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Article
PREPARATION AND STUDY OF AMOXICILLIN SELECTIVE ELECTRODES AND THEIR APPLICATION WITH DERIVATIVE SPECTROPHOTOMETER IN PHARMACEUTICAL DRUGS

Authors: Shahbaz A. Maki --- Nabil S. Nassory --- Khaleda H. Al-Saidi
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2009 Volume: 12 Issue: 1 Pages: 29-37
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Amoxicillin trihydrate selective electrodes were prepared based on amoxicillin-phosphotungstate (Amox-PT) as an active sensor with different plasticizers, di-butyl phosphate (DBP), di-butyl phthalate (DBPH), di-octyl phthalate (DOPH), tri-butyl phosphate (TBP) and o-nitro phenyl octyl ether (NPOE) in PVC matrix membranes. The study was carried out to investigate the electrode parameters, effect of pH, selectivity and UV-derivative spectrophotometer technique. Internal filling solution of 10-3 M + 10-3 M NaCl was used to fill the electrodes. The best electrode was based on DBP plasticizer which gave a slope 58.7 mV/decade and detection limit of 2 x 10-6 M displayed good stability and reproducibility. The electrode was used to determine the amoxicillin in oral suspension and capsules. The results were compared with UV-derivative spectrophotometer technique and the recovery for the drugs obtained by second derivative are quite comparable with the recovery obtained by amoxicillin electrodes.

حضرت أقطاب ﺇنتقائية للأموكسيسلين بتحضير المادة الفعالة (أموكسيسلين- فوسفوتنكستيت) Amox-PT مع الملدنات المختلفة وهي داي بيوتيل فوسفيت (DBP) , داي بيوتيل فثاليت (DBPH) ,داي اوكتيل فثاليت (DOPH) ,ثراي بيوتيل فوسفيت (TBP) و اورثو نيترو فنيل ﺇيثر (NPOE) في غشاء اصله من بولي فاينيل كلورايد .(PVC) الدراسة شملت خواص ألأقطاب كتأثير الدالة الحامضية pH, المحلول الداخلي للأقطاب, الأنتقائية . ﺇن أفضل قطب المحضر باستعمــال المـلدن DBP والمحـلول الداخلـي (10-3M Amox+10-3M NaCl) حيث ان الميل 58.7 mV/decade وبحدود تحسس 2x10-6M وله ثبوتية وتكرارية جيدة. ﺇن هذا القطب أستخدم لتقدير الأموكسيسلين في المستحضرات الدوائية الكبسول والمعلق الفموي. النتائج تطابقت مع نتائج المشتقة الطيفية الثانية.


Article
SIMULTANEOUS DETERMINATION OF AMILORIDE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE IN PHARMACEUTICALS BY DERIVATIVE SPECTROPHOTOMETRY

Authors: Khaleda, H. Al-Saidi --- Suhad Abdlaziz --- Sahar Semer
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2010 Volume: 13 Issue: 4 Pages: 52-61
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Method is established for simultaneous determination of Amiloride hydrochloride (Amilo) andhydrochlorothiazide in tablets. The method is based on employing normal and derivativespectrophotometry using the zero order via described by measuring the absorbance at 361 nm andthe first order derivative spectra at peak 340 and valley 382 nm for (Amilo), while the zerocrossingmethod is applied for hydrochlorothiazide. The first order derivative absorption spectra atvalleys 285 and 239 nm were used for hydrochlorothiazide. No interferences found betweenboth determined and those of matrices. A good accuracy and precision of simultaneousdetermination of (Amilo), and hydrochlorothiazide were confirmed by statistical analysis. Thepercentage recovery of the individual drags under the established conditions is ranged from 97.79%to 101.5 %. Linearity is maintained within a wide concentration range from 2.00 mg/L to 40.00mg/L for Amiloride hydrochloride and hydrochlorothiazide. The detection limit was 0.5 and 1.0mg/L for Amiloride hydrochloride and hydrochlorothiazide respectively.


