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Article
The Association between Hyponatremia and Recurrent Febrile Convulsions

Authors: Hadeel Rashied --- Shamel sharba --- Jasim Mohammed Hashim
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2017 Volume: 10 Issue: 1 Pages: 2613-2619
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: Febrile seizures are common pediatric problem, yet there is a great deal of disagreement about the appropriate diagnostic evaluation of a child with this disorder. Different predisposing factors have been suggested to enhance the susceptibility to febrile seizure and its recurrence. Fever play an important role in causing disturbances in fluid and electrolytes balance, hyponatremia has been thought to enhance the susceptibility to seizures.Objective: To determine the effect of hyponatremia in recurrent febrile convulsions.Patients And Methods: A case-control study which carried out in Al- Zahraa teaching hospital in Al-Najaf city during the period between 1st of January to end of October 2015. One hundred fifty children were included in this study. We classified the patients into three groups; group (A) included (50) children presented with fever without seizure, group (B); (50) children presented with simple febrile convulsion, group (C); (50) children presented with recurrent febrile convulsions. Group A conceder as control group. The serum level of Na were estimated in these 3 groups by Na kits.Results: One hundred fifty children were studied with age range between (6months-6years) old. We compare the S. Na among the three groups;It is found that male in group A represented 26 (52%) and 24 (48%), 28(56%) in group B and C respectively, while female represented by 24 (48%), 26 (52%), 22 (44%) in groups A, B, C respectively, with p value of 0.726.There were no significant difference between male and female, in all age groups.Also it is shown that family history of febrile convulsion represented 20%, 50%, 50% in group A, B, C respectively, in family history of recurrent febrile convulsion, represented 4%, 4%, 10%, in group A, B, C respectively, and with family history of epilepsy show group A (0%), group B (4%), group C (0%).While p value in family history of febrile convulsion (0.002), in family history of recurrent febrile convulsion (0.345), in family history of epilepsy (0.132).So there were no significant difference in all parameters except family history of febrile convulsion which is significant in all three groups, P value=0.002.Also the study will show no significant difference in age, white blood cell count, and random blood surge while there is significant difference in temperature.A significant difference in serum sodium level which is lowest in group C. Regarding Calcium level, there is significant difference between group A and B.Conclusion:-There is a significant association between recurrent febrile convulsion and lower level of serum sodium, in which serum sodium concentration is lowest in those patient with recurrent febrile convulsion


Article
ASSESSMENT OF SERUM ZINC LEVEL IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME

Author: Iqbal G. Farhood اقبال غالب فرهود
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2017 Volume: 15 Issue: 1 Pages: 39-47
Publisher: Al-Nahrain University جامعة النهرين

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Background: Polycystic ovary syndrome (PCOS) is the most common endocrine-metabolic disorder affecting women of reproductive age characterized by multiple hormonal imbalances, reflecting on a clinical presentation dominated by manifestations of hyperandrogenism, which generate short and long term consequences on female health. Skin is a major target for androgen activity, several hyperandrogenemia-triggered dermatologic alterations can be seen in PCOS, most commonly hirsutism, androgenic alopecia, acne, seborrhea, onycholysis, and onychorrhexis. Zinc is one of the most important trace elements required as a catalytic, structural, and regulatory ion for the activities of more than 300 enzymes, proteins, and transcriptional factors. Zinc insufficiency in the female can lead to complications such as impaired synthesis/secretion of follicular stimulating hormone (FSH) and luteinizing hormone (LH), abnormal ovarian development.Objective:To assess serum zinc level in patients with PCOS.Methods:A case-controlled study was conducted in Al-Imamein Al-Kadhemein Medical City from the period of March to June 2016. Eighty females were enrolled in this study; their age ranged from 20 to 32 years. They were divided into 4 groups: Group I: Twenty patients with PCOS with body mass index (BMI) ranged from 30.0-40.0. Group II: Twenty normal healthy control obese ladies with BMI ranged from 30.0-40.0. Group III: Twenty patients with polycystic ovary syndrome with BMI ranged from 18.5-29.9. Group IV: Twenty females as a healthy control non-obese ladies with BMI ranged from 18.5-29.9.Results:Serum zinc level was significantly decreased in obese PCO group than in non-obese PCO group. Serum prolactin (PRL) level and LH levels were elevated in PCO group which was highly significant. There was negative correlation between serum zinc level and BMI in PCO patients. Also, negative correlation was observed between serum zinc level and serum PRL level in non-obese PCO patients.Conclusion:Serum zinc level reduced in obese PCOS than in non-obese PCO.Keywords: Serum zinc level, polycystic ovary syndrome


