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Article
21- STUDY THE EFFECT OF CAFFEINE ON BODY WEIGHT GAIN AND LIPID PROFILE IN ADULT MALE RATS TREATED WITH HYDROGEN PEROXIDE.

Author: Faraj H.Joni AL-Bidhani , .Adel M. Hassen Alzobidy .Abdul Razzak N. Khudair
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2018 Volume: 17 Issue: 1 Pages: 246-256
Publisher: Basrah University جامعة البصرة

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Abstract

The present study was aimed to determine the ameliorative effect of caffeine onBody weight and lipid profile in male rats treated with hydrogen peroxide (H2O2) .Seventy Two adult male rats were used in this study . The study included twoexperiments ,in each experiments 36 males were randomly assigned two six equal groupsof six animals in each group .The animals in both experiments were treated with thesame substances and doses for each group as follows .Group one (control) animals weredrenched normal saline ,Group two animals were treated (5.63 mg/kg. Bw )H2O2 dailyby oral gavage also group three , animals were treated with low dose caffeine (150 mg/kg Bw) daily .Group four , animals were treated with high dose caffeine (250 mg /kgBw) daily . Group five . animals were treated (5.63 mg/kg. Bw )H2O2 dose after 1 hanimals were given low dose of caffeine (150 mg/kg Bw) .Group Six animal weretreated with H2O2 dose(5.63 mg/kg Bw) each rat after one hour was given high dose ofcaffeine (250 mg /Kg Bw) . The first experiments lasted for one month and secondexperiments lasted for two months . At the end of the two experiments, animals of allgroup were sacrificed under chloroform anesthesia .Blood samples were collected from the heart directly by cardiac puncture and the serum was separated to measure the lipidprofile .The result revealed a significant decreased in body weight gain in H2O2in first andsecond experiments compared with control group . While a significant improvementswere recorded in body weight gain in all treated groups compared with H2O2 group butstill significantly lower compared with those of control group. A significant increase inTC ,TG and LDL-c were recorded in H2O2 group in both experiments compared withcontrol group on the other hand no significant difference was recorded in HDL-c levelin H2O2group in first experiments while a significant decreased was recorded in secondexperiments compared with control group . Finally a significant degrees ofimprovement were observed in lipid profile in all treated group compared with H2O2 .


Article
EFFECT OF POLICOSANOL EXTRACT ADMINISTRATION ON LIPID PROFILE IN HYPERCHOLESTROLEMIC FEMALE RATS DURING LACTATION
تاثیر مستخلص البولیكوسانول على صورة الدھون في إناث الجرذان مفرطة الكولیستیرول خلال فترة الرضاعة

Author: Ashwaq Jabbar Al-Miahy* ; Jassim M. A. Alkalby أشواق جبار المیاحي ، جاسم محمد احمد
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2018 Volume: 17 Issue: 2 Pages: 173-182
Publisher: Basrah University جامعة البصرة

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Abstract

The present study designed to investigate the effects of the extracted policosanol on lipidprofile of hypercholestrolemic lactating female rats (Ratus norvigicus). Forty eight female rat(10-12) weeks old,and weighting (200-250 gm) were used in the current study. After dailyvaginal smear for 3 sequences estrus cycles, they mated with twenty four healthy adult fertilemales weighting (280-350 gm), 24 of these females were induced to be hypercholestrolemicduring the pregnancy,and others still healthy. Sugarcane were collected from Mesan provinceand policosanol was extracted from sugarcane wax. Immediately after birth the animals weredivided into 6 groups: Group 1 (n=8) (Control) : Normal rats were given only 0.5 ml/ animal ofDimethyl Sulphoxide (DMSO) daily immediately after birth. Group 2 (n=8) hyperchol. (HC):Hpercholestrolemic rats were given only DMSO 0.5 ml/ animal daily immediately after birth.Group 3(n=8) (HC+SM): Hpercholestrolemic rats were given simvastatine at dose 20mg/kgBW/ day dissolved in DMSO orally by gavages' immediately after birth. Group 4(n=8) (SM) :Normal rats were given only simvastatine at dose 20mg/kg BW/ day dissolvxsqqs ed inDMSO orally by gavages' immediately after birth. Group 5 (n= 8) (HC+ST. pol):Hpercholestrolemic rats were given standard policosanol at dose 20mg/kg BW/day orally bygavages' immediately after birth. Finally group 6(n=8)( HC+EX. pol): Hpercholestrolemic ratswere given policosanol extraction at dose 20mg/kg BW/day orally by gavages immediatelyafter birth. The treatment continued until weaning ( 30 days).

