groups ) first group was control , the second and third groups received (50 mgkg and 100 mgkg) of Phenytoin respectively, fourth and fifth groups received (25 mg/kg and 50 mg/kg) of Carbamazepine respectively. Serum total cholesterol (TC), triglycerides (TGs) and High-density lipoprotein (HDL) levels were measured after 20 days period of treating, Low-density lipoprotein (LDL) and Very low-density lipoprotein (VLDL) was calculated also. Our data revealed that, the administration of PHT (50 mgkg) and CBZ (25 mgkg) didn’t affect serum lipid profile significantly compared to control group in male rats except the levels of VLDL in CBZ (25 mgkg) group which increased significantly (p-value <0.05) compared to control group, on the other hand we found that the administration of double dose (PHT 100 mgkg and CBZ 50 mg/kg) in group3 and group5 respectively caused a significant increase in TC, TGs, LDL and VLVL in both groups compare to control group. According to our results we conclude that the doubling the dose of CBZ and PHT cause an increase in cholesterol, TGs, LDL and VLDL and switching from CBZ and PHT to another drugs or decrease the dosage could contributes to avoid effects on the lipid metabolism profile of patients with chronic epilepsy.

تهدف الدراسة الحالية إلى تقدير التغييرات في مستويات الكوليسترول الكلي والبروتينات الدهنية اعتمادا على كمية الجرعة لاثنين من ادوية الصرع، الفينيتوين (PHT) و الكاربامازيبين (CBZ)، وإجراء مقارنة بينهما. (30) من ذكور الجرذان المختبرية (150-200غم) (قسمت إلى خمس مجموعات) وكانت المجموعة الأولى مجموعة السيطرة، جرعت المجموعتين الثانية والثالثة بــ(50 ملغ كغ و 100 ملغ كغم) من الفينيتوين على التوالي , المجموعة الرابعة و الخامسة تم تجريعها بـ(25 ملغ كغ و 50 ملغم كغم) من كاربامازيبين على التوالي. و بعد فترة 20 يوما من التجريع اليومي تم قياس الكولسترول الكلي (TC)، و الكليسيريدات الثلاثية (TGs) والبروتينات الدهنية عالية الكثافة (HDL) ، اما البروتينات الدهنية منخفضة الكثافة (LDL) و البروتينات الدهنية ذات الكثافة الواطئة جدا (VLDL) تم حسابها من خلال معادلة خاصة. أظهرت نتائج الدراسة أن الجرعة (50 ملغ كغم) فينتوين و ) 25ملغ كغم) كاربامازيبين لم يؤثر على مستوى الدهون في الدم بشكل ملحوظ مقارنة مع مجموعة السيطرة في ذكور الجرذان باستثناء مستويات VLDL في المجموعة التي عوملت بـ(25 ملغ كغم) كاربامازيبين ارتفعت معنويا عند مستوى معنوية (p-value <0.05) مقارنة بمجموعة السيطرة، من ناحية أخرى وجدنا أن اعطاء جرعة مضاعفة من العلاجين تسبب في زيادة في مستويات TC، TGs، LDL وVLVL في كلا المجموعتين مقارنة بمجموعة عند مستوى معــــــنوية (p-value <0.05). وفقا لنتائج الدراسة الحالية، نستنتج أن مضاعفة جرعة الفينتوين و الكاربامازيبين سبب زيادة في الكولسترول، TGs، LDL وVLDL , وان التحول من هذين العلاجين الى ادوية أخرى او تقليل الجرعة يمكن ان يساعد في تقليل اثارهما الجانبية.

Keywords

AEDs --- CBZ --- PHT --- lipid profile --- Cholesterol --- TGs --- HDL --- LDL --- VLDL.


Article
Prevalence of Toxoplasma gondii among immunocompromised patients (heamodialysis and cancer) in the province of Thi-Qar-Iraq

Authors: Bassad A.AL-Aboody --- Noor Kadhim Matar AL-Rekaby
Journal: JOURNAL OF THI-QAR SCIENCE مجلة علوم ذي قار ISSN: 19918690 Year: 2017 Volume: 6 Issue: 3 Pages: 101-106
Publisher: Thi-Qar University جامعة ذي قار

