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Article
THE ROLE OF ESTROGEN AND PROGESTERONE ON VAGINAL CYTOLOGY DURING PROLIFERATIVE AND SECRETARY PHASES OF MENSTRUAL CYCLE IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME

Authors: Huda R. Kareem هدى رشيد كريم --- Haider A. Jaafer حيدر عبدالرسول جعفر --- Zainab H. Hashim زينب حسن هاشم
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2017 Volume: 15 Issue: 1 Pages: 78-87
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:In the course of cyclic hormonal fluctuation, cytological changes in the vaginal epithelium can be correlated with the phases of the menstrual cycle, this can be utilized in diagnosis of hormonal status in women with pathological cycles as in polycystic ovarian syndrome (PCOS). Objective:To evaluate the effects of estrogen (E2) and progesterone hormones in PCOS on the vaginal cytology in different phases of menstrual cycle, and its relation to ovulation period.Methods:A non-random sample of one hundred women were enrolled in this study, divided into two groups; 50 women free from PCOS, and 50 were PCOS according to the criteria of Rotterdam 2003. All were underwent hormonal assay including estrogen and progesterone on 2nd and 21st day of the cycle respectively, vaginal smears cytology on the 2nd day, 14th and 21st day of the cycle, stained with H&E, the (parabasal, squamous, leukocytes) were identified and counted, ultrasound examination was done on 14th day of the cycle, that divide the sample into ovulatory and an ovulatory subgroups accordingly.Results:At the 2nd day of the cycle, there was a significant reduction in squamous cell count, highly significant increase in leukocyte, E2 hormone level increased markedly, with a significant negative correlation to leukocytes cells in patients' groups at P≤0.05. Squamous cells of vaginal smear attained more acidophilic cytoplasm and increase in nuclear pyknosis. At the 14th day of the cycle, a significant increase in squamous cells count at P≤0.05, cornified squamous cells predominantly seen associated with low ovulation rates of 44%. Ovulation showed significant reduction in parabasal cells count in patients group at P≤0.05. At 21st day of the cycle, progesterone level was reduced with a significant reduction in squamous cells, parabasal cells and leukocytes counts in patients, with no significant correlation between progesterone and vaginal cytology cells, squamous cells consisted of mature cornified cells that seen predominantly in vaginal smear.Conclusion:Hormonal changes in PCOS presented mainly by the effect of elevated E2 hormone, that associated with increase in squamous cells count and cornification, with reduction in leukocytes and parabasal cells toward mid cycle. Progesterone hormone exert no significant effect on vaginal cytology in PCOS.Keywords: PCOS, vaginal cytology, ovulation

Keywords

PCOS --- vaginal cytology --- ovulation


Article
COMPARISON OF ANTIMULLERIAN HORMONE LEVEL BETWEEN WOMEN WITH POLYCYSTIC OVARY SYNDROME AND NORMAL OVULATORY INFERTILE WOMEN OF REPRODUCTIVE AGE

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Abstract

Background: Polycystic ovary syndrome (PCOS) is the most common cause of chronic anovulation and hyperandrogenism in young women. This syndrome is characterized by an increase in the number of small antral follicles that are between 5-8 mm in size. Antemüllerian hormone (AMH) is secreted mostly by this type of follicle and when it is much too high, the production of a healthy egg every cycle can be halted as it works by reducing the receptors of the ovary to follicle stimulating hormone (FSH).Objective: To compare the AMH level between women presented with PCOS with its level in normal ovulatory infertile women and to determine its correlation with the clinical, hormonal and ultrasonographic parameters in both groups.Methods: This is a prospective cross-sectional study done at Um-Albaneen Infertility Center in Al-Imamein Al-Kadhimein Medical City from march 2015 to January 2016. One hundred infertile women were recruited in this study, 50 women with PCOS and 50 women have other factors of infertility apart from PCOS and ovulatory dysfunction. Sera were taken from all the participants at day (2-3) of menstrual cycle and were investigated for AMH, FSH, luteinizing hormone (LH), androstenedione, testosterone and estradiol (E2) levels. The number of early antral follicles (2-9 mm in diameter) was estimated by transvaginal ultrasound scanning.Results: Level was significantly higher in PCOS women (42.6±23.8) compared to the normal ovulatory infertile women (16±7.5), P-value <0.001. There was positive correlation between AMH and LH, testosterone, androstenedione, number of antral follicles (antral follicle count) and ovarian volume. However, the correlation was negative with age, body mass index, estradiol, and FSH.Conclusion: AMH strongly correlated with testosterone level and the number of small antral follicles in PCOS women, so it can be considered as a good diagnostic marker for PCOS.Keywords: Antimullerian hormone, PCOS. Citation: Almoayad HA, Abdulrasul EA. Jumaa NA. Comparison of antimullerian hormone level between women with polycystic ovary syndrome and normal ovulatory infertile women of reproductive age. Iraqi JMS. 2017; Vol. 15(3): 234-241. doi: 10.22578/IJMS.15.3.4


