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Article
Malondialdehyde in preeclampsia

Authors: Suha Hussien Hayawii --- Eaman Hussein Raoof --- Takwa Nehad Mohammad
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2016 Volume: 15 Issue: 3 Pages: 1-4
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Background: Preeclampsia is multiorgan disorder, and important cause of maternal, fetal, neonatal morbidity and mortality ,It is characterized by hypertension and proteinuria. Lipid peroxidation is an important factor in the pathophysiology of preeclampsia. Objective: To study the relation of lipid paroxidation which is measured by plasma Malondialdehyde (MDA) to preeclampsia. Design: Case –control study. Setting: The study was carried out at the Al-Imamain Al-Kadhemain Medical City/ Department of obstetrics and gynecology. Methods: The study included 70 women. We studied 30 patient preeclamptic women 30 apparently healthy women, 10 apparently healthy non pregnant ladies. Their age range between 18-30 year ,gestational age is between 24-40week /primigravida/non smoker or have evidence of nutritional deficiencies. Lipid peroxidation assessed by (Fong etal)method ,and it is end products,particularly Malondialdehyde . Results: We observed that serum malondialdehyde were significantly increased in preeclamptic women (P<0.000) as compared to that of normotensive pregnant women. Conclusion: Increased levels of lipid peroxidation product –MDA may contribute to pathophysiology of preeclampsia.


Article
Serum Erythropoietin Concentration In Normal And Preeclamptic Pregnancies

Authors: Athba A. kadhim عذبه عبد كاظم --- Lilyan W. Sersam لليان وديع سرسم
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2017 Volume: 16 Issue: 2 Pages: 43-49
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Background: Preeclampsia is a multisystem disease and a threat to the well-being of both the mother and her newborn; it contributes significantly to the causes of maternal and perinatal morbidity and mortality. An increase in maternal plasma of erythropoietin in women with preeclampsia may be of placental origion and a reflection of an underlying placental hypoxic condition. Aims: To compare serum erythropoietin concentrations among patients with and without preeclampsia and to investigate the association between serum erythropoietin levels and preeclampsia.Methods: This case-control study involved one hundred pregnant women in their third trimester of singleton pregnancy with gestational age (28-40wk). Fifty patients were with preeclampsia (study group) and fifty patients were with normal healthy pregnancies (control group). For both groups maternal blood samples were collected for Erythropoietin concentration measured by ELISA method. Statistical analysis was performed to compare maternal serum erythropoietin levels in preeclamptic women and normal heathy pregnant women, and to evaluate the association between serum erythropoietin and preeclampsia. Results: Mean erythropoietin level for the preeclamptic group was (41.66±26.76) ranging from 10.716-159.121(mIU/ml) with a median of 36.101 mIU/ml, while for the control group, the mean value was (28.71±14.38) ranging from 6.482-65.228 (mIU/ml) with a median of 26.741 mIU/ml. Erythropoietin levels were significantly (P=0.003) higher among preeclamptic patients compared with controls.Conclusion: Women with preeclampsia have significantly higher levels of serum erythropoietin compared to normal healthy pregnancy.


Article
Homocysteine Changes in Preeclampsia
التغيرات في تركيز مادة الهوموسستائين في الدم في حالة مقدمة الارتعاج

Authors: Maha Al-Bayati مها البياتي --- Ali Taki Al-baldawi علي تقي
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2007 Volume: 20 Issue: 3 Pages: 426-431
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

AbstractObjective: To determine whether homocysteine, a relatively new risk factor for possible endothelial cell dysfunction and premature vascular disease, is elevated in pregnant women with preeclampsia.Methods: A case-control study design conducted at Al-kadimiya teaching hospital for the period from September 2000 through April 2001. The study sample consisted of 100 pregnant women in labour subdivided into three groups (40 pregnant women with severe preeclampsia, 30 pregnant women with mild preeclampsia and 30 normotensive pregnant women as a control). Plasma homocysteine concentration measurement and observation of the maternal and fetal outcome was done for all groups.Results: The incidence of hyperhomocysteinemia was significantly higher among patients with severe preeclampsia (80%) compared to those with mild preeclampsia (67%) and the normotensive group (7%) and the incidence of adverse maternal and neonatal outcome is significantly higher among patients with severe preeclampsia compared to the others.Conclusion: Plasma total homocysteine concentration is elevated in pregnant women with preeclampsia during labour being significantly higher in cases with severe preeclampsia so hyperhomocysteinemia is considered a risk factor for adverse maternal and neonatal outcome.