Article
Prevalence of anemia and determination of some hematological parameters among pregnant women in Baghdad city
انتشار فقر الدم وتحديد بعض المحددات الدموية بين النساء الحوامل في مدينة بغداد

Author: Zena Kassim Khalil زينة قاسم خليل
Journal: Iraqi Journal of Science المجلة العراقية للعلوم ISSN: 00672904/23121637 Year: 2017 Volume: 58 Issue: 2C Pages: 1001-1008
Publisher: Baghdad University جامعة بغداد

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Abstract

From 124 women in different stage of pregnancy ,there were 83 (67%) conceded anemic and 41(33%) were non anemic ,there were 54(65%) suffering from iron deficiency anemia. According to the form of anemia , 27 (32.5%) were suffering from mild anemia, 41 (49.4%) moderately anemia while15 (18.1%) severe anemia The number of anemic pregnant women from Baghdad was 39 (47%) and the internally displaced anemic pregnant women 44 (53%). the anemic pregnant women who were primigravida 36 (43.4%), while the pregnant women who were multipart gravida 47 (56.6%) .The number of anemic pregnant women was 26(31.3%) for age of 17-27y ,33(39.8%) for age of 28-37y and 24(28.9% )for age of 38-45y .while the number of anemic pregnant women was 43(41%) at the 1st trimester ,31(37%) at the 2nd trimester and 18(22%) at the 3nd .There were 62(69 %) from the total pregnant women got iron pills during the pregnancy period .From the total anemic pregnant women 9 (11%) recorded with pregnancy diabetes, 11 (13.3%) had pregnancy hypertension and 21(25%) suffered from placental previa,. The total RBCs and WBCs count during the 1st ,2nd and 3rd trimesters were (3.70±0.30, 3.96±0.59 and 4.76±0.24) .( 4.62±1.23 , 8.31±2.45 and 13.22±3.60) respectively ,while the Hb levels were 8.78±1.39 , 10.93±1.21 and 12.33±0.18 at the pregnancy trimesters. Serum iron and serum firrtin levels in iron deficiency ,non- iron deficiency anemia were (31.24±9.7 and 37.2±12.7) ,( 4.90±3.4 and 311.10±135.2) respectively.

من بين 124 سيدة حامل في مختلف مراحل لحمل وجد ان 83 (67%) لديها فقر دم و41(33%) لا تعاني من فقر الدم وان 54(65%) تعاني من فقر الدم بسبب نقص الحديد. واعتمادا على نوع فقر الدم فأن 27(32%) لديها مرحلة بسيطة من فقر الدم41 (49,4%) تعاني من فقر دم متوسط و15 (18,1%)تعاني من فقر دم شديد .عدد النساء الحوامل المصابات بفقر الدم من سكنة بغداد 39(47%)والنازحات 44 (53%) عدد الحوامل المصابات بفقر الدم36 (43,4%) لأول حمل اما الحوامل ولديهم اكثر من ولادة فكانوا 47(56,6%) .اعمار النساء الحوامل 17-27 سنة كان عددهم 26(31,3%) و28- 37سنة عددهم 33 (39,8%) و 24(28,9%) للاعمار 38-45 سنة . في الثلث الاول من الحمل بلغ عدد النساء الحوامل والمصابين بفقر الدم 43(41%) و 31 (37%) خلال الثلث الثاني و 18 (22%) للثلث الاخير من الحمل , ومن بين جميع النساء الحوامل كان 62 (69%) يتناولون ااقراص الحديد خلال فترة الحمل .اما عدد الحوامل المصابات بمرض السكري فكان عددهم 9 (11%) و ارتفاع ضغط الدم 11 (13,3%) و21 (25%) لديهن تقدم في المشيمة بالإضافة الى فقر الدم , اعداد كريات الدم الحمراء والبيضاء خلال مراحل الحمل الثلاث كانت (3,70±0,30 ,3,96 ± 0,59 و4,76 ±0,24 ) و( 4,62 ±1,25 ,8,31 ±2,45 و13,22 ±3,60 ) بالتتابع. اما معدلات الهيموكلوبين فكانت 8,78 ±1,39 ,10,93 ±1,21 و 12,33 ±0,18 خلال مراحل الحمل , اما معدلات الحديد والفرتيين بين الحوامل المصابات بفقر الدم بسبب بنقص او عدم نقص الحديد فكانت (31,24 ±9,7 و37,2 ±12,7) و(4,90 ±3,4 و311,10 ±135,2 ) بالتتابع.