Article
Simultaneous determination of amoxicillin and potassium clavulanate antibiotics in pharmacueutical sample using derivative spectrophotometric method
التحليل المتعاقب للمضادات الحيوية لدواء ألأموكسيسيلين و كلافونيت البوتاسيوم باستخدام المشتقات الطيفية

Authors: Sarah S. Abdulameer سارة ساجد عبد الأمير --- Khaleda H. Al-Saidi خالدة حميد محمد
Journal: Jornal of Biotechnology Research Center مجلة مركز بحوث التقنيات الاحيائية ISSN: 18151140 Year: 2011 Volume: 5 Issue: 3 Pages: 49-60
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Derivatives spectrophotometric techniques were developed for the determination of Amoxicillin Trihydrate (Amox) with Potassium Clavulanate (PC) antibiotic binary mixtures. The simultaneous determination of these compounds was accomplished by derivative (1D, 2D and 3D) spectrophotometric technique and applying zero-crossing technique used for determination of (Amox) and (PC) in tablets. The second order derivative absorption spectra at valley λ=299 nm were used for (Amox) and also the second order derivative spectra at peak λ=239.5 nm were used for (PC). No interferences were found between both determined constituents and those of matrix. A good accuracy and precision of simultaneous determination of (Amox) and (PC) were confirmed by statistical analysis. The recovery of individual constituents under established conditions is very high and ranges for synthetic standards mixture and tablets from 100.11, 99.33 and 96.98, 96.84 respectively. Linearity is maintained within a wide concentration range from 2.0 to 90.0 μg.mL-1 and from 10.0 to 90.0 μg.mL-1 for (Amox) and (PC) and linearity percentage 99.98 and 99.99 respectively. The detection limit is 0.211 μg.mL-1 for (Amox) and 0.259 μg.mL-1 for (PC). The corresponding quantitation limits are 0.704 μg.mL-1 (Amox) and 0.864 μg.mL-1 for (PC).

أستخدم في هذا البحث المشتقات الطيفية لتقدير المضادات الحيوية في المزيج المزدوج من الأموكسيسلين كلافونيت البوتاسيوم . التحليل المتعاقب لهذه المركبات تم باشتقاق كل من المشتقة الأولى والثانية و الثالثة مع طريقة التقاطع الصفري لتحديد الأطوال الموجية المناسبة لتقديركل منهما في حبات الأدوية . وجد أن المشتقة الثانية كانت مناسبة لتقدير الأموكسيسلين كلافونيت البوتاسيوم وفي الأطوال الموجية (299 ،239.5)نم على التوالي ، وبدون تداخلات من مكونات الدواء ، ودقة وحدود ثقة جيدة للتقدير المتعاقب لكليهما اعتمادا على التحليل الاحصائي وكمايلي : نسبة استرجاع لكل منهما في النموذج القياس والحبات الدوائية 100.11، 99.33 ، 96.98 ، 96.84 على التوالي . ومدىخطي عريض لتركيزالأموكسيسيلين (2.0 - 90.0)ملغم/لتر ونسبة مئوية خطية 99.98 و كلافونيت البوتاسيوم (10.0 -90.0) ملغم/لتر وبنسبة مئوية خطية 99.99. أما حد الكشف 0.211 ملغم/لترللأموكسيسيلين و 0.259 ملغم/لتر كلافونيت البوتاسيوم . وان الحد الكمي 0.704 ملغم/لترللأموكسيسيلين و 0.864 ملغم/لتر كلافونيت البوتاسيوم .


Article
Simultaneous determination of paracetamol and cephalexin binary mixtures by using derivative spectrophotometry and H-point standard addition methods

