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Article
Protective effects of simvastatin and/or telmisartan on cardiovascular system in patients with mild to moderate chronic obstructive pulmonary disease (COPD).

Authors: Ali, M. H علي محمد هادي --- Kasim, J. Al-Shamma قاسم الشماع --- Qais, A. H قيس
Journal: Al-Mustansiriyah Journal for Pharmaceutical Sciences مجلة المستنصرية للعلوم الصيدلانية ISSN: 18150993 Year: 2012 Volume: 12 Issue: 2 Pages: 161-170
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Abstract:The objective of this study is to evaluate the protective effects ofsimvastatin, telmisartan or their combination on cardiovascular system inpatients with COPD.Eighty patients with mild to moderate COPD were participated in thisstudy. They were recruited into four groups where the first group includes 20patients on an inhaled β2- agonist only (control), the second group includes 20patients on an inhaled β2- agonist plus 20mg/d simvastatin, the third groupincludes 20 patients on an inhaled β2- agonist plus 40mg/d telmisartan and thefourth group includes 20 patients on an inhaled β2- agonist plus combination ofboth simvastatin and telmisartan. Twenty apparently healthy subjects wereselected to be a normal group for comparison. Baseline, 3 and 6 months periodswere used to monitor patients. Assessing the plasma levels of hs-CRP, VCAM-1and lipid profile. ANOVA method for statistics were used to compare theresults.There was a great reduction in hs-CRP and VCAM-1 in addition tomodulation of lipid profile after the use of simvastatin 20mg/d, telmisartan40mg/d and their combination in COPD patients.Simvastatin 20mg/d, telmisartan 40mg/d and their combination exerted aprotective effect on the cardiovascular system in COPD patients after 3 and 6months of therapy by reducing hs-CRP, VCAM-1 and lipid profile.

الخلاصة:إن مرض التهاب الرئتین ألانسدادي المزمن، تلك الحالة المرضیة التي تتمیز بقصور والتهابالمجرى الهوائي وهبوط وظیفة الرئتین لأمد طویل، هو أحد أهم الأسباب التي تنتهي بالوفاة في كل أنحاءالعالم. لقد بینت العدید من الدراسات الوبائیة بان الأشخاص المصابین بمرض التهاب الرئتین ألانسداديالمزمن تكون لدیهم خطورة الإصابة بأمراض الجهاز القلبي الوعائي ثلاثة مرات أعلى من جمهورالأصحاء.ان الهدف من هذه الدراسة هو لتقییم التأثیرات الوقائیة لعقار السمفاستاتین و/أو التلمیسارتان علىالجهاز القلبي الوعائي لمرضى التهاب الرئتین ألانسدادي المزمن البسیط أو المتوسط.تم مشاركة 80 مریضا مصابین بالتهاب الرئتین ألانسدادي المزمن في هذه الدراسة وتم توزیعهمعلى أربعة مجموعات تضمنت المجموعة الأولى 20 مریضا یستخدمون منشقة السالبیوتامول فقط(كمجموعة مقارنة)، المجموعة الثانیة تضمنت 20 مریضا یستخدمون منشقة السالبیوتامول مع عقارالسمفاستاتین 20 ملغ یومیا، المجموعة الثالثة تضمنت 20 مریضا یستخدمون منشقة السالبیوتامول مععقار التلمیسارتان 40 ملغ یومیا وتضمنت المجوعة الرابعة 20 مریضا یستخدمون منشقة السالبیوتامولمع خلیط العقارین معا. تم اختیار 20 شخصا من الأصحاء ظاهریا كمجموعة طبیعیة للمقارنة أیضا. لقدتم مراقبة المرضى عند بدء الدراسة، بعد 3 و 6 أشهر من العلاج. تم قیاس البروتین النشط عاليالحساسیة، جزیئة الالتصاق الوعائیة ومستوى الدهون في الدم.لقد بینت النتائج أن هناك انخفاضا شدیدا في المستویات الدمویة للبروتین النشط عالي الحساسیة،جزیئة الالتصاق الوعائیة ومستوى الدهون في الدم بعد استخدام عقار السمفاستاتین أو التلمیسارتان أوكلیهما.یمكن الاستنتاج بان استخدام عقار السمفاستاتین 20 ملغ یومیا أو التلمیسارتان 40 ملغ یومیا أوكلیهما لمدة 3 و 6 أشهر له تأثیر وقائي على الجهاز القلبي الوعائي لمرضى التهاب الرئتین ألانسداديالمزمن البسیط أو المتوسط.


