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Article
2.ASSESSMENT OF SERUM ZINC LEVEL IN PATIENTS WITH ATOPIC DERMATITIS

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Abstract

Background:Atopic dermatitis (AD) is a common inflammatory skin disease with a chronic relapsed-remitting course with manifestations started at early childhood. AD is two types; extrinsic and intrinsic. Zinc has a crucial role in the immune system functions and antioxidant mechanisms, it also serves in the metabolism and cell growth through signaling several enzymes.Objective:To assess serum zinc level in patients with childhood AD.Methods:A case-controlled study was conducted in Dermatology outpatient’s clinic in Al-Imamein Al-Kadhimein Medical City, from the period of September 2016- June 2017. Twenty patients with AD were enrolled in this study. AD severity was graded using the Scoring Atopic Dermatitis Index (SCORAD). The control group consisted of age-matched and sex-matched twenty healthy children were taken with weight above 80%. Fasting blood samples were taken from patients and controls between 8 AM and 10 AM.Results:Of the twenty patients of AD, 13 (65%) were males and 7 (35%) were females. Their mean age was 4.58±3.13. Regarding the control group 9 (45%) were males and 11 (55%) were females, their mean age was 4.29±2.46. No statistical difference in serum zinc level between AD patients and control groups. Concerning zinc level in males and females, no statistical differences was found in AD patients, but highly significant difference was found in control group. Serum zinc level was highly significantly low in patients with moderate AD than in those with mild AD. There was negative correlation between serum zinc level and severity of AD.Conclusion:There is a negative correlation between serum zinc level and severity of AD, also there is a gender variation in serum zinc level in normal children.Keywords:Serum zinc level, atopic dermatitisCitation: Farhood IG, Ahmed MA, Al-Bandar RT, Farhood RG. Assessment of serum zinc level in patients with atopic dermatitis. Iraqi JMS. 2019; 17(2): 103-107. doi: 10.22578/IJMS.17.2.2


Article
STATUS OF SERUM ZINC LEVELS IN FEMALES WITH THYROID DYSFUNCTION
حالة مستويات مصل الزنك في الإناث المصاحب مع خلل في الغدة الدرقية

Authors: DHIA J. AL-TIMIMI ضياء التميمي --- KAJEEN R. HUSSEN كازين حسين --- SHERWAN F. SALIH شيروان فرمان صالح
Journal: Duhok Medical Journal مجلة دهوك الطبية ISSN: ISSN: 20717334 (online)/ ISSN: 20717326 (Print) Year: 2019 Volume: 13 Issue: 1 Pages: 74-82
Publisher: University of Dohuk جامعة دهوك

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Abstract

Background: Low serum zinc levels have been connected to thyroid function in more than one way, but to date there is still arguments about the association between zinc deficiency and thyroid disease, particularly in females. The aim of this study was to assess status of serum zinc levels in a sample of females with thyroid dysfunction in comparison with those of normal thyroid function and to ascertain its association with thyroid hormone levels.Patients and Methods: A case control study was conducted on 225 females referred to the Endocrine Unit for definitive diagnosis of thyroid dysfunction and 100 females with normal thyroid function, serves as a control group.Results: The results revealed that the serum zinc levels were significantly lower inHypothyroid females(62.2±16.3µg/dl) as compared to hyperthyroid (80.5±13.9µg/dl) and controls (86.2±13.2 µg/dl) with p=0.001.The prevalence of severe zinc deficiency (<50 µg/dl) was found to be significantly higher in hypothyroid females (25.0%) as compared to hyperthyroid females (3.0%), p-value of 0.01, whereas none of the controls had severe zinc deficiency. In the hypothyroid group, positive correlations of zinc were observed with FreeT3 and FreeT4 (p=0.007, p<0.001, respectively) and a negative correlation was observed with thyroid stimulating hormone (TSH), p<0.001.In the overall studied subjects, negative correlation was also found for zinc with TSH (p< 0.001).We did not observe a significant correlation ofFT3, FT4 and TSH with zinc in controls or in hyperthyroid group.Conclusions: Decreased serum zinc levels may lead to hypothyroidism in females. Efforts to increase zinc status in this group may help correct abnormal levels of thyroid hormones.