هدف الدراسة : بيان ومعرفة هل ان تركيز مادة الهوموسستائين في الدم والذي يعتبر نسبيا كعامل خطر جديد لاحتمال الاختلال الوظيفي في الخلايا البطانية والإصابة المبكرة بأمراض الأوعية الدموية يزداد لدى الحوامل في حالة مقدمة الارتعاج. أجريت هذه الدراسة في مستشفى الكاظمية التعليمي/ قسم النسائية والتوليد على مائة سيدة في حالة ولادة وقد قسمت السيدات الى ثلاثة مجاميع :1- المجموعة ا: تتالف من 40 سيدة تعاني من مقدمة الارتعاج الشديدة .2- المجموعة ب: تتالف من 30 سيدة تعاني من مقدمة الارتعاج البسيطة. 3- المجموعة ج: تتالف من 30 سيدة حامل تتمتع بصحة جيدة (كمجموعة ضبط ).شملت الدراسة قياس تركيز مادة الهوموسستائين في الدم ومتابعة صحة الأم والطفل بعد الولادة لكل المجاميع.تمخض تحليل النتائج إحصائيا عن مايلي : 1- وجدت علاقة وثيقة بين تركيز مادة الهومو سستائين في الدم وشدة مقدمة الارتعاج حيث ان تركيزه أعلى لدى السيدات الحوامل في المجموعة ا (80%) عنه في المجموعة ب (67%) و المجموعة ج (7%). 2- الزيادة في تركيز مادة الهوموسستائين في الدم مصحوبة بارتفاع نسبة المضاعفات لدى الام والطفل .الاستنتاج:تركيز مادة الهوموسستائين في الدم أعلى لدى السيدات الحوامل المصابات بمقدمة الارتعاج الشديد أثناء الولادة عنه لدى المصابات بمقدمة الارتعاج البسيط ومجموعة الضبط وزيادة تركيز مادة الهوموسستائين في الدم قد تسبب ارتفاع في نسبة المضاعفات لدى الأم والطفل.


Article
Maternal serum Alpha-fetoprotein Level at 12, 22 and 32weeks’ gestation in screening for pre-eclampsia
مستوى (الفا فيتوبروتين) في مصل الام للأسابيع 12, 22 و 32 من الحمل للتحري عن مرض ما قبل الارجاج الحاد

Authors: Arwa M. Ahmed اروى مجيد احمد --- Israa' H. Abid Al-Kareem اسراء هاشم عبد الكريم
Journal: Tikrit Journal of Pure Science مجلة تكريت للعلوم الصرفة ISSN: 18131662 Year: 2018 Volume: 23 Issue: 8 Pages: 1-9
Publisher: Tikrit University جامعة تكريت

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Abstract

Pre-eclampsia is a major cause of maternal and perinatal morbidity and mortality. Alpha_fetoprotein is measured in pregnant women, as a screening test for pre-eclampsia.This study aimed to examine the maternal serum alpha-fetoprotein at 12, 22 and 32 weeks ’gestation in singleton pregnancies and its performance as a screening test for Pre eclampsia. The study designed as prospective (Cohort) study, it was conducted in Obstetrics department in Salah AL Din Teaching Hospital, from the period of the 15th of December 2016 to the 1st of July 2017. Ninety six pregnant women at first trimester participated in the study, followed up prospectively sixty three of them was attended a second test in second trimester and seventy five of them was attended a third test in a third trimester. The mean age of the studied group was 27.1 ± 5.8 (range: 17-30) years .It had been observed that the mean level of Alphafetoprotein was increased and the mean Multi of Median( MoM) was significantly reduced with advanced gestational age., there are highly significant differences at the different check-points in both mean and MoM, of the maternal alpha-fetoprotein. The mean alpha-fetoprotein level was higher in pre-eclampsia group compared to non-preeclampsia in all of the three testing points. The Comparison of mean alpha-fetoprotein levels of pre-eclampsia vs. non-preeclampsia women revealed that the mean, alpha-fetoprotein level was higher in pre-eclampsia group compared to non-preeclampsia in all of the three testing points, alpha-fetoprotein level at the second test was the better than the first and third test.

