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Article
Clinical Usefulness of IgE as a Serological Marker for Diagnosis of Nodular Scabies in Diyala Province

Authors: Burug Mohammad براق محمد --- Ali Ibrahim Ali علي ابراهيم علي --- Khudir khalaf Ibrahim خضير خلف ابراهيم
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2012 Volume: 2 Issue: 1 Pages: 60-65
Publisher: Diyala University جامعة ديالى

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Abstract

This study designed to evaluate the clinical usefulness of IgE as a serological marker for diagnosis of nodular scabies.Sixty eight patients suffering from nodular scabies and twenty apparently healthy subjects as control group were included .The mean age of patients group was ( 31.67±1.67)years compared with (33.5 ±2.27) years in control group .Among patients group, males represent(76.5%) compared with (23.5%) females. Among control group males represent (55%) versus (45%) females .The mean of IgE concentration among control group was (59.25 ± 5.36 U/ml) compared with (160.16 ±16.78 U/ml )among patients group with statistical significant difference (p>0.05 ).In (34/ 68) of scabietic patients, the concentration of IgE was lower than cutoff concentration with the mean (46.23 ±5.09IU/ml ).The rest (34/ 68) scabietic patients have elevated concentration of IgE(274.08 ±18.18IU/ml ).There was a statistical significant difference (p>0.05) between patients groups in IgE concentrations.This study concludes that the diagnostic value of IgE as a serological marker cannot be considered as a single parameter for diagnosis of nodular scabies without clinical manifestations. This study proved that the serological concentration of IgE not necessarily elevated in all cases of nodular scabies

Keywords

nodular scabies --- IgE --- serology --- diagnosis


Article
THE RELATIONSHIP BETWEEN HLA-DRB1*0103 AND HLA-DQA1*0201 GENOTYPES AND SPECIFIC IGE RESPONSES TO UNRELATED ALLERGENS IN ATOPIC PATIENTS
العلاقة بين النمطين الجينيينHLA-DRB1*0103 and HLA- DQA1*0201واستجابةIgE الخاصة بالمستارجاتعديمة الصلة في مرضى الحساسية

Author: Falih H.Mezban*Fawziah A. Abdulla فالح حمود مزبان* فوزيه علي عبدالله**
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: 18138497 Year: 2014 Volume: 13 Issue: 1 Pages: 260-273
Publisher: Basrah University جامعة البصرة

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Abstract

Because of the pivotal role of the human leukocyte antigen (HLA) class II molecules in regulating the immune response and their extensive polymorphism, it is not surprising that particular HLA class II alleles have been implicated in susceptibility to allergic diseases and in restriction of the IgE responses to a variety of allergens. We investigated the relationship between HLA-DRB1*0103 and HLA- DQA1*0201 genotypes and allergies to amoxicillin(AX) and love bird (LB) and explored their restriction of IgE responses to these allergens.Enzyme Linked Immunosorbent Assay test (ELISA) was used to examine the specific IgE antibodies in the sera of 175 subjects including 145 atopic patients and 30 healthy individuals without any allergic reaction. All of them were chosen for HLA genotyping by polymerase chain reaction . Compared with seropositive all control and seronegative individuals showed negative PCR HLA genotyping results.The higher overall rate (39.4%) of PCR positivity was observed inseropositive patients with positive PCR HLA-DQA1*0201 genotyping results .Also PCR HLA-DQA1*0201 genotyping revealed the higher rates of the PCR positivity in the males and females of the second age group in comparison with those of the first age groups but without significant difference (P > 0.05). The same result was also observed in positive PCR result for the patients with HLA-DRB1*0103 and those with both HLA -DRB1*0103 and HLA-DQA1*0201 as the non-significant higher PCR positive rates was observed in the males and females of the 2ndage groups.Also the females of the second age group showed the higher PCR positivity rates (100%,50% and30%)for HLA-DQA1*0201 and HLA-DRB1*0103) and both respectivelyELISA results revealed that the overall rate of seropositivity in tested individuals to amoxicillin(AX) or love bird dropping extract (LBDE) allergens was 54.9% .The females were not significantly different (P ≥ 0.05) from males and they showed the higher rate of seropositivity against AX(57.9%)and LBDE(58.9%)allergens.In contrast there was no significant effect(P > 0.05)for the age on the seropositivity against LBDE and the patients of the 1st age group showed higher rate (55.9%) of seropositivity in comparison with rate (43.7%) of 2ndage group patients

