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Article
Metformin versus Insulin in the Management of Gestational Diabetes Mellitus

Author: Ola Amer Mahmood
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2019 Volume: 16 Issue: 4 Pages: 346-350
Publisher: Babylon University جامعة بابل

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Abstract

Background: Gestational diabetes mellitus (GDM) is one of the most common medical conditions complicating pregnancy and itsprevalence increasing nowadays due to the increasing obesity in our society. The whole story is due to insulin resistance which is bestmanaged by metformin rather than insulin. Objective: The main objective of the study is to compare the efficacy of metformin in controllinghyperglycemia in GDM or their effect on the pregnancy outcome versus insulin therapy. Materials and Methods: This study was carriedout at the Obstetrics and Gynecology Department of Al‑Zahraa Teaching Hospital in Al‑Najaf from February 2015 to November 2015, as100 pregnant ladies from (20 to 32) weeks of gestational age were already diagnosed to have GDM or we diagnosed them by formal 75 goral glucose tolerance test. Results: Metformin was better in controlling blood sugar (111 mg/dl versus 145 mg/dl in insulin). Neonatalcomplication and cesarean section rates were higher in insulin limb. Conclusion: Metformin was better in controlling blood sugar in GDMthan insulin, with better neonatal outcome.


Article
Effect of Metformin and Glimepiride Treatment on Some Biochemical Parameters in Diabetic Male Patients with Chronic Renal Failure

Author: Ali Mohammed Abbed
Journal: Ibn Al-Haitham Journal For Pure And Applied Science مجلة ابن الهيثم للعلوم الصرفة والتطبيقية ISSN: 16094042/ 25213407 Year: 2019 Volume: 32 Issue: 2 Pages: 38-44
Publisher: Baghdad University جامعة بغداد

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Abstract

The present study was included a measurements of fasting serum glucose, total protein, potassium, and calcium levels in the sera of 25 diabetic male patients suffer from chronic renal failure; their ages range were (32-75) and compared them with 25 healthy males as control group. The aim of this study was to study the effects of antidiabetic drugs on some biochemical parameters such as fasting serum glucose, serum total protein, serum potassium and calcium. The current results demonstrated a hyperkalemia in patients and this increasing of potassium is significantly (p = 0.03), but calcium level showed no significant variations (p>0.05), and serum total protein was significantly decreased in patients as compared to the controls (p = 0.0002).


Article
Comparative study of Vitamin D levels in diabetic and non- diabetic women and its correlation with age and seasonal variation
دراسة مقارنه لمستويات فيتامين D لدى النساء المصابات بالسكري والنساء غير المصابات وعلاقتها مع الاختلافات الموسمية والعمر

Author: Abdulhadi Mohamed Jumaa عبدالهادي محمد جمعة
Journal: Tikrit Journal of Pure Science مجلة تكريت للعلوم الصرفة ISSN: 18131662 Year: 2019 Volume: 24 Issue: 2 Pages: 23-29
Publisher: Tikrit University جامعة تكريت

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Abstract

Background vitamin D has characteristics features of a hormone, and accordingly vitamin D is a pro-hormone, rather than a true vitamin. Active form of vitamin D is binding to vitamin D receptors (VDR) then started its main action inside the body. This study is aimed to compare concentration of vit. D in a patients with diabetes mellitus, and healthy Iraqi women and its correlation with seasonal variation, and age.Subjects and methods This study was conducted in the first of August 2017 till the first of April 2018, at the outpatient unit in especial private hospital at karbalaa city in the south of Iraq. 163 women have been enrolled in present study. The sample was divided into 3 groups in both diabetic and non-diabetic subjects. Results the distribution of subjects in this study, 163 persons participated as a sample in a present research; 82 subjects are normal healthy women as controls, while 51 women suffering from non-insulin dependent diabetic mellitus, (T2DM), and 30 pregnant women suffering from gestational DM, (GDM). Stander deviation and mean of Vit. D levels in a non-insulin dependent diabetes mellitus and normal healthy women. There is significant reduction in the levels of vit.D that measured by using sera of women patients suffering from T2DM, (12.97 ± 8.9) as compared with control subjects, (18.95 ± 7.1). Conclusions the present study conclude that, the measurement of vit.D are significantly reduced when measured in women patients with non-insulin dependent diabetes sera, as compare to healthy subjects and also reduced in the sera of women patients suffering from GDM, as compared with control subjects.