Article
Molecular Diagnosis of Brucella species in Baghdad
التشخيص الجزيئي لجنس البروسيلا في بغداد

Authors: Ashna Jamal Faik** آشنا جمال فائق** --- Khaled A. Habeb خالد عبد الرزاق حبيب --- Inas Saad mohammed إيناس سعد محمد
Journal: Baghdad Science Journal مجلة بغداد للعلوم ISSN: 20788665 24117986 Year: 2013 Volume: 10 Issue: 1 Pages: 109-115
Publisher: Baghdad University جامعة بغداد

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Abstract

Brucellosis is possess a significant public health problem in Baghdad. In this study, we investigated the potential role of the PCR assay in detection of Brucella species, from patients suspect to have brucellosis, using blood samples in both human and animal.To establish a PCR technique for diagnosis of active brucellosis in our samples, DNA extraction was carried out using a commercial kit, and a laboratory extraction procedure. PCR amplification was done using 1 set of primers: B4/B5 for Brucella species. Extraction of Brucella DNA using the commercial kit was successful. The laboratory extraction was successful and more economic. A total of 178 peripheral blood specimens were collected from patients with high suspected brucellosis, and 15 samples from animals. When PCR technique was applied to blood samples, 13 cases for patients blood and 9 cases for animals blood, were positive for Brucella species.

يشكل داء البروسيلا مشكلة صحية عامة في بغداد. في هذه الدراسة, نحن تقصينا عن الدور الكامن للــ PCR في الكشف عن جنس البروسيلا, من المرضى المشتبه بهم داء البروسيلا, بأستخدام عينات الدم في الأنسان والحيوان. بنى العمل على تقنية الــ PCR لتشخيص داء البروسيلا في كل العينات, إستخلاص الدنا بأستخدام الكت التجاري. تضخيم الــ PCRبأستخدام نوع من البادئات: B4/B5 لجنس البروسيلا .من مجموع 178 عينة دم جمعت من المرضى المحتمل إصابتهم بداء البروسيلا, و 15 عينة من الحيوانات. أظهرت النتائج بأستخدام تقنية الــ PCR , إن النتائج الأيجابية للعينات كانت 13 من دم المرضى من مجموع 178 و 9 من الحيوانات من مجموع 15 كانت مصابة بداء البروسيلا.


Article
Microclimate Performance inDifferent Urban Fabric in Mosul City(eng)
الأداء المناخيالموضعي لأنسجة حضرية مختلفة في مدينة الموصل

Authors: Turki Hassan Ali الدكتور تركي حسن علي --- BahjatRashadShaheen الدكتور بهجت رشاد شاهين
Journal: AL Rafdain Engineering Journal مجلة هندسة الرافدين ISSN: 18130526 Year: 2013 Volume: 21 Issue: 3 Pages: 111-118
Publisher: Mosul University جامعة الموصل

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Abstract

Abstract City of Mosul has a traditional urban core called old city, side by side with a modern fabric adopted by municipal authority since the rapid urbanization which the city had witnessed in the fifties of the last century, the traditional one characterizes with a compact and organic tissue introverted courtyard buildings built with a heavy thick masonry structure, while the modern is open geometric one with wide streets and extraverted buildings build with concrete. This research aim to make a comparative study for the urban micro climate performance (air temperature and relative humidity) in the two deferent urban fabrics (traditional and modern), during both the hottest and the coldest period of the year, using the meteorological data as a reference for evaluating the performance. The way cities are planned and built is therefore important for the global energy use and environmental comfort. So it’s important to study the relationship between urban form and outdoor climate. The preliminary results confirm that the climatic conditions are much more stable in the traditional city than in the modern part of the city, regarding both air temperature and relative humidity. Key words:Urban, Microclimate, Fabric.