لبعض الاليل الجينات ا لخاصة بمستضدات كريات الدم البيضاء من الصنف الثاني في الانسان علاقه بامراض الحساسية وتحديد استجابة الضد IgE لانواع مختلفه من المستارجات. وذلك بسبب دورها الحيوى في تنظبم الاستجابه المناعية والتغير المفرط في اشكالها وقد تم التحقق من العلاقة بين النمطين الجينيينHLA-DRB1*0103 and HLA- DQA1*0201والحساسية للاموكسيسيلين وروث طيور الحب و التحري عن دورها في تحديد استجابة IgE لهذه المستارجات .استخدم اختبار ELISA للكشف عن الضد IgE في مصول 175 شخص تتضمن145 مريض بالحساسية و 30شخص سليم جميع هؤلاء الاشخاص تم اختيارهم للتنميط الجيني بواسطة تفاعل سلسلة البلمره PCR.بالمقارنة مع الاشخاص اللذين اظهرو نتائج ايجابية مصلية فان جميع اشخاص السيطره وذوي النتائج المصلية السلبية اظهرو نتائج سلبية في التنميط الجيني بواسطة تفاعل سلسلةالبلمره ولوحظ النمط الجينيHLA-DQA1*0201 باعلى نسبة ايجابية (39.4%)للتنميط الجيني بختبارPCR في المرضى ذوي النتائج المصلية الايجابية كذلك ظهر هذا النمط الجيني باعلى نسبه ايجابية لاختبارPCR في ذكور واناث مرضى الفئه العمرية الثانية بالمقارنة مع مرضى الفئةالعمرية الاولى ولكن بدون فارق احصائي معنوى(P > 0.05).لوحظت نفس النتائج الايجابية لاختبار PCRلمرضىى الفئة العمرية الثانية ذكورا واناثا فيما يخص النمط الجينيHLA-DRB1*0103 كنمط جيني منفردا او مشتركا معHLA-DQA1*0201وبدون فرق احصائي معنوى 0.05) (P > وكذلك اظهرت الاناث من الفئة العمرية الثانية نسب PCRايجابية عالية (100%و50%و30%) وعلى التوالي لكل من النمطين الجينيين DQA1*0201 وHLA-DRB1*0103 وللاثنين معا.اظهرت نتائج ELISA بان اعلى نسبة كلية للايجابية المصلية للاشخاص المفحوصين بمستضدات الاموكسيسيلين وبراز طيور الحب كانت بمقدار54.9%.لم تختلف الاناث عن الذكور احصائيا(P ≥ 0.05) وفي الاشخاص المفحوصين كانت نسبة الايجابية المصلية ضد الاموكسيسيلين(57.9%)ومستارجاات براز طيور الحب(58.9%). لا يوجد تاثير محسوس احصائيا(P > 0.05)للعمرعلى الايجابية المصلية ضد مستارجات براز طير الحيوان لمرضى الفئه العمرية الاولى اظهرو اعلى نسب (55.9%)للايجابية المصلية بالمقارنة مع نسب مرضى الفئه العمرية الثانية (43.7%).


Article
Possible Role for Interleukin-5 in Asthma

Authors: Wala'a E. Jasim --- Batool A. Al-Haidary --- Yacoob Y. Al-Rubaeyi
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2006 Volume: 48 Issue: 4 Pages: 425-430
Publisher: Baghdad University جامعة بغداد

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Abstract


Background: Asthma is an allergic disease characterized by airway obstruction as a result of cellular accumulation due to the liberation of certain mediators. Among those mediators are the cytokines such as IL-5.
Patients & Methods: Interleukin-5 concentration has been estimated in 94 sera samples of Asthmatic patients in comparison with 41 non-asthmatic bronchitis as patient controls in addition to 30 apparent healthy control group using ELISA method.
Results & Conclusions: There is highly significant elevation of IL-5 in the asthmatic cases in comparison with healthy controls (P< 0.001). We conclude that this cytokine may play the major role in asthmatic attack & it may be a good marker for the disease.