Article
Impact Of Hypoxemia In Patient With Chronic Obstructive Pulmonary Disease On Renal Function Tests

Authors: Amjed Hassan Abbas --- Samir Sawadi Hammuod
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2017 Volume: 14 Issue: 1 Pages: 140 -147
Publisher: Babylon University جامعة بابل

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Abstract

Chronic obstructive pulmonary disease (COPD) is one of the most common chronic diseases and is expected to be progressively increasing. There are many co-morbidities associated with it, but the relation between it and changes in renal function tests is still unclear. The aim of this work was to illustrate the extent of kidney dysfunction in patients who suffer from COPD. This study was performed in Merjan Medical City, the period of study was from November 2013 to June 2014, it included 86 patients with COPD and 70 control healthy subjects who completed medical questionnaires, pulmonary function tests and measurement of blood urea and serum creatinine. The data was statistically analyzed, the level of statistical significance that was depended for this study was P values ≤0.05. The results of this study revealed significant difference in the mean values of blood urea (Bur), serum creatinine (Scr), and creatinine clearance (Ccr) before and after treatment for all patients, Bur increased and Ccr decreased significantly in hypoxic group in comparison with non hypoxic group (P ˂ 0.05); while no significant changes in Scr (P = 0.1). In addition, the study showed a significant correlation between blood urea and creatinine clearance (Ccr) with SPO2 (before treatment) (p < 0.05), while non-significant negative correlation between serum creatinine and SPO2 (before treatment) (r = 0.1, P > 0.05).The results illustrated that the Bur and Scr increased; while Ccr decreased significantly in male group in comparison to female group (P˂0.05). Also there was no significant correlation between blood urea, serum creatinine, and creatinine clearance with forced expiratory volume in first second (FEV1) (before treatment) (P > 0.05). From this study, we conclude that abnormalities of renal function tests are common in patients with COPD at the first days of admission to hospital.


Article
Salivary and Serum Oxidant/Antioxidant Level in Behçet’s Disease Patients

Author: Noor H. Mohammad
Journal: Journal of Oral and Dental Research مجلة طب الفم والاسنان ISSN: 23106417 Year: 2017 Volume: 4 Issue: 2 Pages: 149-157
Publisher: Iraqi Association for Oral Research الجمعية العراقية لبحوث طب الفم

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Abstract

Background Behçet’s disease (BD) is a multi-systemic inflammatory disorder characterized by recurrent oral and genital ulceration. Free oxygen radicals may have a role in the pathogenesis of BD and can relate to the existence of the disease.Objectives This study had been designed to assess salivary and serum lipid per-oxidation as malondialdehyde (MDA) and status of antioxidant as total glutathione (GSH) in patients with BD in comparison with healthy subjects to detect the possible involvement of oxidative stress in BD. Materials and methods This is a case–control study, salivary and serum samples were taken from ffty BD patients with an age range 20 to 56 years with mean age 35.3 ± 7.6 years and ffty healthy control subjects with age range 16 to 58 years and mean age 34.8± 9.1 years. All were analyzed for MDA and GSH spectrophotometrically. Data was analyzed using descriptive statistics, t-test, P (ANOVA) test, Chi-square (2X) test, Pearson correlation and Receiver Operating Characteristic statistical analyses. Results The study showed that salivary and serum MDA level was higher in BD patients than in healthy subjects (P<0.05 and P<0.001 respectively). The levels of saliva and serum total GSH were signifcantly lower in BD patients than in healthy subjects. (P <0.001). Conclusion The results of this study revealed that BD patients were subjected to oxidative stress damage and saliva could be used as pain-free alternatively to serum in determining oxidative stress in Behçet’s disease.

Keywords

Behçet’s disease --- MDA --- GSH --- saliva --- serum


Article
The Association of Gestational Diabetes with Serum Ferritin

Author: Dina Akeel Salman *,Thanaa Jameel Al-Khishali **, Nada Salih Ameen ***
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2017 Volume: 16 Issue: 1 Pages: 47-56
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND: Serum ferritin is the standard measurement for the body iron stores, and is the most reliable marker for iron status. During pregnancy, there is a gradual decline in serum ferritin level. However, elevated maternal serum ferritin was notified in women with gestational diabetes mellitus (GDM).OBJECTIVE: To investigate the association between maternal serum ferritin level and gestational diabetes. METHODS: A prospective case control study of 50 women with singleton pregnancy that had gestational diabetes compared to 50 healthy pregnant women. The study was performed in Baghdad teaching hospital for one year period from June 2010 through June 2011. Serum iron, total iron binding capacity, and serum ferritin level were assayed. Mean serum ferritin was elevated (95.6027±99 ng/ml) in women with gestational diabetes, compared to that in the control group (31.7213±42ng/ml). RESULTS: There was a statistically significant elevation of serum ferritin in women with gestational diabetes. CONCLUSION:We concluded that there is a positive association between the elevated serum ferritin and gestational diabetes.


