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Traumatic ulcertive granuloma with stromal eosinophilia (a clinicopathological study of 18 cases)

Author: Bashar H. Abdullah
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2011 Volume: 23 Issue: 4 Pages: 59-64
Publisher: Baghdad University جامعة بغداد


Background: Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a benign chronic ulcerative lesion
of the oral mucosa of an unclear pathogenesis characterized by a mixed infiltrate of inflammatory cells including
large mononuclear cells, lymphocytes and eosinophils. This study was designed to find any possible correlation
between the number of different cells infiltrates and the clinical features.
Method: A histopathological objective analysis was performed on ten highpower fields and the number of different
types of cells was correlated with the clinical data.
Results: No relationship was found between clinical and the quantifiable histopathological features studied.
Conclusion: No correlation is existed between the type of cell infiltrate and the size, site or the duration of the lesion
was found.
Keywords: traumatic ulcer, oral, eosinophilic granuloma. (J Bagh Coll Dentistry 2011;23(4):59-64).
من الافات الفمویة الحمیدة غیر واضحة الخواص المرضیة، و تتمیز برشائح مختلطة من الخلایا الالتھابیة كالخلایا (TUGSE) خلفیة الدراسة: یعد التقرح الفموي مع كثرة الیوزینیات
وحیدة النواة، الخلایا اللمفیة و الخلایا الیوزینیة.
ھدف الدراسة: ایجاد اي علاقة محتملة بین عدد الخلایا المرتشحة باختلاف انواعھا مع الخواصالسریریة.
طریقة العمل: باستخدام القوة التكبیریة العظمى اجري تعداد مجھري للخلایا بمختلف انواعھا ومن ثم تمت مقارنة الاعداد الناتجة بالخواصالسریریة المختلفة احصائیاً.
النتائج: لم یتم ایجاد علاقة معنویة بین الخواصالسریریة والبیانات المجھریة التي اجري قیاسھا في الدراسة.
الاستنتاج: لا توجد غالبیة مفردة لاحدى انواع الخلایا الالتھابیة المرتشحة ولا ایة علاقة بین الخلایا المرتشحة مع الحجم ، الموقع ، او المدى الزمني للتقرح.


Histopathological and Immunohistochemical Study of Giant Cell Granuloma of the Jaw and Giant Cell Tumor of Long Bones (Comparative Study)

Authors: Luay Edward. M --- Bashar H. Abdullah --- Omar A. Kader
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 1 Pages: 33-39
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية


ABSTRACT:BACKGROUND:Central giant cell granuloma (CGCG) and peripheral giant cell granuloma (PGCG) are tumor like lesions that affect jaw bones, while giant cell tumor (osteoclastoma) is a tumor that affects the long bones (e.g. tubular bones). Its affection of the jaw bones is a matter of debate. Both are very similar in their histopathological features while they vary in their clinical behavior. GCT shows a more aggressive behavior than GCG.OBJECTIVE:To evaluate the expression of (Proliferating cell nuclear antigen) and (P53) in peripheral and central giant cell lesion of the jaw and giant cell tumor of long bones with correlation to histopathological parameters.METHODS:A total of 17 (GCT), 15 (CGCG) and 16 (PGCG) cases where enrolled in this study. Immunohistochemical staining with PCNA and P53 monoclonal antibody was performed.RESULTS:A non-significant difference in proliferative activities was recorded among different histological giant cell lesion subtypes. Giant cell granuloma expressed the same proliferative potential to that of giant cell tumor, moreover PCNA expression was not statistically correlated to different histopathological paramters of lesion subtype.On the other hand. The anti-apoptotic potential of giant cell granuloma which expressed by anti P53 monoclonal antibody was the same of that of giant cell tumor.CONCLUSION:Results of this study proved that the biological behavior namely P53 and PCNA activities was comparable between giant cell lesions and giant cell tumor. This suggest that these two conditions may act as one disease entity with a spectrum of clinical behavior, possibly due to certain differences in anatomical location which by itself affect its biological behavior. This hypothesis needs further verification concerning the clonality of the lesion to be accepted or refused

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