Article
Correlation between vitamin D receptor gene polymorphisms and levels of some hormones in Iraqi infertile women with polycystic ovary syndrome

Author: Sanaa Jasim Kadhim , Ismail A. Abdul-hassan
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2017 Volume: 16 Issue: 4 Pages: 104-113
Publisher: Baghdad University جامعة بغداد

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Abstract

The polycystic ovary syndrome (PCOS) is a disorder that characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphologic features. As defined by the diagnostic criteria of the National Institutes of Health (i.e., hyperandrogenism plus ovulatory dysfunction). The purpose of this study was to investigate the correlation between VDR gene polymorphisms and level of LH, FSH, TSH and Prolactin hormones .This study was carried out in the Institute of Genetic Engineering and Biotechnology for Postgraduate Studies - University of Baghdad through the period from November 2016 - August 2017, The PCOS patients were taken from the Kamal Al-Samarraee Infertility Treatment Hospital in Baghdad.Women with PCOS (n=50) and apparently healthy control group (n=50) , were enrolled . Genotyping of VDR gene (rs2228570) (rs7975232) , as well as (rs731236) SNPS between groups were determined by using Taqman genotyping assay . Hormonal analysis for LH, FSH, TSH and Prolactin was performed by using Automated Immune Assay (AIA). the results of the present study indicate that serum LH , FSH and TSH concentrations were unaffected by the studied SNPs of VDR gene within carriers of genotypes of rs2228570 , rs7975232 and rs731236 SNPs in VDR gene, while serum prolactin levels were significantly (p<0.05) higher in PCOS patients versus controls.

Keywords

PCOS --- VDR --- Polymorphism --- Infertile.


Article
Association of T45G Genetic Polymorphism in The ADIPOQ Gene with Polycystic Ovary Syndrome Patients in Al-Najaf Province

Author: Karrar Saleem Zayed
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2017 Volume: 14 Issue: 3 Pages: 413 -421
Publisher: Babylon University جامعة بابل

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Abstract

This study was suggested to investigate genetic variation in ADIPOQ gene as a risk factor for polycystic ovary syndrome progression. Fifty-four Iraqi women with PCOS consulting at a Fertility and infertility treatment center were inducted into this study with a mean age was (24.23+5.19) years for these patients. Also, the study includes forty-eight normal healthy women collected randomly with mean age (23.81+6.01) years as a control group. The collection of blood samples carries out from PCOS and healthy control individuals for detection of biochemical diagnostic parameters in serum which include luteinizing hormone (LH) and follicles stimulating hormone (FSH), testosterone and adiponectin. Then, DNA was extracted from the blood of these two groups for a revelation of 45T/G genetic polymorphism in exon 2 of ADIPOQ gene for revealing of Polycystic Ovary Syndrome (PCOS) as a prognostic marker for this disease. The result of the current study appears that the serum adiponectin levels in PCOS decreased significantly when compared its level in control. In contrast, the level of LH and testosterone increased significantly in PCOs group than control. In regarding to genetic polymorphism 45(T/G) in exon 2 of ADIPOQ gene, the TT alleles polymorphism were increased significantly in control than PCOS patients while TG, GG alleles polymorphism were increased significantly in PCOS than control. The correlation between ADIPOQ polymorphism and level of adiponectin in serum demonstrated that the level of adiponectin is decreased significantly in presence of G allele in ADIPOQ gene in PCOS patients. This study concluded that the 45T/G polymorphism in ADIPOQ gene is highly elevated in PCOS patients especially polymorphism in GG alleles may be regarded as one of the main causes of PCOS occurrence. This result was proven the role of ADIPOQ gene in the pathogenesis of this syndrome.