لمدينة الموصل نواة تقليدية حضرية تدعى المدينة القديمة، وتتواجد جنبا الى جنب مع النسيج الحديث الذي اعتمدته السلطات البلدية منذ التحضر السريع الذي شهدته المدينة في خمسينات القرن الماضي، يتميز جزؤها التقليدي بنسيج عضوي متضام وبمباني متوجه نحو فناء ات داخلية مع بني انشائية سميكة وثقيلة، في حين يتميز جزؤها الحديث بنسيج هندسي مفتوح أي بشوارع عريضة وواسعة ومباني متجه نحو الخارج وببنى اشائية خرسانية. هذا البحث يهدف إلى إجراء دراسة مقارنة لأداء المناخ الموضعي في المناطق الحضرية (درجة حرارة الهواء والرطوبة النسبية) في اثنين من الانسجة الحضرية (التقليدية والحديثة)، وخلال فترتي الحر والبرد الشديدين من السنة، وباستخدام بيانات الأرصاد الجوية كمرجع لتقييم الأداء. ان طريقة تخطيط المدن وبنائها لهما دور مهم في الراحة الحرارية لساكني هذه المدن فضلا عن مجمل استخدام الطاقة. لذلك من المهم دراسة العلاقة بين الشكل الحضري والمناخ الموضعي للفضاءات الحضرية المفتوحة. النتائج الأولية تؤكد أن المؤشرات المناخية في المدينة التقليدية كانت افضل وأكثر استقرارا مما كان عليه في الجزء الحديث من المدينة، وعلى حد سواء فيما يتعلق بدرجة حرارة الهواء أوالرطوبة النسبية.


Article
Studying the Incidence of Pseudomonas Species as A Causative Agent of Otitis in Iraqi Patients

Authors: Nahi Yousif Yaseen ناهي يوسف ياسين --- Dawood Salim Edan داود سالم عيدان الطائي
Journal: Al-Mustansiriyah Journal for Pharmaceutical Sciences مجلة المستنصرية للعلوم الصيدلانية ISSN: 18150993 Year: 2014 Volume: 14 Issue: 1 Pages: 136-142
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

AbstractOtitis can affect the inner or outer parts of the ear. Sometimes it is difficult in a rapid response to the treatment. The condition is classified according to occurrence suddenly andfor a short time (acute) or repeatedly over a long period (chronic).The types of treatmentsand sustainability were depended on most cases on bacterial infections.Twenty three samples of Iraqi patients infected with otits were collected from Yarmook hospital. Theaural exudates screened to determine whether the infection was external or interior ear onMacConkey agar, and the negative Gram bacteria has been selected due to its higher connectivitywith human diseases.The growth colonies diagnosed by assay of biochemical reaction and we geneticallyconfirmed the availability of Pseudomonas aeruginosa by conventional PCR. The diversity of bacterialinfection showed the dominancy of Pseudomonas spp. (60%) and Pseudomonas aeruginosa(17%) in it compared to other bacteria such as Proteus Vulgaris (13%), Morganella morganii(4%) and Klebsiella spp. (4%).

الخلاصة:ان التھاب الاذن قد یكون داخلي او خارجي یصعب شفاءة وعلاجة بصورة سریعة ویتوقف ذلك على مدى ونوعوظروف الاصابة اي عندما تكون الاصابة حدیثة تكون استجابتھا للعلاج اسرع واكثر فاعلیة من الاصابة القدیمة وھذا یعتمدایضا على نوع البكتریا المسببة للالتھاب، ولمعرفة اغلب البكتریا المسببة لالتھاب الاذن تم جمع عینات من مرضى مصابونبالتھابات الاذن من مستشفى الیرموك من حزیران 2013 وحتى ایلول من نفس العام تم زرع وتنمیة المسحات مباشرة علىاطباق المكاونكي لتنمیة البكتریا لسالبة لصبغة كرام فقط وذلك لانھا مقاومة اكثر للمضادات الحیویة من البكتریا الموجبة لصبغةكرام. بعد التنمیة تم اجراء فحوصات كیمیائیة حیویة لمعرفة نوع البكتریا وتم تاكید منھا الاخطر امراضیة بواسطة تفاعلالبلمرة المتسلسل جینیا .،( بنسبة (% 60 Pseudomonas spp. اظھرت النتائج تنوع في البكتریا المسببة لالتھاب الاذن مع تفوق لاصاباتبنسبة (% 4) واصابات Klebsiella spp. بنسبة ( 17 %) مقارنة باصابات Pseudomonas aeruginosa وبكتریا.(% بنسبة ( 4 Morganella morganii بنسبة ( 13 %) و Proteus Vulgaris


Article
A Prospective Randomized Controlled Study of Phototherapy Using Blue LED and Conventional Phototherapy in Neonatal Hyperbilirubinemia