صممت ھذه الدراسة للتقصي عن تأثیر مستخلص البولیكوسانول في بعض المعاییر الدھنیة لإناث الجرذان المختبریةمن نوع) (Rattus norvegicusمفرطة الكولیسترول في فترة الرضاعة. استخدمت في ھده الدراسة ثمانیة وأربعون أنثىجرذ بأعمار تراوحت بین ) (١٢-١٠أسبوع و بأوزان تراوحت ما بین ) ( ٢٥٠-٢٠٠غرام. بعد عمل مسحات مھبلیة یومیالثلاث دورات شبق متتالیة خضعت ھذه الجرذان للتزاوج بذكور بالغة بعدد ٢٤ذكر بأوزان تراوحت ما بین )(٣٥٠-٢٨٠غرام توزعت بمعدل ذكر واحد لكل ٢من الإناث. بعد التأكد من حمل ھذه الجرذان خضعت فقط ٢٤من الإناث لاستحثاثفرط الكولیستیرول في الدم خلال فترة الحمل،والباقي تركن بدون استحثاث .استخلصت مادة البولیكوسانول التي استعملت فيھذه الدراسة من قصب السكر بعد جمعھ من محافظة میسان وتجفیفھ وطحنھ ومعاینة مكوناتھ باستعمال تقنیة كروماتوكرافیاالغاز .GC/ MSبعد الولادة مباشرة وفي فترة الرضاعة تحدیدا قسمت الإناث إلى ٦مجامیع


Article
Hypercholesterolemia as a risk factor for coronary heart disease

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Abstract

Familial Hypercholesterolemia (FH) is a genetic disorder, an expression of a defect in the gene that is responsible for the production of LDL-C receptor. The current study was designed to determine the FH patients in the city of Sulaymaniyah for both sexes. The study included 213 samples, the number of males was 99 and the number of females was 114, both sexes ranged from (30-79) years.The results of cholesterol, triglyceride, high density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C) in patients with hypercholesterolemia showed highly significant (P ˂ 0.01) for cholesterol and the concentration level in patients with hypercholesterolemia compared to the level of concentration of healthy.As concerns the effect of hypercholesterolemia on coronary heart disease, the results showed a significant increase (P ˂ 0.01) in cholesterol, triglycerides and LDL-C with a significant decrease in HDL-C concentration in people with heart disease compared with healthy people. triglyceride in patients with compared healthy people. (HDL-C and LDL-C) showed a significant decrease (P ˂ 0.01) in the concentration of HDL-C in patients with hypercholesterolemia compared to their level of concentration in healthy individuals, in relation to low-density lipoprotein (LDL-C) -C is the other (P ˂ 0.01) in.

فرط كولسترول الدم العائلي FH) Familial Hypercholesterolemia) هو إضطراب وراثي وهو تعبير عن خلل في الجين المسؤول عن إنتاج مستقبلReceptor البروتين الدهني منخفض الكثافة ( Low – Density – Lipoprotein (LDL-C . صممت الدراسة الحالية لمرضى فرط كولسترول الدم العائلي (FH) في مدينة السليمانية لكلا الجنسين ، وشملت الدراسة (213) عينة وكان عدد الذكور (99) وعدد الأناث (114) وتراوحت أعمار كلا الجنسين من (30-79) سنة .أشارت نتائج قياس تركيز كل من ( الكولسترول ، الدهون الثلاثية ، البروتينات الدهنية عالية الكثافة HDL-C والبروتينات الدهنية واطئة الكثافة LDL-C ) لدى المرضى المصابين بفرط كولسترول الدم ارتفاعاﹰ عالي المعنوية ملحوظاﹰ (0.01 ˂ P) ﹰللكولسترول والدهون الثلاثية لدى المرضى مقارنةﹰ بالأصحاء ، في حين أظهرت نتائج البروتينات الدهنية ( HDL-C و LDL-C) إنخفاضاﹰ معنوياﹰ كبيراﹰ (0.01 ˂ P) في مستوى تركيز البروتينات الدهنية العالية الكثافة HDL-C لدى مرضى فرط كولسترول الدم مقارنةﹰ بمستوى تركيزه لدى الأصحاء ، أمـﱢــا بالنسبة للبروتين الدهني المنخفض الكثافة LDL-C فهو الأخر عالي المعنويةﹰ (0.01 ˂ P) في مستوى تركيزه لدى مرضى فرط كولسترول الدم مقارنة بمستوى تركيزه للاصحاء . أمــﱢـا عن تأثير العامل المرضي على المصابين بفرط كولسترول الدم وهو مرض القلب التاجي coronary heart disease ، فقد أظهرت النتائج وجود زيادة معنوية (P ˂ 0.01) في الكولسترول والكليسيريدات الثلاثية TG و LDL-C مع أنخفاض ملحوظ لتراكيز HDL-C لدى الأشخاص المصابين بأمراض القلب مقارنةﹰ بالأصحاء .