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Abstract

The current study was conducted in Thi-Qar province to investigate of Toxoplasma gondii prevalence among renal dialysis and cancer patients by using anti-Toxoplasmosis IgG and IgM by ELISA also the study determined of some factors that may affected the prevalence of infection, such as age, sex, marital status, place of residence and a number of chemical dosing that exposed to it cancer patient or the number of times the dialysis for renal dialysis patients. The results of the current study showed that the prevalence of toxoplasmosis in Thi-Qar province in both renal dialysis and cancer patients and control group were 28% and 36% and 24% respectively. recorded results of Enzyme Linked Immunosorbent Assay ELISA test results for a positive antibody IgG in both renal dialysis and cancer patients and control group 25% , 30% , 22% respectively. As for the IgM antibody study did not record any positive result in both categories of the study (dialysis and cancer) only control group was 2%. The result of IgG & IgM together in renal dialysis and cancer and control group 3%, 6%, 0% respectively.The study found that the increase in the number of times the dialysis increased incidence of infection prevalence it was 25.53% for patients who conducted the dialysis treatment more than six times and 16.66% for patients who have less than six times.For factor chemical dosing show high infection rates in patients who have been exposed to more than one dose of a chemical 37.63% As for those who were not exposed to any chemical dose was ratios have 14.29% .


Article
Study of Effect of Methomyl on Some Hematological, Biochemical Parameters and Histological Changes in Male Albino Rats
تأثيرالميثوميل على بعض الصفات الدموية والكيموحيوية والتغير النسجي في ذكور الجرذان البيض

Authors: Kalthum Asaaf Maulood كلثوم عساف مولود --- Gawhar Ahmad Shekha كوهر احمد شيخه
Journal: Diyala Journal For Pure Science مجلة ديالى للعلوم الصرفة ISSN: 83732222 25189255 Year: 2017 Volume: 13 Issue: 2 - part 2 Pages: 235-253
Publisher: Diyala University جامعة ديالى

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Abstract

This study has been designed to study the effect of methomyl on hemodynamic, liver and kidney in rats. Methomyl compound (0.5, 1, and 2 mg/kg. bw) was orally administered once per a day during a period of 28 days of experiment. Results showed a significant(P<0.05) decrease in the level of WBC, HCT, MCHC and a non-significant decrease in the level of RBC, HB, MCV, MCH, was observed in the methomyl group, while the level of PLT significantly increased in Methomyl group in comparison with control group. Non-significant decrease in a level of serum urea in all three groups of Methomyl, while serum creatinine level deceased non-significantly in group1 and group 2, but increased non-significantly in group3 of Methomyl when compared with control group. A Significant decrease in the level of HDL, with significant increase in the level of serum cholesterol, ALT and AST. A non-significant increase in the level of TG, LDL, VLDL and ALP of methomyl group when compared with control group. The Histology of liver of rat treated with 0.5,1 and 2, mg / kg bw. methomyl showed that dilation of central vein, sinusoids between hypertrophied hepatocytes and cytoplasmic vacuolization with loss of radial arrangement of cells, Meanwhile, kidney showed some changes including glomerular degeneration, tubular degeneration, hemorrhage, infiltration and glomerular shrinkage.

صممت هذه التجربة لدراسة تأثير مبيد الميثوميل على بعض مكونات الدم والكبد والكلية في الجرذ . الجرعات المستخدمة كانت (0.5 و1 و2 ملغم/كغم وزن الجسم). تم تجريع الجرذان عن طريق الفم يوميا ولمدة 28 يوما. أشارت النتائج ظهورانخفاض معنوي(0.05> ) في مستوى كريات الدم البيض و حجم خلايا الدم المتراصة ومعدل تركيز خضاب الدم وانخفاض غير معنوي في مستوى كريات الدم الحمر ونسبة خضاب الدم ومعدل حجم الكريات ومعدل خضاب الدم في مجموعة الميثوميل.ارتفع مستوى الصفائح الدموية في مجموعة الميثوميل عند مقارنتها بمجموعة التحكم.بين النتائج انخفاض غير معنوي في مستوى اليوريا في مصل الدم في المجاميع الثلاثة للميثوميل وانخفاض غير معنوي في مستوى الكرياتينين في المجموعة الاولى والثانية وارتفاع غير معنوي في المجموعة الثالثة للميثوميل عند مقارنتها بمجموعة التحكم.انخفض مستوى بروتين دهني عالي الكثافة بشكل معنوي مع ارتفاع معنوي في مستوى مصل الكوليستيرول وانزيم الانين ترانزامينيز واسبارتيت ترانس امينيزوارتفاع غير معنوي في مستوى جليسيرايدات الثلاثية وبروتين دهني منخفضة الكثافة والفوسفاتيز القاعدي في مجموعة الميثوميل عند مقارنتها بمجموعة التحكم.أظهر التغير النسجي لكبد الجرذان المجرعة ب (0.5 و1 و2 ملغم/كغم وزن الجسم ) ميثوميل اتساع في الوريد المركزي و تضخم في الجيوب الدموية بين الخلايا الكبدية مع تلاشي الترتيب الشعاعي للخلاياوالتغير النسجي للكلية شملت انحلال الكبيبات و النبيبات الكلوية ونزف الدم وارتشاح الخلايا وانكماش للكبيبات.

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