يعد مرض ما قبل الارجاج الحاد هو سبب رئيسي لاعتلال ووفيات الأمهات يصيب 2-3% من جميع حالات الحمل. يتم تقدير تركيز هورمون الفا فيتو بروتين في النساء الحوامل من خلال دم الام او السائل الامنيوسي ويستخدم للتحري عن مرض ما قبل الارجاج الحاد والتشوهات الخلقية الولادية. جاءت هذه الدراسة لاختبار توزيع نسبة (الفا فيتو بروتين) في مصل الام للاسابيع 12, 22 و 32 من الحمل المفرد اللواتي تعانين من مرض ما قبل الارجاج الحاد واستخدام هذه العلامة البايلوجية للتحري عن مرض ما قبل الارجاج الحاد.تم اجراء الدراسة في قسم النسائية والتوليد في مستشفى صلاح الدين التعليمي للفترة من 15 كانون الاول 2016 ولغاية 1 تموز 2017. كان عدد النساء الحوامل 96 امراة في الثلث الاول من الحمل في الفحص الاول: وتمت متابعتها بشكل محتمل و63 في الفحص الثاني في الثلث الثاني و 75 الفحص الثالث في الثلث الاخير من الحمل اللواتي شاركن في الدراسة. بينت الدراسة ان متوسط اعمار المجموعة المدروسة في بداية الدراسة كان بحدود 27,1 ± 5,8 (المدى: 17-30 سنة), تم ملاحظه متوسط مستوى (AFP) وكان مرتفعاً بصورة كبيرة في مجموعة مرضى ما قبل الارجاج الحاد مقارنة بالنساء الخاليات من المرض على مدى الفحوصات الثلاثة. ومن خلال المقارنة بين مستوى (AFP) لمرضى ما قبل الارجاج الحاد والنساء الخاليات من المرض تبين ان مستوى (AFP) كان عاليا في مجموعة مرضى ما قبل الارجاج الحاد مقارنة بالنساء الخاليات من المرض على مدى الفحوصات الثلاثة, كان مستوى (AFP) في الثلث الثاني افضل من الثلثين الاول والثالث, والفحص الاول افضل من الثالث.


Article
SOME HISTOCHEMICAL CHANGES IN THE PLACENTAE OF PREECLAMPSIA
بعض التغيرات الكميائية النسيجية في مشايم مقدمة الأرتعاج

Authors: , RANA M. RAUF رنا رووف --- MUNA Z. ALHAMDANI منى الحمداني --- MAHA A. AL-SAMMAK مها السماك
Journal: Duhok Medical Journal مجلة دهوك الطبية ISSN: ISSN: 20717334 (online)/ ISSN: 20717326 (Print) Year: 2007 Volume: 1 Issue: 1 Pages: 32-41
Publisher: University of Dohuk جامعة دهوك

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Abstract

Background The placenta has been implicated in the pathophysiology of preeclampsia. Preeclampsia is more common in multifetal gestations which have an increased placental mass compared to singleton pregnancies Objective Detecting the effects of preeclampsia on the availability of enzymes in the full term placenta. Methods Two groups of placentae were taken from full term pregnant women immediately after labour, each consisting of ten placentae. The first group are placentae obtained from women having an uneventful pregnancy with no history of disease or complication (as a control group) while the second group consists of placentae obtained from women with a history of preeclampsia.The materials were obtained from Al-Batool and Al-Khansaa Teaching Hospitals in Mosul, between February and July (2006). Results Significant histochemical changes were detected in the placentae of the second group when compared with those from the first group, such changes result from syncytial damage and destruction affecting the preeclamptic placentae, leading to the loss of alkaline phosphatase enzyme with an increase in the amount of the degenerating acid phosphatase enzyme.

الهدف: دراسة بتأثير مقدمة الأرتعاج على توفر الانزيمات المهمة داخل المشيمة.مواد و طرق البحث: اخذت مجموعتين من المشايم الكاملة المدة كل منها تحتوي على عشرة من الحوامل بعد الولادة.المجموعة الاولى تضم مشايم الحوامل اللواتي ليس لديهن اصابة بأي مرض قبل او بعد الحمل, اما المجموعة الثانية فتضم مشايم حوامل مصابات بمقدمة الأرتعاج. أخذت عينات المشايم من مستشفى البتول و الخنساء التعليميين في . الفترة من شباط الى تموز 2006النتائج: وجدت تغيرات مهمة في مشايم المحموعة الثانية وهذا يرجع الى تحطم خلايا الطبقة المخلوية في مشايمالمجموعة الثانية ولهذا وجد ان هناك فقدان في انزيم الفسفاتازالقلوي من هذه الطبقة بالاضافة الى زيادة كميةالفسفاتازالحامضي وهو انزيم يدل على وجود تحلل داخل المشيمة.