Article
EFFECT OF OXIDATIVE STRESS ON LIPID PROFILE AND BLOOD PARAMETERS TO A SAMPLE OF STUDENTS AT UNIVERSITY OF ZAKHO DURING EXAMES
تاثير الاجهاد التاكسدي على مرتسم الدهون وبعض المتغيرات الدميه لنموذج من الطلاب في جامعة زاخو اثناء الامتحانات

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Abstract

Worry, anxiety through Study and preparative to exam may lead to mental stress. Mental stress may contribute to oxidative stress in the body which is the change in balance between oxidants and antioxidants.In this study a concentration of Malondialdehyde (MDA) as a lipid oxidation biomarker, lipid profile and some blood parameters like Minmum Inhibitory dilution (MID) were estimated in twenty chemistry and biology students at the day of exam as Stress Condition (SC) compared with the same parameters which obtained from the same students during the university vacation after a month of doing the latest exam as non-Stress Condition (nSC).A significant increase in MDA (p=0.0019), Total Cholesterol (p<0.05), Triglyceride (p<0.05), Low Density Lipoprotein LDL-Cholesterol (p<0.05), Very Low density lipoprotein VLDL-cholesterol (p<0.05) and A significant decrease in High - Density Lipoprotein HDL - Cholesterol (p<0.05), HDL-Cholesterol to total cholesterol ratio(p=0.0012) in stress condition were observed when compared with “non-stress” conditions. Also there were high significant decreases in lymphocyte and minimum inhibitory dilution (MID) (p=0.0001, p<0.0001 respectively) and significant increases in granulocyte and platelets (PLT) (P=0.0113, P=0.0031 respectively) in stress condition compared to non-stress condition. Whereas no significant changes in total WBCs and RBCs in stress and non-stress conditions. These results suggested that during university examinations when students are under mental stress or psychiatric disorder may put them at risk of developing inflammatory disorders like atherosclerosis and/or coronary arteries disorders.

القلق والضغط النفسي خلال المذاكرة والاستعداد للامتحان قد يؤديان الى أجهاد ذهني والذي ربما يساهم بإحداث كرب تأكسدي في الجسم ناتج عن تغيير في التوازن ما بين المؤكسدات ومضادات الاكسدة. في هذه الدراسة تم تقدير تركيز المالون داي الديهايد (MDA)كمؤشر حيوي لأكسدة الدهون وايضا مرتسم الدهون وبعض قياسات الدم مثل التخفيف المثبط الادنى (MID) لعشرين طالب من قسم الكيمياء وقسم علوم الحياة في يوم الامتحان كحالة اجهاد (SC) بالمقارنة مع نفس القياسات لنفس الطلاب خلال العطلة الجامعية بعد شهر من ادائهم اخر امتحان كحالة عدم اجهاد (nSC).تمت ملاحظه زياده معنوية في المالونيل داي الديهايد (MDA) (P=0.0019) والكولسترول الكلي (P<0.05) و الدهون الثلاثية (P<0.05) والبروتين الدهني واطئ الكثافة (P<0.05) والبروتين الدهني واطئ الكثافة جدا (P<0.05) وانخفاض معنوي في البروتين الدهني عالي الكثافة الكوليسترول (P<0.05) وفي نسبة البروتين الدهني عالي الكثافة الى الكوليسترول الكلي( (HDL-cholesterol/T-cholesterol (P=0.0012) لدى الطلاب في حالة الاجهاد مقارنة بحالة عدم الاجهاد بالإضافة الى انخفاض معنوي عالي في الخلايا اللمفاوية والتخفيف المثبط الادنى (MID)(P<0.0001 , P=0.0001 بالتعاقب( وزيادة معنوية بالخلايا الحبيبية والصفائح الدموية P=0.0113) ،p=0.0031 بالتعاقب( في حالة الاجهاد مقارنة بحالة عدم الاجهاد. بينما لم يوجد اي اختلاف معنوي في كريات الدم البيضاء والحمراء في حالة الاجهاد مقارنة بحالة عدم الاجهاد. تقترح الدراسة انه خلال الامتحانات الجامعية يكون الطلاب تحت تاثير اجهاد ذهني ونفسي ربما يؤدي الى تطور امراض التهابية كتصلب الشرايين او اعتلال الشرايين التاجية.