Authors: Nada Ail Ahmed AL-Ali --- Ghaith Wadah Hamdoon
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2013 Volume: 12 Issue: supplement Pages: 668-674
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:High intensity light emitting diodes (LEDs) are being studied as possible light sources for the phototherapy of neonatal jaundice, as they can emit high intensity light of narrow wavelength band in the blue region of the visible light spectrum corresponding to the spectrum of maximal bilirubin absorption. We used a new blue gallium nitride LED phototherapy unit with high intensity, and compared its efficacy to commercially used halogen quartz phototherapy device. The prototype device with two focused arrays, each with 20blue LEDs, generated greater irradiance than the conventional device tested. OBJECTIVE:To determine the efficacy of blue LED light versus conventional phototherapy lamp in treatment of neonatal jaundice.PATIENTS AND METHODS:A total of 101 jaundiced otherwise healthy, term and preterm neonate who had hyperbilirubinemia were prospectively randomized to either LED (n=57) or conventional phototherapy (n=44). Entry criteria to phototherapy followed the American Academy of Pediatrics’ Practice Parameter.RESULTS:One hundred and one neonate were included in this study , the mean rate of TSB lowering increase with increase age was significant in LED group (p value =0.000), according to the maturity the mean rate of TSB lowering increase with increase age also was significant in LED group (p- value= 0.000), no significant correlation was found in regarding birth weight and rate of lowering of TSB (P=0.263),there where a significant correlation between mean rate of TSB lowering and initial TSB level in LED group(P-value= 0.000 )and lastly there was a significant higher rate of lowering of TSB in LED group than those with conventional one.CONCLUSION: A blue LED phototherapy unit showed higher efficacy in bilirubin photodegradation compared to that of commercially used halogen quartz phototherapy device. And a significant correlation between the rate of lowering of TSB and each of (age, maturity , weight and initial TSB level) in the two groups. Additional studies will be necessary to prove its clinical efficacy..


Article
Complications of Bone Marrow Aspiration and Biopsy: a New Unexpected Ris

Author: Najlaa Badr Alawadi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2013 Volume: 12 Issue: supplement Pages: 712-715
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Bone marrow examination represents an essential tool for diagnosis and monitoring of haematological and non-haematological disorders. Although some hazards are recognized, bone marrow aspiration and trephine biopsy are generally thought to be safe procedures. OBJECTIVE:The aim of this study is to identify the possible complications associated with the bone marrow aspiration and biopsy procedures.METHODS: In this study, 2156 cases of bone marrow aspiration with or without trephine biopsy were done in Merjan Teaching Hospital, Babil governorate, Iraq during a five year period from 1st Feb 2006 to 1st Feb 2011. These procedures were done under local anesthesia. The complications associated with these procedures were reported.RESULTS: A new previously unreported complication was seen in 2 patients as they developed sudden apnea and loss of consciousness.The final diagnosis in both patients was acute lymphoblastic leukemia with huge mediastinal widening and they were lying in prone position during the procedure.Bleeding was seen in 2/2156 (0.09%) cases. Prolonged pain was documented in one case. No infection was reported.CONCLUSION: Bone marrow examination is generally safe, however apnea and loss of consciousness can occur in patients with a huge mediastinal mass compressing trachea and/or major chest vessels when the procedure is done in prone position.KEY WORDS: Bone marrow aspiration.


Article
Colonoscopy at the National Center for Early Detection of Cancer: Evaluating Indications and Diagnostic Yield

Authors: Maral F.Thabit --- Mohammad A. Hashim --- Hani M.S.M.Kadhum Al-Ansari
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2014 Volume: 13 Issue: 1 Pages: 1-6
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND: Colonoscopic procedure is an accepted modality for the evaluation of colonic disease and an accurate procedure in the workup and screening of patients with lower gastrointestinal symptoms. The clinical spectrum and diagnostic yield depend upon the indications for the procedure.OBJECTIVE:To identify the yield of the major indications for the procedure, and the pattern of colon pathology in study population.Study design and Setting: A retrospective study was conducted over a period of 6 months extending From 18th November 2011 to 18th May 2012 at the National Center for Early Detection of Cancer by reviewing the records of 224 colonoscopy examinations which were done in the center between January 2010 and December 2012.RESULTS: The patients comprised 66 females (29.4%) and 158 males (70.6%) and their mean ages was (46.6) years. There were 114 patients (50.9%) who were aged less than 50 years. Complete examination to the caecum was possible in 114 cases (50.9%).Pathological findings were identified in 127patients (56.7%). The diagnostic yield of patients referred for lower abdominal pain and alternation in bowel habit was low, of (29.72%) and (46.66%), respectively. The yield was high for those with lower gastrointestinal bleeding (71.15%), diarrhea (61.9%), category 'others' (65%). The diagnostic pattern showed that non-specific colitis and double colonic lesions were identified in (29.13%), and (16.53%) respectively. Colonic cancer was diagnosed in 19patients (14.96%), ulcerative colitis in 9patients (7.08%), polyps were detected in13patients (10.23%), and internal hemorrhoids in17patients (13.38%).CONCLUSION: The highest diagnostic yield of colonoscopy procedure was for lower gastrointestinal bleeding and diarrhea and the main pattern of colonic pathology was nonspecific colitis and double colonic lesions.


