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The indirect induction of human scabies to initiation autoimmune disease (SLE): Comprehensive study in marshes population of Thie-Qar
الحث الغير مباشر لمرض الجرب لنشوء مرض المناعة الذاتية (الذؤابة الحمراء): دراسة شاملة على سكان الاهوار في محافظة ذي قار

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Abstract

Scabies is one of the disease that is considered an endemic and epidemic in Iraq, in this study it has been observed that other disease were found to be associated with scabies patients, and in order to investigate the mechanism by which the scabies may induce other disease (such as SLE) an immunological, hematological and immunobiochemical tests were investigated both in patients having scabies and scabies-SLE disease. High sensitive C-reactive protein was higher significant in all groups compared with control and higher significant in scabies-SLE as compare with scabies patients, IgG was higher significant in all groups as compare with control, lower significant in scabies-SLE as compare with scabies patients. IgM was higher significant in scabies patients as compare with control and lower significant in scabies-SLE. IgA was higher significant in all groups as compare with control. IgE was higher significant in all groups as compare with control, but lower significant in scabies-SLE as compare with scabies patients. C3 and C4 was lower significant in scabies-SLE as compare with both control and scabies patients. IL-6, IFN-γ, IL-18 and TNF-α was higher significant in all groups as compare with control also higher significant in scabies-SLE as compare with control. IL-1β was higher significant in all groups as compare with control, but not as compare scabies patients. IL-5 was higher significant in scabies as compare with control, but lower significant in scabies-SLE as compare with scabies. Eosinophil and neutrophil were higher significant in scabies as compare with control. Eosinophil, neutrophil, basophil and monocyte have lower significant in scabies-SLE as compare with control and scabies patients. superoxide dismutase (SOD) activity was higher significant in scabies patient only as compare with control, but lower significant in in scabies-SLE as compare with both control and scabies patients. Malondialdehyde (MAD) level was higher significant in scabies-SLE as compare with control. All data were considered significant at (P<0.05). The mechanisms of inflammation induced by mites may be related to the generation of excessive level of cytokines and antibodies against its proteins, so that triggering of excessive inflammatory responses, then developing autoimmune disease likes SLE.

يعتبر مرض الجرب في العراق من الامراض الوبائية المتوطنة, تم ملاحضة الاصابة بأمراض اخرى بالاضافة الى مرض الجرب, لمعرفة الميكانيكية المناعية التي من خلالها يحث الجرب على ظهور امراض اخرى, تم اجراء بعض الفحوصات المناعية و البايوكيميائية وبعض فحوصات الدم, اظهرت النتائج ات هناك ارتفاع معنوي لكل من((hs-CRP, IgG, IgE, IgA في كل مجاميع الدراسة مقارنة يمجموعة السيطرة, وارتفاع معنوي في مستوى (IgM) في مجموعة مرضى الجرب مقارنة بمجموعة السيطرة, كان كل من IL-1β, IL-18, IL-6) IFN-γ, TNF-α) مرتفع معنويا في كل المجاميع مقارنة بمجموعة السيطرة, كانت (Eosinophil and neutrophil) مرتفعة معنويا في مرضى الجرب مقارنة بالسيطرة, كانت فعالية (SOD) مرتفعة معنويا في مرضى الجرب مقارنة بالسيطرة, اظهر (MAD) ارتفاع معنوي في مرضى الذؤابة الحمراء مقارنة بالسيطرة. نستنتج من هذه الدراسة ان بروتينات طفيلي الجرب تثير تفاعلات التهابية مناعية مفرطة , تحفز ظهور امراض اخرى.

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