Article
Evaluation of lipid profile among Iraqi patients with the Breast Cancer

Author: Mushtaq T. Hasan1 , Zafir H. Al-Qaissi 2 , Wathiq A. Al-Draghi 1
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2018 Volume: 17 Issue: 2 Pages: 68-74
Publisher: Baghdad University جامعة بغداد

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Abstract

Breast cancer is most common cancer among women worldwide. In this study, the association between serum concentration of cholesterol, triglycerides( TG|), low density lipoproteins (LDL), high density lipoproteins (HDL),( VLDL) very low density lipoproteins and breast cancer has been investigated. These case control study include three groups: thirty women with breast cancer and fifteen healthy women as control group. Serum lipids: cholesterol,( LDL),( HDL) and (VLDL) were analyzed in all subjects of study using conventional method. The results of this study showed that there was a significant increase in the rate of the levels of total cholesterol (TC), triglycerides (TG), low density lipoproteins( LDL),( VLDL) very low density lipoproteins in the work group when compared with control (P=0.028, P=0.017, P=0.024 and P=0.033) respectively, except high density lipoproteins (HDL). We conclude that high concentration of cholesterol, triglyceride, (LDL), and (VLDL) may be associated with breast cancer.

Keywords

: Lipid profile --- Breast cancer --- TG --- HDL --- VLDL .


Article
The role of von Willebrand factor in determining the risk of ischemic stroke in Hawler city: a case-control study
دور عامل فون ويلبراند في تحديد خطر الإصابة بالسكتة الدماغية في مدينة هولير: دراسة الحالات و الشواهد

Authors: Salar Adnan Ahmed --- Sazgar Anwar Hameed
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2018 Volume: 22 Issue: 1 Pages: 120-125
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Ischemic stroke is classically characterized as a neurological deficit attributed to an acute focal injury of the central nervous system by a vascular cause, it occurs as a result of obstruction by a blood clot (thrombus) or plugs within a blood vessel supplying blood to the brain. In this study, we investigated the association of von Willebrand factor-antigen and serum lipids with ischemic stroke.Methods: The following retrospective study was conducted on 138 participants; 88 patients with ischemic stroke and 50 healthy controls.Results: In crude analyses, Plasma von Willebrand factor antigen, fasting serum Total cholesterol, Triglycerides and LDL-C were significantly higher in patients with ischemic stroke than in controls (P <0.001, P <0.001, P = 0.003, P <0.001, respectively), while the difference in the level of serum HDL-C between patients with ischemic stroke and control was significantly lower (P = 0.023).Conclusion: These data suggest that von Willebrand factor, total cholesterol, triglycerides, LDL-C and HDL-C gives some contribution to stroke risk even in the elderly and that von Willebrand factor antigen and lipid profile assessment must be taken into account in estimating the individual risks of stroke.


Article
Evaluation of serum C-reactive protein and lipid profile in patients with myocardial infarction
تقييم بروتين سي التفاعلي والشاكلة الدهنية في في المصل عند المرضى الذين يعانون من احتشاء عضلة القلب

Author: Leweza B. Abbass
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2018 Volume: 22 Issue: 3 Pages: 349-354
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Myocardial infarction is the irreversible death (necrosis) of heart muscle secondary to prolonged lack of oxygen supply (ischemia), when the blood supply to a part of the heart is interrupted, most commonly due to rupture of a vulnerable plaque. The resulting ischemia or oxygen shortage causes damage and potential death of heart tissue. It is a medical emergency, and the leading cause of death worldwide. In this study, we investigated the association of serum C-reactive protein and serum lipid profile with myocardial infarction.Methods: A cross-sectional study was carried out from January to May 2016 in College of Medicine, Hawler Medical University. The study involved 108 patients with myocardial infarction (70 men and 38 women) in comparison with 50 healthy individuals as the control group (29 men and 21 women).Results: The levels of serum C-reactive protein were significantly higher (P <0.05) in patients with myocardial infarction in both genders when compared with the control group. There was no statistically significant difference in serum total cholesterol, serum triglyceride and serum LDL-C in patients with myocardial infarction and control group. Regarding serum high-density lipoprotein (HDL-C), there was a statistically significant difference (P <0.01) in patients with myocardial infarction when compared with the control group.Conclusion: C-reactive protein may play an important role in providing clinicians and biochemists with valuable information regarding diagnosis and following up the patient with suspected myocardial infarction.