الخلفية والأهداف: لقد تم ربط مستويات الخارصين المنخفضة في الدم بوظائف الغدة الدرقية في اكثر من طريقة واحدة.الهدف من الدراسة الحالية هو تقييم حالة مستويات الخارصين في مصل الدم لدى الاناث اللواتي يعانين من خلل في وظائيف الغدة الدرقية و تاكيد العلاقة مع هورمونات الغدة الدرقية . المواضيع و طرق البحث: تم اجراء الدراسة على 225 حالة من الاناث اللواتي حضرن وحدة الغدد الصماء للتشخيص النهائي من الخلل في وظيفة الغدة الدرقية و 100 من الاناث مع وظيفة الغدة الدرقية العادية بمثابة المجموعة الضابطة.النتائج: اظهرت النتائج ان مستويات الخارصين في مصل الدم كانت اقل بشكل ملحوظ في الاناث المصابين بخمول الغدة الدرقية (62.2±16.3ميكروغرام/ديسيليتر) بالمقارنة مع الاناث المصابين بزيادة نشاط الغدة الدرقية (80.5±13ميكروغرام/ديسيليتر) والاناث الاصحاء (86.2±13.2ميكروغرام/ديسيليتر) ,(P=0.001)تم العثور على انتشار نقص الخارصين الشديد (˃50ميكروغرام/ديسيليتر) لتكون اعلى بكثير لدى الاناث المصابين بخمول في الغدة الدرقيه (25%) بالمقارنة مع الاناث المصابين بزيادة نشاط الغدة الدرقية ( 3.0%), بينما لم تكن هناك اي حالة لنقص شديد للخاصين بين مجموعة الاصحاء.في المجموعة الخمول في الغدة الدرقية لوحظ ارتباط ايجابي من الخارصين مع هورمون الغدة النخامية .ولم تكن هناك ارتباط كبير بين الخارصين وكل من TSH ,FT3,FT4 في مجموعة الاصحاء ومجموعة زيادة نشاط الغدة.الاستنتاجات: انخفاض مستويات الزنك في الدم قد يؤدي إلى قصور الغدة الدرقية عند الإناث. قد تساعد الجهود المبذولة لزيادة حالة الزنك في هذه المجموعة على تصحيح مستويات غير طبيعية من هرمونات الغدة الدرقية


Article
Single Serum Progesterone Measurement in Pregnancy Prognosis
واحد مصل البروجسترون القياس في تشخيص الحمل

Authors: Saba Shamran صبا شمران --- Ghufran J.E. Al Sereah غفران جبار السريح
Journal: Al-Qadisiyah Medical Journal مجلة القادسية الطبية ISSN: 18170153 Year: 2019 Volume: 15 Issue: 1 Pages: 113-118
Publisher: Al-Qadisiyah University جامعة القادسية

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AbstractBackground:Aim of the study: To assess the value of single serum progesterone in diagnosis of viable, ectopic and failing pregnancy.Patients and methods: This cross sectional study was done in Al Basra general hospital and Al Basra maternity and child hospital from June 2013 through January 2014. The study included 64 patient, all have 1st trimester vaginal bleeding and/or abdominal pain. From each patient a 5 cc blood sample was obtained for assessment of progesterone and β-HCG, and then patients were sent to ultrasound examination. Result:Mean age of women enrolled in the present study was 31.21± 4.23 years and it ranged from 20 to 35 years.Mean gestational age was 8.30 ±2.15 and it ranged from 6 to 12 weeks. Ultrasound examination revealed that 36 patients (56.3%) had viable pregnancy, 18 patients (28.1 %) had failing pregnancy and 10 patients (15.6%) had ectopic pregnancy. Mean serum progesterone in women with viable, failed and ectopic pregnancies was 20.01 ± 1.7 ng/ml, 9.09 ± 8.2 ng/ml and 19.7± 16.3 ng/ml.The sensitivity and specify of single serum progesterone measurement in diagnosis of pregnancy failure in this study were 72.2% and 66.6%, respectively while those of serum β-HCG were 95.4% and 98.1%.Conclusion: Single serum progesterone is not of significant value in predicting pregnancy outcome.