Article
Serum Irisin Levels in Normotensive and Preeclamptic Pregnancies

Authors: Lilyan W. Sersam --- Sura Basil Findakly --- Fatin Shallal Farhan
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2018 Volume: 17 Issue: 2 Pages: 80-84
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Background: Early prediction of preeclampsia represents a big dilemma for obstetricians, but the discovery of a novel biomarker highlightsthe way for its prediction during the early stage of the pregnancy. Objective: The objective of this study was to evaluate serum irisin levels in preeclamptic and healthy pregnant women in the third trimester of pregnancy. Materials and Methods: This study was a prospectivecase–control study conducted at Al‑Yarmouk Teaching Hospital during the period from October 1, 2017, to May 1, 2018. Totally 80 pregnantwomen were enrolled in the study; 40 of them were preeclamptic patients and the other 40 were healthy pregnant women assigned as a controlgroup. Serum irisin levels were measured to all participants by enzyme‑linked immunosorbent assay method. The results were compared for both groups. Results: Serum irisin was lower in preeclamptic patients compared to controls (280.7 vs. 311.3 μg/L, respectively), but the difference was not statistically significant as the P value was 0.189. Conclusion: Irisin might be involved as a biomarker for pregnancy‑associated problems such as preeclampsia.

Keywords

Biomarker --- irisin --- preeclampsia


Article
Association between preeclampsia and hyperandrogenemia

Author: Wisam Akram
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2014 Volume: 13 Issue: 2 Pages: 1-6
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Background; Insulin resistance and increased serum free testosteroneare well known to be associated with preeclampsiaType of study; case controlAim of the study; to compare serum levels of free testosterone amonghypertensive preeclamptic women versus controlMethods; two groups were constructed from primigravida womentaken from labor ward. Study group (N=30) were preeclamptic versuscontrol (n=30). For all women serum testosterone was assayed andcompared and correlated to mean arterial blood pressure and othervariables in preeclampsiaResult; serum free testosterone was significantly higher among womenwith preeclampsia compared with control 5.00±0.72 versus 1.28±0.97, P< 0.001. No Significant change was found between serum estriol levelsin both groups. Analysis of co-variants has shown that fetal gender(Male) has no effect on maternal serum testosterone levels.Conclusions; preeclamptic women in the third trimester havesignificantly higher free testosterone serum levels than control women.It is not clear yet whether this increase in free testosterone is related toinsulin resistance in the placenta or other factors. Further studies arerequired to explore the significance of increased testosterone levels inthe blood with prediction of preeclampsia and assessment of itsseverity.


Article
SERUM SOLUBLE FMS-LIKE TYROSINE KINASE-1 (SFLT-1) LEVEL AT THIRD TRIMESTER OF PREGNANCY AND ONE MONTH FOLLOWING DELIVERY IN WOMEN WITH PREECLAMPSIA

Authors: Radhwan M. Hussein رضوان محمد حسين --- Najat A. Hasan نجاة عبد الرزاق حسن --- Bushra J. Al-Rubayae
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2016 Volume: 14 Issue: 1 Pages: 15-24
Publisher: Al-Nahrain University جامعة النهرين

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Background:Preeclampsia is characterized by abnormal vascular response to placentation that is associated with increased systemic vascular resistance, enhanced platelet aggregation, activation of the coagulation system, and endothelial cell dysfunction.Objective:To investigate the serum level of anti angiogenic factor soluble fms-like tyrosine kinase-1 (sFlt-1) in the third trimester of preeclamptic pregnants in relation to the Doppler ultrasonography indices.Methods:One hundred and five pregnant women at the Pediatric and Maternity Teaching Hospital in Hilla City were studied. All of them were in their third trimester and with singleton pregnancy. All participants were reexamined one month following delivery.Results:The body mass index, spot urine protein to creatinine ratios and mean pulsatility index, resistance index), systolic and diastolic blood pressures were increased in preeclamptic groups. Post-delivery systolic and diastolic blood pressures increased in the control pregnant group and significant reduction in the both preeclamptic groups compared with the systolic and diastolic blood pressures at third trimester of pregnancy. sFlt-1 levels were increased in severe than mild preeclampsia and control groups. In post-delivery period, the sflt-1 decreases in the control pregnant, mild and severe preeclamptic groups in comparison to the third trimester. In preeclampsia, the sflt-1 is positively correlated with blood pressure, protein: creatinine ratio, body mass index, resistance index, pulstality index, total serum protein, and negatively correlated with neonatal weight and gestational age at delivery.Conclusion:The changes in anti angiogenic factors sFlt-1 during pregnancy and in post-delivery period stress its role in the pathogenesis of preeclampsia and could be used to predict the disease progression and impact on the outcome of pregnancy.Keywords: Preeclampsia, sFlt-1, Doppler indices.