Keywords

Asthma --- IL-5 --- bronchitis --- Eosinophilia --- IgE


Article
IgE LEVEL AND EOSINOPHIL COUNT IN RELATION WITH TYPE OF FEEDING IN CHILDREN WITH ATOPIC DERMATITIS

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Abstract

Background: Atopic dermatitis (AD) is a chronic inflammatory disease of the skin that occurs in persons of all ages but is more common in children.Objective: To determine the effect of breast feeding on atopic dermatitis.Methods: A descriptive study carried on pediatric patients visiting asthma and allergy center and pediatrics out patient in Tikrit Teaching Hospital from March 2007 to August 2007. This study included 100 patients with AD; 58 cases (58%) were males and 42 cases (42%) were females, they all underwent full history, clinical examination and blood sampling for total WBC count, eosinophil cells count, and total serum IgE.Results: Statistical analysis was done by using (ANOVA, Chi-square test). There was significant association between severity of AD according to scorad index (S.I) and type of infant feeding, the mean severity score (S.S) for the breast fed (B.F) children was 21.48±4.96, while the mean S.S for the formula fed (F.F) children was 35.70±9.79, p value ≤ 0.05. There was a significant association between the hematological parameters of disease activity (total serum IgE level, eosinophil count) and type of infants feeding; the mean total serum IgE level for the B.F children was 211±178.7 IU/ml, was lower than mean total serum IgE level for F.F children (638.2±355.8 IU/ml). The mean eosinophil cells count for the B.F children (355.7±193.1) cell/μl was lower than the mean eosinophil cells count for the F.F children (654.8±236.3) cell/μl.Conclusions: There is significant association between the type of feeding and the level of hematological parameters (IgE and eosinophil count), and that breast feeding is protective against development of severe AD.Key words: atopic dermatitis, breast feeding, IgE, eosinophil


Article
Patterns of Sensitization to Inhalant Allergens among Asthmatic Children in Karbala Province

Authors: Mohammad R. I. Ghazal --- Zuhair M. Al-Musawi --- Haidar A. N. Abood*,
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2013 Volume: 6 Issue: 2 Pages: 1630-1636
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: The patterns of sensitization to inhalant allergens among asthmaticchildren varies greatly in different countries. The detection of sensitization to inhalantallergens in asthmatic patients is used primarily to establish the diagnosis of allergicasthma. Also it is helpful in reducing asthma exacerbations through allergen exposureavoidance.Objectives: This study aims to determine the most common inhalant allergens associatedwith childhood asthma in Karbala province using allergen-specific IgE immunoassay.Patients and Methods: The present study was conducted in Karbala Teaching Hospital forChildren on 75 asthmatic children with elevated total serum IgE levels. All patients werescreened for the presence of specific IgE against inhalant allergens most frequently involvedin childhood asthma using EUROLINE Pediatric Inhalation IgE test kit that include 20inhalant allergens. The position of the band was used to determine the specific allergen whilethe color intensity of the band was used as predictive for the specific IgE concentration inserum samples.Results: Among 75 patients screened for specific IgE, 60 patients (80%) were sensitized to atleast one allergen and allergen-specific IgE was not detected in 15 (20%) patients. 30% ofsensitized patients, were sensitized to single allergen and 70% were sensitized to multipleallergens. Cat allergen was found in 60% of sensitized patients followed by European housedust mite allergen (55%). However, dog and aspergillus fumigatus allergens accounted for45% and 33.3% respectively. Most patients sensitized to cat and dog allergens (55.5% and52% respectively) showed clear bands signal intensity (moderate allergen-specific IgEconcentration). However the majority of patients sensitized to other inhalant allergensshowed weak bands signal intensity (low allergen-specific IgE concentration).Conclusions: Animal allergens (mostly cat) are the predominant inhalant allergens associatedwith childhood asthma in Karbala province with relatively higher allergen-specific IgEconcentrations than house dust mite and fungal allergens.