نبذة مختصرةخلفية:الهدف من الدراسة: تقييم قيمة هرمون البروجسترون في مصل الدم في تشخيص الحمل القابل للحياة والتشريح والفشل.المرضى والطرق: أجريت هذه الدراسة المقطعية في مستشفى البصرة العام ومستشفى البصرة للأمومة والطفولة من يونيو 2013 إلى يناير 2014. وشملت الدراسة 64 مريضاً ، جميعهم يعانون من نزيف مهبلي في الفصل الأول و / أو ألم في البطن. من كل مريض تم الحصول على عينة دم 5 سم مكعب لتقييم البروجسترون و HC-HCG ، ثم تم إرسال المرضى لفحص الموجات فوق الصوتية.النتيجة: كان متوسط ​​عمر النساء المسجلات في هذه الدراسة 31.21 ± 4.23 سنة وتراوحت بين 20 و 35 عامًا. كان عمر الحمل من 8.30 ± 2.15 وكان يتراوح بين 6 إلى 12 أسبوعًا. كشف الفحص بالموجات فوق الصوتية أن 36 مريضاً (56.3٪) لديهم حمل ناجع ، و 18 مريضاً (28.1٪) عانوا من فشل في الحمل و 10 مرضى (15.6٪) حملوا خارج الرحم. كان متوسط ​​هرمون البروجسترون في المصل لدى النساء ذوات الحمل القابل للحمل والفشل خارج الرحم 20.01 ± 1.7 نانوغرام / مل ، 9.09 ± 8.2 نانوغرام / مل و 19.7 ± 16.3 نانوغرام / مل.حساسية وتحديد قياس بروجستيرون المصل الفردي في تشخيص فشل الحمل في هذا كانت الدراسة 72.2 ٪ و 66.6 ٪ ، على التوالي في حين أن مصل HCG كان 95.4 ٪ و 98.1 ٪.الخلاصة: هرمون البروجسترون في الدم ليس ذا قيمة كبيرة في التنبؤ بنتيجة الحمل.


Article
Evaluation of Serum Level of Soluble Lectin‑like Oxidized Low‑density Lipoprotein Receptor‑1 and its Relationship with Severity of Preeclampsia and Birth Weight

Author: Hiba Ghassan Rajab, Mohammed A. M. Ali1, Hala Abdulqader Al‑Moayad
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2019 Volume: 16 Issue: 1 Pages: 31-35
Publisher: Babylon University جامعة بابل

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Background: Lectin‑like oxidized low‑density lipoprotein receptor‑1 (LOX‑1) is one of the pattern recognition receptors that plays a critical rolein vascular diseases and host immune response, LOX‑1 can induce endothelial dysfunction through pathways implicated with oxidative stress andinflammation that ends with vascular lesions. Objective: The objective of the study is to evaluate the serum level of soluble LOX‑1 (sLOX‑1)in preeclampsia (PE) and normal pregnancy to study its relationship with the severity of PE and birth weight. Materials and Methods: A totalof 56 patients with PE were allocated to the study together with 28 healthy pregnant women as normal controls. PE patients divided into 28mild and 28 severe PE. Levels of serum sLOX‑1 were measured by sandwich enzyme‑linked immunosorbent assay technique. Results: Resultsshowed a significant increase in the serum sLOX‑1 in preeclamptic patients (P < 0.01) compared to normal controls. The significance increasedin serum levels of sLOX‑1, was noted in mild (P = 0.001) and severe patients (P = 0.001), compared to normal controls. There was a significantdecrease in fetal birth weight in severe PE as compared to mild and control groups which was correlated with sLOX‑1, furthermore, logisticregression of the variables for the presence of low birth weight <2.5 kg. Conclusion: High level of serum sLOX‑1 is associated with theoccurrence and severity of PE, which provides additional information for predicting of PE and preventing its complications and for betterunderstanding pathogenesis of PE and the results highlight the involvement of innate immunity molecules and inflammation in pathogenesisof PE through binding to apoptotic cells and angiogenic process.