Article
Doppler Ultrasound Hemodynamic Assessment in Preeclampsia

Author: Azad Saleem Hassan, Maysaloon Shaman Saeed
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2018 Volume: 15 Issue: 2 Pages: 191-194
Publisher: Babylon University جامعة بابل

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Abstract

Background: Preeclampsia (PE) is the main factor in maternal mortality across the world, affecting 5%–8% of pregnant women. The impairmentin placental perfusion due to vascular abnormalities leads to clinical presentations and is detectable by Doppler ultrasound. Objective: Theaim of the study is to assess the hemodynamic changes in pregnant women with and without PE, using Doppler ultrasound of the uterine,the umbilical, and the middle cerebral arteries. Materials and Methods: Forty pregnant women aged 19–40 years old, diagnosed with PE,were recruited from the outpatient gynecology clinic into a case–control study. Their Doppler ultrasound hemodynamic assessment of theuterine artery and its early diastolic notching, the middle cerebral artery, and the umbilical artery was compared to that of 60 matched controlnon‑preeclampsia (non‑PE) pregnant women aged 19–40 years old. Results: The proportions of patients with uterine artery, umbilical artery,and middle cerebral artery Doppler ultrasound abnormalities were 77.5%, 62.5%, and 37.5% in the PE group, compared to nil, 8.3%, and11.7% in the non‑PE women, respectively. Similarly, mean resistance index of each artery and proportions of notch parameters of the uterineartery showed significant differences between PE and non‑PE patients (P < 0.001). Conclusions: Doppler ultrasound assessment in pregnantwomen of the uterine, the umbilical, and the middle cerebral arteries can be used to determine hemodynamic dysfunction associated with PE.


Article
The possible role of cytomegalovirus infection and pro-inflammatory IL_2 cytokine in preeclampsia
الدور المحتمل لعدوى cytomegalovirus و اpro-inflammatory IL_2 cytokine في تسمم الحمل

Authors: Saeed Khulam Hussain --- Payman A. Hamasaeed --- Khonaw Kader Salh --- Razao Kamal Al Barzangy
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2018 Volume: 22 Issue: 1 Pages: 126-133
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and Objective: Fragmentary evidence suggests that trophoblast viral infection may play a role in placental dysfunction leading to complications like Preeclampsia. Among these, placental exposure to CMV induces an inflammatory response that precedes invasive trophoblast cell death. This study aimed to assess the frequency of anti-CMV IgG seropositivity and IL2 level in serum in patients with preeclampsia compared to normotensive control pregnant women.Methods: A total of 90 women were enrolled, of which 60 had preeclampsia and 30 normotensive pregnant women as the control. A serum sample was collected from each subject and was investigated for anti-CMV IgG serostatus and IL-2 concentration using Enzyme-Linked Immunosorbent Assay (ELISA) based kits.Results: In preeclamptic and normotensive pregnant women, 33.3% and 16.6% of the tested sera were seropositive for anti CMV IgG antibodies respectively (P = 0.136). Early onset preeclamptic women revealed a high frequency of anti-CMV seropositivity (80%) when compared with late onset Preeclampsia (20%). Cytokine assessment revealed a higher IL-2 level in preeclamptic women seropositive for anti-CMV IgG although statistically was not significant (P = 0.14), but in normotensive women, the IL-2 level was significantly higher in sera seropositive for anti-CMV IgG (P = 0.02).Conclusion: This study delineates a high frequency of anti-CMV IgG antibodies particularly those with early onset preeclampsia; with no significant difference for the IL-2 level.

Keywords

Preeclampsia --- CMV --- IL-2 cytokine

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