Keywords

PCOS --- ADIPOQ --- 45T/G polymorphism


Article
Ameliorative Effect of Fenugreek on sex hormones in Polycystic Ovary Syndrome Female Rats Induced by Letrozole
التأثير المحسن للحلبة على الهرمونات الجنسية في إناث الجرذان المستحدث فيها متلازمة تكيس المبايض المتعدد بوساطة اليتروزول

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Abstract

The present study was carried out in the animal house of the College of Veterinary Medicine/ University of Basrah to investigate the role of the treatment with metformin (Met), ethanolic extract of fenugreek (FN) each alone and their combination on the sex hormones changes in polycystic ovary syndrome induced in female rats. For this purpose, the study included two experiment. First experiment aimed to determine the changes in the hormones concentration of pituitary ovarian axis associated with PCOS, induced by letrozole in rats. Fifty six adult female rats randomly divided in to two group, first group (n=16) administrated 0.5% carboxy Methyl Cellulose (CMC) 0.2ml/rat/orally by gavage and served as control group and second group (n=40) administered Letrozole (1mg/kg B.W/day) dissolved in 1ml of 0.5% carboxymethylcellulose (CMC) orally by gavage for 21 days to induced PCOS. Vaginal smear examination of all female rats was done to ensure the occurrence of PCOS. At the end of the experiment eight rats of each group were sacrificed. Blood samples were collected and serum were separated for hormonal assay. The results revealed a significant increase in serum concentration of luteinizing hormone (LH) and testosterone (T) in PCOS group compared with control group. On other hand a significant decrease in serum concentration of estrogen (E2), and progesterone (P4) in PCOS group compared with control.Second experiment: This experiment was designed to evaluate the role of metformin, fenugreek and their combination therapy in amelioration effect of sex hormones changes of induced PCOS in female rats. The remainder animals from 1st experiment (8 rats from control group and 32 rats from PCOS group) were divided into five equal subgroups including eight rats in each group as follows, First group (Negative control): Rats from the control group of first experiment were administrated of 0.2 ml/rat distilled water (D.W) / daily by oral gavage. Second group (PCOS): PCOS-induced rats administrated 0.2ml/rat D.W daily by oral gavage. Third group (PCOS+Met): PCOS-induced rats were administrated 50mg/kg B.W Met daily by oral gavage. Fourth group,(PCOS+FN): PCOS-induced rats were administrated 15mg/kg B.W FN daily by oral gavage. Fifth group (PCOS+Met+FN): PCOS-induced rats were administrated both Met and FN (50mg and 15 mg)/kg B.W respectively daily by oral gavage. The treatments were extended for 21 days.. Blood samples were collected and serum were separated for hormonal assay. The results revealed that serum concentration of LH and T still significantly higher and serum concentrations of E2 and P4 significantly lower in -Ve PCOS group compared with control after 21 days of treatment. A significant degrees of improvement were recorded in above cited parameters in all treatment groups compared with -Ve PCOS and control groups.

