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The effect of a drug pentostam in male laboratory mice infected with diabetes and Leishmania donovani parasite
تأثیر عقار البنتوستام في ذكور الفئران المختبریة المصابة بداء السكري

Authors: أفراح علي عبد الامیر العزاوي --- فاضل عباس العبادي
Journal: Journal of Education for Pure Science مجلة التربية للعلوم الصرفة ISSN: 20736592 Year: 2017 Volume: 7 Issue: 3 Pages: 57-72
Publisher: Thi-Qar University جامعة ذي قار

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Abstract

AbstractThe present study was conducted to determine the effect of a drug pentostam on laboratory animalsinfected with diabetes and Leishmania donovani, it is done through the use of criteria blood andtissue sections of the liver and spleen and the comparison group of negative control, mice treatedgroup showed the drug and substance alloxan and infected parasite that there was no significantdifference (p < 0.05) in the total number of red blood cells and a significant decrease (p < 0.05) inthe neutrophil and acidophilus and lymphocytes and recorded a significant decrease (p < 0.05), whilelymphocytes showed moral high (p < 0.05) in the total number of cells, white blood while onlymonocyte and basophil did not record any significant differences (p < 0.05) for all groups as well ashistological sections of the liver and a clear expansion in the Hepatic sinusoids with themultiplication of Cofer cells and infiltration clear of inflammatory cells of the type Eosinophil andPhagocyte showed Lama's spleen observed the amyloid gathered around the white pulp with amultiplication of red pulp with the disappearance septa within the lymphoid tissue and the presenceof giant cell nucleus and the exhaustion of a clear white pulp.

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