المقدمة: فيتامين D هو هورمون ستيرويدي ينتج في الجلد من خلال تحويل الكولستيرول تحت تأثير الأشعة الفوق البنفسجية, يوجد فيتامين D ايضا في بعض الأطعمة ومنتجات الالبان. فيتامين D2 و فيتامين D3 يتواجدان في بعض الأغذية.تهدف هذه الدراسة الى المقارنة بين مستويات فيتامين D في مرضى السكري والمرضى الغير مصابين بالسكري من النساء العراقيات ودراسة العلاقة بين مستويات فيتامين D وفصول السنه وكذلك تغيرها مع تغير عمر المشاركين في الدراسة.هذه الدراسة تم تصميمها والبداية بها في بداية شهر آب من عام 2017 واستمرت حتى الاول من نيسان عام 2018 في وحدة الاستقبال للمرضى الخارجيين في احد المستشفيات الخاصة في مدينة كربلاء جنوب العراق. شارك 163 من النساء في هذه الدراسة وقد تم تقسيمهم الى ثلاث مجاميع سواء في مرضى السكري وغير المصابين بالسكري. تم توزيع المشاركين في هذه الدراسة وعددهم 163 من النساء الى 82 امرأه سليمه بينما 51 امرأه كانت مصابه بداء السكري من النوع الثاني وثلاثون امرأه حامل مصابات بسكري الحمل. المعدل والانحراف المعياري لتركيز فيتامين دي يبين وجود نقصان مهم في مصل المرضى الذين يعانون من داء السكري الثاني بالمقارنة مع مجموعة السيطرة.نستنتج من هذه الدراسة بأن مستويات فيتامين D قلت بشكل كبير في النساء المصابات بداء السكري الثاني وكذلك النساء الحوامل بالمقارنه مع مجموعة السيطرة.


Article
Assessment of the Alteration of Blood Indices in Patients with Type 2 Diabetic Mellitus: A Cross‑Sectional Study

Authors: Mohammad Hasan Ali --- Abeer J. Hassan
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2019 Volume: 18 Issue: 1 Pages: 24-29
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: The prevalence of diabetes mellitus has a major impact on national and global health. Diabetes, a noncommunicable disease,was considered one of the top ten causes of death. Diabetic patients with chronic hyperglycemia have increased risk of macrovascularand microvascular complications in the long term. Diabetes is associated with an increased risk for morbidity from anemia which leads todysfunction and structural change in all formed elements. Objective: This study focused on the alteration of blood parameters in diabetic patientscompared with healthy controls. Materials and Methods: This is a comparative study including 230 patients treated at a specialized center forendocrinology and diabetes from December 2017 to January 2018. Of the total 230 diabetic patients enrolled in this study, 46 were male and 184were female, their age range was 20–70 years, and they were compared with 100 healthy individuals that served as control group. Aquestionnairewas administered as data collection form. Body mass index was estimated. Fasting blood glucose, HbA1c, and formed element indices werelaboratory investigated and analyzed by using autohematology analyzer (Huroba ABX). Data were statistically analyzed using SPSS softwareversion 17. Results: The results of the current study revealed that there were statistically significant differences in blood parameters such as redblood cell (RBC) and white blood cell (WBC) count, mean cell volume (MCV) level, and red cell distribution width (RDW) level (P ≤ 0.05),whereas no significant differences were recorded in RBC (hemoglobin, hematocrit, mean cell hemoglobin [MHC], and MCH concentration)and platelet (platelet count, MPV, and PDW) parameters (P ≥ 0.05) when compared with the control group. Conclusions: The present studyconcluded that blood parameters such as RBCs, MCV, RDW, and WBCs are significantly higher among diabetic patients.


Article
Association of Transforming Growth Factor Beta1 Gene Polymorphism with Diabetes Mellitus Risk in Iraq Patients

Author: Rasha Saleh Nuhiar1 , Ali Naeem Salman2 , Hassan Raysan AL-Rekaby2
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2019 Volume: 18 Issue: 2 Pages: 49-56
Publisher: Baghdad University جامعة بغداد