Article
Study of Pathological Effect Caused by Certain Parasites in The Digestive Tract of Broiler Chickens in Kirkuk City
دراسة التأثير المرضي التي تحدثها بعض الطفيليات في الجهاز الهضمي لفروج اللحم في مدينة كركوك

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Abstract

The current study was carried out in the veterinary hospital of Medicine from (the period 2nd March until 15th July). 200 spcimen were taken from chicken various places in Kirkuk city. The chicken age varied from (3 month-12month). Histological study showed the absence of any changes occurred in the mouth lining, pharynx, esophagus and stomachof infected birds while histological changes was observed in the intestine villi in abnormal shapes, They appeared to be disconnected with alternating in its original appearance, It was found that cecae and the small Intestine of some infective chicken was suffering from infection to the epithelial layer followed by a high level of infiltration to the inflammatory cells and occurrence of relapse in the muscular fiber bindles.

اجريت هذه الدراسة في مستشفى البيطري في كركوك للفترة (2 اذار2015 ولغاية15 تموز 2015) تم فحص وتشريح 200 عينة جهاز هضمي لفروج اللحم من مناطق مختلفة في مدينة كركوك وبأعمار مختلفة تراوحت بين ( 3اشهر-12شهر) واظهرت الدراسة النسجية عدم وجود تغيرات مرضية في التجويف الفمي والبلعوم والمريء والمعدة للطيور المصابة فيما ظهرت تغيرات نسجية على الامعاء اذ ظهرت الزغابات باشكال غير طبيعية وبدت مفككة وفاقدة لمعالمها الاصلية ووجد ان الاعاور والامعاء الدقيقة لبعض الدجاج المصاب تعاني من التهاب واحتقان دموي وحدوث نزف جراء الاصابة وما صاحب من الاصابة الطفيلية من حدوث التهاب للطبقة الطلائية مصحوبا بارتشاح هائل للخلايا الالتهابية وحدوث التنكس في حزم الالياف العضلية.


Article
Neutrophil gelatinase associated lipocalin (NGAL) in early detection of nephropathy in type 2 diabetic Iraqi patients

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Background: Diabetic nephropathy is a common complication of diabetes mellitus type2. The neutrophil gelatinase Associated lippocallin (NGAL) is an ubiquitous protein consist of 178 amino acid. NGAL can be identified in plasma and urine starting 2- 4 hours after a kidney injury resulting changes in glomerular filtration and tubular reabsorption and with increased secretion in tubular epithelial cells.Objective: This study aimed to evaluate the role of serum Neutrophil Gelatinse Associated Lipocallin (NGAL) in early detection nephropathy.Method : This study was conducted in Medical City, Baghdad Teaching Hospital during the period from December 2015to June 2016.The study included (90) subjects with age range between (30 – 56)years, divided in to three groups , 30 healthy control,30 type 2 diabetic mellitus patients with normal albuminuria and 30 type2 diabetic mellitus patients with micro albuminuria .Body mass index (BMI) was determined, serum NGAL, Fasting serum glucose (FBS),serum creatinine ,serum urea ,andglycated hemoglobin (HbA1c%) were measured for each individual in addition to the concentration of albumin in urine and Glomerular Filtration Rate (eGFR) was calculated.Results:The results of the present study showed that the levels of NGAL, FBS, HbA1c, urea creatinin, were significantly higher in micro albuminuria than normal albuminuria and healthy control. In diabetic patients with micro albuminuria, Serum NGAL shows significant positive correlation with FBS, HbA1c% and urine albumin. Serum NGAL shows significant positive correlation with duration of diabetes but significant negative correlation with GFR.Conclusion:Serum NGAL increased markedly with the reduction of GFR.Serum NGAL is may be considered predictive marker for early detection of diabetic nephropathy in type2 diabetes mellitus.Keywords:diabetic mellitus,diabetic nephropathy,micro albuminuria, serum NGAL, HbA1c.