Authors: Asraa A. Al-Abaas --- Firyal Waly Askar --- Khaleda, H. Al-saidi
Journal: Journal of College of Education مجلة كلية التربية ISSN: 18120380 Year: 2010 Issue: 1 Pages: 43-58
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Two methods are applied for simultaneous determination of paracetamol (para) and cephalexin (ceph) in combined mixtures, derivative spectrophotometric technique and H-Point standard addition method (HPSAM) spectrophotometry. The first procedure is based on the use of the, second derivative ( 2D ) and used the suitable wave lengths at zero crossing at valley 250.5 and 290.2 nm for determination paracetamol and cephalexin respectively.. Calibration graphs were established for 2-60 mg/L for Para and 2-70 mg/L for ceph in binary mixture. The proposed method were successfully applied to the determination of these drugs in synthetic mixtures, linearity was excellent (r2>0.999) over the concentration tested (2–60 mg/L) with good precision and accuracy. Recoveries were good (>98%) with limits of detection of 1 and 1.5 mg/L ,(%R.S.D.= 0.757- 1.207) for para and ceph, respectively.. The second procedure HPSAM was applied to the simultaneous determination of Para and ceph. respectively. (HPSAM) method was based on the difference in the absorbance of para and ceph.at choosing wavelengths (265 and 257 nm). Results of the analysis of the different mixtures in the proposed system revealed a dynamic range of 2-35 and 2-50 mg/L, with limits of detection of 2 and 3 mg/L for para and ceph, respectively. The relative error are between -0.605-1.64 and -1.230-1.43, for para and ceph respectively. RSD% 0.151-1.775 for para and ceph, respectively. The two methods were found to be precise, accurate, simple and rapid..

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Article
Construction of New Ion Selective Electrodes for Determination Fe(III) and Their Application in Pharmaceutical samples
تصنيع اقطاب انتقائية جديدة لتقدير الحديد الثلاثي وتطبيقاتها في المستحضرات الصيدلانية

Authors: Weaam R. Aziz وئام رعد عزيز --- Khaleda H. Al-Saidi خالدة حميد السعيدي
Journal: Baghdad Science Journal مجلة بغداد للعلوم ISSN: 20788665 24117986 Year: 2013 Volume: 10 Issue: 4 Pages: 1211-1217
Publisher: Baghdad University جامعة بغداد

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Abstract

Liquid membrane electrodes for the determination iron(III) were constructed based on chloramphenicol sodium succinate and iron(III) CPSS-Fe(III) as ion pair complex, with four plasticizers Di-butyl phosphate (DBP); Di-butyl phthalate (DBPH); Di-octyl phthalate (DOP); Tri-butyl phosphate (TBP); in PVC matrix . These electrodes give Nernstian and sub-Nernstian slopes (19.79, 24.60, 16.01 and 13.82mV/decade) and linear ranges from (1x10-5-1x10-2 M, 1x10-5-1x10-2 M, 1x10-6-1x10-2 M and 1x10-5-1x10-2 M) respectively. The best electrode was based on DBP plasticizer which gave a slope 19.79 mV/decade, correlation coefficient 0.9999, detection limit of 9×10-6 M, lifetime 37 day displayed good stability and reproducibility and used to determine iron(III) in pharmaceutical samples. The selectivity coefficient interferences of (K+, Na+, Cu+2, Mn+2, Zn2+, Al3+,Folic acid) were studied using separate and mixed methods for selectivity coefficient determination. The pH and life time of the electrodes were also studied.

حضرت أقطاب انتقائية سائلة لتقدير الحديد الثلاثي والتي تعتمد على المعقد (الكلورامفينيكول صوديوم ساكسينيت مع الحديد الثلاثي) مع أربعة من الملدنات, داي بيوتيل فثاليت, داي بيوتيل فوسفيت, داي اوكتيل فثاليت وتراي بيوتيل فوسفيت مع بوليمر الفاينيل كلورايد. اعطت هذة الأقطاب انحدارا نيرنيستي و شبه نيرنيستي 19.79, 26.60 ,16.01 و 13.82 ملي فولت/حقبة ومدى التركيز الخطى حوالي من 10-5 الى 10-2 على التوالي. وكان أفضل قطب الذي يعتمد على داي بيوتيل فوسفيت كملدن حيث اعطى انحدارا 19.79 ,معامل ارتباط 0.9999 , حد كشف 9X10-6 وعمره 37 يوم مع استفرارية وتكرارية جيدة ,لتقديرالحديد الثلاثي في المستحضرات الصيدلاتية.كذلك درست التدخلات لحساب معامل الانتقائية بطريقة المحاليل المنقصلة وطريقة المحاليل الممزوجة بوجود الايونات المواد التالية (K+, Na+, , Al+3, Cu+2, Mn+2,Zn+2,Folic acid) ودراسة حدود الدالة الحامضية وعمر القطب.

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