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Abstract

Diabetes mellitus (DM) refers to a group of multifactorial metabolic disorders characterized by elevated blood glucose levels (hyperglycemia) that result from defects in the body's ability to produce and/or insufficiency of insulin action .This study was to investigate the correlation between TGFβ1 polymorphism and Diabetes Mellitus .The present study carried out in the labs of college of education for pure science and Center for Diabetes and Endocrinology of the Health Directorate in Thi- Qar province, the period of research was extended from January- July 2017. To test for the association of Polymorphisms in promoter region (G-800A) and (C-509T ) of transforming growth factor- β 1 (TGF-β1) gene with diabetes mellitus in Iraqian patients. The study included a total of 120 patients with type I and II diabetes and their age between 1-51 years. in addition to 52 healthy controls . DNA has been isolated and RFLP-PCR was performed by using primers specific for genotypes of two region of the TGF β1 gene (C509T)and (G800A). The results showed that only C509T polymorphism of the TGFβ1 gene is significantly different in genotype distribution in allelic frequencies between DM patients and control subjects and association with clinical characteristics. Thus this SNP seems to be related to DM susceptibility. This study supports the involvement of TGFβ1 gene polymorphism in the incidence of DM in Thi-Qar population.

Keywords

Diabetes Mellitus --- TGF-β1 --- G800A --- C509T.


Article
Satisfaction of Patients with Type II Diabetes on Health Service in Specialized Center for Endocrinology and Diabetes /Baghdad 2019

Authors: Nazik L Kadium --- Wijdan A Hussein,
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2019 Volume: 15 Issue: 2 Pages: 87-90
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Patient satisfaction is of increasing importance and widely recognized as an important indicator of quality of the medical care. There was no homogeneous definition of patient satisfaction, since satisfaction concerns different aspects of care or settings, as well as care given by various professions.Objective: The objective of this study is to assess the patients’ level of satisfaction with diabetes care and to identify the underlying factors influencing it.Methods: This cross-sectional study had been conducted in the Specialized Center for Diabetes and Endocrinology in Baghdad Al- Rusafa 2018. Where150 type two diabetic patients attending their follow-up were requested to fill the questionnaire. The questionnaire identified patients, doctors, and practice related factors. For statistical analysis of the data, SPSS Version 24 was used, and the Chi-square statistical test was applied, A p-value less than 0.05 was considered statistically significant. Results: The study showed that the overall level of satisfaction was 79.3%. There was a statistically significant association between age group, gender, profession, educational level and marital status where P value 0.001 for all variables.Conclusion: It was concluded from the study that patients’ satisfaction was high. Majority of the diabetic patients were satisfied with health services, the level of satisfaction increases with age, female gender, and married patients, but it decreases with a high level of education and profession. High level of dissatisfaction seen on treatment services


Article
3.THE POSSIBLE ASSOCIATION BETWEEN EPSTEIN-BARR VIRUS AND TYPE 1 DIABETES MELLITUS

Authors: Ahmed H. Mohammed احمد حسن --- Alzahraa Albatool I. Sabr الزهراء البتول
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2019 Volume: 17 Issue: 3-4 Pages: 175-182
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:Type-1-diabetes (T1D) also known as insulin-dependent diabetes mellitus (IDDM) or juvenile onset diabetes results from the progressive destruction of pancreatic beta cells resulting in insulin deficiency. Genetic factors are thought to be a major component for the development of T1D. The studies on the risk of developing T1D suggesting that the environmental factors, particularly viruses may be implicated in the initiation of beta cell destruction leading to T1D.Objective:To investigate the possible relationship between Epstein-Barr virus and T1D.Methods:The sera were collected from 56 T1D patients and 30 controls of age range 3-22 years old and from both sexes. The sera divided into two parts, one part for serology for detection anti-EBV EBNA-1 IgM and IgG antibodies by enzyme linked immunosorbent assay (ELISA) technique and the other for viral genomic extraction and conventional polymerase chain reaction (PCR) to detect the viral target gene.Results:The results by ELISA technique indicated that only 7 (12.5%) of T1D patients were positive for anti-EBV IgM antibody and 24 (42.9%) of T1D patients showed positive results for anti-EBV IgG antibody. In contrast, the control group showed negative results for both anti-EBV IgM and IgG antibodies. The results of PCR technique revealed that 15 (26.79%) of T1D patients have EBV DNA compared with none of the controls have EBV DNA (P<0.001).Conclusion:EBV infection may contribute to the pathogenesis or progression of T1D.Keywords:EBV, Type 1 Diabetes Mellitus, ELISA, PCRCitation:Mohammed AH, Sabr AI. THE possible association between Epstein-barr virus and type 1 diabetes mellitus. Iraqi JMS. 2019; 17(3&4): 175-182. doi: 10.22578/IJMS.17.3&4.3

Keywords

EBV --- Type 1 Diabetes Mellitus --- ELISA --- PCR


Article
Knowledge, Attitudes, and Practice of Complementary and Alternative Medicine among Diabetic Patients

