research centers


Search results: Found 2

Listing 1 - 2 of 2
Sort by

Article
Association of Adiponectin Gene Promoter Polymprphism (rs266729) With Ischemic Heart Diseases

Authors: Maha Radhi Abass --- Majid Kadhum Hussain --- Zuhair Mohammed Ali Jeddoa
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2018 Volume: 11 Issue: 1 Pages: 3889-3893
Publisher: Kerbala University جامعة كربلاء

Loading...
Loading...
Abstract

background: Ischemic Heart Disease is a group of diseases of the blood vessels supplying the heart muscle. Adiponectin is a protein secreted by adipocyte with insulin-sensitizing, Anti-inflammatory and anti-atherogenic properties. Several studies have shown that polymorphisms within the adiponectin gene can be associated with Ischemic heart disease. Aim: The aim of the present study was to evaluate the impact of (rs266729) SNP in the promoter region of the ADIPOQ gene on the occurrence of Ischemic heart disease (IHD).Methods: The study included 150 patients with IHD randomly selected based on World Health Organization (WHO) guideline and 150 as controls group. DNA was extracted from blood and genotyped by PCR-RFLP by using (Hha1) enzyme. Result: The frequency of G allele of rs266729 (C/G) polymorphism was significantly (p=0.0001) in IHD (19.6%) compared with control (13.3%). The homozygous genotype (GG) significantly (0R=1.71, CI 95%=0.65-4.96, P= 0.0001) increased the risk of Ischemic Heart Disease compared with wild type (CC) after adjustment age, sex, and BMI, furthermore the heterozygous (CG) genotype significantly (0R=1.61, CI 95%=0.96-2.87, P= 0.0001) raised the risk of Ischemic Heart Disease.Conclusion: Adiponectin gene polymorphism rs266729 is involved in the pathogenesis Ischemic heart disease.


Article
Unstable Angina Risk Factors and Influence of Age and Gender in relation to In-Hospital Outcome

Author: Eman Jasim Mohammed Al- Akkam *, Harith younis serrheed
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2018 Volume: 17 Issue: 3 Pages: 285-290
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND: Unstable angina (UA) is a type of acute coronary syndrome. It has been recognized as a distinct syndrome intermediate between stable exertional angina and myocardial infarction. It includes many types according to the onset, duration, intensity and frequency of pain. OBJECTIVE :The objective of this study to estimate the frequency of risk factors of ischemic heart disease, influence of age and gender, also to predict the in-hospital outcome.METHODS: One hundred patients with unstable angina of all ages and both gender were enrolled in a cross-sectional study from October 2010 – June 2011 who were admitted to coronary care unit of Baghdad Teaching Hospital / Medical City.Descriptive analyses were performed to assess the relationship between unstable angina and risk factors and influence of age and gender and in-hospital outcome. RESULTS: This study showed a highest incidence of unstable angina among males and females in the age of 50-54years.Hypertension was the major risk factor (58%) while, smoking (48%), diabetes (38%), family history of ischemic heart disease (35%), hypercholesterolemia (34%) and obesity (22%).There were significant differences between both gender with unstable angina and the following risk factors: hypertension, smoking, hypercholesterolemia and obesity. There were 22% of patients with persistent chest pain who developed non- fatal acute myocardial infarction and 6% died in the hospital.CONCLUSION: The following risk factors; hypertension, smoking, diabetes, family history of ischemic heart disease, hypercholesterolemia and obesity play an important role in occurrence of unstable angina and prognosis. The incidence of UA was higher among ages of (50 -54) years of both gender. Persistence of chest pain at rest was greatly associated with unfavorable outcome.

Listing 1 - 2 of 2
Sort by
Narrow your search

Resource type

article (2)


Language

English (2)


Year
From To Submit

2018 (2)