Article
Interaction of Two Variants of IL4 Receptor-Α Gene with Serum IgE Level and Some Risk Factors for Childhood Asthma in Karbala Governorate

Author: Ali Mansoor Al-Ameri علي منصور
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2014 Volume: 7 Issue: 1 Pages: 1744-1759
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: Asthma and related allergic diseases are complex genetic diseases with major environmental influences that occur in a developmental context. Susceptibility to asthma is influenced by genes and environment; implicated genes may indicate pathways for therapeutic intervention.Aim: The present study aims to test the linkage association of IL-4Ra gene polymorphisms, E375A and C406R, determined by PCR/RFLP assay, with asthma development from 100 asthmatic children. In addition to their association with elevated serum IgE level in asthmatic children and possible interaction with other contributing factors including high BMI, history of prematurity, neonatal jaundice or vitamin D deficiency, exposure to bottle feeding and family history of atopy and/or asthma. Patients and methods: This is a cross sectional survey study done in Kerbala Pediatric teaching Hospital during April, 2011 through February, 2013. Results & Discussion: Data of the current study suggested a significant linkage association between IL4RA single nucleotide polymorphisms, SNPs, (E375A and C406R) and development of childhood asthma in the recruited participants, r= 0.82 and 0.67, respectively. Interestingly, the latter effect is synergistically increased upon gene-environment interaction with any of the studied risk factors tested in this study, except past history of neonatal jaundice.The presence of E375A and C406R SNPs of IL4RA gene have potential effect on development of childhood asthma. Secondly, this effect is synergistically reinforced via gene-environment interaction of these SNPs with other asthma contributors including high BMI, history of prematurity, formula feeding, vitamin D deficiency and positive family history of asthma.Conclusion: Our study reinforced the theory that asthma is a multifactorial disease suggesting a noticeable interaction between genetic and environmental factors in the development of this disease.


Article
Detection of Human Rhinovirus Antigen (RhV-Ag) and Total IgE in Serum Samples from Common Cold Patients
الكشف عن مستضد الفايروس المسبب للرشح والجسم المضاد إي في مصل المرضى المصابين بنزلات البرد الشائعة

Authors: Noor N. Al-Hayani نور ناجي رديف الحياني --- Israa H. Saadoon اسراء هاشم سعدون --- Mushtak T. Salih مشتاق طالب صالح الندا
Journal: Al- Anbar Medical Journal مجلة الأنبار الطبية ISSN: PISSN: 27066207 / EISSN: 26643154 Year: 2017 Volume: 14 Issue: 1 Pages: 15-23
Publisher: University of Anbar جامعة الانبار

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Abstract

Background: Human rhinovirus infections account for approximately 50% of common colds and up to 80% or more of all infections during respiratory epidemic outbreaks. Rhinovirus infections are considered as a major trigger of asthma exacerbations. Almost all children have experienced at least one rhinovirus infection by the age of two years. An enzyme linked immunosorbent assay (ELISA) can detect rhinovirus specific antibodies in both sera and nasal secretions of patients with a rhinovirus infection. An enzyme linked immunosorbent assay was shown to be more sensitive and reliable than the traditional neutralization test.Patients and Methods: A cross sectional study was carried out in Al- Ramadi city from the first of December, 2012 to the end of April 2013. The number of patients recruited in this study who having a common cold was 150. All of them were tested for the RhV-Ag and IgE tests. An interview was carried out with these patients using questionnaire prepared by the investigators and it's include the following: name, age, residency and occupation …etc.Results: Out of 150 patients, RhV-Ag was found in 104 (69.33%) as detected by the technique of Enzyme Linked Immunosorbent assay. The simple linear correlation coefficient between RhV-Ag and IgE readings was calculated and found to be significant (r=0.242, p<0.05). The two-sample t-test was used in order to compare means RhV-Ag and IgE between adults and children of the considered sample, the t-test revealed that means RhV-Ag and IgE of the children were significantly lower than that of the adults. Conclusion: Means of RhV-Ag and IgE were compared with respect to age groups (adults and children), in both comparisons adults found to have significantly higher means than children. IgE and RhV-Ag were found to be significantly linearly correlated.