Author: Esraa Kadhum Mehdi, Hadeel Fadhil Farhood
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2019 Volume: 16 Issue: 1 Pages: 13-19
Publisher: Babylon University جامعة بابل

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Abstract

Background: Complementary and alternative medicine (CAM) is defined as a group of various medical and healthcare systems, practices,and products that are not generally considered part of conventional western medicine. Objective: This study was carried out to estimatethe prevalence of CAM use among diabetic patients and to assess knowledge, attitudes, and practice of CAM among diabetic patients.Materials and Methods: This is a hospital‑based cross‑sectional study done at diabetic center of Merjan teaching hospital on 200 patients.Results: This study estimated that the prevalence of CAM use among diabetic patients at Babylon province was 48.5%; the most common typeof CAM used by diabetic patients was Herbal products (24.7%), while nutritional supplements and spiritual healing together used by (18.6%)of(CAM) users, herbal products and nutritional supplements together at rate of (14.4%) and (40.2%) use the 3 types of CAM modalities together.The most common type of Herbal products used by diabetic patients were Garlic which used at (16.9%), while Lemon used by (19.1%) ofDiabetic patients, Cinnamon (Darcin) (10.2%), Fenugreek (Helba) (8.8%), (7.3%) bitter gum, and (18.3%) were a mixture of herbs, (7.3%)black seed. (62%)of Subjects had good knowledge about (CAM),(28%) had fair knowledge and (10%) poor knowledge. (66%) of (CAM )users had negative attitudes toward (CAM) and (34%) had positive attitude. Conclusion: Our study estimated the prevalence of CAM useamong diabetic patients, revealed good knowledge of the diabetic patients and negative attitudes of CAM users, and showed five significantassociations with score of knowledge and attitudes (age, educational level, residence, family history of DM, and follow‑up visits), which wasconsistent with some studies in other eastern and western countries.


Article
Relationship between type II diabetes mellitus and Helicobacter pylori infection in Erbil city

Authors: Rawaz D. Tawfeeq --- Zahra A. Amin --- Aveen Jalal --- Sayran K. Hama Baiz
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2019 Volume: 23 Issue: 1 Pages: 43-50
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Type 2 diabetes mellitus is a metabolic disorder characterized by the increase in blood glucose due to insulin resistance or deficiency of insulin. The subjects are more likely to be prone to infection. So, it could be correlated with Helicobacter pylori infection, which means that gastrointestinal inflammation might be affected by uncontrolled glycemic level. This study aimed to examine the correlation of type II diabetes and infection of gastrointestinal in order to illustrate such complication of diabetes mellitus apart from others. Methods: A total of 64 persons from Erbil city participated in this cross-sectional study. They were divided into two groups, each group involving 32 persons. The cases group included those suffering from type II diabetes and were selected by simple random sampling method. The other group included those not possessing any types of disease including diabetes mellitus. Examination of Helicobacter pylori, glycated hemoglobin (HbA1c), besides measuring blood pressure and body mass index were performed for all individual subjects in both groups. Chi-Square and unpaired t-test were used for data analysis. Results: There was a 59% positively Helicobacter pylori in diabetes group whereas there was a 31% positively Helicobacter pylori in non-diabetes mellitus. The difference between the rates of Helicobacter pylori in both groups was statistically significant (P <0.05).Conclusion: The prevalence of Helicobacter pylori infection in diabetics was significantly higher than the non-diabetics.


Article
Biochemical and Histopathological study Of The Proteinaceous Compounds Separated From Aqueous Extract Of Marus Albul L. Fruit in alloxan diabetic mice
دراسة كيموحيوية ونسجية للمركبات البروتينية المفصولة من المستخلص المائي لثمرة نبات التوت Marus albaL. في الفئران المصابة بداء السكر المستحدث بالالوكسان

Author: Shihab A. Al-Bajari شهاب احمد يوسف البجاري
Journal: Tikrit Journal of Pure Science مجلة تكريت للعلوم الصرفة ISSN: 18131662 Year: 2019 Volume: 24 Issue: 3 Pages: 44-51
Publisher: Tikrit University جامعة تكريت