Article
Regional Differences of Drinking Water Iodine and Its Association with Thyroid Disorder and Serum Iodine

Author: Jwan Ibrahim Jawzali
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2017 Volume: 14 Issue: 1 Pages: 198 -208
Publisher: Babylon University جامعة بابل

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Abstract

The study aims to evaluate relationship between drinking water iodine and serum iodine with thyroid disorders in patients with symptomatic thyroid disease in Erbil province, Iraq. Outpatients attending Rizgariy and Hawler teaching hospital, Erbil province, were participated in this cross sectional study and samples of drinking water were collected randomly from different geographical region of Erbil province. Biochemical analyses included; serum thyroid hormones, serum iodine and drinking water iodine. Level of water and serum iodine were deficient 24.1± 6.8 μg/l (SD)μg/l and 24.4 ± 21.4 (SD) μg/l respectively. Highest level of the water iodine was in south west of Erbil city and the lowest one was in the east districts. Water iodine showed significant negative correlation with thyroid stimulating hormone (TSH) in patients with abnormal thyroid function and significant increase risk of hypothyroidism in regions with low water iodine. 20% of patient had hypothyroidism. Serum iodine didn’t correlated with water iodine while there was significant negative correlation of it with TSH hormone. Deficiency of drinking water iodine reflects effect of environmental factors on water quality. It is a potential risk factor for developing thyroid disorder especially hypothyroidism in reproductive age of housewives. Continued monitoring treatment and iodized salt programs could prevent hypo and hyperthyroidism.


Article
Serum Level of TNF-α and IL-17 in Patient Have Chronic Periodontitis Associated Rheumatoid Arthritis

Authors: Munir Nasr Hamed, منير نصر حامد --- Basima Gh. Ali
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2017 Volume: 29 Issue: 1 Pages: 104-110
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: chronic periodontitis and rheumatoid arthritis are widely prevalent diseases and are characterized by tissue destruction due to chronic inflammation. Recently, there is growing evidence that the two diseases share many pathological features the aims of the study To determine the periodontal health status in patient have chronic periodontitis with rheumatoid arthritis and compare it with those having chronic periodontitis without Rheumatoid arthritis and determine the serum levels of interleukin -17(IL-17), tumor necrosis factor- alpha (TNF-α ) in both groups and compare with the control group (subject samples neither have periodontitis nor arthritis ) and correlate these immunological markers with the periodontal parameters Plaque index , gingival index , bleeding on probing, probing depth, clinical attachment level and number of missing teeth.Materials and methods: Eighty (80) males and females subjects with age range (30-45) years were recruited in this study they were divided into three main groups The chronic periodontitis with rheumatoid arthritis group consist of thirty (30) subjects and second group consist of thirty (30) subjects have chronic periodontitis and third group consist of twenty (20) subject case control group. All subjects had normal weight and height range according to BMI (body mass index) that it value is (18.5-25), Clinical periodontal parameters used in this study were Plaque index, gingival index, bleeding on probing, clinical attachment level index, probing pocket depth and number of missing teeth was measured in all groups at four surfaces of all presented teeth Blood samples were collected from all individuals and examined to determined serum level of interleukin -17 and tumor necrosis factor-a by mean of enzyme-linked immune–sorbent assay.Results: The present study showed patients with chronic periodontitis and rheumatoid arthritis had higher prevalence of sites presenting dental plaque, a higher rate of gingival inflammation and bleeding on probing greater probing depth, greater attachment loss and high number of missing teeth compared to those had chronic periodontitis only and control subjects . Also highly significant differences between studied group regarding serum level of IL-17 and TNF-α atp < 0.001, as well as, it revealed that mean serum levels of IL-17 were statistically higher in chronic periodontitis with rheumatoid arthritis group (607.9 ± 79.9) than Chronic Periodontitis group (421.4 ± 5.9) and Control groups (15.9 ± 2.7) similarly serum level of TNF-α (402.2 ± 41.2 319.4 ± 526 85.3 ± 4.9) respectively at p < 0.001. Regarding correlation, the current study observed strong positive correlation between serum levels of IL-17 andTNF-α with PL.I, GI, BOP, PPD CAL and the number of missing teeth in the PRA at p<0.001. Also this study reveal significant correlation between the two immunological markers (TNF-α and IL-17) in chronic periodontitis with rheumatoid arthritis group and in Chronic Periodontitis group.Conclusion: It was concluded that there was higher potentiality to chronic periodontitis involvement among rheumatoid arthritis patients, that correlated positively with increase the level of serum levels of IL-17 and TNF-α accordingly with high score of clinical parameters that had recorded. That mean TNF –a and IL-17 may play an important role in increase the severity of periodontitis as well as rheumatoid arthritis

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