Article
Comprative Study between LAT and Elisa in Detection of Toxoplasmosis in Groups of Women

Authors: Lazim H. Al-Taie --- Abed. A. Al-Shaw --- Yasser Sh. Mohammed
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2014 Volume: 13 Issue: 1 Pages: 51-54
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND: Toxoplasmosis is a zoonotic disease caused by the parasitic protozoan Toxoplasma gondii . This parasite is an obligate intracellular organism and is found in two forms in humans. widespread throughout the world, approximately half a billion humans have antibody to T. gondii. OBJECTIVE:This study aimed to compare the efficiency of two methods in diagnosis of toxoplasmposis in pregnant and non-pregnant women.METHODS: Blood samples were collected from 350 (15-46 year-old, 100 pregnant and 250 non-pregnant) females. Two serological methods were used: Latex agglutination test (LAT) and Enzyme linked immune-sorbent assay for IgM detection (ELISA). RESULTS: The study showed that 38.86% of women had given positive results for LAT, of which 31 were pregnant and 105 were non-pregnant, while only 14.28% of the total subjects had given positive results for ELISA.CONCLUSION: These results indicate that positive sera for LAT should be further investigate by more reliable method in order to confirm the infection with toxoplasmosis.


Article
The Role of anti –DNA Abs. in Chronic Renal Failure in Diabetes Mellitus Type I and Type II

Authors: Suha A.AL-Fakhar --- Manal Kamal Rasheed --- Mohammed Kamal Rasheed
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2014 Volume: 13 Issue: 2 Pages: 165-168
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT: BACKGROUND: Diabetic nephropathy (DN) is the leading cause of CKD and end-stage renal disease (ESRD). CKD is characterized by a progressive loss of renal function, chronic inflammationOBJECTIVE:To compare the relationship between the anti –DNA Abs in diabetic patients type 1 and type 2 and their relation with chronic renal failure.METHODE:The ELISA methods was used to detect the presence of anti-DNA –Abs in sera of diabetic patients with type 1 and type 2 D.M. with CRF.RESULT: The concentration of anti-DNA Abs. were more in type II D.M. patients with CRF than those with type I D.M. without CRF and control group. CONCLUSION:The anti-DNA Abs. play an important role in the CRF in patients with long duration of D.M. type II ,while in patients with short duration of D.M. type I , anti-DNA Abs. do not play a role.


Article
The Pattern of Drug Resistance in Iraqi Pulmonary Tuberculosis Patients Referred to the Specialized Center for Chest and Respiratory Disease

Authors: Arwa Tahrir Ramadhan --- Ahmed Asmer Mankhi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2014 Volume: 13 Issue: 2 Pages: 181-186
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Tuberculosis control in the world today must face the challenge posed by the global spread of Mycobacterium tuberculosis strains that are resistant to standard anti-TB drugs. OBJECTIVE:This study was done to identify the drug resistance to the first line antituberculosis drugs in Iraqi Patients.METHODS:This prospective study conducted in National Center for Tuberculosis and Chest Diseases in Baghdad from January 2012 to August 2012.For study the demographic characters and drug sensitivity test (DST) in a total number of 155 case of sputum smear positive pulmonary tuberculosis (97 old and58 New) For each patient 3 consecutive sputum samples were taken for direct smear microscopy and cultured to test drug resistance for First Line anti-TB drugs (INH, Rifampicin ,Ethambutol and pyrazinamide). RESULTS:In this study we found ethambutol resistant in 20(34.5%)of samples in the new group and in 49(50.5%) of samples in old group. On the other hand,our study showed that resistance to rifampicin in the new group was 58.6% while in the old group was 75.3%. In regard to the INH drug resistance it seen in 72.4% of samples in new group and in 83.5% of samples in old group.This study showed that reistance to streptomycin present in 44.8% of new group samples and in 55.7% of old group samples .The pattern of drug resistance according to patient group show high frequency of polyresistance 82 cases in both patient group(new and old) and low frequency in other group of resistance 14 cases,and MDR type of resistance in total of 17 cases .CONCLUSION:The study showed 11%(17/155) of patients with pulmonary tuberculosis in this sample of patients had multidrug resistance MDR tuberculosis . .

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