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Abstract

ABSTRACTThis work was concerned with isolating and molecular weight determination of the proteinous compounds isolated from the cold and boiled aqueous extract of Marus Albal L. using different biochemical techniques . Also this study indicated the effect of the proteinaceous compounds Ac, Bc and Ab, Bb on some biochemical parameters including glucose, cholesterol and total lipids levels in blood serum and glycogen content in liver tissues in normal and diabetic mice . A single intraperitoneal injection of these isolated compounds with a dose of 75 mg / kg body weight was used .As well as pancreas were removed and stained with H and E of pancreatic sections. Results indicated that intraperitoneal injection of insulin and all the proteinaceous compounds Ac , Bc and Ab, Bb obtained by gel filtration chromatography from the plant used had hypoglycemic effect on serum glucose level in normal and diabetic mice. The rate of decrease was from (18.2) to (43.7) % in the normal and form (29.57) to (50.20) % in the diabetic mice respectively. While compounds (Bb) showed a negligible to an increasing effect (3.91) % in the normal and (7.99)% in the diabetic mice. Also the highest decrease was obtained for compound (Ac), this decrease were (16.8 )% and (15.73) % for serum cholesterol levels in the normal and the diabetic mice respectively .As well as the highest decrease was obtained for compound (Ac) , this decrease were(23.62) % and (28.88) % for serum total lipids levels in the normal and the diabetic mice respectively. Also a decrease between (5.8 , 14.1) % and (6.4 , 12.9) % glycogen content in liver tissues was obtained when the normal and in the diabetic mice respectively were injected intraperitoneally by the proteinaceous compounds Ac, Bc and Ab , Bb from plants used. Finally alloxan induced diabetic mice group, the endocrine pancreas histologically showed decreased in the size and number of Langerhans islets with vacuolar degeneration and necrosis of almost all cell in the atrophied islets as compared with control group. The histomorphometic study of the pancreas of the treated group didn't show a significant change of the pancreatic tissue.

تضمن البحث دراسة تاثير المركبات البروتينية Ac , Bc , Ab , Bc المفصولة بتقنية الترشيح الهلامي من المستخلصات المائة الباردة والمغلية لثمرة نبات التوت الابيض على بعض المتغيرات كيموحيوية ( كلوكوز ,الكوليستيرول والدهون الكلية) في مصل دم الفئران السليمة والمصابة بداء السكر المستحدث بالالوكسان, وكذلك محتوى الكلايكوجين في كبد الفئران السليمة والمصابة. حيث تم في هذا البحث اعطاء جرعة واحدة من المركبات البروتينية عن طريق الحقن في التجويف البريتوني بمقدار 75 ملغم / كغم من وزن الجسم. فضلا عن ذلك تم استئصال البنكرياس لتحضير مقاطع نسيجية من البنكرياس صبغت بالهيماتوكسلين والايوسن. اظهرت نتائج حقن الانسولين وكل من المركبات البروتينية Ac , Bc , Ab , Bc في الفئران السليمة والمصابة الى انخفاض معنوي ملحوظ في مستوى الكلوكوز يتراوح بين (18.2)و(43.7) % للسليمة وبين (29.57) و (50.20) % للمصابة، بالمقارنة مع مجاميع السيطرة السليمة والمصابة على التوالي. ماعدا المركب البروتيني (Bb) العائد للمستخلص المائي المغلي لثمرة التوت، حيث ادى الى ارتفاع معنوي في مستوى الكلوكوز في الفئران السليمة والمصابة وبمقدار (3.91) و (7.99) % على التوالي. كما ابدى المركب (Ac) تاثير اكثر تخفيضا في مستوى الكوليستيرول من بقية المركبات مقداره (16.8) % في السليمة و (15.73) % في المصابة على التوالي. اما بالنسبة للدهون الكلية فقد ابدى المركب Ac)) اكثر انخفاضا بمقدار (23.62) % في الفئران السليمة و 28.88)) % في الفئران المصابة . كما اشارت النتائج الى ان المركبات Ac , Bc , Ab , Bc والتي تم فصلها من النبات ادت الى حدوث انخفاض كلايكوجين الكبد بين (14.1)% و (5.83) % للفئران السليمة و بين (12.9)% و (6.4)% للفئران المصابة على التوالي. اخيرا فقد اظهرت الدراسة النسجية للفئران المحقونة بالالوكسان وجود نقصان في حجم وعدد جزر لانكرهانس فضلا عن نخر وتحطم واحتقان شديد للاوعية الدموية في خلايا البنكرياس مقارنة بالسيطرة السليمة. كما بينت النتائج عدم وجود اي تغير معنوي بين المجاميع المصابة المعالجة بالمركبات Ac , Bc , Ab , Bc مع المجموعة المصابة غير المعالجة بتلك المركبات في انسجة البنكرياس

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