خلفية البحث: يشكل الفايروس المسبب للرشح في الانسان تقريبا 50% من حالات نزلات البرد الشائع وحوالي اكثر من 80% من مجموع امراض الجهاز التنفسي المنتشرة . تعتبر الاصابة بفايروس الرشح ايضا السبب الرئيسي لتفاقم حالات الربو.غالبا جميع الاطفال تحدث لديهم اصابة واحدة على الاقل بالفايروس المسبب للرشح خلال السنتين الاولى من العمر. تم استخدام اختبار مقاسية الامتصاصية للأنزيم المرتبط كونه من الاختبارات المهمة في قياس الاجسام المضادة للفايروس المسبب للرشح في مصل الدم وافرازات الانف كما يعتبر هذا الاختبار الاكثر حساسية من اختبار التحديد التقليدي.طريقة العمل وعدد المرضى:اجريت دراسة متكاملة في مدينة الرمادي للفترة من الاول من شهر كانون الاول للعام 2012 ولغاية نهاية شهر نيسان للعام 2013 شملت تلك الدراسة 150 مريض كانوا يعانون من حالات البرد الشائع تم تشخيصهم سريريا كما تم جمع عينات دم منهم واخضاعها لاختبار مستضد الفايروس المسبب للرشح واختبار الجسم المضاد اي. تم ايضا تم جمع معلومات عن المرضى تضمنت الاسم والعمر ومحل الاقامة ووظيفة المريض.النتائج:من مجموع 150 مريض وجد ان 104 (69.33%) منهم يمتلكون نتيجة ايجابية للمستضد الخاص بالفايروس المسبب للرشح الذي تم فحصه عن طريق اختبار مقاسية الامتصاصية للأنزيم المرتبط وقد تم اختبار معامل الارتباط البسيط بين مستضد الفايروس المسبب للرشح والجسم المضاد اي وقد وجدت ان العلاقة معنوية بينهما كما تم اجراء مقارنة بين نتائج الاطفال والبالغين من خلال قيم المستضد للفايروس المسبب للرشح والجسم المضاد اي حيث وجد ان قيمتها لدى الاطفال اقل من البالغين.الاستنتاج:تم الاستنتاج من خلال هذه الدراسة ان متوسط المستضد المسبب للرشح والجسم المضاد اي والتي تم مقارنتها بالعمر ( لكل من الاطفال والبالغين) في البالغين ذات فروقات معنوية اكثر من الاطفال كما ان هناك علاقة معنوية بين الفايروس المسبب للرشح والجسم المضاد اي من خلال قياس معامل الارتباط الخطي.


Article
The Study of Serum Complement C3, C4 and Immunoglobulin E IgE in Psoriasis Patients
دراسة المستوى المصلي لبروتينات المتمم C3,C4والامينوكلوبيولين IgE الكلي في مرضى مصابين بداء الصدفية

Authors: Hind Y. khalaf هند يوسف خلف --- Talib A. Hussein طالب عبد الله حسين --- Basman M. fadheel بسمان مدحت فضيل
Journal: Baghdad Science Journal مجلة بغداد للعلوم ISSN: 20788665 24117986 Year: 2015 Volume: 12 Issue: 4 Pages: 708-714
Publisher: Baghdad University جامعة بغداد

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Abstract

The present study was aimed to find out the role of humoral immunity in the pathogenesis of psoriasis. Complements C3, C4 and immunoglobulin IgE .The study included 55 Iraqi patients with psoriasis 30 (15 females ,15 males) were untreated with any drugs. The other patient group consisted of 25 (9 female and 16 male) treated with a biological treatment (infliximab) ,and 30 (13 males ,12 females) healthy control group. Blood sample were withdrawn (5) ml of venous blood for both patients and members of the control ,to conduct the Immunological tests to determine the quantitative for each of total IgE by using (ELISA) and C3,C4 by Single Radial Immunodiffuse (SIRD). The results showed significant increase in the level of probability (P <0.05) in the rate of total IgE immunoglobulin and C3 in patients compared to the control (healthy) .As well as the result also showed no significant increases of C4. From this we can deduce that elevation of total serum IgE is associated with psoriasis. Alternate pathway is a way of complement in pathogenesis of psoriasis.