أجريت الدراسة الحالية في البيت الحيواني لكلية الطب البيطري / جامعة البصرة للتحري في دور العلاج بالميتفورمين (Met) والمستخلص الإيثانولي للحلبة (FN) كل بمفرده وكلاهما معا على التغيرات بتركيز الهرمونات الجنسية في متلازمة تكيس المبايض المتعدد المستحدثة في إناث الجرذان. لهذا الغرض، شملت الدراسة تجربتين.التجربة الأولى: هدفت هذه التجربة للتعرف على بعض التغيرات الكيموحيوية والنسجية المرتبطة بمتلازمة تكيس المبايض المستحدثة بوساطة اليتروزول في إناث الجرذان. استخدم في هذه الدراسة ستة وخمسين من إناث الجرذان البالغة قسمت عشوائيا إلى مجموعتين، المجموعة الأولى (n=16) أعطيت كربوكسي ميثيل السليلوز (CMC)0.2 ml /جرذ بتركيز 0.5% عن طريق الفم واعدت مجموعة سيطرة والمجموعة الثانية ( n=40) أعطيت ليتروزول (1mg/kg B.W/day) مذاب في 1ml من 0.5%كاربوكسي ميثيل السيلولوز (CMC) عن طريق الفم. استمرت المعاملة لمدة 21 يوما لاستحداث متلازمة تكيس المبايض. تم إجراء فحص لمسحات من المهبل لجميع إناث الجرذان خلال هذه الفترة للتأكد من حدوث متلازمة تكيس المبايض. في نهاية التجربة تم التضحية ب ثمانية جرذان من كل مجموعة. جمعت عينات الدم وتم فصل مصل الدم لقياس مستوى الهرمونات. وقد أظهرت النتائج ما يلي:. أظهرت النتائج وجود زيادة معنوية في تركيز مصل الهرمون اللوتيني (LH) وهرمون الشحمون الخصوي (T) في مجموعة تكيس المبايض مقارنة مع مجموعة السيطرة. من ناحية أخرى لوحظ انخفاض معنوي بتركيز هرمون الاستروجين (E2)، والبروجسترون (P4) في مجموعة تكيس المبايض مقارنة مع السيطرة.التجربة الثانية: تم تصميم هذه التجربة لتقييم دور الميتفورمين (Met) والمستخلص الكحولي للحلبة (FN) كل لوحده أوكلاهما في تحسين التغيرات في تركيز مستوى الهرمونات الجنسية الناتجة من متلازمة تكيس المبايض في إناث الجرذان . تم تقسيم الحيوانات المتبقية من التجربة الأولى 8 جرذان من مجموعة السيطرة و 32 جرذان من مجموعة تكيس المبايض إلى خمس مجموعات فرعية متساوية بواقع ثمانية جرذان في كل مجموعة على النحو التالي، المجموعة الأولى (السيطرة السلبية): (n=8)جرذان من مجموعة السيطرة المتبقية من التجربة الأولى اعطيت 0.2ml/ جرذ ماء مقطر يوميا عن طريق الفم. المجموعة الثانية (تكيس مبايض): ثمانية جرذان أعطيت 0.2ml/ جرذ ماء مقطر يوميا عن طريق الفم. المجموعة الثالثة (تكيس مبايض + ميتفورمين): أعطيت 50mg/kg من وزن الجسم ميتفورمين عن طريق الفم . المجموعة الرابعة، (تكيس مبايض + مستخلص الحلبة): أعطيت 15mg/kgمن وزن الجسم مستخلص الحلبة يوميا عن طريق الفم. المجموعة الخامسة (تكيس مبايض + ميتفورمين + مستخلص الحلبة): تم إعطاؤها ميتفورمين( 50mg/kg) + مستخلص الحلبة (15mg/kg) من وزن الجسم يوميا عن طريق الفم. واستمرت المعاملة لمدة 21 يوما.تم جمع عينات الدم وتم فصل مصل الدم لاجراء الفحص الهرموني. أظهرت النتائج أن تركيز الهرمون اللوتيني (LH) وهرمون الشحمون الخصوي ( T ) لا يزال أعلى معنويا وتراكيز الايستروجين E2 و والبروجسترون P4 أقل معنويا في مجموعة تكيس المبايض السالبة مقارنة مع مجموعة السيطرة بعد 21 يوما من العلاج. وسجلت درجات معنوية من التحسن في مستوى الهرمونات المذكورة أعلاه في جميع مجموعات المعاملة مقارنة بمجموعتي تكيس المبايض السالبة والسيطرة

Keywords

Fenugreek --- sex hormones --- PCOS --- Letrozole.


Article
Study the Effect of Interleukin36 Gamma and AMH in Iraqi Women with PCOS

Author: Wafa R. Alfatlawi
Journal: Al-Mustansiriyah Journal of Science مجلة علوم المستنصرية ISSN: 1814635X Year: 2017 Volume: 28 Issue: 3 Pages: 151-156
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Polycystic ovary syndrome (PCOS) is one of the most common female endocrine disorders and affect approximately (5-10) % of women of reproductive age. Anti-Müllerian hormone (AMH) is a homodimeric glycoprotein, a member of the transforming growth factor-β superfamily, it is secreted exclusively from women by granulose cells of ovarian follicles and it is considered as the precise marker of follicle pool size. AMH has been shown to be a good surrogate marker for polycystic ovary syndrome (PCOS). Interleukins are considered as strong risk markers of inflammation. Interleukin-36 gamma (IL36) also known as interleukin-1 family member 9 (IL1F9) is a protein that in humans is encoded by the IL36G gene. Serum samples were collected on day 2 of the menstrual cycle. Serum IL36ɣ, FSH and LH concentration were measured by using ELISA. This study aimed to evaluate the association between IL36ɣ and AMH and study the relationship between obesity and AMH of women in the age of reproductive (25-35) yrs. This study included 28 infertile women with PCOS their husbands were apparently normal (hormones and seminal fluid analysis), their aged (25-35) years, and 20 healthy women aged (25-33) years as control. All control women & patients were from outpatients unit of Alkadumia teaching hospital at Baghdad and all the parameters were measured in Sigma Laboratory. Serum IL-36 ɣ elevated in PCOS patients mainly those with high AMH levels. This hormone increased in PCOS patients compared with control. There was a non-significant difference between patients and control to LH and FSH levels