Article
Effect of aqueous extract of Agaricus bispporus on lipid profile of female albino mice treated with peroxide

Author: Dina khudhair Hussein Ali
Journal: Iraqi Journal of Science المجلة العراقية للعلوم ISSN: 00672904/23121637 Year: 2018 Volume: 59 Issue: 4C Pages: 2168-2172
Publisher: Baghdad University جامعة بغداد

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Abstract

Agaricus bisporus is cultivated edible mushroom . This study is made to evaluate the activity of A. bisporus extract on lipid profile in mice treated with peroxide. 40 females albino mice were chosen and divided into 4 groups (ten mice per each group). The first group was treated with normal saline as a control, the second group received 2ml/kg body weight of peroxide , While the third set received 2ml/kg body weight of peroxide plus 25 mg/ml A bisporus .Besides, the last fourth group received 25 mg/ml of A. bisporus. The Results have showed a significant increase (p≤ 0.05) in cholesterol(CH) in group 2 (250.01± 1.05)and group3 (204.25±1.80), while there was no significant decrease in CH level of group 4(170.01±2.01) as compared with control group(184.00± 1.02). As well, there was a significant increase in Low Density Lipoprotein (LDL) in group 2 (159.23±0.9) and group 3 (158.32±2.00), while there was a significant decrease (110.95±1.3) in the level of this parameter in group 4 as compared with the control group(115.98±2.2). Moreover, there was a significant differences in the levels High Density Lipoprotein ( HDL) ,Very Low Density Lipoprotein (VLDL) Triglyceride and in all treated groups compared with the control group.


Article
Sirtuin1, Inducible Nitric Oxide Synthase in Newly Diagnosed Iraqi Diabetic Patients

Authors: Mahmood Abdulhameed Hazim --- Perry H. Saifullah --- Beydaa Ahmed Abd
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2018 Volume: 21 Issue: 1 Pages: 1-7
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

In Mammals Sirtuins (SIRTs) are members of the silent information regulator two family Sirtuin1 regulate a variety of cellular functions. It shows anti-oxidative, anti-inflammatory, and anti-apoptotic effects against cellular damage.SIRT1 conserves the cells by the mitochondrial biogenesis organizing, cellular energy and oxido reduction state. Vascular tissues are protected by SIRT1 too. In diabetic patients mutation in exon1 of SIRT1 (L107P) in insulin-generating cells conducted in over production of nitric oxide synthase (iNOS), TNF-α.Assessment of SIRT1 protein levels in newly diagnosed Iraqi diabetic in regards to family history Age, gender, and duration of disease, and its correlation with biochemical parameter in the same group. Measurement of iNOS, TNF-α.This study involved totally 40 volunteers. This group were subdivided (20) volunteers as newly diagnosis (DMT1) duration disease ˂1 year, group1 was subdivided to 10 male and 10 female: (10 with family history and 10 without family history) and group two healthy volunteers. Group1 All DMT1 were under insulin treatment. Healthy Volunteers (20) included in this study as control groups. None Healthy Volunteers were alcoholic, smoke, or having a history of (CVD) cardiovascular disease, thyroid disease, and hormonal abnormalities problems were exempted from this study.In the present study SIRT1, TNF-alpha, iNOS were measured by enzyme linked immune absorbent assay (ELISA). Biochemical parameters fasting glucose, body mass index (BMI), urea, creatinine and lipid profile that were measured by spectrophotometer technique in patients and healthy volunteers groups.The Statistical Analysis System- SAS (2012) program was used to effect of difference factors in study parameters. Least significant difference –LSD test (ANOVA) was used to significant compare between means. Estimate of correlation coefficient between difference parameters in this study.The results showed that a highly significant increase in levels of FBG, Urea, creatinine and lipid profile except HDL was decrease levels, BMI was decrease in newly diagnosis DMT1 with healthy volunteers groups. A significant decrease in SIRT1 protein, and a highly significant increase in TNF-alpha and iNOS in newly diagnosis DMT1 with healthy volunteers groups. A highly negative significantly correlation coefficient between SIRT1 and F.G., TG., VLDL,TG/HDL, A.I. and negative significantly correlation duration, urea, creatinine,T.CH., LDL. And non-significant correlation with age, BMI, HDL, CH/HDL and LDL/HDL.. Effect of gender were insignificant of SIRT1. Effect of family history in patients. SIRT1 were all insignificant in patients with family history as with non-family history group. SIRT1 could decreases in the sera of DMT1 patients with family history, the decreased SIRT1 level reflect a mutation in SIRT1 gene, the decreases in SIRT1 on increases the incident of DMT1 complication

Keywords

SIRT1 --- DMT1 --- iNOS --- alfa-TN --- lipid profile --- body mass index.