صممت الدراسة الحالية بهدف تقييم مستوى بروتينات المتمم C3,C4والامينوكلوبيولين IgE الكلي في عينة المرضى المصابين بداء الصدفية اذا شملت الدراسة 55 مريضا ( ذكر وأنثى ) تراوحت أعمارهم ما بين 6-70 سنة وكان 30 منهم غير معالجين(15ذكورا و15اناثا) و 25 من المعالجين بعلاج بايلوجي Infliximab(16ذكورا و9 اناثا ) ومجاميع سيطرة بأجناس وفئات عمرية مماثلة لأغراض المقارنة مكونة من 25 فردا أصحاء ظاهريا (13ذكورا و12 اناثا) . تم سحب (5) مل من الدم الوريدي لكل من المرضى وافراد السيطرة. لإجراء الفحوصات المناعية للتحديد الكمي لكل من مستوى الامينوكلوبيولين IgE الكلي والتي قيست بطريقة (الأليزا) ELISA , وبروتينات المتمم C3,C4 بطريقة الانتشار المناعي المفرد, أظهرت النتائج ارتفاعا معنويا عند مستوى احتمالية (P<0.05 ) لكن من بروتين المتمم C3والامينوكلوبيولين IgE الكلي عند المرضى مقارنة بسيطرة (الأصحاء) وعدم وجود ارتفاع معنوي لبروتين المتمم C4 .ومن هنا نستنتج وجود علاقة بين ارتفاع الجسم المضاد ومرض الصدفية وان نظام المتمم يسلك الطريق البديل وذلك لارتفاعC3 وعدم ارتفاع C4.


Article
Study of serum interleukin-12 and total serum immunoglobulin-E in relation to bronchial asthma severity in childhood
دراسة الانترلوكين 12 والغلولوبين المناعي نوع E وعلاقتهما في شدة الربو القصبي عند الأطفال

Author: Sattar jabbar Rahi •ستار جبار راهي
Journal: karbala journal of pharmaceutical sciences مجلة كربلاء للعلوم الصيدلانية ISSN: 70272221 Year: 2011 Issue: 2 Pages: 103-110
Publisher: Kerbala University جامعة كربلاء

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Abstract

Bronchial asthma is a major public health concern affecting 100-150 million people worldwide. Elevated total serum immunoglobulin E (IgE) is considered as an objective marker of allergy and has been associated with a number of respiratory disorder.Interleukin-12(IL-12) is a key cytokine involved in regulating the balance between TH1and TH2 cells by promoting TH1 response .Reduced capacity to produce this cytokine could lead aberrant TH2 development .The objective in this to find if any correlation between serum IgE level and serum interleukin-12 with severity of bronchial asthma for both the definitive diagnosis and the therapeutic strategy. A total of fifty patients with age 12years and below ( 28 males and 22 females) and twenty five of case controls with matched age and sex were randomly selected from apparently healthy individuals from January to June of 2010 who were attending the outpatient department in Kerbala teaching pediatrics hospital with symptoms suggestive of bronchial asthma .The patients who were not on any anti asthma medication in previous one week were included in the study. Blood sample was taken from each patient at time of attending , sera were separated and kept frozen at -200C until used .Serum interleukin -12 and total IgE levels were done by solid phase enzyme –linked immunosorbent assay (ELISA). A significant decrease of serum levels of IL-12 was found in bronchial asthmatic children compared with normal controls .This significant decrease of IL-12was observed in sever asthmatic patients compared with mild and moderate cases. However there is increase of mean serum total IgE in bronchial asthmatic children compared to healthy control groups .mean serum IgE levels were increased as the severity of asthma increased . The present study suggested that the increased serum total levels IgE in bronchial asthmatic patients beside decreasing the serum interleukin-12 could be considered as a key component in bronchial asthma pathogenesis and hence their therapeutic manipulation may be help in bronchial asthma management.

