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Article
Spectrophotometric Determination of Ibuprofen and Nystatin Via Ion Pair Complex Formation Using Chromotrope 2R

Authors: Intisar A. Shihab --- Theia'a N. Al-Sabha
Journal: JOURNAL OF EDUCATION AND SCIENCE مجلة التربية والعلم ISSN: 1812125X Year: 2019 Volume: 28 Issue: 2 Pages: 289-299
Publisher: Mosul University جامعة الموصل

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Abstract

This research paper tackles a developed method for Ibuprofen and Nystatin drugs determination both in their pure form and pharmaceutical formulations. The proposed method is based on the formation of binary complexes (ion association complexes) between the above drugs and Chromotrope 2R (C2R) in acidic medium forming a reddish orange colours .The complexes show maximum absorption at 562 nm and 566 nm for Ibuprofen and Nystatin respectively. The method was adhering to the Beer's law over concentration range 10-90 and 2-40 µg/ml with molar absorptivity values 1.36×103 and 7.59×103 l. mol-1. cm-1and average recovery 99.77% and 100.60 % for the above mentioned drugs respectively. No observed interferences appeared from the excipients commonly existed in pharmaceuticals. Successfully, application for both Ibuprofen and Nystatin was conducted in their pharmaceutical formulations.


Article
Studies 0n Ion Association of Some Α-Amino Acids with L-Ascorbic Acid In Aqueous Solution at Different Temperature

Author: Muhammed J. Kadhim
Journal: Iraqi Journal of Science المجلة العراقية للعلوم ISSN: 00672904/23121637 Year: 2019 Volume: 60 Issue: 1 Pages: 1-11
Publisher: Baghdad University جامعة بغداد

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Abstract

Molar conductivity of ascorbic acid (AA) with some α–amino acids (glycine(Gly), methionine (Met), cysteine (Cys) and tryptophan (Trp)) in aqueous solutionwas measured at range temperatures from 298 K to 313 K. Λo. The limiting molarconductivity, KA, the association constant was calculated using the Shedlovskymethod, and R, the association distance calculated by Stokes–Einstein equation. Thethermodynamic parameters (The heat of association ΔHo, the change in Gibbs freeenergy ΔGo, the change of entropy ΔSo), and (ΔES), the activation energy were alsocalculated. All of the results obtained were discussed. The data showed theincreasing in Λo, with the increasing of temperature. The positive values for (ΔSo)and (ΔES) showed a decrease in solvation of ion–pair and signifying the highermobility of the ions. The negative value of ΔHo, refers that the association processesare exothermic. The negative values of ΔGo, are for ion association in aqueoussolution and increase with the increase in temperature.


Article
Spectrophotometric Determination of Cinnarizine and Domperidone Maleate in Pharmaceutical Preparations by Ion Pair Complex Formation with Rose Bengal Dye
التقدير الطيفي المباشر للسيناريزين وماليت الدومبيريدون في المستحضرات الصيدلانية بتكوين معقد المزدوج الأيوني مع صبغة الروز بنكال

Authors: Elham S. Salih --- Abdussamed M. A. Saeed
Journal: JOURNAL OF EDUCATION AND SCIENCE مجلة التربية والعلم ISSN: 1812125X Year: 2019 Volume: 28 Issue: 3 Pages: 87-105
Publisher: Mosul University جامعة الموصل

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Abstract

A simple, rapid and sensitive spectrophotometric method has been developed for the determination of cinnarizine (CIN) and domperidone maleate (DOM) in bulk and pharmaceutical formulations. The method is based on the formation of ion-pair complexes between the studied drugs and rose Bengal dye in buffer solution (pH5). The complexes give maximum absorbance at 571 nm. The method obeys Beer’s law in the range of 0.5-34 and 0.5-36 µg ml-1 with molar absorptivity of 2.55×104 and 2.42×104 l.mol-1.cm-1 for CIN and DOM respectively. The method has been successfully applied for the determination of studied drugs on pharmaceutical dosages with no interferences. The results have been compared with official method and standard procedure with a good agreement.

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