Article
β-Catenin Protein and Its Association with Helicobacter Pylori as A Possible Marker for Gastric Cancer

Authors: Mustafa K. Al-Bayaty --- Salma A. Abass --- Mohammed F. Al-Marjani
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2019 Volume: 22 Issue: 3 Pages: 43-49
Publisher: Al-Nahrain University جامعة النهرين

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Gastric cancer is still the main health threat being the third leading cause of deaths from cancers in the world, the major risk behind this disease is that it remains asymptomatic in the early stages and in (97 %) cases it metastasizes to other organs. Gastric cancer is a multifactorial disease with Helicobacter pylori (H. pylori) being the major risk factor, however, patients with gastritis, especially atrophic gastritis and gastric ulcer have been shown to be at an increased risk for developing gastric cancer. In this research, serum β-catenin, carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) were measured in patients diagnosed with gastric cancer, gastric ulcer and gastritis and also in healthy volunteers. Infection with Helicobacter pylori (H. pylori) was diagnosed by histological test, rapid urease test (RUT) and by serological tests which included IgG and IgA antibodies. The results showed that there was a large significant increase in the levels of serum β-catenin in patients with gastric cancer compared to the control group as well as to the gastritis and gastric ulcer patients. A significant increase was also seen in gastric ulcer and gastritis patients when compared to the control group. In addition, a significant increase was seen in β-catenin serum levels in patients with gastric cancer and gastric ulcer infected with H. pylori compared to the uninfected gastric cancer and gastric ulcer patients. A non-significant change was observed in the levels of CEA and CA 19-9 in all the patients compared to the control group. The results of this study suggest that β-catenin can serve as a potential biomarker for the diagnosis of gastric cancer and that H. pylori has a significant effect on the levels of this protein.


Article
Estimating sugar concentration in human blood serum using Surface Plasmon Resonance (SPR) –based optical fiber sensor
حساب تركيز السكرفي مصل دم الانسان باستخدام متحسس الالياف البصرية المستندة الى رنين بلازمون السطح

Authors: Namaa Salem Raham نماء سالم رحيم --- Sudad S. Al – Bassam سؤدد سلمان احمد
Journal: Iraqi Journal of Physics المجلة العراقية للفيزياء ISSN: 20704003 Year: 2019 Volume: 17 Issue: 43 Pages: 41-48
Publisher: Baghdad University جامعة بغداد

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This paper presents the Surface Plasmon Resonance (SPR)-based plastic optical fiber sensor for estimating the concentration and refractive index of sugar in human blood serum. (SPR) response curve for different samples of the blood serum was recorded in this work and exhibited a dip in the position of the resonance.it is found that the change in the refractive index of the sensing medium (blood serum) led to the change in the resonance wavelengths in the (SPR) response curve. The resonance wavelength increase as the refractive index increase and this has been proven work at resonance wavelength (613 nm) the refractive index is (1.3628) and this value increased by increasing the resonance wavelength until it reaches the highest value it is (1.387) at resonance wavelength (734 nm).

يقدم هذا البحث متحسس الالياف البصرية البلاستيكية المستندة الى رنين بلازمون السطح (SPR) لحساب تركيز ومعامل انكسار السكر في مصل دم الانسان. تم تسجيل منحني استجابة لعينات مختلفة من مصل الدم في هذا العمل وعرض التراجع في موقع الرنين. وجد ان التغير في معامل انكسار الوسط المتحسس (مصل الدم) يؤدي الى التغير في الاطوال الموجية الرنينية في منحني استجابة (SPR). يزداد الطول الموجي الرنيني كلما زاد معامل الانكسار وقد أثبت هذا العمل فعند الطول الموجي الرنيني (613 nm) معامل الانكساريكون (1.3628) وتزداد هذه القيمة بزيادة الطول الموجي الرنيني حتى تصل الى اعلى قيمة وهي (1.387) عند الطول الموجي الرنيني (734 nm).