ان الربو القصبي من الأمراض الرئسيه في الصحة العامة يُوثر على حوالي 100- 150 مليون شخص حول العالم. ان تركيز المصل الكلي للغلوبيولين المناعي نوع E يعتبر ُ كعلامة موضوعية مِنْ الحساسيةِ وكذلك مرتبط به عدد من الأمراض التنفسية. انترلوكين - 12 له دور رئيسي للمشاركة في تنظيم التوازن بين الخلايا المناعيه المساعده الأولى والثانيه .ان أي انخفاظ في انتاج انترلوكين 12 قد يودي الى زياده قدره الخلايا المناعيه المساعده الثانيه وبالتالي يفقد التوازن بين الخلييتين . ن الهدف من هذه الدراسه هولايجاد علاقه بين مستوى الانترلوكين 12 الغلوبيوليين المناعي نوع Eمع الربو القصبي للاطفال من حيث فائده لتشخيص مرحله المرض وللعلاج . شملت الدراسه 50 طفل مصابين بالربو القصبي واعمارهم من حوالي 12 سنه فمادون بالاضافه الى 25 طفل سليما انضموا الى الدراسه لغرض المقارنه كمجاميع ظابطه. تمت الدراسه في مستشفى كربلاء التعليمي للاطفال للفتره من كانون الثاني لغايه حزيران لسنه 2010هولاء المرضى تم تشخيصهم حسب الاعراض السريريه من قبل اخصائي الاطفال وقد تم التاكد بانهم لم يتعاطوا أي علاجات ضد الحساسيه قبل سحب الدم لهم . وباستخدام تقنيه الروز المناعي تم قياس الغلوبيوليين المناعي نوع Eوالانترلوكين 12 . كشفت الدراسه على ان هنالك انخفاظا معنويا في مستويات الانترلوكين 12 وارتفاعا في مستويات الغلوبيولين المناعي نوع E في المرضى المصابين بالربو القصبي مقارنه بالاطفال الاصحاء. ولوحظ ايظا هنالك علاقه بين الانترلوكين12 والغلوبيولين المناعي نوع E وشده المرض ..حيث وجد قله في تركيز الانترلوكين 12 مع الدرجه الحاده للمرض اذا قارنا باالحاله الخفيفه والمعتدله للمرض . على العكس من ذلك المستويات المصليه للغلوبيولين المناعي E قد سجل ارتفاعا معنويا في شده المرض .ونتيجة للاعتبارهم المكون الرئيسي في التسبب للربو القصبي أي تغيرات في نسبهم قد يفيد في الكشف عن مرحله شده المرض و العلاج له .


Article
A Study of Immunological and Clinical Effects of Alslergen Immunotherapy on Asthmatic Patients in Babylon Province

Author: Amjed H. A. Al-Mansoury
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2009 Volume: 2 no.8, 9 Issue: 5 Pages: 635-644
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: Allergen immunotherapy has important benefits on asthmaticpatients by reducing symptoms and medication use and it can be used as analternative treatment.Objectives: This study aimed to assess the effects of allergen immunotherapy (AI) onasthmatic patients of Babylon Province.Materials and methods: The study was performed on 35 asthmatic patients asimmunotherapy group who received allergen immunotherapy and 15 asthmaticpatients as control group who remained on pharmacotherapy, the patients wereassessed by measurement of peak expiratory flow rate (PEFR), total immunoglobulinE (IgE) and immunoglobulin G (IgG) symptoms and medication use score at 0 time, 3months, and 6 months.Results: The study showed that 30-40 years age group population were more affectedwith asthma (44%) and then the incidence decreased with increasing age. Femalesmight be more affected than males (60% compared to 40%).There were significantincrease in the mean levels of PEFR and total IgG and significant increase in themean levels of total IgE. In addition, the study revealed larger reduction in symptomsand medications use score in immunotherapy group in comparison to control group.Conclusion: AI should be used in allergic asthma as one of the modalities oftreatment because it can reduce the symptoms and medications use by changing thebasic mechanism of asthma.

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