Keywords

AMH --- PCOS --- IL-36 --- FSH


Article
EVALUATION THE EFFECT OF METFORMIN ON HORMONES SERUM LEVELS IN WOMEN WITH POLYCYSTIC OVARY SYNDROME
تقييم تاثير علاج المتفورمين علي مستويات الهرمونات في مصل النساء المصابات بمتلازمة تعدد الاكياس في المبيض

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Background: Polycystic ovary syndrome [PCOS] is a common disease that affected the reproductive problem. Aim: the study tried to determine the association between PCOS with the body mass index (BMI) and the effect of metformin as treatment for PCOS. Patients and Methods: This case control prospective experimental study was carried out in Kirkuk General Hospital from January 2014 to July 2014. The recruited cases divided into three groups; Group I, 68 women with normal menstrual cycle as control group; Group II, 61 cases diagnosed as a PCOS; and Group III :- 30 cases selected from group two to receive treatment with Metformin to determine the effect of the treatment on different variables. Results: The highest percentage of PCOS (36.1%) was found in those with age group between (20-25) years. Most (65.6%) of PCOS subjects were with overweight or obese. BMI mean value was (28.92±6.68) in women with PCOS, while in control the corresponding value was (25.09±4.35). FSH, and testosterone were significantly higher in women with PCOS than in control. Metformin reduced serum FSH, LH, prolactin and testosterone, with non-significant difference. Conclusion: PCOS is independently associated with elevated BMI. Metformin treatment of PCOS induced t reduction in serum testosterone and FSH, LH and serum prolactin but not reach significant level. This warranted performance a large scale clinical trial to evaluate the therapeutic effect of metformin alone or in combination with diet control approach for treatment of PCOS. These findings have implications for the pathophysiology of obesity development and management in PCOS.

متلازمة تعدد الاكياس في المبيض هي من اكثر الامراض شيوعا التي توثر على مستوى الانجاب المشتركة مع التاثير الاجتماعي والصحي.الهدف من الدراسة: هدفت الدراسة التي أجريت لتحديد العلاقة بين مؤشر كتله الجسم ومتلازمة تعدد الاكياس في المبيض والأثر العلاجي للمتفورمين.طريقة العمل: أجريت الدراسة التجريبية المحتملة لهذه الحالة في مستشفي كركوك العام في الفترة من كانون الثاني/ 2014 إلى تموز/ 2014. وتنقسم الحالات المعينة إلى ثلاث مجموعات؛ المجموعة الأولى ثمانية وستون من النساء السليمات ظاهريا من خلال الدوره الحيضية المنتظمة كمجموعة سيطرة؛ المجموعة الثانية احدى وستون حالة تم تشخيصها بأنها من المصابات بمتلازمة تعدد الاكياس في المبيض؛ والمجموعة الثالثة:-ثلاثون حالة من المجموعة الثانية تتلقي العلاج مع المتفورمين لتحديد تاثيره على متغيرات مختلفة لدى النساء المصابات النتائج: تم العثور علي اعلي نسبه مئوية من متلازمة تعدد الاكياس وهي (36.1 في المائة) في الفئات العمرية بين السنوات (20-25) سنة . كان معظمهم (65.6 في المائة) من النساء المصابات بفرط الوزن أو السمنة. وكانت القيمة المتوسطة لمؤشر كتله الجسم (28.92 ± 6.68) في النساء ذوات متلازمة تعدد الاكياس في المبيض، بينما كانت في مجموعة السيطرة مؤشر كتلة الجسم (25.09 ± 4.35). وكانت تراكيز هورمونات FSH, LH ، وهرمون التستوستيرون اعلي في النساء ذوات متلازمة تعدد الاكياس في المبيض من مجموعة السيطرة. وقد ادى علاج المتفورمين الى انخفاض في تراكيز هورمونات FSH, LH, وهورمون الحليب وهورمون التستوستيرون دون الوصول الى فارق معنوي.الاستنتاجات: متلازمة تعدد الاكياس في المبيض ترتبط بشكل مستقل مع ارتفاع مؤشر كتله الجسم. وعلاج المتفورمين لمتلازمة تعدد الاكياس في المبيض سبب انخفاضاً في هرمون التستوستيرون و FSH ،LH وهورمون الحليب ولكن ليس بشكل معنوي . وهذا ما يبرر الأداء على نطاق واسع التجربة السريرية لتقييم الأثر العلاجي للمتفورمين وحده أو بالاقتران مع اسلوب تحكم في النظام الغذائي لعلاج متلازمة تعدد الاكياس في المبيض. هذه النتائج لها اثارها علي الفسيولوجية المرضية لتقدم السمنة وعلاج متلازمة تعدد الاكياس في المبيض