Article
The Association between Serum Zinc Levels and Insulin Resistance among Polycystic Ovary Syndrome Patients in Duhok City, Kurdistan Region, Iraq

Author: Lashkar Abdullah Jasem, Dhia Mustafa Sulaiman
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2019 Volume: 16 Issue: 1 Pages: 1-4
Publisher: Babylon University جامعة بابل

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Background: Polycystic ovary syndrome (PCOS) is a relatively common endocrine and metabolic problem. Patients with PCOS are knownto have a higher incidence of insulin resistance. The homeostasis model assessment (HOMA) is an indirect, rapid, accurate, and cost‑effectivemethod of assessing insulin resistance based on patient’s fasting plasma insulin and glucose concentrations. Several studies have reporteda significant correlation between HOMA and the traditional hyperinsulinemic‑euglycemic clamp method. Zinc deficiency promotes insulinresistance, and that zinc supplementation can prevent or, at least, alleviate insulin resistance in selected patient populations. Objective: Thecurrent study primarily aims at defining the association between insulin resistance and zinc deficiency among both PCOS and selectedcontrols. It also looks at certain risk factors associated with obesity among the study population in Duhok City, Kurdistan Region, Iraq.Materials and Methods: The current case–control study was performed at Azadi Teaching Hospital/Gynecological Outpatient Clinic inDuhok City/Kurdistan Region/Iraq. The study included 80 women (40 cases with PCOS and 40 controls of healthy women). Results: Therewas no age difference between both groups (Mean = 26.77 years, standard deviation [SD] = 6.42 years for PCOS cases versus mean and SDof 27.57 years and 6.45 years, respectively; P = 0.48). Likewise, there was no difference in the serum zinc levels between cases and controls.However, patients with PCOS had significantly higher Body mass index and HOMA scores compared to the controls (P = 0.005 and 0.007,respectively). Conclusion: Higher serum zinc levels are independently associated with lower HOMA. Patients with PCOS had significantlyhigher insulin resistance when compared to the controls of similar age and zinc level.


Article
Effect of Quinoa Seeds on Enzymatic and Non-Enzymatic Antioxidants in Serum of Stressful Local Rabbits by Hydrogen Peroxide
تاثير بذور الكينوا على مضادات الاكسدة الانزيمية واللانزيمية في مصل دم الاارانب المحلية المجهدة بفعل بيروكسيد الهيدروجين

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The present study aimed to determine the content of the quinoa seed extract from the active substances. The study also included the effect of powder and extract of quinoa seeds on the enzymatic and non- enzymatic antioxidants in the serum of local rabbit which is stressed by hydrogen peroxide. The level of Malondialdehyde in the serum of the rabbit was also measured. The results of the study showed that the quinoa extract contains phenols, alkaloids, glucosides, flavonoids, resins and tannins. The local rabbit dosage with the extract of quinoa seeds or powder resulted in higher levels of the efficacy of Glutathione Peroxidase, Catalysis and Glutathione compared to the control group, which decreased levels of hydrogen peroxide. There was also a significant increase in the concentration of Malondialdehyde for the group of stressful rabbits and its decreased significantly when feeding on quinoa powder or extract.

هدفت الدراسة الحالية الى معرفة محتوى مستخلص بذور الكينوا على المواد الفعالة ودراسة تاثير مسحوق ومستخلص بذور الكينوا على مضادات الاكسدة الانزيمية واللانزيمية في مصل دم الاارانب المحلية المجهدة بفعل بيروكسيد الهيدروجين مع قياس مستوى المالون ثنائي الالديهايد في مصل دم الاارانب. اوضحت نتائج الدراسة احتواء المستخلص الكحولي لبذور الكينوا على الفينولات والقلويدات والكلايكوسيدات و الفلافونيدات والراتنجات والتانينات. كما اوضحت نتائج التجربة ا ان تجريع الارانب المحلية بالمستخلص الكحولي لبذور الكينوا ومسحوقها ادى الى ارتفاع مستويات فعالية انزيم كلوتاثيون بيروكسيديز وانزيم الكاتليز والكلوتاثيون مقارنة بمجموعة السيطرة التي انخفضت فيها مستوياتها بفعل بيروكسيد الهيدروجين. وكذلك لوحظ ارتفاع معنوي في تركيز المالون الديهايد لمجموعة الاارانب المجهدة وانخفاض مستواه معنويا عند التغذية على مسحوق ومستخلص بذور الكينوا.


