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Immunohistochemical expression of endocan, as a marker of assessment of angiogenic potential in benign vascular lesions (hemangioma, lymphangioma and lobular capillary hemangioma) of head and neck region

Authors: Jawaher M.Tater --- Bashar H. Abdullah --- Wisam A.Hussain
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2018 Volume: 30 Issue: 4 Pages: 24-27
Publisher: Baghdad University جامعة بغداد

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Abstract

BACKGROUND: Vascular tumors are a heterogeneous group of diseases with biological behavior ranging from a hamartomatous growth to frank malignant. The pathophysiology of lymphangioma, vascular malformation and hemangioma is interconnected, blood vessels known to be the site of origin of hamartomas, venous malformations and some neoplasms as benign, tumor-like growth of vessels (hemangiomas). Angiogenesis is the process of formation of new blood vessels from an existing structure.Aims of study Assessment of angiogenic potential in benign vascular lesions (hemangioma, lymphangioma and lobular capillary hemangioma) of head and neck region.Materials and Methods: Twenty-two formalin-fixed paraffin-embedded tissue blocks of Hemangioma/vascular malformation, thirty of lobular capillary hemangioma and another twenty of lymphangioma to be stained with Endothelial cell-Specific Molecule-1 (ESM-1) monoclonal antibody.Results: Microvessel density expressed by Endothelial cell-Specific Molecule-1 (ESM-1) immunomarker was found in all cases with mean density of (37.44±23.16) for lobular capillary hemangioma and (25.02±13.89) for hemangioma and (6.34±3.52) for lymphangioma. According to post hoc test ESM-1 marker expression showed a high significant difference between (hemangioma and lymphangioma=0.001), (lymphangioma, pyogenic granuloma=0.000), and it was significantly different between (hemangioma, pyogenic granuloma=0.011)Conclusions: The obvious capillary growth in lobular capillary hemangioma revealed that lobular capillary hemangioma showed the highest activity of angiogenic potential in comparison to hemangioma and lymphangioma


Article
Oral Hemangiopericytoma: Literature Review and Two Cases from Sulaimani. (An Analytic Study)

Authors: Marwa A. Hamied --- Salwa M. Al-Shaikhani --- Bayad J. Mahmood --- Balkees T. Garib --- et al.
Journal: Journal of Oral and Dental Research مجلة طب الفم والاسنان ISSN: 23106417 Year: 2018 Volume: 5 Issue: 1 Pages: 2-21
Publisher: Iraqi Association for Oral Research الجمعية العراقية لبحوث طب الفم

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Abstract

Background Hemangiopericytoma (HPC) is an uncommon vascular neoplasm.Objectives This study was designed in order to review and summarize published cases with oral HPC since 1949, and unpublished cases from histopathological centers in Kurdistan region/Sulaimani/Iraq. The specifc objective is to correlate cases related medical data with treatment option and prognosis. Materials and Methods A web-based search was initiated for published articles and case reports by using PubMed, and Google. Another search was done in the database of histopathological centers in Sulaimani. Results Two new cases of oral HPC diagnosed in the Department of Oral and Maxillofacial Pathology - Dentistry College - Sulaimani University were reported in details. Literature review disclosed sixty-six HPC of the oral cavity and additional fve cases were reported from Sulaimani (total 71 cases). Male to female ratio was 1:1.5, with a wide age range from newborn to 91 years, 50% of oral HPC was between 15 and 51 years. The tongue was the most common site that HPC originated from, then jawbones, and buccal mucosa. Neither sex nor age seems to have any effect on the outcome of oral HPC (p>0.05). HPCs that originate from oral mucosa including 13 cases from buccal mucosa and gum were benign, while jaw bones HPC was with malignant behavior in six cases. The behavior of twenty-six cases was not recorded. Different sites had no effect on the tumor outcome (p=0.08). Most cases which were treated only by surgery showed no recurrence (p=0.01). Conclusion HPC has a high rate of recurrence with undeterminable malignant potential, and require surgical excision with adequate margins and long-term follow up.

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