Keywords

PCOS --- Metformin --- FSH --- LH --- Prolactin --- Testosterone


Article
Effect of Anti Mullerian Hormone (AMH) on Hyperthyroidism with and without polycystic ovarian syndrome (PCOS) in female patients
تأثير هرمون مخزون المبيض (AMH) على فرط نشاط الغدة الدرقية مع وبدون متلازمة المبيض المتعدد الكيسات (PCOS) في المرضى الإناث

Authors: Samah. M.A Al-Qaisi سماح مشعان عبدالله القيسي --- Nawal. M.J Al-Shammaa نوال محمد جواد الشماع
Journal: Iraqi Journal of Science المجلة العراقية للعلوم ISSN: 00672904/23121637 Year: 2017 Volume: 58 Issue: 4A Pages: 1808-1818
Publisher: Baghdad University جامعة بغداد

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Abstract

Effect Anti-Mullerian Hormone (AMH) on thyroid levels in patients with and without polycystic ovarian syndrome PCOS was studied, The results showed an increase in AMH ,T3 ,T4 with increase of age while TSH , BMI decreased with increase of age comparing to control in hyperthyroidism with PCOS patients. Otherwise an increase in AMH, TSH, BMI, T3 and T4 with increase of Age compared to healthy group in hyperthyroidism without PCOS. Effect of ovarian hormones (AMH) on inventory levels of thyroid and perturbations in terms of increases and its impact obesity as well as fertility in women was declared in this research. Serum Anti-Müllerian Hormone (AMH) was assessed using enzyme linked immunosorbent kit [Elisa] while Thyroid stimulating hormone (TSH), Triiodothyronine (T3), Thyroxin (T4) were determined by VIDAS kit method(enzyme linked fluorescent assay).

دراسة تأثير هرمون مخزون المبيض على مستويات الغدة الدرقية في المرضى الذين يعانون من وبدون متلازمة تكيس المبايض المتعدد الكيسات، وأظهرت النتائج زيادة فيT3، T4، AMH مع زيادة في العمر بينما انخفاض فيBMI، TSHمع زيادة في العمر مقارنة مع مجموعة صحية في فرط نشاط الغدة الدرقية مع مرضى متلازمة تكيس المبايض. خلاف ذلك زيادة فيBMI ، TSH، T3، T4 و AMH مع زيادة العمر مقارنة مع مجموعة صحية في فرط نشاط الغدة الدرقية دون متلازمة تكيس المبايض, وتأثير هرمونات المبيض (AMH) على مستويات الغدة الدرقية والاضطرابات من حيث الزيادة في الوزن (السمنة) وكذلك الخصوبة لدى النساء. في هذا البحث تم تقييم مصل هرمون مخزون المبيض (AMH) باستخدام مجموعة مناعية مرتبطة بالإنزيم [Elisa] في حين تم تحديد هرمونات الغدة الدرقية ثلاثي يودوثيرونين (T3)، ثيروكسين (T4) والهرمون المحفز للغدة (TSH) بواسطة طريقة .VIDAS