Article
Association of febrile convulsion with serum sodium and hematological indices among Iraqi children in Diyala province
علاقة التشنجات الحموية بمستوى الصوديوم وبعض مؤشرات الدم عند الأطفال في محافظة ديالى - العراق

Authors: Suadad M. Abdulalameer سؤدد مصطفى --- Jalil I. Kadhim جليل ابراهيم --- Nameer F. Gaeb نمير فاضل
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2019 Volume: 32 Issue: 1 Pages: 28-32
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

AbstractBackground: Several studies had documented the relationship between iron deficiency and low serum sodium levels with the risk of developing recurrent seizure among children within the same febrile illness.Objectives: To figure out the association between serum sodium levels and iron deficiency with occurrence of febrile convulsion in children between 6 months to 6 years old in Diyala province.Patients and Methods: A case control study was conducted in Al-Batool Teaching Hospital for Maternity and Children, Diyala-Iraq during a period from September 2017 to March 2018. 200 patients aged between 6 months to 6 years were enrolled, 100 of them were diagnosed with febrile convulsion and the other 100 were age and sex matched apparently health children as controls. Patients aged < 6 months or > 6 years, cerebral palsy, meningitis, epilepsy, severe gastroenteritis and dehydration, history of chronic drug use, and history of developmental delay were excluded from this study. Diagnosis of febrile convulsion was based on initial evaluation focusing on the source of the fever and thorough physical examination for the presence of meningeal signs and the child's level of consciousness. All patients were subjected to detailed history, complete physical and neurological examination, laboratory investigations and lumbar puncture which proceeded by fundoscopy examination. Human privacy was respected by taken child's parents consent. Accumulated data were analyzed using the SPSS version 25. The independent t-test (two tailed) was used and P value less than 0.05 were considered significant.Results: There was a significant lower means in patients regarding total red blood cells (4.61 vs 4.76, P= 0.032), hemoglobin concentration (11.38 vs 11.85, P= 0.003), packed cell volume (34.07 vs 37.67, P= 0.001), mean corpuscles volume (74.06 vs 78.01, P= 0.001), and higher red distribution width mean (14.73 vs 13.51, P= 0.001). Furthermore, a significantly lowered means in serum iron (mg/dl) (4.02 vs 4.74, P= 0.008), serum ferritin (ng/mL) (46 vs 58.58, P= 0.001), serum sodium (mEq/L) (131.11 vs 139.89, P= 0.001) and higher total iron binding capacity (μg/dL) (80.84 vs 66.12, P= 0.001) among patients compared to controls. Conclusion: Children with febrile convulsion are more likely to have iron deficiency anemia and hyponatremia.