Article
Melatonin Improves Lipid Profile and Ameliorates Lipid Peroxidation in Patients with Chronic Kidney Disease.

Author: Hayder Chasib Assad Al Lami حيدر جاسب
Journal: Al-Mustansiriyah Journal for Pharmaceutical Sciences مجلة المستنصرية للعلوم الصيدلانية ISSN: 18150993 Year: 2018 Volume: 18 Issue: 1 Pages: 38-45
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Dyslipidemia and oxidative modifications of lipid are frequently associated in patients with chronic kidney diseases (CKD) and considered the most important risk factors for cardiovascular events. Melatonin is a well known potent antioxidant and has beneficial effect on lipid metabolism. the study was designed to evaluate if Melatonin could improve lipid profile and ameliorates lipid peroxidation. This single blind placebo controlled clinical study carried out on 41 patients with CKD who were randomized into two groups, control groups (n=20) those who received placebo cap and melatonin group those who received 5mg melatonin (n=21). Lipid profile [total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C)] and parameters of lipid peroxidation [oxidized LDL (oxLDL) and malondialdehyde (MDA) were measured before and after 12 weeks of the treatment. After 12 weeks of treatment, melatonin significantly increased HDL-C and decreased LDL-C compared to the initial value. The elevation in HDL-C and reduction in LDL-C were significantly different from that in placebo group. Also both oxLDL and MDA levels significantly lowered by melatonin compared to the baseline and to the placebo group. Collectively, the results of our study showed that melatonin has advantageous effect on lipid profile and inhibit lipid peroxidation in patients with CKD.

اضطرابات الدهون والتغييرات الحاصلة في اكسدة الدهون غالبا ما ترتبط مع المرضى الذين يعانون من أمراض الكلى المزمنة وتعتبرمن أهم عوامل الخطورة لأمراض القلب والأوعية الدموية. الميلاتونين وهومعروف جيدا كمضاد قوي للأكسدة وله تأثير مفيد على ايض الدهون ، لذلك، فإن الدراسة الحالية تهدف إلى تقييم ما إذا كان الميلاتونين يمكن أن يحسن من مستوى الدهون ويخفف اكسدتها. وهذه الدراسة هي تجربة سريرية مسيطرعليها,عمياء من جهة واحدة أجريت على 41 مريضا يعانون من أمراض الكلى المزمنة ,وزعوا عشوائيا في مجموعتين ,مجموعة السيطرة (ع= 20) أولئك الذين تلقوا علاج وهمي ومجموعة الميلاتونين (ع= 21)أولئك الذين تلقوا 5 ملغم من الميلاتونين. وقد تم قياس مستوى الدهون [الكوليسترول الكلي ، الدهون الثلاثية، البروتين الدهني عالي الكثافة, البروتين الدهني منخفض الكثافة] ومقاييس اكسدة الدهون [البروتين الدهني منخفض الكثافة المؤكسد و مالونديالدهيد] قبل وبعد 12 أسبوعا من بدأ العلاج. و بعد 12 أسبوعا من العلاج، سبب الميلاتونين زيادة معنوية في البروتين الدهني عالي الكثافة وانخفاض في البروتين الدهني منخفض الكثافة مقارنة مع القيمة الأولية. و قد كان الارتفاع في البروتين الدهني عالي الكثافة والانخفاض في البروتين الدهني منخفض الكثافة يختلف اختلافا معنويا عن ذلك في المجموعة الوهمية. و أيضا مستوى كل من البروتين الدهني منخفض الكثافة المؤكسد و مالونديالدهيد قد انخفض بشكل كبير من قبل الميلاتونين مقارنة مع المستوى الاولي ومع مجموعة الدواء الوهمي. بشكل ملخص، لقد أظهرت نتائج دراستنا أن الميلاتونين له تأثير مفيد على مستوى الدهون ويمنع اكسدة الدهون في المرضى الذين يعانون من أمراض الكلى المزمنة.

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