Article
2.THE RELATION OF SERUM OMENTIN-1 LEVEL WITH INSULIN RESISTANCE IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME AND ITS RELATION WITH METFORMIN TREATMENT

Authors: Jumana M. Kareem جمانة مهدي كريم --- Zainab H. Hashim زينب حسن هاشم --- Hala A. Almoayed هالة عبد القادر المؤيد
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2017 Volume: 15 Issue: 4 Pages: 327-338
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background: Polycystic ovary syndrome (PCOS) is still a matter of research looking for the true pathogenesis of this enigmatic syndrome. Although the majority of cases are familial, genetic studies have failed so far to identify the specific genes involved. The presentations of PCOS are heterogeneous and may change throughout the lifespan, starting from adolescence to post-menopausal age, and may have health impaction later in life. Omentin-1 is a fat depot-specific secretory protein produced by visceral stromal vascular cells. Recent studies showed that omentin-1 is correlated inversely with obesity and insulin resistance.Objective: To assess the serum omentin-1 concentration in PCOS women and the effect of metformin on omentin-1 level, to evaluate the role of omentin-1 on insulin resistance and hyperandrogenemia in PCOS women and to look for the correlation of omentin-1 with body mass index (BMI) in PCOS women.Methods: Eighty women involved in this study; 40 women with PCOS diagnosed according to Rotterdam ESHRE/ASRMS 2003 criteria and 40 apparently healthy women considered as the control group. The participants were allocated into six groups: “10 obese women with PCOS (BMI ≥30 kg/m2, without metformin treatment)”. “10 obese women with PCOS (BMI ≥30 kg/m2, taking metformin)”. “10 non-obese women with PCOS (BMI <30 kg/m2, without metformin treatment)”. “10 non-obese women with PCOS (BMI <30 kg/m2, taking metformin)”. “20 obese controls and 20 non-obese controls. Blood samples were taken from them for estimation of fasting blood glucose, insulin and omentin-1 levels. Hirsutism score was also evaluated according to Ferriman–Gallwey score. Results: There was a significant increase in omentin-1 in non-obese PCOS (taking metformin) (3.02±0.71) compared to obese PCOS (taking metformin) (1.59±1.48) (P value = 0.0132) and in PCO non-obese (taking metformin) (3.02±0.71) compared with control non-obese (1.96±1.65) (P value = 0.121). No significant correlation was found between serum omentin-1 level and insulin resistance as well as with hyperandrogenemia in any of the six study groups.Conclusion: Omentin-1 is found to be inversely related to body weight in PCOS women. Serum omentin-1 level has no effect on insulin resistance and hyperandrogenism states.Keywords: Polycystic ovaries PCOS, omentin, hyperandrogenemia, insulin resistanceCitation: Kareem JM, Hashim ZH, Almoayed HA. The relation of serum omentin-1 level with insulin resistance in patients with polycystic ovary syndrome and its relation with metformin treatment. Iraqi JMS. 2017; Vol. 15(4): 327-338. doi: 10.22578/IJMS.15.4.2


Article
Evaluation of Hormones and Trace Elements in Women with Unexplained Infertility
تقدير الهرمونات والعناصر الندرة لدى النساء المصابات بالعقم غير المفسر

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Abstract

This study aims to Evaluation of prolactin (PRL), thyroid stimulating hormone (TSH), luteinizing (LH)and Follicle stimulating hormone(FSH)and trace elements (iron and copper) in women with unexplained infertility (UI). 60 women with unexplained infertility as well as (40) women with polycystic ovarian syndrome (PCOS) aged (20-35) year were included in this study. The women were divided according the type of infertility into primary and secondary groups (1ºUI, 2ºUI, 1ºPCO and 2ºPCO) respectively. Fifty healthy fertile women with the same age were included in this study as a control group. The results showed a significant increase in serum of Prolactin, TSH, LH levels in the two groups of women with explained infertility (pcos) compared to control and the two groups of women with unexplained infertility. In contrast no significant differences in Prolactin, TSH, FSH and LH levels in women with unexplained infertility in comparison with the control.Serum levels of iron and copper significantly increase in unexplained infertility groups in comparison with women with explained infertility and control groups. This study concluded that is Prolactin, TSH and LH hormone are not associated statistically with unexplained female infertility. The increase in Cu and iron may have an important etiological role in the pathogenicity of unexplained infertility.

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