الخلاصة:الخلفيــة: اشارت العديد من الدراسات السابقة عن وجود علاقة بين نقص الحديد وانخفاض مستوى الصوديوم مع خطورة تطور نوبات متكررة من التشنجات (convulsions) لدى الاطفال الذين يعانون من الاختلاجات الحموية.الهدف من الدراسة: لتحديد العلاقة بين مستوى الصوديوم والحديد في المصل وبعض مؤشرات قيم الدم مع حدوث التشنجات االحموية المصاحبة للاختلاجات الحرارية في الأطفال بين ستة أشهر - ستة سنوات من العمر.العينات وطرق البحث: اجريت هذه الدراسة في قسم طب الأطفال في مستشفى البتول التعليمي في محافظة ديالى- العراق خلال الفترة من سبتمبر 2017 إلى مارس 2018. شملت الدراسة 200طفل, 100 منهم ادخلوا الى المستشفى بسبب التشنجات الحموية تراوحت أعمارهم بين 6 أشهر و6 سنوات ، و100 طفل اخرين من الاصحاء ظاهريا كمجموعة سيطرة. تم استبعاد المرضى الذين تتراوح أعمارهم اقل من 6 أشهر أواكثرمن 6 سنوات، والشلل الدماغي، والتهاب السحايا،والصرع، والتهاب المعدة والأمعاء الشديد المصحوب بالجفاف، ومن لهم تاريخ باستخدام الادوية المزمنة، ومن لهم تاريخ التأخر التنموي من الدراسة. استند تشخيص التشنج الحموي على التقييم الأولي مع التركيز على سبب الحمى والفحص البدني الدقيق لوجود علامات سحائية ومستوى وعي الطفل. خضع جميع المرضى لتاريخ مفصل ، والفحص البدني والعصبي الكامل ، والفحوص المختبرية والبزل القطني الذي سبقه فحص (fundoscopy). تم احترام الخصوصية البشرية من خلال الحصول على موافقة الوالدين. تم تحليل البيانات المتراكمة باستخدام إصدار SPSS 25. تم استخدام اختبار t المستقل واعتبرت قيمة P أقل من 0.05 ذات دلالة احصائيةالنتائـــــــج: اظهرت النتئج الحالية ان هناك انخفاض كبير لدى المرضىى بإجمالي عدد كريات الدم الحمراء 4.61 مقابل 4.76 (P = 0.032)، وتركيز خضاب الدم 11.38 مقابل 11.85، ( P = 0.003) PCV و 34.07 مقابل 37.67 (P = 0.001) وMCV 74.06 مقابل 78.01 P = 0.001) ) ، و RDW أعلى 14.73 مقابل 13.51 (P = 0.001) و أقل في حالة نسبة الحديد في الدم (ملغم / ديسيلتر) 4,02 مقابل 4.74 P = 0.008)) ، ferritin و (ng / mL) 46.0 مقابل 58.58،P = 0.001)) ، ونسبة الصوديوم (mEq / L) 131.11 مقابل 139.89،P = 0.001) ) و TIBC أعلى (ميكروغرام / ديسيلتر) 80.84 مقابل 66.12 P = 0.001) )0الاستنتاج: الأطفال الذين يعانون من تشنجات حموية أكثر عرضة للإصابة بفقر الدم ونقص الصوديوم في الدم عند مقارنتهم بمجموعة السيطرة 0الكلمات المفتاحية : التشنجات الحموية , مؤشرات الدم، الصوديوم في الدم، محافظة ديالى


Article
Evaluation of serum gamma glutamyl transferase activity among type-2 diabetic patients in Erbil

Authors: Vyan Asad Qadir --- Sardar Nouri Ahmed
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2019 Volume: 23 Issue: 2 Pages: 171-176
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Gamma-glutamyl transferase is an enzyme that catalyzes the transfer of a glutamyl residue the acceptor through the glutamates gamma carboxylic acid to an amino acid. This study aimed to evaluate the serum gamma glutamyl transferase activity in type 2 diabetic patients and find out other confounding factors like age and gender effects.Methods: A cross-sectional study was carried out from January to June 2016 in collaboration between the Clinical Biochemistry Department at the College of Medicine, Hawler Medical University and the Chemistry Department at the Faculty of Science and Health of Koya University. The study included 50 type 2 diabetic patients (group 1), and 50 healthy individuals (group 2).Results: The mean value of serum gamma glutamyl transferase activity was significantly higher in type 2 diabetic patients (group 1) than that of healthy individuals (group 2) (P <0.001). The mean value of serum gamma glutamyl transferase activity in men diabetic patients was non significantly lower than women diabetic patients. The mean value of serum gamma glutamyl transferase activity in diabetic patients whose age was ≥50 years was non significantly higher than diabetic patients whose age was <50 years.Conclusion: Based on the findings of the present study, it can be concluded that high serum gamma glutamyl transferase activity is an independent factor and has considerable potential in diagnosing and monitoring for type 2 diabetic patients.

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